EC 4.4.1.1: cystathionine gamma-lyase

LyasesOpen in Browse

CatLog read 69 records for EC 4.4.1.1 from 5 papers, for 3 organisms. Names in these papers: cystathionine γ-lyase (yCGL), cystathionine γ-lyase (TgCGL), cystathionine γ-lyase (CSE), polymorphic variant S403, cystathionine γ-lyase (polymorphic variant S403) and 1 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 84 records for EC 4.4.1.1 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 4.4.1.1 in Browse.

Papers

Papers with records for EC 4.4.1.1
Paper	Organisms	Records
A role for glutamate-333 of Saccharomyces cerevisiae cystathionine γ-lyase as a determinant of specificity	Saccharomyces cerevisiae	33
Functional Characterization and Structure-Guided Mutational Analysis of the Transsulfuration Enzyme Cystathionine γ-Lyase from Toxoplasma gondii	Toxoplasma gondii	11
Kinetic properties of polymorphic variants and pathogenic mutants in human cystathionine gamma-lyase	Homo sapiens	10
Interconversion of a pair of active-site residues in Escherichia coli cystathionine gamma-synthase, E. coli cystathionine beta-lyase, and Saccharomyces cerevisiae cystathionine gamma-lyase and…	Saccharomyces cerevisiae	8
H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia	Homo sapiens	7

Records

Records for EC 4.4.1.1 read from the paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Paper	Open record
cystathionine γ-lyase (CSE), polymorphic variant S403	Homo sapiens	L-cystathionine	2.3	0.28	8.2	pH 7.4, 37 °C	PMID 19261609	Open record: cystathionine γ-lyase (CSE), polymorphic variant S403, L-cystathionine
cystathionine γ-lyase (CSE), polymorphic variant S403	Homo sapiens	L-cysteinereaction 2; α,β-elimination of cysteine	0.31	3.7	0.08	pH 7.4, 37 °C	PMID 19261609	Open record: cystathionine γ-lyase (CSE), polymorphic variant S403, L-cysteine
cystathionine γ-lyase (CSE), polymorphic variant S403	Homo sapiens	L-cysteinereaction 2; α,β-elimination of cysteine; 0.4 mM lead acetate	0.47	1.7	0.27	pH 7.4, 37 °C	PMID 19261609	Open record: cystathionine γ-lyase (CSE), polymorphic variant S403, L-cysteine
cystathionine γ-lyase (CSE), polymorphic variant S403	Homo sapiens	L-cysteinereaction 3; 0.4 mM lead acetate	0.85	—	—	pH 7.4, 37 °C	PMID 19261609	Open record: cystathionine γ-lyase (CSE), polymorphic variant S403, L-cysteine
cystathionine γ-lyase (CSE), polymorphic variant S403	Homo sapiens	L-homocysteinereaction 4; α,γ-elimination of homocysteine	0.92	2.7	0.35	pH 7.4, 37 °C	PMID 19261609	Open record: cystathionine γ-lyase (CSE), polymorphic variant S403, L-homocysteine
cystathionine γ-lyase (CSE), polymorphic variant S403	Homo sapiens	L-homocysteinereaction 5; 0.4 mM lead acetate	4.9	—	—	pH 7.4, 37 °C	PMID 19261609	Open record: cystathionine γ-lyase (CSE), polymorphic variant S403, L-homocysteine
cystathionine γ-lyase (CSE), polymorphic variant S403	Homo sapiens	L-homocysteine	0.15	—	—	37 °C	PMID 19261609	Open record: cystathionine γ-lyase (CSE), polymorphic variant S403, L-homocysteine
