EC 1.1.1.149: 20alpha-hydroxysteroid dehydrogenase

OxidoreductasesOpen in Browse

CatLog read 117 records for EC 1.1.1.149 from 8 papers, for 3 organisms. Names in these papers: 20α-hydroxysteroid dehydrogenase (AKR1C5), AKR1C1, 20alpha-hydroxysteroid dehydrogenase, 20α-hydroxysteroid dehydrogenase (AKR1C1) and 1 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 150 records for EC 1.1.1.149 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.1.1.149 in Browse.

Papers

Papers with records for EC 1.1.1.149
Paper	Organisms	Records
Substrate specificity and inhibitor sensitivity of rabbit 20α-hydroxysteroid dehydrogenase	Homo sapiens, Oryctolagus cuniculus	64
Selective and potent inhibitors of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) that metabolizes neurosteroids derived from progesterone	Homo sapiens	22
Purification and characterization of a novel dimeric 20 alpha-hydroxysteroid dehydrogenase from Tetrahymena pyriformis	Tetrahymena pyriformis	18
Human cytosolic hydroxysteroid dehydrogenases of the aldo-ketoreductase superfamily catalyze reduction of conjugated steroids: implications for phase I and phase II steroid hormone metabolism	Homo sapiens	4
Factorizing the role of a critical leucine residue in the binding of substrate to human 20alpha-hydroxysteroid dehydrogenase (AKR1C1): molecular modeling and kinetic studies of the Leu308Val mutant…	Homo sapiens	4
An indomethacin analogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3alpha-HSD, type 5 17beta-HSD, and prostaglandin F synthase), a potential target…	Homo sapiens	2
A new branch of mammalian vitamin B₆ metabolism: AKR1C-mediated conversion of pyridoxal to pyridoxine and 4-pyridoxolactone	Homo sapiens	2
Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone…	Homo sapiens	1

Records

Records for EC 1.1.1.149 read from the paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Paper	Open record
20alpha-hydroxysteroid dehydrogenase	Tetrahymena pyriformis	1,2-Cyclohexanedione	—	0.125	—	pH 6.5, 25 °C	PMID 8280099	Open record: 20alpha-hydroxysteroid dehydrogenase, 1,2-Cyclohexanedione
20alpha-hydroxysteroid dehydrogenase	Tetrahymena pyriformis	17α,20α-Dihydroxypregn-4-en-3-one	—	0.013	—	pH 10, 25 °C	PMID 8280099	Open record: 20alpha-hydroxysteroid dehydrogenase, 17α,20α-Dihydroxypregn-4-en-3-one
20alpha-hydroxysteroid dehydrogenase	Tetrahymena pyriformis	17α,21-Dihydroxy-5β-pregnane-3,11,20-trione	—	0.02	—	pH 6.5, 25 °C	PMID 8280099	Open record: 20alpha-hydroxysteroid dehydrogenase, 17α,21-Dihydroxy-5β-pregnane-3,11,20-trione
20alpha-hydroxysteroid dehydrogenase	Tetrahymena pyriformis	17α,21-Dihydroxy-5β-pregnane-3,20-dione	—	0.022	—	pH 6.5, 25 °C	PMID 8280099	Open record: 20alpha-hydroxysteroid dehydrogenase, 17α,21-Dihydroxy-5β-pregnane-3,20-dione
20alpha-hydroxysteroid dehydrogenase	Tetrahymena pyriformis	17α-hydroxypregn-4-ene-3,20-dione	—	0.0029	—	pH 6.5, 25 °C	PMID 8280099	Open record: 20alpha-hydroxysteroid dehydrogenase, 17α-hydroxypregn-4-ene-3,20-dione
20alpha-hydroxysteroid dehydrogenase	Tetrahymena pyriformis	2,4-Pentanedione	—	0.21	—	pH 6.5, 25 °C	PMID 8280099	Open record: 20alpha-hydroxysteroid dehydrogenase, 2,4-Pentanedione
20alpha-hydroxysteroid dehydrogenase	Tetrahymena pyriformis	20α-Hydroxy-5β-pregnan-3-one	—	0.073	—	pH 10, 25 °C	PMID 8280099	Open record: 20alpha-hydroxysteroid dehydrogenase, 20α-Hydroxy-5β-pregnan-3-one
20alpha-hydroxysteroid dehydrogenase	Tetrahymena pyriformis	3β,17α-dihydroxypregn-5-en-20-one	—	0.0034	—	pH 6.5, 25 °C	PMID 8280099	Open record: 20alpha-hydroxysteroid dehydrogenase, 3β,17α-dihydroxypregn-5-en-20-one
20alpha-hydroxysteroid dehydrogenase	Tetrahymena pyriformis	4-Nitrobenzaldehyde	—	0.34	—	pH 6.5, 25 °C	PMID 8280099	Open record: 20alpha-hydroxysteroid dehydrogenase, 4-Nitrobenzaldehyde
20alpha-hydroxysteroid dehydrogenase	Tetrahymena pyriformis	Camphorquinone	—	0.078	—	pH 6.5, 25 °C	PMID 8280099	Open record: 20alpha-hydroxysteroid dehydrogenase, Camphorquinone
20alpha-hydroxysteroid dehydrogenase	Tetrahymena pyriformis	D-Glyceraldehyde	—	0.67	—	pH 6.5, 25 °C	PMID 8280099	Open record: 20alpha-hydroxysteroid dehydrogenase, D-Glyceraldehyde
20alpha-hydroxysteroid dehydrogenase	Tetrahymena pyriformis	Ethyl acetoacetate	—	0.067	—	pH 6.5, 25 °C	PMID 8280099	Open record: 20alpha-hydroxysteroid dehydrogenase, Ethyl acetoacetate
20alpha-hydroxysteroid dehydrogenase	Tetrahymena pyriformis	Isatin	—	0.064	—	pH 6.5, 25 °C	PMID 8280099	Open record: 20alpha-hydroxysteroid dehydrogenase, Isatin
