EC 1.1.1.399: 2-oxoglutarate reductase
OxidoreductasesOpen in Browse
CatLog read 24 records for EC 1.1.1.399 from 5 papers, for 5 organisms. Names in these papers: D-3-phosphoglycerate dehydrogenase (PHGDH), D-3-phosphoglycerate dehydrogenase (mtPGDH), D-3-phosphoglycerate dehydrogenase (ecPGDH), 3-phosphoglycerate dehydrogenase (SerA) and 3 more.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.
CatLog also holds 8 records for EC 1.1.1.399 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.1.1.399 in Browse.
Papers
| Paper | Organisms | Records |
|---|---|---|
| Determinants of substrate specificity in D-3-phosphoglycerate dehydrogenase. Conversion of the M. tuberculosis enzyme from one that does not use α-ketoglutarate as a substrate to one that does | Escherichia coli, Mycobacterium tuberculosis | 9 |
| Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate | Homo sapiens | 6 |
| Saccharomyces cerevisiae Forms D-2-Hydroxyglutarate and Couples Its Degradation to D-Lactate Formation via a Cytosolic Transhydrogenase | Saccharomyces cerevisiae | 4 |
| A novel alpha-ketoglutarate reductase activity of the serA-encoded 3-phosphoglycerate dehydrogenase of Escherichia coli K-12 and its possible implications for human 2-hydroxyglutaric aciduria | Escherichia coli | 3 |
| Substrate specificity of 2-hydroxyglutaryl-CoA dehydratase from Clostridium symbiosum: toward a bio-based production of adipic acid | Acidaminococcus fermentans | 2 |
Records
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Paper | Open record |
|---|---|---|---|---|---|---|---|---|
| (R)-2-hydroxyglutarate dehydrogenase (HgdH) | Acidaminococcus fermentans | 2-oxo-4-hexenedioic acid | — | 1.1 | 220 | pH 8 | PMID 21434666 | Open record: (R)-2-hydroxyglutarate dehydrogenase (HgdH), 2-oxo-4-hexenedioic acid |
| (R)-2-hydroxyglutarate dehydrogenase (HgdH) | Acidaminococcus fermentans | 2-oxohexanedioic acid | — | 0.88 | 550 | pH 8 | PMID 21434666 | Open record: (R)-2-hydroxyglutarate dehydrogenase (HgdH), 2-oxohexanedioic acid |
| 3-phosphoglycerate dehydrogenase (SerA) | Escherichia coli | alpha-ketoglutarate (2-oxoglutarate) | 33.3 | 0.088 | 380 | pH 7.5, 37 °C | PMID 8550422 | Open record: 3-phosphoglycerate dehydrogenase (SerA), alpha-ketoglutarate (2-oxoglutarate) |
| 3-phosphoglycerate dehydrogenase (SerA) | Escherichia coli | D-2-hydroxyglutaric acid | 0.71 | 0.37 | 1.9 | pH 8.8, 37 °C | PMID 8550422 | Open record: 3-phosphoglycerate dehydrogenase (SerA), D-2-hydroxyglutaric acid |
| 3-phosphoglycerate dehydrogenase (SerA) | Escherichia coli | L-2-hydroxyglutaric acid | 0.25 | 2.9 | 0.09 | pH 8.8, 37 °C | PMID 8550422 | Open record: 3-phosphoglycerate dehydrogenase (SerA), L-2-hydroxyglutaric acid |
| D-3-phosphoglycerate dehydrogenase (ecPGDH) | Escherichia coli | phosphohydroxypyruvate | 3.1 | 0.068 | 46 | pH 7 | PMID 31344342 | Open record: D-3-phosphoglycerate dehydrogenase (ecPGDH), phosphohydroxypyruvate |
| D-3-phosphoglycerate dehydrogenase (ecPGDH) | Escherichia coli | α-ketoglutarate | 2.1 | 0.45 | 4.7 | pH 7 | PMID 31344342 | Open record: D-3-phosphoglycerate dehydrogenase (ecPGDH), α-ketoglutarate |
| D-3-phosphoglycerate dehydrogenase (ecPGDH)variant K141R | Escherichia coli | phosphohydroxypyruvate | 9.6 | 0.081 | 120 | pH 7 | PMID 31344342 | Open record: D-3-phosphoglycerate dehydrogenase (ecPGDH) variant K141R, phosphohydroxypyruvate |