cystathionine γ-lyase (polymorphic variant I403)	Homo sapiens	cystathionine	1.9	0.6	3.2	37 °C	PMID 18476726	Open record: cystathionine γ-lyase (polymorphic variant I403), cystathionine
cystathionine γ-lyase (polymorphic variant I403)	Homo sapiens	cysteine	0.67	3.4	0.2	pH 7, 37 °C	PMID 18476726	Open record: cystathionine γ-lyase (polymorphic variant I403), cysteine
cystathionine γ-lyase (polymorphic variant I403)	Homo sapiens	homocysteine	3.7	7	0.53	pH 7, 37 °C	PMID 18476726	Open record: cystathionine γ-lyase (polymorphic variant I403), homocysteine
cystathionine γ-lyase (polymorphic variant S403)	Homo sapiens	cystathionine	1.7	0.4	4.2	37 °C	PMID 18476726	Open record: cystathionine γ-lyase (polymorphic variant S403), cystathionine
cystathionine γ-lyase (polymorphic variant S403)	Homo sapiens	cysteine	0.67	3.5	0.19	pH 7, 37 °C	PMID 18476726	Open record: cystathionine γ-lyase (polymorphic variant S403), cysteine
cystathionine γ-lyase (polymorphic variant S403)	Homo sapiens	homocysteine	3.5	5.4	0.65	pH 7, 37 °C	PMID 18476726	Open record: cystathionine γ-lyase (polymorphic variant S403), homocysteine
cystathionine γ-lyase (polymorphic variant S403)variant Q240E	Homo sapiens	cystathionine	0.02	0.72	0.028	37 °C	PMID 18476726	Open record: cystathionine γ-lyase (polymorphic variant S403) variant Q240E, cystathionine
cystathionine γ-lyase (polymorphic variant S403)variant T67I	Homo sapiens	cystathionine	0.45	0.6	0.86	37 °C	PMID 18476726	Open record: cystathionine γ-lyase (polymorphic variant S403) variant T67I, cystathionine
cystathionine γ-lyase (polymorphic variant S403)variant T67I	Homo sapiens	cysteine	0.3	4.1	0.07	pH 7, 37 °C	PMID 18476726	Open record: cystathionine γ-lyase (polymorphic variant S403) variant T67I, cysteine
cystathionine γ-lyase (polymorphic variant S403)variant T67I	Homo sapiens	homocysteine	0.82	8	0.1	pH 7, 37 °C	PMID 18476726	Open record: cystathionine γ-lyase (polymorphic variant S403) variant T67I, homocysteine
cystathionine γ-lyase (TgCGL)	Toxoplasma gondii	djenkolic acid	0.24	0.51	0.47	pH 9, 37 °C	PMID 30036991	Open record: cystathionine γ-lyase (TgCGL), djenkolic acid
cystathionine γ-lyase (TgCGL)	Toxoplasma gondii	L-cystathionine	2	0.9	2.2	pH 9, 37 °C	PMID 30036991	Open record: cystathionine γ-lyase (TgCGL), L-cystathionine
cystathionine γ-lyase (TgCGL)	Toxoplasma gondii	L-cysteine	0.009	0.21	0.043	pH 9, 37 °C	PMID 30036991	Open record: cystathionine γ-lyase (TgCGL), L-cysteine
cystathionine γ-lyase (TgCGL)	Toxoplasma gondii	S-(2-aminoethyl)-L-cysteine	0.037	1.3	0.028 calc.	pH 9, 37 °C	PMID 30036991	Open record: cystathionine γ-lyase (TgCGL), S-(2-aminoethyl)-L-cysteine
cystathionine γ-lyase (TgCGL)variant N360S	Toxoplasma gondii	djenkolic acid	0.19	0.86	0.22	pH 9, 37 °C	PMID 30036991	Open record: cystathionine γ-lyase (TgCGL) variant N360S, djenkolic acid
cystathionine γ-lyase (TgCGL)variant N360S	Toxoplasma gondii	L-cystathionineDTNB assay of thiol product (α,γ- plus α,β-elimination)	0.24	6.1	0.039	pH 9, 37 °C	PMID 30036991	Open record: cystathionine γ-lyase (TgCGL) variant N360S, L-cystathionine