20alpha-hydroxysteroid dehydrogenase	Tetrahymena pyriformis	NADP+	—	0.008	—	pH 7, 25 °C	PMID 8280099	Open record: 20alpha-hydroxysteroid dehydrogenase, NADP+
20alpha-hydroxysteroid dehydrogenase	Tetrahymena pyriformis	NADPH	—	2 × 10⁻⁴	—	pH 7, 25 °C	PMID 8280099	Open record: 20alpha-hydroxysteroid dehydrogenase, NADPH
20alpha-hydroxysteroid dehydrogenase	Tetrahymena pyriformis	Phenylglyoxal	—	0.43	—	pH 6.5, 25 °C	PMID 8280099	Open record: 20alpha-hydroxysteroid dehydrogenase, Phenylglyoxal
20alpha-hydroxysteroid dehydrogenase	Tetrahymena pyriformis	Pyridine-3-aldehyde	—	0.081	—	pH 6.5, 25 °C	PMID 8280099	Open record: 20alpha-hydroxysteroid dehydrogenase, Pyridine-3-aldehyde
20alpha-hydroxysteroid dehydrogenase	Tetrahymena pyriformis	trans-1,2-dihydroxycyclohexa-3,5-diene	—	2.1	—	pH 10, 25 °C	PMID 8280099	Open record: 20alpha-hydroxysteroid dehydrogenase, trans-1,2-dihydroxycyclohexa-3,5-diene
20α-hydroxysteroid dehydrogenase (AKR1C1)	Homo sapiens	β-Ionol	0.053	0.0012	44 calc.	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C1), β-Ionol
20α-hydroxysteroid dehydrogenase (AKR1C1)variant L308A	Homo sapiens	(S)-1,2,3,4-tetrahydronaphthalen-1-ol	—	0.47	0.83	pH 7.4, 25 °C	PMID 20656485	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C1) variant L308A, (S)-1,2,3,4-tetrahydronaphthalen-1-ol
20α-hydroxysteroid dehydrogenase (AKR1C1)variant L308V	Homo sapiens	(S)-1,2,3,4-tetrahydronaphthalen-1-ol	—	0.016	13	pH 7.4, 25 °C	PMID 20656485	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C1) variant L308V, (S)-1,2,3,4-tetrahydronaphthalen-1-ol
20α-hydroxysteroid dehydrogenase (AKR1C1)variant L308V	Homo sapiens	5α-pregnane-3α,20α-diol	—	4 × 10⁻⁴	270	pH 7.4, 25 °C	PMID 20656485	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C1) variant L308V, 5α-pregnane-3α,20α-diol
20α-hydroxysteroid dehydrogenase (AKR1C1)variant L308V	Homo sapiens	5β-pregnan-3α-ol-20-one	—	0.0062	27	pH 7.4, 25 °C	PMID 20656485	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C1) variant L308V, 5β-pregnan-3α-ol-20-one
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	(S)-1-Indanol	0.2	0.131	1.53	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), (S)-1-Indanol
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	(S)-1-Tetralol	0.22	0.112	2	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), (S)-1-Tetralol
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	1-Hexanal	0.043	0.0076	5.7	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 1-Hexanal
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	1-Nonanal	0.032	9 × 10⁻⁴	35	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 1-Nonanal
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	17β-Estradiol	0.0112	0.0013	8.7	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 17β-Estradiol
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	2-tert-butyl-1,4-benzoquinone	0.18	0.001	180	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 2-tert-butyl-1,4-benzoquinone
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	20α-Hydroxyprogesterone	0.048	0.0022	22	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 20α-Hydroxyprogesterone
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	3-Deoxyglucosone	0.18	1.4	0.13	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 3-Deoxyglucosone
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	4-Androstene-3,17-dione	0.043	0.001	43	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 4-Androstene-3,17-dione
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	4-Chromanol	0.068	0.152	0.45	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 4-Chromanol
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	4-Hydroxy-2-nonenal	0.0087	0.0053	1.63	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 4-Hydroxy-2-nonenal
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	4-Nitroacetophenone	0.112	0.0012	93	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 4-Nitroacetophenone
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	4-Oxo-2-hexenal	0.0115	0.0059	1.8	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 4-Oxo-2-hexenal
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	4-Oxo-2-nonenal	0.112	0.0018	62	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 4-Oxo-2-nonenal
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	4-Pregnen-3α-ol-20-one	0.032	0.001	32	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 4-Pregnen-3α-ol-20-one
