CatLogenzyme kinetics catalog

EC 1.1.1.22: UDP-glucose 6-dehydrogenase

OxidoreductasesOpen in Browse

CatLog read 83 records for EC 1.1.1.22 from 11 papers, for 4 organisms. Names in these papers: UDP-glucose dehydrogenase (hUGDH), UDP-glucose 6-dehydrogenase Cj1441, UDP-glucose 6-dehydrogenase (hUGDH), UDP-glucose dehydrogenase and 6 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 91 records for EC 1.1.1.22 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.1.1.22 in Browse.

Papers

PaperOrganismsRecords
Functional and Structural Characterization of the UDP-Glucose Dehydrogenase Involved in Capsular Polysaccharide Biosynthesis from Campylobacter jejuniCampylobacter jejuni16
Structural and kinetic evidence that catalytic reaction of human UDP-glucose 6-dehydrogenase involves covalent thiohemiacetal and thioester enzyme intermediatesHomo sapiens14
Active site residues and mechanism of UDP-glucose dehydrogenaseStreptococcus pyogenes9
Hysteresis and Allostery in Human UDP-Glucose Dehydrogenase Require a Flexible Protein CoreHomo sapiens9
Cryo-EM Structure of Recombinantly Expressed hUGDH Unveils a Hidden, Alternative Allosteric InhibitorHomo sapiens8
Allostery and Hysteresis Are Coupled in Human UDP-Glucose DehydrogenaseHomo sapiens7
Genome-wide analysis of the UDP-glucose dehydrogenase gene family in Arabidopsis, a key enzyme for matrix polysaccharides in cell wallsArabidopsis thaliana6
Alteration of the quaternary structure of human UDP-glucose dehydrogenase by a double mutationHomo sapiens4
Cofactor binding triggers a molecular switch to allosterically activate human UDP-α-D-glucose 6-dehydrogenaseHomo sapiens4
Hysteresis and negative cooperativity in human UDP-glucose dehydrogenaseHomo sapiens4
Properties and kinetic analysis of UDP-glucose dehydrogenase from group A streptococci. Irreversible inhibition by UDP-chloroacetolStreptococcus pyogenes2

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
UDP-alpha-D-glucose 6-dehydrogenase (hUGDH)Homo sapiensnicotinamide adenine dinucleotide (oxidized)1.8——pH 7.5, 25 °CPMID 23363239Open
UDP-alpha-D-glucose 6-dehydrogenase (hUGDH)Homo sapiensUDP-alpha-D-glucose1.40.01688 calc.pH 7.5, 25 °CPMID 23363239Open
UDP-alpha-D-glucose 6-dehydrogenase (hUGDH)variant K94EHomo sapiensnicotinamide adenine dinucleotide (oxidized)0.0552.9190.019 calc.pH 7.5, 25 °CPMID 23363239Open
UDP-alpha-D-glucose 6-dehydrogenase (hUGDH)variant K94EHomo sapiensUDP-alpha-D-glucose0.0120.2690.045 calc.pH 7.5, 25 °CPMID 23363239Open
UDP-glucose 6-dehydrogenase (hUGDH)Homo sapiensNAD+pH profile (pH 5.0-10.5); ionic strength 0.1 M——2.71525 °CPMID 22123821Open
UDP-glucose 6-dehydrogenase (hUGDH)Homo sapiensNAD+initial rates from NADH absorbance at 340 nm1.1——25 °CPMID 22123821Open
UDP-glucose 6-dehydrogenase (hUGDH)Homo sapiensUDP-alpha-D-glucose1.1——25 °CPMID 22123821Open
UDP-glucose 6-dehydrogenase (hUGDH)variant D280AHomo sapiensNAD+——2 × 10⁻⁶pH 7.5, 25 °CPMID 22123821Open
UDP-glucose 6-dehydrogenase (hUGDH)variant D280AHomo sapiensUDP-alpha-D-glucose—0.07—pH 7.5, 25 °CPMID 22123821Open
