CatLogenzyme kinetics catalog

Values CatLog read from this paper

Selective and potent inhibitors of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) that metabolizes neurosteroids derived from progesterone

PMID 12604236doi:10.1016/s0009-2797(02)00206-5Open in Browse

The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.

CatLog read 71 records (173 values) from this paper: AKR1C1, AKR1C2, AKR1C4 and 1 more from Homo sapiens.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.

EC 1.1.1.51, EC 1.1.1.53, EC 1.1.1.62, EC 1.1.1.64, EC 1.1.1.112, EC 1.1.1.149, EC 1.1.1.188, EC 1.1.1.209, EC 1.1.1.210, EC 1.1.1.225, EC 1.1.1.239, EC 1.1.1.270, EC 1.1.1.357, EC 1.3.1.20

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)Conditions
AKR1C1Homo sapiens(S)-1,2,3,4-tetrahydro-1-naphthol0.430.00762pH 7, 25 °COpen
AKR1C1Homo sapiens4-pregnen-20α-ol-3-one0.1520.0169.5pH 7, 25 °COpen
AKR1C1Homo sapiens5α-pregnan-20α-ol-3-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.017 × 10⁻⁴14.3pH 7, 25 °COpen
AKR1C1Homo sapiens5α-pregnan-20α-ol-3-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.1520.002757pH 7, 25 °COpen
AKR1C1Homo sapiens5α-pregnan-3α-ol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.0730.00237pH 7, 25 °COpen
AKR1C1Homo sapiens5α-pregnan-3α-ol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.00130.00330.33pH 7, 25 °COpen
AKR1C1Homo sapiens5α-pregnane-21-ol-3,20-dione0.00930.00127pH 7, 25 °COpen
AKR1C1Homo sapiens5α-pregnane-3,20-dione0.0430.001140pH 7, 25 °COpen
AKR1C1Homo sapiens5α-pregnane-3α,20α-diol0.0379 × 10⁻⁴40pH 7, 25 °COpen
AKR1C1Homo sapiens5α-pregnane-3α,21-diol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.0017——pH 7, 25 °COpen
AKR1C1Homo sapiens5α-pregnane-3α,21-diol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.00370.00261.3pH 7, 25 °COpen
AKR1C1Homo sapiens5β-pregnan-20α-ol-3-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.0370.001328pH 7, 25 °COpen
AKR1C1Homo sapiens5β-pregnan-20α-ol-3-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.0930.00193pH 7, 25 °COpen
AKR1C1Homo sapiens5β-pregnan-3α-ol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.180.003355pH 7, 25 °COpen
AKR1C1Homo sapiens5β-pregnan-3α-ol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.0060.00451.3pH 7, 25 °COpen
AKR1C1Homo sapiens5β-pregnan-3α-ol-20-oneKm from secondary plots; reduction of 3α,5β-THP—0.0012—pH 7, 25 °COpen
AKR1C1Homo sapiens5β-pregnane-3,20-dione0.050.001242pH 7, 25 °COpen
AKR1C1Homo sapiens5β-pregnane-3α,20α-dioloxidation direction with 0.25 mM NADP+0.160.0015107pH 7, 25 °COpen
AKR1C1Homo sapiens5β-pregnane-3α,20α-diolKm from secondary plots—0.0011—pH 7, 25 °COpen
AKR1C1Homo sapiensNADP+—9 × 10⁻⁴—pH 7, 25 °COpen
AKR1C1Homo sapiensNADPH—0.0021—pH 7, 25 °COpen
AKR1C1Homo sapienspregn-4-ene-3,20-dione0.0250.001320pH 7, 25 °COpen
AKR1C2Homo sapiens(S)-1,2,3,4-tetrahydro-1-naphthol0.270.261pH 7, 25 °COpen
AKR1C2Homo sapiens4-pregnen-20α-ol-3-one0.00220.00730.33pH 7, 25 °COpen
AKR1C2Homo sapiens5α-pregnan-20α-ol-3-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.0085 × 10⁻⁴16pH 7, 25 °COpen
AKR1C2Homo sapiens5α-pregnan-20α-ol-3-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.001——pH 7, 25 °COpen
AKR1C2Homo sapiens5α-pregnan-3α-ol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.00430.00311.3pH 7, 25 °COpen
AKR1C2Homo sapiens5α-pregnan-3α-ol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.00470.0280.17pH 7, 25 °COpen
AKR1C2Homo sapiens5α-pregnane-21-ol-3,20-dione0.00828 × 10⁻⁴10.2pH 7, 25 °COpen
AKR1C2Homo sapiens5α-pregnane-3,20-dione0.0086 × 10⁻⁴11.7pH 7, 25 °COpen
AKR1C2Homo sapiens5α-pregnane-3α,20α-diol0.00320.00181.8pH 7, 25 °COpen