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	5-Androstene-3β,17β-diol	0.1	0.0031	32	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5-Androstene-3β,17β-diol
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	5α-androstan-17β-ol-3-onereduction; 0.1 mM NADPH; NADPH absorbance; cosubstrate NADPH	0.025	0.0034	7.3	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5α-androstan-17β-ol-3-one
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	5α-androstan-17β-ol-3-oneoxidation; 0.25 mM NADP+; NADPH fluorescence	0.047	0.018	2.7	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5α-androstan-17β-ol-3-one
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	5α-Androstan-3α-ol-17-one	0.085	0.0041	20	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5α-Androstan-3α-ol-17-one
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	5α-Androstan-3β-ol-17-one	0.083	0.006	13.8	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5α-Androstan-3β-ol-17-one
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	5α-Androstane-3α,17β-diol	0.27	0.0042	63	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5α-Androstane-3α,17β-diol
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	5α-Androstane-3β,17β-diol	0.032	0.0022	14.3	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5α-Androstane-3β,17β-diol
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	5α-Pregnan-20α-ol-3-onereduction; 0.1 mM NADPH; NADPH absorbance; cosubstrate NADPH	0.077	0.0059	13	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5α-Pregnan-20α-ol-3-one
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	5α-Pregnan-20α-ol-3-oneoxidation; 0.25 mM NADP+; NADPH fluorescence	0.158	0.011	14.3	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5α-Pregnan-20α-ol-3-one
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	5α-Pregnan-3α-ol-20-one	0.032	0.0013	25	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5α-Pregnan-3α-ol-20-one
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	5α-Pregnane-3,20-dione	0.018	5 × 10⁻⁴	37	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5α-Pregnane-3,20-dione
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	5α-Pregnane-3α,20α-diol	0.025	8 × 10⁻⁴	30	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5α-Pregnane-3α,20α-diol
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	5α-Pregnane-3α,21-diol-20-one	0.018	0.0062	3	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5α-Pregnane-3α,21-diol-20-one
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	5β-Androstan-17β-ol-3-one	0.153	0.0062	25	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5β-Androstan-17β-ol-3-one
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	5β-Androstan-3α-ol-17-one	0.067	0.0017	40	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5β-Androstan-3α-ol-17-one
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	5β-Androstan-3β-ol-17-one	0.045	0.0028	16	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5β-Androstan-3β-ol-17-one
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	5β-Androstane-3α,17β-diol	0.25	0.0014	180	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5β-Androstane-3α,17β-diol
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	5β-Androstane-3β,17β-diol	0.033	0.0025	13.3	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5β-Androstane-3β,17β-diol
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	5β-Pregnan-20α-ol-3-one	0.153	0.0057	27	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5β-Pregnan-20α-ol-3-one
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	5β-Pregnan-3α-ol-20-one	0.03	0.001	30	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5β-Pregnan-3α-ol-20-one
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	5β-Pregnane-3,20-dione	0.028	0.001	28	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5β-Pregnane-3,20-dione
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	5β-Pregnane-3α,20α-diol	0.28	0.0078	37	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5β-Pregnane-3α,20α-diol
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	5β-Pregnane-3α,21-diol-20-one	0.017	0.0026	6.3	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 5β-Pregnane-3α,21-diol-20-one
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	6-tert-butyl-2,3-epoxy-5-cyclohexen-1,4-dione	0.17	0.002	83	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 6-tert-butyl-2,3-epoxy-5-cyclohexen-1,4-dione
