Values CatLog read from this paper
An indomethacin analogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3alpha-HSD, type 5 17beta-HSD, and prostaglandin F synthase), a potential target…
PMID 17950253doi:10.1016/j.bcp.2007.09.008Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 6 records (18 values) from this paper: AKR1C1, AKR1C2, AKR1C3 from Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
EC 1.1.1.51, EC 1.1.1.53, EC 1.1.1.62, EC 1.1.1.64, EC 1.1.1.112, EC 1.1.1.149, EC 1.1.1.188, EC 1.1.1.209, EC 1.1.1.210, EC 1.1.1.239, EC 1.1.1.270, EC 1.1.1.357, EC 1.3.1.20
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| AKR1C1 | Homo sapiens | 9,10-phenanthrenequinone | 0.58 | 7.3 × 10⁻⁴ | 800 | pH 7, 37 °C | Open record: AKR1C1, 9,10-phenanthrenequinone |
| AKR1C1 | Homo sapiens | progesterone | 0.0155 | 0.0057 | 3.5 | pH 7, 37 °C | Open record: AKR1C1, progesterone |
| AKR1C2 | Homo sapiens | 5α-dihydrotestosterone | 0.063 | 0.0046 | 13.7 | pH 7, 37 °C | Open record: AKR1C2, 5α-dihydrotestosterone |
| AKR1C2 | Homo sapiens | 9,10-phenanthrenequinone | 1.83 | 0.0011 | 1.7 × 10³ | pH 7, 37 °C | Open record: AKR1C2, 9,10-phenanthrenequinone |
| AKR1C3 | Homo sapiens | 9,10-phenanthrenequinone | 1.4 | 0.0015 | 920 | pH 7, 37 °C | Open record: AKR1C3, 9,10-phenanthrenequinone |
| AKR1C3 | Homo sapiens | androst-4-ene-3,17-dione | 0.0027 | 0.0066 | 0.4 | pH 7, 37 °C | Open record: AKR1C3, androst-4-ene-3,17-dione |