AKR1C2Homo sapiens5α-pregnane-3α,21-diol-20-one0.00220.00680.33pH 7, 25 °COpen
AKR1C2Homo sapiens5β-pregnan-20α-ol-3-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.01083 × 10⁻⁴37pH 7, 25 °COpen
AKR1C2Homo sapiens5β-pregnan-20α-ol-3-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.0012——pH 7, 25 °COpen
AKR1C2Homo sapiens5β-pregnan-3α-ol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.0070.00451.5pH 7, 25 °COpen
AKR1C2Homo sapiens5β-pregnan-3α-ol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.00450.00281.7pH 7, 25 °COpen
AKR1C2Homo sapiens5β-pregnane-3,20-dione0.0187 × 10⁻⁴27pH 7, 25 °COpen
AKR1C2Homo sapiens5β-pregnane-3α,20α-diol0.00370.0013.7pH 7, 25 °COpen
AKR1C2Homo sapienspregn-4-ene-3,20-dione6.7 × 10⁻⁴——pH 7, 25 °COpen
AKR1C3Homo sapiens(S)-1,2,3,4-tetrahydro-1-naphthol0.581.40.5pH 7, 25 °COpen
AKR1C3Homo sapiens4-pregnen-20α-ol-3-one5 × 10⁻⁴——pH 7, 25 °COpen
AKR1C3Homo sapiens5α-pregnan-20α-ol-3-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.00870.00214.2pH 7, 25 °COpen
AKR1C3Homo sapiens5α-pregnan-20α-ol-3-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+1.7 × 10⁻⁴——pH 7, 25 °COpen
AKR1C3Homo sapiens5α-pregnan-3α-ol-20-one0.0013——pH 7, 25 °COpen
AKR1C3Homo sapiens5α-pregnane-21-ol-3,20-dione0.001——pH 7, 25 °COpen
AKR1C3Homo sapiens5α-pregnane-3,20-dione0.001——pH 7, 25 °COpen
AKR1C3Homo sapiens5α-pregnane-3α,20α-diol0.001——pH 7, 25 °COpen
AKR1C3Homo sapiens5α-pregnane-3α,21-diol-20-one1.7 × 10⁻⁴——pH 7, 25 °COpen
AKR1C3Homo sapiens5β-pregnan-20α-ol-3-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.0189 × 10⁻⁴20pH 7, 25 °COpen
AKR1C3Homo sapiens5β-pregnan-20α-ol-3-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+5 × 10⁻⁴——pH 7, 25 °COpen
AKR1C3Homo sapiens5β-pregnan-3α-ol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.001——pH 7, 25 °COpen
AKR1C3Homo sapiens5β-pregnan-3α-ol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.001——pH 7, 25 °COpen
AKR1C3Homo sapiens5β-pregnane-3,20-dione0.0032——pH 7, 25 °COpen
AKR1C3Homo sapiens5β-pregnane-3α,20α-diol0.0280.0271pH 7, 25 °COpen
AKR1C4Homo sapiens(S)-1,2,3,4-tetrahydro-1-naphthol0.20.111.8pH 7, 25 °COpen
AKR1C4Homo sapiens4-pregnen-20α-ol-3-one0.00573 × 10⁻⁴18pH 7, 25 °COpen
AKR1C4Homo sapiens5α-pregnan-20α-ol-3-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.0220.001120pH 7, 25 °COpen
AKR1C4Homo sapiens5α-pregnan-20α-ol-3-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.01072 × 10⁻⁴53pH 7, 25 °COpen
AKR1C4Homo sapiens5α-pregnan-3α-ol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.019 × 10⁻⁴11.2pH 7, 25 °COpen
AKR1C4Homo sapiens5α-pregnan-3α-ol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.0672 × 10⁻⁴330pH 7, 25 °COpen
AKR1C4Homo sapiens5α-pregnane-21-ol-3,20-dione0.0350.001720pH 7, 25 °COpen
AKR1C4Homo sapiens5α-pregnane-3,20-dione0.026 × 10⁻⁴33pH 7, 25 °COpen
AKR1C4Homo sapiens5α-pregnane-3α,20α-diol0.0672 × 10⁻⁴330pH 7, 25 °COpen
AKR1C4Homo sapiens5α-pregnane-3α,21-diol-20-one0.073 × 10⁻⁴230pH 7, 25 °COpen
AKR1C4Homo sapiens5β-pregnan-20α-ol-3-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.0230.001515.5pH 7, 25 °COpen
AKR1C4Homo sapiens5β-pregnan-20α-ol-3-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.00833 × 10⁻⁴28pH 7, 25 °COpen
AKR1C4Homo sapiens5β-pregnan-3α-ol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.01225 × 10⁻⁴25pH 7, 25 °COpen
AKR1C4Homo sapiens5β-pregnan-3α-ol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.0274 × 10⁻⁴67pH 7, 25 °COpen
AKR1C4Homo sapiens5β-pregnane-3,20-dione0.0577 × 10⁻⁴82pH 7, 25 °COpen
AKR1C4Homo sapiens5β-pregnane-3α,20α-diol0.022 × 10⁻⁴100pH 7, 25 °COpen
AKR1C4Homo sapienspregn-4-ene-3,20-dione8.3 × 10⁻⁴——pH 7, 25 °COpen