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	7α-hydroxydehydroepiandrosterone	0.043	0.0029	15	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), 7α-hydroxydehydroepiandrosterone
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	Acetoin	0.097	0.162	1.33	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), Acetoin
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	Acrolein	0.035	0.014	2.5	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), Acrolein
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	all-trans-Retinal	0.0085	0.0089	0.95	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), all-trans-Retinal
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	Befunolol	0.117	0.034	13.2	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), Befunolol
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	dehydroepiandrosterone (5-androsten-3β-ol-17-one)	0.155	0.006	27	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), dehydroepiandrosterone (5-androsten-3β-ol-17-one)
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	dehydroepiandrosterone 3-sulfate	0.08	0.0042	18	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), dehydroepiandrosterone 3-sulfate
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	Diacetyl	0.158	0.019	8.3	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), Diacetyl
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	Estrone	0.017	0.0011	15.2	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), Estrone
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	Estrone-3-sulfate	0.098	0.0067	14.7	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), Estrone-3-sulfate
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	Geraniol	0.033	0.18	0.18	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), Geraniol
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	Isatin	0.137	6 × 10⁻⁴	230	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), Isatin
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	Isocaproaldehyde	0.023	0.068	0.35	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), Isocaproaldehyde
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	Ketotifen	0.02	0.111	0.18	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), Ketotifen
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	Menadione	0.125	0.018	2	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), Menadione
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	Methylglyoxal	0.12	0.088	1.37	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), Methylglyoxal
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	Progesterone	0.027	6 × 10⁻⁴	45	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), Progesterone
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	Pyridine-3-aldehyde	0.132	0.061	2.2	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), Pyridine-3-aldehyde
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	Testosterone	0.057	0.013	4.3	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), Testosterone
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	trans-2-Hexenal	0.025	0.0074	3.3	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), trans-2-Hexenal
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	trans-2-Nonenal	0.02	0.0055	3.7	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), trans-2-Nonenal
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	trans-Benzene dihydrodiol	0.108	0.26	0.42	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), trans-Benzene dihydrodiol
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	α-Tetralone	0.053	0.053	1	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), α-Tetralone
20α-hydroxysteroid dehydrogenase (AKR1C5)	Oryctolagus cuniculus	β-Ionol	0.23	0.018	10.2	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C5), β-Ionol
AKR1C1	Homo sapiens	(S)-1,2,3,4-tetrahydro-1-naphthol	0.43	0.007	62	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, (S)-1,2,3,4-tetrahydro-1-naphthol
AKR1C1	Homo sapiens	17β-hydroxy-5α-androstan-3-one (5α-dihydrotestosterone)	0.0125	—	—	pH 7, 37 °C	PMID 14672942	Open record: AKR1C1, 17β-hydroxy-5α-androstan-3-one (5α-dihydrotestosterone)
AKR1C1	Homo sapiens	4-pregnen-20α-ol-3-one	0.152	0.016	9.5	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 4-pregnen-20α-ol-3-one
AKR1C1	Homo sapiens	5α-pregnan-20α-ol-3-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH	0.01	7 × 10⁻⁴	14.3	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5α-pregnan-20α-ol-3-one
