CatLogenzyme kinetics catalog

EC 1.1.1.112: indanol dehydrogenase

OxidoreductasesOpen in Browse

CatLog read 69 records for EC 1.1.1.112 from 9 papers, for 1 organism. Names in these papers: AKR1C1, AKR1C2, 20α-hydroxysteroid dehydrogenase (AKR1C1), 3-alpha hydroxysteroid dehydrogenase type 3 (3α-HSD3, AKR1C2) and 3 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 4 records for EC 1.1.1.112 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.1.1.112 in Browse.

Papers

PaperOrganismsRecords
Selective and potent inhibitors of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) that metabolizes neurosteroids derived from progesteroneHomo sapiens39
Human cytosolic hydroxysteroid dehydrogenases of the aldo-ketoreductase superfamily catalyze reduction of conjugated steroids: implications for phase I and phase II steroid hormone metabolismHomo sapiens8
Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone…Homo sapiens5
An indomethacin analogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3alpha-HSD, type 5 17beta-HSD, and prostaglandin F synthase), a potential target…Homo sapiens4
Factorizing the role of a critical leucine residue in the binding of substrate to human 20alpha-hydroxysteroid dehydrogenase (AKR1C1): molecular modeling and kinetic studies of the Leu308Val mutant…Homo sapiens4
Human 3-alpha hydroxysteroid dehydrogenase type 3 (3α-HSD3): the V54L mutation restricting the steroid alternative binding and enhancing the 20α-HSD activityHomo sapiens4
Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate…Homo sapiens2
A new branch of mammalian vitamin B6 metabolism: AKR1C-mediated conversion of pyridoxal to pyridoxine and 4-pyridoxolactoneHomo sapiens2
Substrate specificity and inhibitor sensitivity of rabbit 20α-hydroxysteroid dehydrogenaseHomo sapiens1

