EC 3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase
HydrolasesOpen in Browse
CatLog read 56 records for EC 3.1.4.17 from 4 papers, for 4 organisms. Names in these papers: phosphodiesterase-1 (yPDE1), phosphodiesterase 3A (PDE3A), catalytic region, 3',5'-cyclic-nucleotide phosphodiesterase (HP1042), Rv0805 metallophosphodiesterase.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 43 records for EC 3.1.4.17 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.1.4.17 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Dual specificity and novel structural folding of yeast phosphodiesterase-1 for hydrolysis of second messengers cyclic adenosine and guanosine 3',5'-monophosphate | Saccharomyces cerevisiae | 36 |
| New insights from the structure-function analysis of the catalytic region of human platelet phosphodiesterase 3A: a role for the unique 44-amino acid insert | Homo sapiens | 14 |
| A phosphate-binding histidine of binuclear metallophosphodiesterase enzymes is a determinant of 2',3'-cyclic nucleotide phosphodiesterase activity | Mycobacterium tuberculosis | 3 |
| Biochemical Characterization of Hypothetical Proteins from Helicobacter pylori | Helicobacter pylori | 3 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| 3',5'-cyclic-nucleotide phosphodiesterase (HP1042) | Helicobacter pylori | adenosine 3',5'-cyclic monophosphate | 33.47 | 0.88 | 38 | pH 4.5, 30 °C | PMID 23825549 | Open record: 3',5'-cyclic-nucleotide phosphodiesterase (HP1042), adenosine 3',5'-cyclic monophosphate |
| 3',5'-cyclic-nucleotide phosphodiesterase (HP1042) | Helicobacter pylori | bis(4-nitrophenyl) phosphate | 18.08 | 0.53 | 34.1 | pH 4.5, 30 °C | PMID 23825549 | Open record: 3',5'-cyclic-nucleotide phosphodiesterase (HP1042), bis(4-nitrophenyl) phosphate |
| 3',5'-cyclic-nucleotide phosphodiesterase (HP1042) | Helicobacter pylori | guanosine 3',5'-cyclic monophosphate | 15.95 | 0.82 | 19.5 | pH 4.5, 30 °C | PMID 23825549 | Open record: 3',5'-cyclic-nucleotide phosphodiesterase (HP1042), guanosine 3',5'-cyclic monophosphate |
| phosphodiesterase 3A (PDE3A), catalytic region | Homo sapiens | adenosine 3',5'-cyclic monophosphate | 1.78 | 2.3 × 10⁻⁴ | 7.78 × 10³ | pH 7.8, 30 °C | PMID 16873361 | Open record: phosphodiesterase 3A (PDE3A), catalytic region, adenosine 3',5'-cyclic monophosphate |
| phosphodiesterase 3A (PDE3A), catalytic regionvariant C816S | Homo sapiens | adenosine 3',5'-cyclic monophosphate | 0.085 | 3.4 × 10⁻⁴ | 250 | pH 7.8, 30 °C | PMID 16873361 | Open record: phosphodiesterase 3A (PDE3A), catalytic region variant C816S, adenosine 3',5'-cyclic monophosphate |
| phosphodiesterase 3A (PDE3A), catalytic regionvariant D811A | Homo sapiens | adenosine 3',5'-cyclic monophosphate | 1.36 | 1.7 × 10⁻⁴ | 8.02 × 10³ | pH 7.8, 30 °C | PMID 16873361 | Open record: phosphodiesterase 3A (PDE3A), catalytic region variant D811A, adenosine 3',5'-cyclic monophosphate |
| phosphodiesterase 3A (PDE3A), catalytic regionvariant D812A | Homo sapiens | adenosine 3',5'-cyclic monophosphate | 0.5 | 2 × 10⁻⁴ | 2.5 × 10³ | pH 7.8, 30 °C | PMID 16873361 | Open record: phosphodiesterase 3A (PDE3A), catalytic region variant D812A, adenosine 3',5'-cyclic monophosphate |