UDP-glucose 6-dehydrogenase (hUGDH)variant E161QHomo sapiensNAD+—0.10.014pH 7.5, 25 °CPMID 22123821Open
UDP-glucose 6-dehydrogenase (hUGDH)variant E161QHomo sapiensUDP-alpha-D-glucose0.00140.0550.025pH 7.5, 25 °CPMID 22123821Open
UDP-glucose 6-dehydrogenase (hUGDH)variant K220AHomo sapiensNAD+—0.151.3 × 10⁻⁵pH 7.5, 25 °CPMID 22123821Open
UDP-glucose 6-dehydrogenase (hUGDH)variant K220AHomo sapiensUDP-alpha-D-glucose2 × 10⁻⁶0.045 × 10⁻⁵pH 7.5, 25 °CPMID 22123821Open
UDP-glucose 6-dehydrogenase (hUGDH)variant K220AHomo sapiensUDP-alpha-D-glucoseapparent kcat2.3 × 10⁻⁴——pH 7.5, 25 °CPMID 22123821Open
UDP-glucose 6-dehydrogenase (hUGDH)variant N224AHomo sapiensNAD+—2.90.1pH 7.5, 25 °CPMID 22123821Open
UDP-glucose 6-dehydrogenase (hUGDH)variant N224AHomo sapiensUDP-alpha-D-glucose0.30.181.7pH 7.5, 25 °CPMID 22123821Open
UDP-glucose 6-dehydrogenase (hUGDH)variant T131SHomo sapiensNAD+—0.70.6pH 7.5, 25 °CPMID 22123821Open
UDP-glucose 6-dehydrogenase (hUGDH)variant T131SHomo sapiensUDP-alpha-D-glucose0.450.0411.3pH 7.5, 25 °CPMID 22123821Open
UDP-glucose 6-dehydrogenase Cj1441Campylobacter jejuniNAD+0.80.194.2pH 8.7, 25 °CPMID 33621065Open
UDP-glucose 6-dehydrogenase Cj1441Campylobacter jejuniUDP-alpha-D-glucoseapparent kcat1.1——pH 8.7, 25 °CPMID 33621065Open
UDP-glucose 6-dehydrogenase Cj1441Campylobacter jejuniUDP-alpha-D-glucoseapparent Km—0.21—pH 8.7, 25 °CPMID 33621065Open
UDP-glucose 6-dehydrogenase Cj1441Campylobacter jejuniUDP-alpha-D-glucoseapparent kcat/Km——5.2pH 8.7, 25 °CPMID 33621065Open
UDP-glucose 6-dehydrogenase Cj1441Campylobacter jejuniUDP-alpha-D-glucosewith 2.0 mM ethanolamine; apparent kcat0.9——pH 8.7, 25 °CPMID 33621065Open
UDP-glucose 6-dehydrogenase Cj1441Campylobacter jejuniUDP-alpha-D-glucosewith 2.0 mM ethanolamine; apparent Km—0.3—pH 8.7, 25 °CPMID 33621065Open
UDP-glucose 6-dehydrogenase Cj1441Campylobacter jejuniUDP-alpha-D-glucosewith 2.0 mM ethanolamine; apparent kcat/Km——3pH 8.7, 25 °CPMID 33621065Open
UDP-glucose 6-dehydrogenase Cj1441Campylobacter jejuniUDP-alpha-D-glucosewith 2.0 mM ethanolamine phosphate; apparent kcat0.8——pH 8.7, 25 °CPMID 33621065Open
UDP-glucose 6-dehydrogenase Cj1441Campylobacter jejuniUDP-alpha-D-glucosewith 2.0 mM ethanolamine phosphate; apparent Km—0.21—pH 8.7, 25 °CPMID 33621065Open
UDP-glucose 6-dehydrogenase Cj1441Campylobacter jejuniUDP-alpha-D-glucosewith 2.0 mM ethanolamine phosphate; apparent kcat/Km——3.8pH 8.7, 25 °CPMID 33621065Open
UDP-glucose 6-dehydrogenase Cj1441Campylobacter jejuniUDP-alpha-D-glucosewith 2.0 mM serinol; apparent kcat0.8——pH 8.7, 25 °CPMID 33621065Open
UDP-glucose 6-dehydrogenase Cj1441Campylobacter jejuniUDP-alpha-D-glucosewith 2.0 mM serinol; apparent Km—0.23—pH 8.7, 25 °CPMID 33621065Open
UDP-glucose 6-dehydrogenase Cj1441Campylobacter jejuniUDP-alpha-D-glucosewith 2.0 mM serinol; apparent kcat/Km——3.5pH 8.7, 25 °CPMID 33621065Open
UDP-glucose 6-dehydrogenase Cj1441Campylobacter jejuniUDP-alpha-D-glucosewith 2.0 mM serinol phosphate; apparent kcat0.8——pH 8.7, 25 °CPMID 33621065Open
UDP-glucose 6-dehydrogenase Cj1441Campylobacter jejuniUDP-alpha-D-glucosewith 2.0 mM serinol phosphate; apparent Km—0.2—pH 8.7, 25 °CPMID 33621065Open