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
20α-hydroxysteroid dehydrogenase (AKR1C1)Homo sapiensβ-Ionol0.0530.001244 calc.pH 7.4, 25 °CPMID 23995665Open
20α-hydroxysteroid dehydrogenase (AKR1C1)variant L308AHomo sapiens(S)-1,2,3,4-tetrahydronaphthalen-1-ol—0.470.83pH 7.4, 25 °CPMID 20656485Open
20α-hydroxysteroid dehydrogenase (AKR1C1)variant L308VHomo sapiens(S)-1,2,3,4-tetrahydronaphthalen-1-ol—0.01613pH 7.4, 25 °CPMID 20656485Open
20α-hydroxysteroid dehydrogenase (AKR1C1)variant L308VHomo sapiens5α-pregnane-3α,20α-diol—4 × 10⁻⁴270pH 7.4, 25 °CPMID 20656485Open
20α-hydroxysteroid dehydrogenase (AKR1C1)variant L308VHomo sapiens5β-pregnan-3α-ol-20-one—0.006227pH 7.4, 25 °CPMID 20656485Open
3-alpha hydroxysteroid dehydrogenase type 3 (3α-HSD3, AKR1C2)Homo sapiens5α-dihydrotestosterone0.06120.0021828pH 7.4, 37 °CPMID 24434280Open
3-alpha hydroxysteroid dehydrogenase type 3 (3α-HSD3, AKR1C2)Homo sapiensprogesterone0.00358.4 × 10⁻⁴4.2pH 7.4, 37 °CPMID 24434280Open
3-alpha hydroxysteroid dehydrogenase type 3 (3α-HSD3, AKR1C2)variant V54LHomo sapiens5α-dihydrotestosterone0.11530.071031.7pH 7.4, 37 °CPMID 24434280Open
3-alpha hydroxysteroid dehydrogenase type 3 (3α-HSD3, AKR1C2)variant V54LHomo sapiensprogesterone0.03920.0021318.3pH 7.4, 37 °CPMID 24434280Open
AKR1C1Homo sapiens(S)-1,2,3,4-tetrahydro-1-naphthol0.430.00762pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens17β-hydroxy-5α-androstan-3-one (5α-dihydrotestosterone)0.0125——pH 7, 37 °CPMID 14672942Open
AKR1C1Homo sapiens4-pregnen-20α-ol-3-one0.1520.0169.5pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5α-pregnan-20α-ol-3-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.017 × 10⁻⁴14.3pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5α-pregnan-20α-ol-3-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.1520.002757pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5α-pregnan-3α-ol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.0730.00237pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5α-pregnan-3α-ol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.00130.00330.33pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5α-pregnane-21-ol-3,20-dione0.00930.00127pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5α-pregnane-3,20-dione0.0430.001140pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5α-pregnane-3α,20α-diol0.0379 × 10⁻⁴40pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5α-pregnane-3α,21-diol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.0017——pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5α-pregnane-3α,21-diol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.00370.00261.3pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5β-pregnan-20α-ol-3-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.0370.001328pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5β-pregnan-20α-ol-3-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.0930.00193pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5β-pregnan-3α-ol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.180.003355pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5β-pregnan-3α-ol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.0060.00451.3pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5β-pregnan-3α-ol-20-oneKm from secondary plots; reduction of 3α,5β-THP—0.0012—pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5β-pregnane-3,20-dione0.050.001242pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5β-pregnane-3α,20α-dioloxidation direction with 0.25 mM NADP+0.160.0015107pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5β-pregnane-3α,20α-diolKm from secondary plots—0.0011—pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens9,10-phenanthrenequinone0.587.3 × 10⁻⁴800pH 7, 37 °CPMID 17950253Open
AKR1C1Homo sapiensNADP+—9 × 10⁻⁴—pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiensNADPH—0.0021—pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapienspregn-4-ene-3,20-dione0.0250.001320pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiensprogesterone0.01550.00573.5pH 7, 37 °CPMID 17950253Open