| phosphodiesterase 3A (PDE3A), catalytic regionvariant G815A | Homo sapiens | adenosine 3',5'-cyclic monophosphate | 0.867 | 2.6 × 10⁻⁴ | 3.4 × 10³ | pH 7.8, 30 °C | PMID 16873361 | Open record: phosphodiesterase 3A (PDE3A), catalytic region variant G815A, adenosine 3',5'-cyclic monophosphate |
| phosphodiesterase 3A (PDE3A), catalytic regionvariant H782A | Homo sapiens | adenosine 3',5'-cyclic monophosphate | 0.223 | 4.5 × 10⁻⁴ | 500 | pH 7.8, 30 °C | PMID 16873361 | Open record: phosphodiesterase 3A (PDE3A), catalytic region variant H782A, adenosine 3',5'-cyclic monophosphate |
| phosphodiesterase 3A (PDE3A), catalytic regionvariant H796A | Homo sapiens | adenosine 3',5'-cyclic monophosphate | 1.656 | 2 × 10⁻⁴ | 8.28 × 10³ | pH 7.8, 30 °C | PMID 16873361 | Open record: phosphodiesterase 3A (PDE3A), catalytic region variant H796A, adenosine 3',5'-cyclic monophosphate |
| phosphodiesterase 3A (PDE3A), catalytic regionvariant H798A | Homo sapiens | adenosine 3',5'-cyclic monophosphate | 1.013 | 2.5 × 10⁻⁴ | 4.14 × 10³ | pH 7.8, 30 °C | PMID 16873361 | Open record: phosphodiesterase 3A (PDE3A), catalytic region variant H798A, adenosine 3',5'-cyclic monophosphate |
| phosphodiesterase 3A (PDE3A), catalytic regionvariant K805A | Homo sapiens | adenosine 3',5'-cyclic monophosphate | 0.763 | 2.7 × 10⁻⁴ | 2.88 × 10³ | pH 7.8, 30 °C | PMID 16873361 | Open record: phosphodiesterase 3A (PDE3A), catalytic region variant K805A, adenosine 3',5'-cyclic monophosphate |
| phosphodiesterase 3A (PDE3A), catalytic regionvariant S804A | Homo sapiens | adenosine 3',5'-cyclic monophosphate | 0.69 | 2.8 × 10⁻⁴ | 2.51 × 10³ | pH 7.8, 30 °C | PMID 16873361 | Open record: phosphodiesterase 3A (PDE3A), catalytic region variant S804A, adenosine 3',5'-cyclic monophosphate |
| phosphodiesterase 3A (PDE3A), catalytic regionvariant T810A | Homo sapiens | adenosine 3',5'-cyclic monophosphate | 0.369 | 5.3 × 10⁻⁴ | 690 | pH 7.8, 30 °C | PMID 16873361 | Open record: phosphodiesterase 3A (PDE3A), catalytic region variant T810A, adenosine 3',5'-cyclic monophosphate |
| phosphodiesterase 3A (PDE3A), catalytic regionvariant Y807A | Homo sapiens | adenosine 3',5'-cyclic monophosphate | 0.84 | 0.00679 | 120 | pH 7.8, 30 °C | PMID 16873361 | Open record: phosphodiesterase 3A (PDE3A), catalytic region variant Y807A, adenosine 3',5'-cyclic monophosphate |
| phosphodiesterase 3A (PDE3A), catalytic regionvariant Y807C | Homo sapiens | adenosine 3',5'-cyclic monophosphate | 1.05 | 1.6 × 10⁻⁴ | 6.58 × 10³ | pH 7.8, 30 °C | PMID 16873361 | Open record: phosphodiesterase 3A (PDE3A), catalytic region variant Y807C, adenosine 3',5'-cyclic monophosphate |
| phosphodiesterase 3A (PDE3A), catalytic regionvariant Y814A | Homo sapiens | adenosine 3',5'-cyclic monophosphate | 0.231 | 6.5 × 10⁻⁴ | 360 | pH 7.8, 30 °C | PMID 16873361 | Open record: phosphodiesterase 3A (PDE3A), catalytic region variant Y814A, adenosine 3',5'-cyclic monophosphate |
| phosphodiesterase-1 (yPDE1) | Saccharomyces cerevisiae | adenosine 3',5'-cyclic monophosphate10 mM MgCl2 in assay buffer | — | 0.0988 | — | pH 7.5 | PMID 25050706 | Open record: phosphodiesterase-1 (yPDE1), adenosine 3',5'-cyclic monophosphate |