UDP-glucose 6-dehydrogenase Cj1441Campylobacter jejuniUDP-alpha-D-glucosewith 2.0 mM serinol phosphate; apparent kcat/Km——4pH 8.7, 25 °CPMID 33621065Open
UDP-glucose dehydrogenaseStreptococcus pyogenesnicotinamide adenine dinucleotide (oxidized)—0.065—PMID 14686915Open
UDP-glucose dehydrogenaseStreptococcus pyogenesUDP-glucose1.80.0290 calc.PMID 14686915Open
UDP-glucose dehydrogenasevariant C260AStreptococcus pyogenesuridine diphospho-alpha-D-gluco-hexodialdose1.90.05833 calc.pH 8.7, 30 °CPMID 14686915Open
UDP-glucose dehydrogenasevariant E141QStreptococcus pyogenesnicotinamide adenine dinucleotide (oxidized)—0.135—PMID 14686915Open
UDP-glucose dehydrogenasevariant E141QStreptococcus pyogenesUDP-glucose0.140.062.3 calc.PMID 14686915Open
UDP-glucose dehydrogenasevariant E145QStreptococcus pyogenesnicotinamide adenine dinucleotide (oxidized)—0.187—PMID 14686915Open
UDP-glucose dehydrogenasevariant E145QStreptococcus pyogenesUDP-glucose0.20.1251.6 calc.PMID 14686915Open
UDP-glucose dehydrogenasevariant T118AStreptococcus pyogenesnicotinamide adenine dinucleotide (oxidized)—0.4—PMID 14686915Open
UDP-glucose dehydrogenasevariant T118AStreptococcus pyogenesUDP-glucose0.0110.0590.19 calc.PMID 14686915Open
UDP-glucose dehydrogenase (HasB UDPGDH)Streptococcus pyogenesNAD+—0.06—pH 8.7, 30 °CPMID 9013585Open
UDP-glucose dehydrogenase (HasB UDPGDH)Streptococcus pyogenesUDP-alpha-D-glucose1.70.0285 calc.pH 8.7, 30 °CPMID 9013585Open
UDP-glucose dehydrogenase (hUGDH)Homo sapiensNAD+—0.133790pH 8.7PMID 17927902Open
UDP-glucose dehydrogenase (hUGDH)Homo sapiensNAD+0.76——pH 7.5, 25 °CPMID 27966912Open
UDP-glucose dehydrogenase (hUGDH)Homo sapiensNAD+0.94——pH 7.5, 25 °CPMID 30457329Open
UDP-glucose dehydrogenase (hUGDH)Homo sapiensNAD+kcat from a Hill fit, n = 0.59 ± 0.041.76——pH 7.5, 25 °CPMID 39680853Open
UDP-glucose dehydrogenase (hUGDH)Homo sapiensNAD+1.33——pH 7.5, 25 °CPMID 39680853Open
UDP-glucose dehydrogenase (hUGDH)Homo sapiensNAD+kcat from a Hill fit, n = 0.77 ± 0.071.42——pH 7.5, 25 °CPMID 39680853Open
UDP-glucose dehydrogenase (hUGDH)Homo sapiensNAD+1.39——pH 7.5, 25 °CPMID 39680853Open
UDP-glucose dehydrogenase (hUGDH)Homo sapiensUDP-alpha-D-glucose1050.0176.2 × 10³pH 8.7PMID 17927902Open
UDP-glucose dehydrogenase (hUGDH)Homo sapiensUDP-glucose2.5 mM NAD+ (saturating); UDP-Glc saturation curve0.550.009757 calc.pH 7.5, 25 °CPMID 27966912Open
UDP-glucose dehydrogenase (hUGDH)Homo sapiensUDP-glucose0.550.009558 calc.pH 7.5, 25 °CPMID 27966912Open
UDP-glucose dehydrogenase (hUGDH)Homo sapiensUDP-glucoseUDP-Glc saturation curve with NAD+ fixed at 5 mM (Table 3)0.590.007678 calc.pH 7.5, 25 °CPMID 30457329Open
UDP-glucose dehydrogenase (hUGDH)Homo sapiensUDP-glucoseUDP-Glc saturation curves at 00.590.007480 calc.pH 7.5, 25 °CPMID 30457329Open
UDP-glucose dehydrogenase (hUGDH)Homo sapiensUDP-glucoseUDP-Glc saturation curve in the presence of 2.7 μM UDP-Xyl0.45——pH 7.5, 25 °CPMID 30457329Open
UDP-glucose dehydrogenase (hUGDH)Homo sapiensUDP-glucosehyperbolic fit (Hill = 1); apparent Km; Table 21.20.02157 calc.pH 7.5, 25 °CPMID 39680853Open
