CatLogenzyme kinetics catalog

EC 1.1.1.225: chlordecone reductase

OxidoreductasesOpen in Browse

CatLog read 24 records for EC 1.1.1.225 from 5 papers, for 1 organism. Names in these papers: AKR1C4, aldo-keto reductase AKR1C4 (human type 1 3α-HSD), AKR1C4 (hydroxysteroid dehydrogenase isoform).

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 3 records for EC 1.1.1.225 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.1.1.225 in Browse.

Papers

PaperOrganismsRecords
Selective and potent inhibitors of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) that metabolizes neurosteroids derived from progesteroneHomo sapiens17
Human cytosolic hydroxysteroid dehydrogenases of the aldo-ketoreductase superfamily catalyze reduction of conjugated steroids: implications for phase I and phase II steroid hormone metabolismHomo sapiens4
Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone…Homo sapiens1
Kinetic studies of AKR1B10, human aldose reductase-like protein: endogenous substrates and inhibition by steroidsHomo sapiens1
A new branch of mammalian vitamin B6 metabolism: AKR1C-mediated conversion of pyridoxal to pyridoxine and 4-pyridoxolactoneHomo sapiens1

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
AKR1C4Homo sapiens(S)-1,2,3,4-tetrahydro-1-naphthol0.20.111.8pH 7, 25 °CPMID 12604236Open
AKR1C4Homo sapiens17β-hydroxy-5α-androstan-3-one (5α-dihydrotestosterone)0.0938——pH 7, 37 °CPMID 14672942Open
AKR1C4Homo sapiens4-pregnen-20α-ol-3-one0.00573 × 10⁻⁴18pH 7, 25 °CPMID 12604236Open
AKR1C4Homo sapiens5α-pregnan-20α-ol-3-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.0220.001120pH 7, 25 °CPMID 12604236Open
AKR1C4Homo sapiens5α-pregnan-20α-ol-3-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.01072 × 10⁻⁴53pH 7, 25 °CPMID 12604236Open
AKR1C4Homo sapiens5α-pregnan-3α-ol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.019 × 10⁻⁴11.2pH 7, 25 °CPMID 12604236Open
AKR1C4Homo sapiens5α-pregnan-3α-ol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.0672 × 10⁻⁴330pH 7, 25 °CPMID 12604236Open
AKR1C4Homo sapiens5α-pregnane-21-ol-3,20-dione0.0350.001720pH 7, 25 °CPMID 12604236Open
AKR1C4Homo sapiens5α-pregnane-3,20-dione0.026 × 10⁻⁴33pH 7, 25 °CPMID 12604236Open
AKR1C4Homo sapiens5α-pregnane-3α,20α-diol0.0672 × 10⁻⁴330pH 7, 25 °CPMID 12604236Open
AKR1C4Homo sapiens5α-pregnane-3α,21-diol-20-one0.073 × 10⁻⁴230pH 7, 25 °CPMID 12604236Open
AKR1C4Homo sapiens5β-pregnan-20α-ol-3-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.0230.001515.5pH 7, 25 °CPMID 12604236Open
AKR1C4Homo sapiens5β-pregnan-20α-ol-3-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.00833 × 10⁻⁴28pH 7, 25 °CPMID 12604236Open
AKR1C4Homo sapiens5β-pregnan-3α-ol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.01225 × 10⁻⁴25pH 7, 25 °CPMID 12604236Open
AKR1C4Homo sapiens5β-pregnan-3α-ol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.0274 × 10⁻⁴67pH 7, 25 °CPMID 12604236Open
AKR1C4Homo sapiens5β-pregnane-3,20-dione0.0577 × 10⁻⁴82pH 7, 25 °CPMID 12604236Open
AKR1C4Homo sapiens5β-pregnane-3α,20α-diol0.022 × 10⁻⁴100pH 7, 25 °CPMID 12604236Open
AKR1C4Homo sapienspregn-4-ene-3,20-dione8.3 × 10⁻⁴——pH 7, 25 °CPMID 12604236Open
AKR1C4Homo sapienspyridoxal0.0060.3040.02pH 7, 37 °CPMID 41741972Open
AKR1C4 (hydroxysteroid dehydrogenase isoform)Homo sapiens(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenal (all-trans-geranylgeranial)——13PMID 19464995Open
aldo-keto reductase AKR1C4 (human type 1 3α-HSD)Homo sapiens5α-dihydrotestosterone0.0513——PMID 19218247Open
aldo-keto reductase AKR1C4 (human type 1 3α-HSD)Homo sapiens5α-dihydrotestosterone-17β-glucuronide0.0547——PMID 19218247Open
aldo-keto reductase AKR1C4 (human type 1 3α-HSD)Homo sapiens5α-dihydrotestosterone-17β-sulfate0.0512——PMID 19218247Open
aldo-keto reductase AKR1C4 (human type 1 3α-HSD)Homo sapienstibolone-17β-sulfate0.025 × 10⁻⁴40PMID 19218247Open