| phosphodiesterase-1 (yPDE1) | Saccharomyces cerevisiae | adenosine 3',5'-cyclic monophosphate10 mM MgCl2 in assay buffer | 21 | — | — | pH 7.5 | PMID 25050706 | Open record: phosphodiesterase-1 (yPDE1), adenosine 3',5'-cyclic monophosphate |
| phosphodiesterase-1 (yPDE1) | Saccharomyces cerevisiae | adenosine 3',5'-cyclic monophosphate10 mM MgCl2 in assay buffer | — | — | 213 | pH 7.5 | PMID 25050706 | Open record: phosphodiesterase-1 (yPDE1), adenosine 3',5'-cyclic monophosphate |
| phosphodiesterase-1 (yPDE1) | Saccharomyces cerevisiae | adenosine 3',5'-cyclic monophosphate0.01 mM ZnCl2 in assay buffer | — | 0.1157 | — | pH 7.5 | PMID 25050706 | Open record: phosphodiesterase-1 (yPDE1), adenosine 3',5'-cyclic monophosphate |
| phosphodiesterase-1 (yPDE1) | Saccharomyces cerevisiae | adenosine 3',5'-cyclic monophosphate0.01 mM ZnCl2 in assay buffer | 17.4 | — | — | pH 7.5 | PMID 25050706 | Open record: phosphodiesterase-1 (yPDE1), adenosine 3',5'-cyclic monophosphate |
| phosphodiesterase-1 (yPDE1) | Saccharomyces cerevisiae | adenosine 3',5'-cyclic monophosphate0.01 mM ZnCl2 in assay buffer | — | — | 150 | pH 7.5 | PMID 25050706 | Open record: phosphodiesterase-1 (yPDE1), adenosine 3',5'-cyclic monophosphate |
| phosphodiesterase-1 (yPDE1) | Saccharomyces cerevisiae | adenosine 3',5'-cyclic monophosphate2 mM MnCl2 in assay buffer | — | 0.1175 | — | pH 7.5 | PMID 25050706 | Open record: phosphodiesterase-1 (yPDE1), adenosine 3',5'-cyclic monophosphate |
| phosphodiesterase-1 (yPDE1) | Saccharomyces cerevisiae | adenosine 3',5'-cyclic monophosphate2 mM MnCl2 in assay buffer | 11.8 | — | — | pH 7.5 | PMID 25050706 | Open record: phosphodiesterase-1 (yPDE1), adenosine 3',5'-cyclic monophosphate |
| phosphodiesterase-1 (yPDE1) | Saccharomyces cerevisiae | adenosine 3',5'-cyclic monophosphate2 mM MnCl2 in assay buffer | — | — | 100 | pH 7.5 | PMID 25050706 | Open record: phosphodiesterase-1 (yPDE1), adenosine 3',5'-cyclic monophosphate |
| phosphodiesterase-1 (yPDE1) | Saccharomyces cerevisiae | adenosine 3',5'-cyclic monophosphateno divalent metal ion added to assay buffer | — | 0.1101 | — | pH 7.5 | PMID 25050706 | Open record: phosphodiesterase-1 (yPDE1), adenosine 3',5'-cyclic monophosphate |
| phosphodiesterase-1 (yPDE1) | Saccharomyces cerevisiae | adenosine 3',5'-cyclic monophosphateno divalent metal ion added to assay buffer | 16.9 | — | — | pH 7.5 | PMID 25050706 | Open record: phosphodiesterase-1 (yPDE1), adenosine 3',5'-cyclic monophosphate |
| phosphodiesterase-1 (yPDE1) | Saccharomyces cerevisiae | adenosine 3',5'-cyclic monophosphateno divalent metal ion added to assay buffer | — | — | 153 | pH 7.5 | PMID 25050706 | Open record: phosphodiesterase-1 (yPDE1), adenosine 3',5'-cyclic monophosphate |
| phosphodiesterase-1 (yPDE1) | Saccharomyces cerevisiae | adenosine 3',5'-cyclic monophosphateprotein dialyzed three times against 50 mM Tris-HCl (pH 7.5) | — | 0.0812 | — | pH 7.5 | PMID 25050706 | Open record: phosphodiesterase-1 (yPDE1), adenosine 3',5'-cyclic monophosphate |
| phosphodiesterase-1 (yPDE1) | Saccharomyces cerevisiae | adenosine 3',5'-cyclic monophosphateprotein dialyzed three times against 50 mM Tris-HCl (pH 7.5) | 14.3 | — | — | pH 7.5 | PMID 25050706 | Open record: phosphodiesterase-1 (yPDE1), adenosine 3',5'-cyclic monophosphate |
