EC 3.6.1.56: 2-hydroxy-dATP diphosphatase
HydrolasesOpen in Browse
CatLog read 28 records for EC 3.6.1.56 from 5 papers, for 2 organisms. Names in these papers: Nudix hydrolase 2 (Nud2), hMTH1 (human MutT homologue, 8-OH-dGTPase / 2-OH-dATPase), hMTH1 (human MutT homolog-1, oxidized purine nucleoside triphosphatase), MTH1 (human MutT homologue, 8-OH-dGTPase) and 1 more.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 8 records for EC 3.6.1.56 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.6.1.56 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Enzymatic characteristics of Nudix hydrolase 2 (Nud2), an 8-oxo-dGTP hydrolase from Myxococcus xanthus | Myxococcus xanthus | 13 |
| The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein | Homo sapiens | 6 |
| A molecular basis for the selective recognition of 2-hydroxy-dATP and 8-oxo-dGTP by human MTH1 | Homo sapiens | 5 |
| Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP | Homo sapiens | 3 |
| Optimization of a high throughput screening platform to identify inhibitors of asymmetric diadenosine polyphosphatases | Homo sapiens | 1 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| hMTH1 (human MutT homolog-1, oxidized purine nucleoside triphosphatase) | Homo sapiens | 2-hydroxy-2'-deoxyadenosine 5'-triphosphate | 28.7 | 0.0087 | 3.3 × 10³ | pH 8, 30 °C | PMID 11756418 | Open record: hMTH1 (human MutT homolog-1, oxidized purine nucleoside triphosphatase), 2-hydroxy-2'-deoxyadenosine 5'-triphosphate |
| hMTH1 (human MutT homolog-1, oxidized purine nucleoside triphosphatase) | Homo sapiens | 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate | 25.9 | 0.0151 | 1.71 × 10³ | pH 8, 30 °C | PMID 11756418 | Open record: hMTH1 (human MutT homolog-1, oxidized purine nucleoside triphosphatase), 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate |
| hMTH1 (human MutT homolog-1, oxidized purine nucleoside triphosphatase)variant D119A | Homo sapiens | 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate | 9.54 | 0.0302 | 310 | pH 8, 30 °C | PMID 11756418 | Open record: hMTH1 (human MutT homolog-1, oxidized purine nucleoside triphosphatase) variant D119A, 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate |
| hMTH1 (human MutT homolog-1, oxidized purine nucleoside triphosphatase)variant F27A | Homo sapiens | 2-hydroxy-2'-deoxyadenosine 5'-triphosphate | 31 | 0.017 | 1.82 × 10³ | pH 8, 30 °C | PMID 11756418 | Open record: hMTH1 (human MutT homolog-1, oxidized purine nucleoside triphosphatase) variant F27A, 2-hydroxy-2'-deoxyadenosine 5'-triphosphate |
| hMTH1 (human MutT homolog-1, oxidized purine nucleoside triphosphatase)variant F27A | Homo sapiens | 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate | 25.1 | 0.0403 | 620 | pH 8, 30 °C | PMID 11756418 | Open record: hMTH1 (human MutT homolog-1, oxidized purine nucleoside triphosphatase) variant F27A, 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate |
| hMTH1 (human MutT homologue, 8-OH-dGTPase / 2-OH-dATPase) | Homo sapiens | 2'-deoxyguanosine 5'-triphosphate | 15.7 | 0.258 | 60 | pH 8, 30 °C | PMID 10373420 | Open record: hMTH1 (human MutT homologue, 8-OH-dGTPase / 2-OH-dATPase), 2'-deoxyguanosine 5'-triphosphate |
| hMTH1 (human MutT homologue, 8-OH-dGTPase / 2-OH-dATPase) | Homo sapiens | 2-hydroxy-2'-deoxyadenosine 5'-triphosphate | 13.9 | 0.0083 | 1.68 × 10³ | pH 8, 30 °C | PMID 10373420 | Open record: hMTH1 (human MutT homologue, 8-OH-dGTPase / 2-OH-dATPase), 2-hydroxy-2'-deoxyadenosine 5'-triphosphate |
| hMTH1 (human MutT homologue, 8-OH-dGTPase / 2-OH-dATPase) | Homo sapiens | 2-hydroxy-2'-deoxyadenosine 5'-triphosphate | 4.7 | 0.0057 | 830 | pH 7.2, 30 °C | PMID 10373420 | Open record: hMTH1 (human MutT homologue, 8-OH-dGTPase / 2-OH-dATPase), 2-hydroxy-2'-deoxyadenosine 5'-triphosphate |
| hMTH1 (human MutT homologue, 8-OH-dGTPase / 2-OH-dATPase) | Homo sapiens | 8-hydroxy-2'-deoxyadenosine 5'-triphosphate | 10.8 | 0.0139 | 780 | pH 8, 30 °C | PMID 10373420 | Open record: hMTH1 (human MutT homologue, 8-OH-dGTPase / 2-OH-dATPase), 8-hydroxy-2'-deoxyadenosine 5'-triphosphate |
| hMTH1 (human MutT homologue, 8-OH-dGTPase / 2-OH-dATPase) | Homo sapiens | 8-hydroxy-2'-deoxyguanosine 5'-triphosphate | 12.3 | 0.0152 | 810 | pH 8, 30 °C | PMID 10373420 | Open record: hMTH1 (human MutT homologue, 8-OH-dGTPase / 2-OH-dATPase), 8-hydroxy-2'-deoxyguanosine 5'-triphosphate |
| hMTH1 (human MutT homologue, 8-OH-dGTPase / 2-OH-dATPase) | Homo sapiens | 8-hydroxy-2'-deoxyguanosine 5'-triphosphate | 2.1 | 0.0128 | 160 | pH 7.2, 30 °C | PMID 10373420 | Open record: hMTH1 (human MutT homologue, 8-OH-dGTPase / 2-OH-dATPase), 8-hydroxy-2'-deoxyguanosine 5'-triphosphate |
| MTH1 (human MutT homologue, 8-OH-dGTPase) | Homo sapiens | 2-hydroxyadenosine 5'-triphosphate | 4.7 | 0.0043 | 1.09 × 10³ | pH 8, 30 °C | PMID 11139615 | Open record: MTH1 (human MutT homologue, 8-OH-dGTPase), 2-hydroxyadenosine 5'-triphosphate |
| MTH1 (human MutT homologue, 8-OH-dGTPase) | Homo sapiens | 8-hydroxyadenosine 5'-triphosphate | 1.1 | 0.051 | 20 | pH 8, 30 °C | PMID 11139615 | Open record: MTH1 (human MutT homologue, 8-OH-dGTPase), 8-hydroxyadenosine 5'-triphosphate |
| MTH1 (human MutT homologue, 8-OH-dGTPase) | Homo sapiens | 8-hydroxyguanosine 5'-triphosphate | 2.6 | 0.055 | 50 | pH 8, 30 °C | PMID 11139615 | Open record: MTH1 (human MutT homologue, 8-OH-dGTPase), 8-hydroxyguanosine 5'-triphosphate |
| Nudix hydrolase 2 (Nud2) | Myxococcus xanthus | 2'-deoxyadenosine 5'-diphosphate | 0.143 | 0.447 | 0.32 | pH 8, 37 °C | PMID 31292314 | Open record: Nudix hydrolase 2 (Nud2), 2'-deoxyadenosine 5'-diphosphate |
