CatLogenzyme kinetics catalog

EC 1.1.1.270: 3beta-hydroxysteroid 3-dehydrogenase

OxidoreductasesOpen in Browse

CatLog read 84 records for EC 1.1.1.270 from 9 papers, for 1 organism. Names in these papers: DHRS11 (dehydrogenase/reductase SDR family member 11), AKR1C1, 20α-hydroxysteroid dehydrogenase (AKR1C1), aldo-keto reductase AKR1C1 (human 20α-HSD) and 1 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 54 records for EC 1.1.1.270 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.1.1.270 in Browse.

Papers

PaperOrganismsRecords
Human dehydrogenase/reductase (SDR family) member 11 is a novel type of 17β-hydroxysteroid dehydrogenaseHomo sapiens46
Selective and potent inhibitors of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) that metabolizes neurosteroids derived from progesteroneHomo sapiens22
Human cytosolic hydroxysteroid dehydrogenases of the aldo-ketoreductase superfamily catalyze reduction of conjugated steroids: implications for phase I and phase II steroid hormone metabolismHomo sapiens4
Factorizing the role of a critical leucine residue in the binding of substrate to human 20alpha-hydroxysteroid dehydrogenase (AKR1C1): molecular modeling and kinetic studies of the Leu308Val mutant…Homo sapiens4
Production, purification, and functional analysis of recombinant human and mouse 17beta-hydroxysteroid dehydrogenase type 7Homo sapiens2
An indomethacin analogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3alpha-HSD, type 5 17beta-HSD, and prostaglandin F synthase), a potential target…Homo sapiens2
A new branch of mammalian vitamin B6 metabolism: AKR1C-mediated conversion of pyridoxal to pyridoxine and 4-pyridoxolactoneHomo sapiens2
Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone…Homo sapiens1
Substrate specificity and inhibitor sensitivity of rabbit 20α-hydroxysteroid dehydrogenaseHomo sapiens1