| phosphodiesterase-1 (yPDE1) | Saccharomyces cerevisiae | adenosine 3',5'-cyclic monophosphateprotein dialyzed three times against 50 mM Tris-HCl (pH 7.5) | — | — | 176 | pH 7.5 | PMID 25050706 | Open record: phosphodiesterase-1 (yPDE1), adenosine 3',5'-cyclic monophosphate |
| phosphodiesterase-1 (yPDE1) | Saccharomyces cerevisiae | adenosine 3',5'-cyclic monophosphateprotein dialyzed three times against 50 mM Tris-HCl (pH 7.5) | — | 0.0773 | — | pH 7.5 | PMID 25050706 | Open record: phosphodiesterase-1 (yPDE1), adenosine 3',5'-cyclic monophosphate |
| phosphodiesterase-1 (yPDE1) | Saccharomyces cerevisiae | adenosine 3',5'-cyclic monophosphateprotein dialyzed three times against 50 mM Tris-HCl (pH 7.5) | 11.1 | — | — | pH 7.5 | PMID 25050706 | Open record: phosphodiesterase-1 (yPDE1), adenosine 3',5'-cyclic monophosphate |
| phosphodiesterase-1 (yPDE1) | Saccharomyces cerevisiae | adenosine 3',5'-cyclic monophosphateprotein dialyzed three times against 50 mM Tris-HCl (pH 7.5) | — | — | 144 | pH 7.5 | PMID 25050706 | Open record: phosphodiesterase-1 (yPDE1), adenosine 3',5'-cyclic monophosphate |
| phosphodiesterase-1 (yPDE1) | Saccharomyces cerevisiae | guanosine 3',5'-cyclic monophosphate10 mM MgCl2 in assay buffer | — | 0.0968 | — | pH 7.5 | PMID 25050706 | Open record: phosphodiesterase-1 (yPDE1), guanosine 3',5'-cyclic monophosphate |
| phosphodiesterase-1 (yPDE1) | Saccharomyces cerevisiae | guanosine 3',5'-cyclic monophosphate10 mM MgCl2 in assay buffer | 15.1 | — | — | pH 7.5 | PMID 25050706 | Open record: phosphodiesterase-1 (yPDE1), guanosine 3',5'-cyclic monophosphate |
| phosphodiesterase-1 (yPDE1) | Saccharomyces cerevisiae | guanosine 3',5'-cyclic monophosphate10 mM MgCl2 in assay buffer | — | — | 156 | pH 7.5 | PMID 25050706 | Open record: phosphodiesterase-1 (yPDE1), guanosine 3',5'-cyclic monophosphate |
| phosphodiesterase-1 (yPDE1) | Saccharomyces cerevisiae | guanosine 3',5'-cyclic monophosphate0.01 mM ZnCl2 in assay buffer | — | 0.1048 | — | pH 7.5 | PMID 25050706 | Open record: phosphodiesterase-1 (yPDE1), guanosine 3',5'-cyclic monophosphate |
| phosphodiesterase-1 (yPDE1) | Saccharomyces cerevisiae | guanosine 3',5'-cyclic monophosphate0.01 mM ZnCl2 in assay buffer | 10.8 | — | — | pH 7.5 | PMID 25050706 | Open record: phosphodiesterase-1 (yPDE1), guanosine 3',5'-cyclic monophosphate |
| phosphodiesterase-1 (yPDE1) | Saccharomyces cerevisiae | guanosine 3',5'-cyclic monophosphate0.01 mM ZnCl2 in assay buffer | — | — | 103 | pH 7.5 | PMID 25050706 | Open record: phosphodiesterase-1 (yPDE1), guanosine 3',5'-cyclic monophosphate |
| phosphodiesterase-1 (yPDE1) | Saccharomyces cerevisiae | guanosine 3',5'-cyclic monophosphate2 mM MnCl2 in assay buffer | — | 0.1913 | — | pH 7.5 | PMID 25050706 | Open record: phosphodiesterase-1 (yPDE1), guanosine 3',5'-cyclic monophosphate |
| phosphodiesterase-1 (yPDE1) | Saccharomyces cerevisiae | guanosine 3',5'-cyclic monophosphate2 mM MnCl2 in assay buffer | 14.3 | — | — | pH 7.5 | PMID 25050706 | Open record: phosphodiesterase-1 (yPDE1), guanosine 3',5'-cyclic monophosphate |
| phosphodiesterase-1 (yPDE1) | Saccharomyces cerevisiae | guanosine 3',5'-cyclic monophosphate2 mM MnCl2 in assay buffer | — | — | 75 | pH 7.5 | PMID 25050706 | Open record: phosphodiesterase-1 (yPDE1), guanosine 3',5'-cyclic monophosphate |