AKR1C1	Homo sapiens	5α-pregnan-20α-ol-3-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+	0.152	0.0027	57	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5α-pregnan-20α-ol-3-one
AKR1C1	Homo sapiens	5α-pregnan-3α-ol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH	0.073	0.002	37	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5α-pregnan-3α-ol-20-one
AKR1C1	Homo sapiens	5α-pregnan-3α-ol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+	0.0013	0.0033	0.33	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5α-pregnan-3α-ol-20-one
AKR1C1	Homo sapiens	5α-pregnane-21-ol-3,20-dione	0.0093	0.0012	7	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5α-pregnane-21-ol-3,20-dione
AKR1C1	Homo sapiens	5α-pregnane-3,20-dione	0.043	0.0011	40	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5α-pregnane-3,20-dione
AKR1C1	Homo sapiens	5α-pregnane-3α,20α-diol	0.037	9 × 10⁻⁴	40	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5α-pregnane-3α,20α-diol
AKR1C1	Homo sapiens	5α-pregnane-3α,21-diol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH	0.0017	—	—	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5α-pregnane-3α,21-diol-20-one
AKR1C1	Homo sapiens	5α-pregnane-3α,21-diol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+	0.0037	0.0026	1.3	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5α-pregnane-3α,21-diol-20-one
AKR1C1	Homo sapiens	5β-pregnan-20α-ol-3-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH	0.037	0.0013	28	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5β-pregnan-20α-ol-3-one
AKR1C1	Homo sapiens	5β-pregnan-20α-ol-3-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+	0.093	0.001	93	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5β-pregnan-20α-ol-3-one
AKR1C1	Homo sapiens	5β-pregnan-3α-ol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH	0.18	0.0033	55	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5β-pregnan-3α-ol-20-one
AKR1C1	Homo sapiens	5β-pregnan-3α-ol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+	0.006	0.0045	1.3	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5β-pregnan-3α-ol-20-one
AKR1C1	Homo sapiens	5β-pregnan-3α-ol-20-oneKm from secondary plots; reduction of 3α,5β-THP	—	0.0012	—	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5β-pregnan-3α-ol-20-one
AKR1C1	Homo sapiens	5β-pregnane-3,20-dione	0.05	0.0012	42	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5β-pregnane-3,20-dione
AKR1C1	Homo sapiens	5β-pregnane-3α,20α-dioloxidation direction with 0.25 mM NADP+	0.16	0.0015	107	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5β-pregnane-3α,20α-diol
AKR1C1	Homo sapiens	5β-pregnane-3α,20α-diolKm from secondary plots	—	0.0011	—	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5β-pregnane-3α,20α-diol
AKR1C1	Homo sapiens	9,10-phenanthrenequinone	0.58	7.3 × 10⁻⁴	800	pH 7, 37 °C	PMID 17950253	Open record: AKR1C1, 9,10-phenanthrenequinone
AKR1C1	Homo sapiens	NADP+	—	9 × 10⁻⁴	—	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, NADP+
AKR1C1	Homo sapiens	NADPH	—	0.0021	—	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, NADPH
AKR1C1	Homo sapiens	pregn-4-ene-3,20-dione	0.025	0.0013	20	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, pregn-4-ene-3,20-dione
AKR1C1	Homo sapiens	progesterone	0.0155	0.0057	3.5	pH 7, 37 °C	PMID 17950253	Open record: AKR1C1, progesterone
AKR1C1	Homo sapiens	pyridoxalpyridoxal reductase (PLR) activity; PL -> pyridoxine	0.042	0.363	0.115	pH 7, 37 °C	PMID 41741972	Open record: AKR1C1, pyridoxal
AKR1C1	Homo sapiens	pyridoxalpyridoxal dehydrogenase (PLD) activity; 0.2 mM NADP+	0.057	0.629	0.09	pH 7, 37 °C	PMID 41741972	Open record: AKR1C1, pyridoxal
aldo-keto reductase AKR1C1 (human 20α-HSD)	Homo sapiens	5α-dihydrotestosterone	0.0123	0.0042	3		PMID 19218247	Open record: aldo-keto reductase AKR1C1 (human 20α-HSD), 5α-dihydrotestosterone
aldo-keto reductase AKR1C1 (human 20α-HSD)	Homo sapiens	5α-dihydrotestosterone-17β-glucuronide	0.0088	0.0161	0.55		PMID 19218247	Open record: aldo-keto reductase AKR1C1 (human 20α-HSD), 5α-dihydrotestosterone-17β-glucuronide
aldo-keto reductase AKR1C1 (human 20α-HSD)	Homo sapiens	5α-dihydrotestosterone-17β-sulfate	0.0125	0.0052	2.3		PMID 19218247	Open record: aldo-keto reductase AKR1C1 (human 20α-HSD), 5α-dihydrotestosterone-17β-sulfate
aldo-keto reductase AKR1C1 (human 20α-HSD)	Homo sapiens	tibolone-17β-sulfate	0.032	0.0025	12.7		PMID 19218247	Open record: aldo-keto reductase AKR1C1 (human 20α-HSD), tibolone-17β-sulfate