cystathionine γ-lyase (TgCGL)variant N360S	Toxoplasma gondii	L-cystathionine	0.08	1.1	0.073	pH 9, 37 °C	PMID 30036991	Open record: cystathionine γ-lyase (TgCGL) variant N360S, L-cystathionine
cystathionine γ-lyase (TgCGL)variant N360S	Toxoplasma gondii	L-cysteine	0.007	0.4	0.018	pH 9, 37 °C	PMID 30036991	Open record: cystathionine γ-lyase (TgCGL) variant N360S, L-cysteine
cystathionine γ-lyase (TgCGL)variant S77A	Toxoplasma gondii	djenkolic acid	0.22	1.5	0.15	pH 9, 37 °C	PMID 30036991	Open record: cystathionine γ-lyase (TgCGL) variant S77A, djenkolic acid
cystathionine γ-lyase (TgCGL)variant S77A	Toxoplasma gondii	L-cystathionine	0.7	2.4	0.29	pH 9, 37 °C	PMID 30036991	Open record: cystathionine γ-lyase (TgCGL) variant S77A, L-cystathionine
cystathionine γ-lyase (TgCGL)variant S77E	Toxoplasma gondii	djenkolic acid	—	—	0.0022	pH 9, 37 °C	PMID 30036991	Open record: cystathionine γ-lyase (TgCGL) variant S77E, djenkolic acid
cystathionine γ-lyase (yCGL)	Saccharomyces cerevisiae	L-cystathionine	0.9	0.45	1.98	pH 7.8, 25 °C	PMID 19370061	Open record: cystathionine γ-lyase (yCGL), L-cystathionine
cystathionine γ-lyase (yCGL)	Saccharomyces cerevisiae	L-cystathionine	1.81	0.42	4.3	pH 7.8, 25 °C	PMID 19370061	Open record: cystathionine γ-lyase (yCGL), L-cystathionine
cystathionine γ-lyase (yCGL)	Saccharomyces cerevisiae	L-cystathionine50 mM potassium phosphate; 0.01–5.5 mM L-Cth	1.51	0.71	2.1	pH 7.2, 25 °C	PMID 24291053	Open record: cystathionine γ-lyase (yCGL), L-cystathionine
cystathionine γ-lyase (yCGL)	Saccharomyces cerevisiae	L-cystathionineMBP buffer (50 mM MOPS, 50 mM bicine, 50 mM proline); pH 7.2	—	—	2.18	pH 7.2, 25 °C	PMID 24291053	Open record: cystathionine γ-lyase (yCGL), L-cystathionine
cystathionine γ-lyase (yCGL)	Saccharomyces cerevisiae	L-cystathionine	—	—	2.7	pH 7.6, 25 °C	PMID 24291053	Open record: cystathionine γ-lyase (yCGL), L-cystathionine
cystathionine γ-lyase (yCGL)	Saccharomyces cerevisiae	L-cysteine	0.15	0.09	1.7	pH 7.2, 25 °C	PMID 24291053	Open record: cystathionine γ-lyase (yCGL), L-cysteine
cystathionine γ-lyase (yCGL)	Saccharomyces cerevisiae	L-homocysteine	—	—	2.7 × 10⁻⁵	pH 7.2, 25 °C	PMID 24291053	Open record: cystathionine γ-lyase (yCGL), L-homocysteine
cystathionine γ-lyase (yCGL)	Saccharomyces cerevisiae	O-acetyl-L-serine	0.0097	2.5	0.0038	pH 7.2, 25 °C	PMID 24291053	Open record: cystathionine γ-lyase (yCGL), O-acetyl-L-serine
cystathionine γ-lyase (yCGL)	Saccharomyces cerevisiae	O-succinyl-L-homoserine	0.12	17	0.007	pH 7.8, 25 °C	PMID 19370061	Open record: cystathionine γ-lyase (yCGL), O-succinyl-L-homoserine
cystathionine γ-lyase (yCGL)variant E333A	Saccharomyces cerevisiae	L-cystathionine	0.69	5.2	0.132	pH 7.8, 25 °C	PMID 19370061	Open record: cystathionine γ-lyase (yCGL) variant E333A, L-cystathionine
cystathionine γ-lyase (yCGL)variant E333A	Saccharomyces cerevisiae	L-cystathionine	0.78	12	0.065	pH 7.2, 25 °C	PMID 24291053	Open record: cystathionine γ-lyase (yCGL) variant E333A, L-cystathionine