UDP-glucose dehydrogenase (hUGDH)Homo sapiensUDP-glucosehyperbolic fit (Hill = 1); Table 21.340.0105128 calc.pH 7.5, 25 °CPMID 39680853Open
UDP-glucose dehydrogenase (hUGDH)Homo sapiensUDP-glucoseglobal fit (eqs 2 and 3) of saturation curves at 0; Table 31.360.01075127 calc.pH 7.5, 25 °CPMID 39680853Open
UDP-glucose dehydrogenase (hUGDH)Homo sapiensUDP-glucoseglobal fit (eqs 2 and 3) of saturation curves at 0; Table 31.330.01036128 calc.pH 7.5, 25 °CPMID 39680853Open
UDP-glucose dehydrogenase (hUGDH)variant A104GHomo sapiensUDP-glucose0.670.017239 calc.pH 7.5, 25 °CPMID 30457329Open
UDP-glucose dehydrogenase (hUGDH)variant A104LHomo sapiensNAD+0.790.04816 calc.pH 7.5, 25 °CPMID 30457329Open
UDP-glucose dehydrogenase (hUGDH)variant A104LHomo sapiensUDP-glucoseUDP-Glc saturation curve with NAD+ fixed at 5 mM (Table 3)0.820.009487 calc.pH 7.5, 25 °CPMID 30457329Open
UDP-glucose dehydrogenase (hUGDH)variant A104LHomo sapiensUDP-glucoseUDP-Glc saturation curves at 00.840.010382 calc.pH 7.5, 25 °CPMID 30457329Open
UDP-glucose dehydrogenase (hUGDH)variant A104LHomo sapiensUDP-glucose0.850.008897 calc.pH 7.5, 25 °CPMID 30457329Open
UDP-glucose dehydrogenase (hUGDH)variant A136MHomo sapiensNAD+0.830.099.2 calc.pH 7.5, 25 °CPMID 27966912Open
UDP-glucose dehydrogenase (hUGDH)variant A136MHomo sapiensUDP-glucose2.5 mM NAD+ (saturating); UDP-Glc saturation curve0.730.00726100 calc.pH 7.5, 25 °CPMID 27966912Open
UDP-glucose dehydrogenase (hUGDH)variant A136MHomo sapiensUDP-glucoseglobal fit of UDP-Glc saturation curves at 00.740.00734100 calc.pH 7.5, 25 °CPMID 27966912Open
UDP-glucose dehydrogenase (hUGDH)variant A136MHomo sapiensUDP-glucosewith 60 µM UDP-Xyl (inhibitor); separate experiment0.850.0063130 calc.pH 7.5, 25 °CPMID 27966912Open
UDP-glucose dehydrogenase (hUGDH)variant A222Q/S233GHomo sapiensNAD+—0.401240pH 8.7PMID 17927902Open
UDP-glucose dehydrogenase (hUGDH)variant A222Q/S233GHomo sapiensUDP-alpha-D-glucose970.98100pH 8.7PMID 17927902Open
UDP-glucose dehydrogenase UGD2Arabidopsis thalianaNAD+—0.043—pH 8.7PMID 18057039Open
UDP-glucose dehydrogenase UGD2Arabidopsis thalianaUDP-alpha-D-glucose1.920.12315.6 calc.pH 8.7PMID 18057039Open
UDP-glucose dehydrogenase UGD3Arabidopsis thalianaNAD+—0.042—pH 8.7PMID 18057039Open
UDP-glucose dehydrogenase UGD3Arabidopsis thalianaUDP-alpha-D-glucose2.520.3357.52 calc.pH 8.7PMID 18057039Open
UDP-glucose dehydrogenase UGD4Arabidopsis thalianaNAD+—0.044—pH 8.7PMID 18057039Open
UDP-glucose dehydrogenase UGD4Arabidopsis thalianaUDP-alpha-D-glucose1.170.1716.84 calc.pH 8.7PMID 18057039Open
UDP-α-D-glucose 6-dehydrogenase (hUGDH)Homo sapiensNAD+4.3820.38411.4 calc.pH 8.7, 25 °CPMID 23106432Open
UDP-α-D-glucose 6-dehydrogenase (hUGDH)Homo sapiensUDP-α-D-glucose3.1450.0253124 calc.pH 8.7, 25 °CPMID 23106432Open
UDP-α-D-glucose 6-dehydrogenase (hUGDH)variant K94EHomo sapiensNAD+0.02176.30.0034 calc.pH 8.7, 25 °CPMID 23106432Open
UDP-α-D-glucose 6-dehydrogenase (hUGDH)variant K94EHomo sapiensUDP-α-D-glucose0.02352.210.0106 calc.pH 8.7, 25 °CPMID 23106432Open