| D-3-phosphoglycerate dehydrogenase (ecPGDH)variant K141R | Escherichia coli | α-ketoglutarate | 0.49 | 5 | 0.098 | pH 7 | PMID 31344342 | Open record: D-3-phosphoglycerate dehydrogenase (ecPGDH) variant K141R, α-ketoglutarate |
| D-3-phosphoglycerate dehydrogenase (mtPGDH) | Mycobacterium tuberculosis | phosphohydroxypyruvate | 606 | 0.153 | 4 × 10³ | pH 7 | PMID 31344342 | Open record: D-3-phosphoglycerate dehydrogenase (mtPGDH), phosphohydroxypyruvate |
| D-3-phosphoglycerate dehydrogenase (mtPGDH)variant R132K | Mycobacterium tuberculosis | phosphohydroxypyruvate | 458 | 0.015 | 3.1 × 10⁴ | pH 7 | PMID 31344342 | Open record: D-3-phosphoglycerate dehydrogenase (mtPGDH) variant R132K, phosphohydroxypyruvate |
| D-3-phosphoglycerate dehydrogenase (mtPGDH)variant R72A | Mycobacterium tuberculosis | α-ketoglutarate | 16.1 | 53.1 | 0.3 | pH 7 | PMID 31344342 | Open record: D-3-phosphoglycerate dehydrogenase (mtPGDH) variant R72A, α-ketoglutarate |
| D-3-phosphoglycerate dehydrogenase (mtPGDH)variant R72A/R132K | Mycobacterium tuberculosis | phosphohydroxypyruvate | 490 | 0.169 | 2.9 × 10³ | pH 7 | PMID 31344342 | Open record: D-3-phosphoglycerate dehydrogenase (mtPGDH) variant R72A/R132K, phosphohydroxypyruvate |
| D-3-phosphoglycerate dehydrogenase (mtPGDH)variant R72L | Mycobacterium tuberculosis | α-ketoglutarate | 4.3 | 30.6 | 0.14 | pH 7 | PMID 31344342 | Open record: D-3-phosphoglycerate dehydrogenase (mtPGDH) variant R72L, α-ketoglutarate |
| D-3-phosphoglycerate dehydrogenase (PHGDH) | Homo sapiens | 3-phosphoglycerate | 0.075 | 0.26 | 0.29 calc. | pH 7.6, 37 °C | PMID 25406093 | Open record: D-3-phosphoglycerate dehydrogenase (PHGDH), 3-phosphoglycerate |
| D-3-phosphoglycerate dehydrogenase (PHGDH) | Homo sapiens | NAD+ | — | 0.022 | — | pH 7.6, 37 °C | PMID 25406093 | Open record: D-3-phosphoglycerate dehydrogenase (PHGDH), NAD+ |
| D-3-phosphoglycerate dehydrogenase (PHGDH) | Homo sapiens | NADHcosubstrate oxaloacetate | — | 0.004 | — | pH 7.6, 37 °C | PMID 25406093 | Open record: D-3-phosphoglycerate dehydrogenase (PHGDH), NADH |
| D-3-phosphoglycerate dehydrogenase (PHGDH) | Homo sapiens | NADHcosubstrate α-ketoglutarate | — | 0.004 | — | pH 7.6, 37 °C | PMID 25406093 | Open record: D-3-phosphoglycerate dehydrogenase (PHGDH), NADH |
| D-3-phosphoglycerate dehydrogenase (PHGDH) | Homo sapiens | oxaloacetate | 0.177 | 6.5 | 0.027 calc. | pH 7.6, 37 °C | PMID 25406093 | Open record: D-3-phosphoglycerate dehydrogenase (PHGDH), oxaloacetate |
| D-3-phosphoglycerate dehydrogenase (PHGDH) | Homo sapiens | α-ketoglutarate | 0.078 | 10.1 | 0.0078 calc. | pH 7.6, 37 °C | PMID 25406093 | Open record: D-3-phosphoglycerate dehydrogenase (PHGDH), α-ketoglutarate |
| Ser3 | Saccharomyces cerevisiae | 2-oxoglutarate | 0.2 | 0.049 | 4.3 | pH 7.4, 30 °C | PMID 26774271 | Open record: Ser3, 2-oxoglutarate |
| Ser3 | Saccharomyces cerevisiae | 3-phosphoglycerate | — | 0.001 | — | pH 8, 30 °C | PMID 26774271 | Open record: Ser3, 3-phosphoglycerate |
| Ser33 | Saccharomyces cerevisiae | 2-oxoglutarate | 0.25 | 0.054 | 6.6 | pH 7.4, 30 °C | PMID 26774271 | Open record: Ser33, 2-oxoglutarate |
| Ser33 | Saccharomyces cerevisiae | 3-phosphoglycerate | — | 0.004 | — | pH 8, 30 °C | PMID 26774271 | Open record: Ser33, 3-phosphoglycerate |