cystathionine γ-lyase (yCGL)variant E333A	Saccharomyces cerevisiae	L-cysteine	1.3	1.2	0.81	pH 7.2, 25 °C	PMID 24291053	Open record: cystathionine γ-lyase (yCGL) variant E333A, L-cysteine
cystathionine γ-lyase (yCGL)variant E333A	Saccharomyces cerevisiae	O-acetyl-L-serine	0.0058	2.2	0.0026	pH 7.2, 25 °C	PMID 24291053	Open record: cystathionine γ-lyase (yCGL) variant E333A, O-acetyl-L-serine
cystathionine γ-lyase (yCGL)variant E333D	Saccharomyces cerevisiae	L-cystathionine	0.98	12	0.082	pH 7.2, 25 °C	PMID 24291053	Open record: cystathionine γ-lyase (yCGL) variant E333D, L-cystathionine
cystathionine γ-lyase (yCGL)variant E333D	Saccharomyces cerevisiae	L-cysteine	0.24	1.8	0.13	pH 7.2, 25 °C	PMID 24291053	Open record: cystathionine γ-lyase (yCGL) variant E333D, L-cysteine
cystathionine γ-lyase (yCGL)variant E333D	Saccharomyces cerevisiae	O-acetyl-L-serine	0.0045	0.9	0.005	pH 7.2, 25 °C	PMID 24291053	Open record: cystathionine γ-lyase (yCGL) variant E333D, O-acetyl-L-serine
cystathionine γ-lyase (yCGL)variant E333Q	Saccharomyces cerevisiae	L-cystathionine	0.48	13	0.036	pH 7.2, 25 °C	PMID 24291053	Open record: cystathionine γ-lyase (yCGL) variant E333Q, L-cystathionine
cystathionine γ-lyase (yCGL)variant E333Q	Saccharomyces cerevisiae	L-cysteine	0.5	0.7	0.49	pH 7.2, 25 °C	PMID 24291053	Open record: cystathionine γ-lyase (yCGL) variant E333Q, L-cysteine
cystathionine γ-lyase (yCGL)variant E333Q	Saccharomyces cerevisiae	O-acetyl-L-serine	0.0102	5.3	0.0019	pH 7.2, 25 °C	PMID 24291053	Open record: cystathionine γ-lyase (yCGL) variant E333Q, O-acetyl-L-serine
cystathionine γ-lyase (yCGL)variant E333Y	Saccharomyces cerevisiae	L-cystathionine	—	—	0.147	pH 7.8, 25 °C	PMID 19370061	Open record: cystathionine γ-lyase (yCGL) variant E333Y, L-cystathionine
cystathionine γ-lyase (yCGL)variant E48A	Saccharomyces cerevisiae	L-cystathionine	0.67	0.82	0.82	pH 7.8, 25 °C	PMID 19370061	Open record: cystathionine γ-lyase (yCGL) variant E48A, L-cystathionine
cystathionine γ-lyase (yCGL)variant E48A	Saccharomyces cerevisiae	L-cystathionine	0.54	0.76	0.71	pH 7.2, 25 °C	PMID 24291053	Open record: cystathionine γ-lyase (yCGL) variant E48A, L-cystathionine
cystathionine γ-lyase (yCGL)variant E48A	Saccharomyces cerevisiae	L-cysteine	0.09	0.11	0.8	pH 7.2, 25 °C	PMID 24291053	Open record: cystathionine γ-lyase (yCGL) variant E48A, L-cysteine
cystathionine γ-lyase (yCGL)variant E48A	Saccharomyces cerevisiae	O-acetyl-L-serine	0.0142	1.5	0.01	pH 7.2, 25 °C	PMID 24291053	Open record: cystathionine γ-lyase (yCGL) variant E48A, O-acetyl-L-serine
cystathionine γ-lyase (yCGL)variant E48A/E333A	Saccharomyces cerevisiae	L-cystathionine	—	—	0.0037	pH 7.2, 25 °C	PMID 24291053	Open record: cystathionine γ-lyase (yCGL) variant E48A/E333A, L-cystathionine
cystathionine γ-lyase (yCGL)variant E48A/E333A	Saccharomyces cerevisiae	L-cysteine	0.11	0.5	0.21	pH 7.2, 25 °C	PMID 24291053	Open record: cystathionine γ-lyase (yCGL) variant E48A/E333A, L-cysteine