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
17β-hydroxysteroid dehydrogenase type 7 (h17HSD7)Homo sapiens5α-dihydrotestosterone—0.0026—PMID 12732193Open
17β-hydroxysteroid dehydrogenase type 7 (h17HSD7)Homo sapiensestrone—0.00325—PMID 12732193Open
20α-hydroxysteroid dehydrogenase (AKR1C1)Homo sapiensβ-Ionol0.0530.001244 calc.pH 7.4, 25 °CPMID 23995665Open
20α-hydroxysteroid dehydrogenase (AKR1C1)variant L308AHomo sapiens(S)-1,2,3,4-tetrahydronaphthalen-1-ol—0.470.83pH 7.4, 25 °CPMID 20656485Open
20α-hydroxysteroid dehydrogenase (AKR1C1)variant L308VHomo sapiens(S)-1,2,3,4-tetrahydronaphthalen-1-ol—0.01613pH 7.4, 25 °CPMID 20656485Open
20α-hydroxysteroid dehydrogenase (AKR1C1)variant L308VHomo sapiens5α-pregnane-3α,20α-diol—4 × 10⁻⁴270pH 7.4, 25 °CPMID 20656485Open
20α-hydroxysteroid dehydrogenase (AKR1C1)variant L308VHomo sapiens5β-pregnan-3α-ol-20-one—0.006227pH 7.4, 25 °CPMID 20656485Open
AKR1C1Homo sapiens(S)-1,2,3,4-tetrahydro-1-naphthol0.430.00762pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens17β-hydroxy-5α-androstan-3-one (5α-dihydrotestosterone)0.0125——pH 7, 37 °CPMID 14672942Open
AKR1C1Homo sapiens4-pregnen-20α-ol-3-one0.1520.0169.5pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5α-pregnan-20α-ol-3-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.017 × 10⁻⁴14.3pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5α-pregnan-20α-ol-3-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.1520.002757pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5α-pregnan-3α-ol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.0730.00237pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5α-pregnan-3α-ol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.00130.00330.33pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5α-pregnane-21-ol-3,20-dione0.00930.00127pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5α-pregnane-3,20-dione0.0430.001140pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5α-pregnane-3α,20α-diol0.0379 × 10⁻⁴40pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5α-pregnane-3α,21-diol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.0017——pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5α-pregnane-3α,21-diol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.00370.00261.3pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5β-pregnan-20α-ol-3-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.0370.001328pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5β-pregnan-20α-ol-3-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.0930.00193pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5β-pregnan-3α-ol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.180.003355pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5β-pregnan-3α-ol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.0060.00451.3pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5β-pregnan-3α-ol-20-oneKm from secondary plots; reduction of 3α,5β-THP—0.0012—pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5β-pregnane-3,20-dione0.050.001242pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5β-pregnane-3α,20α-dioloxidation direction with 0.25 mM NADP+0.160.0015107pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5β-pregnane-3α,20α-diolKm from secondary plots—0.0011—pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens9,10-phenanthrenequinone0.587.3 × 10⁻⁴800pH 7, 37 °CPMID 17950253Open
AKR1C1Homo sapiensNADP+—9 × 10⁻⁴—pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiensNADPH—0.0021—pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapienspregn-4-ene-3,20-dione0.0250.001320pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiensprogesterone0.01550.00573.5pH 7, 37 °CPMID 17950253Open
AKR1C1Homo sapienspyridoxalpyridoxal reductase (PLR) activity; PL -> pyridoxine0.0420.3630.115pH 7, 37 °CPMID 41741972Open
AKR1C1Homo sapienspyridoxalpyridoxal dehydrogenase (PLD) activity; 0.2 mM NADP+0.0570.6290.09pH 7, 37 °CPMID 41741972Open
aldo-keto reductase AKR1C1 (human 20α-HSD)Homo sapiens5α-dihydrotestosterone0.01230.00423PMID 19218247Open
aldo-keto reductase AKR1C1 (human 20α-HSD)Homo sapiens5α-dihydrotestosterone-17β-glucuronide0.00880.01610.55PMID 19218247Open
aldo-keto reductase AKR1C1 (human 20α-HSD)Homo sapiens5α-dihydrotestosterone-17β-sulfate0.01250.00522.3PMID 19218247Open
aldo-keto reductase AKR1C1 (human 20α-HSD)Homo sapienstibolone-17β-sulfate0.0320.002512.7PMID 19218247Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiens1-Indanone—0.915—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiens1-Phenyl-1,2-propanedione—0.06—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiens17β-Estradiol—0.016—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiens2,3-Heptanedione—0.201—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiens2,3-Hexanedione—0.62—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiens2,3-Pentanedione—4—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiens20α-Hydroxyprogesterone—0.0051—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiens3,4-Hexanedione—0.42—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiens3β-Hydroxyprogesterone—0.022—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiens4-Androsten-3α-ol-17-one—0.019—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiens4-Androstene-3,17-dione—0.0046—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiens4-Androstene-3α,17β-diol—0.023—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiens5-Androstene-3β,17β-diol—0.011—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiens5α-Androstan-3α-ol-17-one—0.0013—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiens5α-Androstan-3β-ol-17-one—0.0022—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiens5α-Androstane-3,17-dione—0.012—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiens5α-Androstane-3α,17β-diol—0.0092—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiens5α-Androstane-3β,17β-diol—0.0011—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiens5α-dihydrotestosterone—0.026—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiens5β-Androstan-3β-ol-17-one—0.036—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiens5β-Androstane-3,17-dione—0.0052—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiens5β-Androstane-3β,17β-diol—0.012—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiens5β-Cholanic acid-3,7-dione—0.0052—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiens5β-dihydrotestosterone—0.102—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiens5β-Pregnan-20β-ol-3-one—7 × 10⁻⁴—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiens5β-Pregnan-3β-ol-20-one—0.036—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiens5β-Pregnane-21-ol-3,20-dione—0.0021—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiens5β-Pregnane-3,20-dione—0.015—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiens5β-Pregnane-3β,20β-diol—0.014—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiens5β-Pregnane-3β,21-diol-20-one—0.0047—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiensDehydrocholic acid—0.029—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiensdehydroepiandrosterone—0.011—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiensdehydroepiandrosterone sulfate—0.012—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiensDehydrolithocholic acid—0.0011—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiensDiacetyl—5.1—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiensEstrone—7 × 10⁻⁴—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiensEthyl pyruvate—1.7—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiensIsolithocholic acid—4 × 10⁻⁴—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiensLoxoprofen—0.74—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiensMethylglyoxal—4.27—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiensNADPH—0.0011—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiensPhenylglyoxal—0.161—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiensProgesterone—0.0034—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiensTaurodehydrocholic acid—0.044—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiensTestosterone—0.03—pH 7, 37 °CPMID 26920053Open
DHRS11 (dehydrogenase/reductase SDR family member 11)Homo sapiensα-Tetralone—0.178—pH 7, 37 °CPMID 26920053Open