| Nudix hydrolase 2 (Nud2) | Myxococcus xanthus | 2'-deoxyadenosine 5'-triphosphate | 0.15 | 0.298 | 0.5 | pH 8, 37 °C | PMID 31292314 | Open record: Nudix hydrolase 2 (Nud2), 2'-deoxyadenosine 5'-triphosphate |
| Nudix hydrolase 2 (Nud2) | Myxococcus xanthus | 2'-deoxyguanosine 5'-diphosphate | 0.128 | 0.134 | 0.95 | pH 8, 37 °C | PMID 31292314 | Open record: Nudix hydrolase 2 (Nud2), 2'-deoxyguanosine 5'-diphosphate |
| Nudix hydrolase 2 (Nud2) | Myxococcus xanthus | 2'-deoxyguanosine 5'-triphosphate | 0.308 | 0.046 | 6.7 | pH 8, 37 °C | PMID 31292314 | Open record: Nudix hydrolase 2 (Nud2), 2'-deoxyguanosine 5'-triphosphate |
| Nudix hydrolase 2 (Nud2) | Myxococcus xanthus | 2-hydroxy-2'-deoxyadenosine 5'-triphosphate | 0.097 | 0.025 | 3.8 | pH 8, 37 °C | PMID 31292314 | Open record: Nudix hydrolase 2 (Nud2), 2-hydroxy-2'-deoxyadenosine 5'-triphosphate |
| Nudix hydrolase 2 (Nud2) | Myxococcus xanthus | 7,8-dihydro-8-oxo-2'-deoxyadenosine 5'-triphosphate | 0.103 | 0.03 | 3.5 | pH 8, 37 °C | PMID 31292314 | Open record: Nudix hydrolase 2 (Nud2), 7,8-dihydro-8-oxo-2'-deoxyadenosine 5'-triphosphate |
| Nudix hydrolase 2 (Nud2) | Myxococcus xanthus | 7,8-dihydro-8-oxo-2'-deoxyguanosine 5'-diphosphate | 0.273 | 0.027 | 10.2 | pH 8, 37 °C | PMID 31292314 | Open record: Nudix hydrolase 2 (Nud2), 7,8-dihydro-8-oxo-2'-deoxyguanosine 5'-diphosphate |
| Nudix hydrolase 2 (Nud2) | Myxococcus xanthus | 7,8-dihydro-8-oxo-2'-deoxyguanosine 5'-triphosphate | 1.128 | 0.027 | 42 | pH 8, 37 °C | PMID 31292314 | Open record: Nudix hydrolase 2 (Nud2), 7,8-dihydro-8-oxo-2'-deoxyguanosine 5'-triphosphate |
| Nudix hydrolase 2 (Nud2) | Myxococcus xanthus | adenosine 5'-diphosphate | 0.102 | 1.173 | 0.087 | pH 8, 37 °C | PMID 31292314 | Open record: Nudix hydrolase 2 (Nud2), adenosine 5'-diphosphate |
| Nudix hydrolase 2 (Nud2) | Myxococcus xanthus | adenosine 5'-triphosphate | 0.158 | 0.455 | 0.35 | pH 8, 37 °C | PMID 31292314 | Open record: Nudix hydrolase 2 (Nud2), adenosine 5'-triphosphate |
| Nudix hydrolase 2 (Nud2) | Myxococcus xanthus | guanosine 5'-diphosphate | 0.187 | 0.319 | 0.58 | pH 8, 37 °C | PMID 31292314 | Open record: Nudix hydrolase 2 (Nud2), guanosine 5'-diphosphate |
| Nudix hydrolase 2 (Nud2) | Myxococcus xanthus | guanosine 5'-triphosphate | 0.338 | 0.598 | 0.57 | pH 8, 37 °C | PMID 31292314 | Open record: Nudix hydrolase 2 (Nud2), guanosine 5'-triphosphate |
| Nudix hydrolase 2 (Nud2) | Myxococcus xanthus | P1,P4-bis(5'-adenosyl) tetraphosphate | 0.103 | 0.385 | 0.27 | pH 8, 37 °C | PMID 31292314 | Open record: Nudix hydrolase 2 (Nud2), P1,P4-bis(5'-adenosyl) tetraphosphate |
| Nudt1 (hMTH1) | Homo sapiens | P1,P5-di(adenosine-5') pentaphosphate | — | 0.026 | 0.0058 | pH 8, 23 °C | PMID 39521360 | Open record: Nudt1 (hMTH1), P1,P5-di(adenosine-5') pentaphosphate |