CatLogenzyme kinetics catalog

Values CatLog read from this paper

Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate

PMID 25406093doi:10.1021/cb500683cOpen in Browse

The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.

CatLog read 6 records (9 values) from this paper: D-3-phosphoglycerate dehydrogenase (PHGDH) from Homo sapiens.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks. CatLog calculated the 3 kcat/Km values marked “calc.” from kcat and Km; no printed kcat/Km was read for those records.

EC 1.1.1.37, EC 1.1.1.95, EC 1.1.1.399

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)Conditions
D-3-phosphoglycerate dehydrogenase (PHGDH)Homo sapiens3-phosphoglycerate0.0750.260.29 calc.pH 7.6, 37 °COpen
D-3-phosphoglycerate dehydrogenase (PHGDH)Homo sapiensNAD+—0.022—pH 7.6, 37 °COpen
D-3-phosphoglycerate dehydrogenase (PHGDH)Homo sapiensNADHcosubstrate oxaloacetate—0.004—pH 7.6, 37 °COpen
D-3-phosphoglycerate dehydrogenase (PHGDH)Homo sapiensNADHcosubstrate α-ketoglutarate—0.004—pH 7.6, 37 °COpen
D-3-phosphoglycerate dehydrogenase (PHGDH)Homo sapiensoxaloacetate0.1776.50.027 calc.pH 7.6, 37 °COpen
D-3-phosphoglycerate dehydrogenase (PHGDH)Homo sapiensα-ketoglutarate0.07810.10.0078 calc.pH 7.6, 37 °COpen