Values CatLog read from this paper
Factorizing the role of a critical leucine residue in the binding of substrate to human 20alpha-hydroxysteroid dehydrogenase (AKR1C1): molecular modeling and kinetic studies of the Leu308Val mutant…
PMID 20656485doi:10.1016/j.bmcl.2010.06.137Open in Browse
The paper itself is not on this site: read it at the publisher. This page lists only the values CatLog read from it.
CatLog read 4 records (8 values) from this paper: 20α-hydroxysteroid dehydrogenase (AKR1C1) from Homo sapiens.
Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units. Values are in CatLog's units; each record opens in Browse with the line the paper prints and the checks.
EC 1.1.1.51, EC 1.1.1.53, EC 1.1.1.62, EC 1.1.1.112, EC 1.1.1.149, EC 1.1.1.209, EC 1.1.1.210, EC 1.1.1.270, EC 1.1.1.357, EC 1.3.1.20
| Enzyme | Organism | Substrate | kcat (s⁻¹) | Km (mM) | kcat/Km (mM⁻¹ s⁻¹) | Conditions | Open record |
|---|---|---|---|---|---|---|---|
| 20α-hydroxysteroid dehydrogenase (AKR1C1)variant L308A | Homo sapiens | (S)-1,2,3,4-tetrahydronaphthalen-1-ol | — | 0.47 | 0.83 | pH 7.4, 25 °C | Open record: 20α-hydroxysteroid dehydrogenase (AKR1C1) variant L308A, (S)-1,2,3,4-tetrahydronaphthalen-1-ol |
| 20α-hydroxysteroid dehydrogenase (AKR1C1)variant L308V | Homo sapiens | (S)-1,2,3,4-tetrahydronaphthalen-1-ol | — | 0.016 | 13 | pH 7.4, 25 °C | Open record: 20α-hydroxysteroid dehydrogenase (AKR1C1) variant L308V, (S)-1,2,3,4-tetrahydronaphthalen-1-ol |
| 20α-hydroxysteroid dehydrogenase (AKR1C1)variant L308V | Homo sapiens | 5α-pregnane-3α,20α-diol | — | 4 × 10⁻⁴ | 270 | pH 7.4, 25 °C | Open record: 20α-hydroxysteroid dehydrogenase (AKR1C1) variant L308V, 5α-pregnane-3α,20α-diol |
| 20α-hydroxysteroid dehydrogenase (AKR1C1)variant L308V | Homo sapiens | 5β-pregnan-3α-ol-20-one | — | 0.0062 | 27 | pH 7.4, 25 °C | Open record: 20α-hydroxysteroid dehydrogenase (AKR1C1) variant L308V, 5β-pregnan-3α-ol-20-one |