| phosphodiesterase-1 (yPDE1) | Saccharomyces cerevisiae | guanosine 3',5'-cyclic monophosphateno divalent metal ion added to assay buffer | — | 0.1047 | — | pH 7.5 | PMID 25050706 | Open record: phosphodiesterase-1 (yPDE1), guanosine 3',5'-cyclic monophosphate |
| phosphodiesterase-1 (yPDE1) | Saccharomyces cerevisiae | guanosine 3',5'-cyclic monophosphateno divalent metal ion added to assay buffer | 11.8 | — | — | pH 7.5 | PMID 25050706 | Open record: phosphodiesterase-1 (yPDE1), guanosine 3',5'-cyclic monophosphate |
| phosphodiesterase-1 (yPDE1) | Saccharomyces cerevisiae | guanosine 3',5'-cyclic monophosphateno divalent metal ion added to assay buffer | — | — | 113 | pH 7.5 | PMID 25050706 | Open record: phosphodiesterase-1 (yPDE1), guanosine 3',5'-cyclic monophosphate |
| phosphodiesterase-1 (yPDE1) | Saccharomyces cerevisiae | guanosine 3',5'-cyclic monophosphateprotein dialyzed three times against 50 mM Tris-HCl (pH 7.5) | — | 0.1474 | — | pH 7.5 | PMID 25050706 | Open record: phosphodiesterase-1 (yPDE1), guanosine 3',5'-cyclic monophosphate |
| phosphodiesterase-1 (yPDE1) | Saccharomyces cerevisiae | guanosine 3',5'-cyclic monophosphateprotein dialyzed three times against 50 mM Tris-HCl (pH 7.5) | 12.1 | — | — | pH 7.5 | PMID 25050706 | Open record: phosphodiesterase-1 (yPDE1), guanosine 3',5'-cyclic monophosphate |
| phosphodiesterase-1 (yPDE1) | Saccharomyces cerevisiae | guanosine 3',5'-cyclic monophosphateprotein dialyzed three times against 50 mM Tris-HCl (pH 7.5) | — | — | 82 | pH 7.5 | PMID 25050706 | Open record: phosphodiesterase-1 (yPDE1), guanosine 3',5'-cyclic monophosphate |
| phosphodiesterase-1 (yPDE1) | Saccharomyces cerevisiae | guanosine 3',5'-cyclic monophosphateprotein dialyzed three times against 50 mM Tris-HCl (pH 7.5) | — | 0.1539 | — | pH 7.5 | PMID 25050706 | Open record: phosphodiesterase-1 (yPDE1), guanosine 3',5'-cyclic monophosphate |
| phosphodiesterase-1 (yPDE1) | Saccharomyces cerevisiae | guanosine 3',5'-cyclic monophosphateprotein dialyzed three times against 50 mM Tris-HCl (pH 7.5) | 11.7 | — | — | pH 7.5 | PMID 25050706 | Open record: phosphodiesterase-1 (yPDE1), guanosine 3',5'-cyclic monophosphate |
| phosphodiesterase-1 (yPDE1) | Saccharomyces cerevisiae | guanosine 3',5'-cyclic monophosphateprotein dialyzed three times against 50 mM Tris-HCl (pH 7.5) | — | — | 76 | pH 7.5 | PMID 25050706 | Open record: phosphodiesterase-1 (yPDE1), guanosine 3',5'-cyclic monophosphate |
| Rv0805 metallophosphodiesterase | Mycobacterium tuberculosis | 4-nitrophenyl phosphate | 0.55 | 1.7 | 0.32 calc. | pH 8.5, 37 °C | PMID 18757371 | Open record: Rv0805 metallophosphodiesterase, 4-nitrophenyl phosphate |
| Rv0805 metallophosphodiesterase | Mycobacterium tuberculosis | adenosine 2',3'-cyclic phosphate | 2.8 | 1.6 | 1.8 calc. | pH 8.5, 37 °C | PMID 18757371 | Open record: Rv0805 metallophosphodiesterase, adenosine 2',3'-cyclic phosphate |
| Rv0805 metallophosphodiesterase | Mycobacterium tuberculosis | bis(4-nitrophenyl) phosphate | 12.4 | 0.9 | 14 calc. | pH 8.5, 37 °C | PMID 18757371 | Open record: Rv0805 metallophosphodiesterase, bis(4-nitrophenyl) phosphate |