cystathionine γ-lyase (yCGL)variant E48A/E333A	Saccharomyces cerevisiae	O-acetyl-L-serine	0.0047	2.9	0.0016	pH 7.2, 25 °C	PMID 24291053	Open record: cystathionine γ-lyase (yCGL) variant E48A/E333A, O-acetyl-L-serine
cystathionine γ-lyase (yCGL)variant E48D	Saccharomyces cerevisiae	L-cystathionine	0.76	1.11	0.68	pH 7.8, 25 °C	PMID 19370061	Open record: cystathionine γ-lyase (yCGL) variant E48D, L-cystathionine
cystathionine γ-lyase (yCGL)variant E48D	Saccharomyces cerevisiae	L-cystathionine	1.4	0.87	1.59	pH 7.2, 25 °C	PMID 24291053	Open record: cystathionine γ-lyase (yCGL) variant E48D, L-cystathionine
cystathionine γ-lyase (yCGL)variant E48D	Saccharomyces cerevisiae	L-cysteine	0.32	0.4	0.72	pH 7.2, 25 °C	PMID 24291053	Open record: cystathionine γ-lyase (yCGL) variant E48D, L-cysteine
cystathionine γ-lyase (yCGL)variant E48D	Saccharomyces cerevisiae	O-acetyl-L-serine	0.0053	1.4	0.0038	pH 7.2, 25 °C	PMID 24291053	Open record: cystathionine γ-lyase (yCGL) variant E48D, O-acetyl-L-serine
cystathionine γ-lyase (yCGL)variant E48D/E333D	Saccharomyces cerevisiae	L-cystathionine	—	—	0.0088	pH 7.2, 25 °C	PMID 24291053	Open record: cystathionine γ-lyase (yCGL) variant E48D/E333D, L-cystathionine
cystathionine γ-lyase (yCGL)variant E48D/E333D	Saccharomyces cerevisiae	L-cysteine	0.029	0.5	0.06	pH 7.2, 25 °C	PMID 24291053	Open record: cystathionine γ-lyase (yCGL) variant E48D/E333D, L-cysteine
cystathionine γ-lyase (yCGL)variant E48D/E333D	Saccharomyces cerevisiae	O-acetyl-L-serine	0.0035	0.7	0.005	pH 7.2, 25 °C	PMID 24291053	Open record: cystathionine γ-lyase (yCGL) variant E48D/E333D, O-acetyl-L-serine
cystathionine γ-lyase (yCGL)variant E48F	Saccharomyces cerevisiae	L-cystathionine	0.398	0.81	0.49	pH 7.8, 25 °C	PMID 19370061	Open record: cystathionine γ-lyase (yCGL) variant E48F, L-cystathionine
cystathionine γ-lyase (yCGL)variant E48Q	Saccharomyces cerevisiae	L-cystathionine	1.29	0.9	1.4	pH 7.2, 25 °C	PMID 24291053	Open record: cystathionine γ-lyase (yCGL) variant E48Q, L-cystathionine
cystathionine γ-lyase (yCGL)variant E48Q	Saccharomyces cerevisiae	L-cysteine	0.18	0.18	1.02	pH 7.2, 25 °C	PMID 24291053	Open record: cystathionine γ-lyase (yCGL) variant E48Q, L-cysteine
cystathionine γ-lyase (yCGL)variant E48Q	Saccharomyces cerevisiae	O-acetyl-L-serine	0.0124	4.4	0.0028	pH 7.2, 25 °C	PMID 24291053	Open record: cystathionine γ-lyase (yCGL) variant E48Q, O-acetyl-L-serine
cystathionine γ-lyase (yCGL)variant E48Q/E333Q	Saccharomyces cerevisiae	L-cystathionine	—	—	0.0169	pH 7.2, 25 °C	PMID 24291053	Open record: cystathionine γ-lyase (yCGL) variant E48Q/E333Q, L-cystathionine
cystathionine γ-lyase (yCGL)variant E48Q/E333Q	Saccharomyces cerevisiae	L-cysteine	0.16	0.4	0.31	pH 7.2, 25 °C	PMID 24291053	Open record: cystathionine γ-lyase (yCGL) variant E48Q/E333Q, L-cysteine
cystathionine γ-lyase (yCGL)variant E48Q/E333Q	Saccharomyces cerevisiae	O-acetyl-L-serine	0.0092	1.5	0.006	pH 7.2, 25 °C	PMID 24291053	Open record: cystathionine γ-lyase (yCGL) variant E48Q/E333Q, O-acetyl-L-serine