AKR1C1Homo sapienspyridoxalpyridoxal reductase (PLR) activity; PL -> pyridoxine0.0420.3630.115pH 7, 37 °CPMID 41741972Open
AKR1C1Homo sapienspyridoxalpyridoxal dehydrogenase (PLD) activity; 0.2 mM NADP+0.0570.6290.09pH 7, 37 °CPMID 41741972Open
AKR1C2Homo sapiens(S)-1,2,3,4-tetrahydro-1-naphthol0.270.261pH 7, 25 °CPMID 12604236Open
AKR1C2Homo sapiens17β-hydroxy-5α-androstan-3-one (5α-dihydrotestosterone)radiometric time courses; apparent kcat0.0492——pH 7, 37 °CPMID 14672942Open
AKR1C2Homo sapiens17β-hydroxy-5α-androstan-3-one (5α-dihydrotestosterone)radiometric assay; [4-14C]DHT; DHT 1.6-41.25 µM—0.0066—pH 7, 37 °CPMID 14672942Open
AKR1C2Homo sapiens17β-hydroxy-5α-androstan-3-one (5α-dihydrotestosterone)radiometric assay; [4-14C]DHT; DHT 1.6-41.25 µM—0.011—pH 7, 37 °CPMID 14672942Open
AKR1C2Homo sapiens17β-hydroxy-5α-androstan-3-one (5α-dihydrotestosterone)0.05170.004311.937 °CPMID 14672942Open
AKR1C2Homo sapiens4-pregnen-20α-ol-3-one0.00220.00730.33pH 7, 25 °CPMID 12604236Open
AKR1C2Homo sapiens5α-dihydrotestosterone0.0630.004613.7pH 7, 37 °CPMID 17950253Open
AKR1C2Homo sapiens5α-pregnan-20α-ol-3-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.0085 × 10⁻⁴16pH 7, 25 °CPMID 12604236Open
AKR1C2Homo sapiens5α-pregnan-20α-ol-3-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.001——pH 7, 25 °CPMID 12604236Open
AKR1C2Homo sapiens5α-pregnan-3α-ol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.00430.00311.3pH 7, 25 °CPMID 12604236Open
AKR1C2Homo sapiens5α-pregnan-3α-ol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.00470.0280.17pH 7, 25 °CPMID 12604236Open
AKR1C2Homo sapiens5α-pregnane-21-ol-3,20-dione0.00828 × 10⁻⁴10.2pH 7, 25 °CPMID 12604236Open
AKR1C2Homo sapiens5α-pregnane-3,20-dione0.0086 × 10⁻⁴11.7pH 7, 25 °CPMID 12604236Open
AKR1C2Homo sapiens5α-pregnane-3α,20α-diol0.00320.00181.8pH 7, 25 °CPMID 12604236Open
AKR1C2Homo sapiens5α-pregnane-3α,21-diol-20-one0.00220.00680.33pH 7, 25 °CPMID 12604236Open
AKR1C2Homo sapiens5β-pregnan-20α-ol-3-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.01083 × 10⁻⁴37pH 7, 25 °CPMID 12604236Open
AKR1C2Homo sapiens5β-pregnan-20α-ol-3-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.0012——pH 7, 25 °CPMID 12604236Open
AKR1C2Homo sapiens5β-pregnan-3α-ol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.0070.00451.5pH 7, 25 °CPMID 12604236Open
AKR1C2Homo sapiens5β-pregnan-3α-ol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.00450.00281.7pH 7, 25 °CPMID 12604236Open
AKR1C2Homo sapiens5β-pregnane-3,20-dione0.0187 × 10⁻⁴27pH 7, 25 °CPMID 12604236Open
AKR1C2Homo sapiens5β-pregnane-3α,20α-diol0.00370.0013.7pH 7, 25 °CPMID 12604236Open
AKR1C2Homo sapiens9,10-phenanthrenequinone1.830.00111.7 × 10³pH 7, 37 °CPMID 17950253Open
AKR1C2Homo sapienspregn-4-ene-3,20-dione6.7 × 10⁻⁴——pH 7, 25 °CPMID 12604236Open
aldo-keto reductase AKR1C1 (human 20α-HSD)Homo sapiens5α-dihydrotestosterone0.01230.00423PMID 19218247Open
aldo-keto reductase AKR1C1 (human 20α-HSD)Homo sapiens5α-dihydrotestosterone-17β-glucuronide0.00880.01610.55PMID 19218247Open
aldo-keto reductase AKR1C1 (human 20α-HSD)Homo sapiens5α-dihydrotestosterone-17β-sulfate0.01250.00522.3PMID 19218247Open
aldo-keto reductase AKR1C1 (human 20α-HSD)Homo sapienstibolone-17β-sulfate0.0320.002512.7PMID 19218247Open
aldo-keto reductase AKR1C2 (human type 3 3α-HSD)Homo sapiens5α-dihydrotestosterone0.0330.002911.3PMID 19218247Open
aldo-keto reductase AKR1C2 (human type 3 3α-HSD)Homo sapiens5α-dihydrotestosterone-17β-glucuronide0.0040.00410.98PMID 19218247Open
aldo-keto reductase AKR1C2 (human type 3 3α-HSD)Homo sapiens5α-dihydrotestosterone-17β-sulfate0.0170.00424PMID 19218247Open
aldo-keto reductase AKR1C2 (human type 3 3α-HSD)Homo sapienstibolone-17β-sulfate0.2020.0012170PMID 19218247Open
human type 3 3α-hydroxysteroid dehydrogenase (h3α-HSD3)variant Y24AHomo sapiensandrost-4-ene-3,17-dione17α-HSD activity (17α-reduction of Δ4)3.3 × 10⁻⁴0.020940.017pH 7.3, 37 °CPMID 17442338Open
human type 3 3α-hydroxysteroid dehydrogenase (h3α-HSD3)variant Y24AHomo sapiensandrost-4-ene-3,17-dione17β-HSD activity (17β-reduction of Δ4 to testosterone)0.02150.029570.73pH 7.3, 37 °CPMID 17442338Open