EC 1.1.1.51: 3(or 17)beta-hydroxysteroid dehydrogenase

OxidoreductasesOpen in Browse

CatLog read 110 records for EC 1.1.1.51 from 12 papers, for 2 organisms. Names in these papers: AKR1C1, AKR1C2, AKR1C4, 17β-hydroxysteroid dehydrogenase 2 (17β-HSD2) and 8 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 92 records for EC 1.1.1.51 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.1.1.51 in Browse.

Papers

Papers with records for EC 1.1.1.51
Paper	Organisms	Records
Selective and potent inhibitors of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) that metabolizes neurosteroids derived from progesterone	Homo sapiens	56
Human cytosolic hydroxysteroid dehydrogenases of the aldo-ketoreductase superfamily catalyze reduction of conjugated steroids: implications for phase I and phase II steroid hormone metabolism	Homo sapiens	12
Purification, reconstitution, and steady-state kinetics of the trans-membrane 17 beta-hydroxysteroid dehydrogenase 2	Homo sapiens	9
Delta 5-3beta-hydroxysteroid dehydrogenase (3 beta HSD) from Digitalis lanata. Heterologous expression and characterisation of the recombinant enzyme	Digitalis lanata	8
Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone…	Homo sapiens	6
An indomethacin analogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3alpha-HSD, type 5 17beta-HSD, and prostaglandin F synthase), a potential target…	Homo sapiens	4
Factorizing the role of a critical leucine residue in the binding of substrate to human 20alpha-hydroxysteroid dehydrogenase (AKR1C1): molecular modeling and kinetic studies of the Leu308Val mutant…	Homo sapiens	4
Human 3-alpha hydroxysteroid dehydrogenase type 3 (3α-HSD3): the V54L mutation restricting the steroid alternative binding and enhancing the 20α-HSD activity	Homo sapiens	4
A new branch of mammalian vitamin B₆ metabolism: AKR1C-mediated conversion of pyridoxal to pyridoxine and 4-pyridoxolactone	Homo sapiens	3
Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate…	Homo sapiens	2
Kinetic studies of AKR1B10, human aldose reductase-like protein: endogenous substrates and inhibition by steroids	Homo sapiens	1
Substrate specificity and inhibitor sensitivity of rabbit 20α-hydroxysteroid dehydrogenase	Homo sapiens	1

Records

Records for EC 1.1.1.51 read from the paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Paper	Open record
17β-hydroxysteroid dehydrogenase 2 (17β-HSD2)	Homo sapiens	(20S)-20-hydroxypregn-4-en-3-one	0.78	5.3 × 10⁻⁴	1.5 × 10³	pH 7.4, 37 °C	PMID 11940569	Open record: 17β-hydroxysteroid dehydrogenase 2 (17β-HSD2), (20S)-20-hydroxypregn-4-en-3-one
17β-hydroxysteroid dehydrogenase 2 (17β-HSD2)	Homo sapiens	Dihydrotestosterone	2.4	2.5 × 10⁻⁴	1 × 10⁴	pH 7.4, 37 °C	PMID 11940569	Open record: 17β-hydroxysteroid dehydrogenase 2 (17β-HSD2), Dihydrotestosterone
17β-hydroxysteroid dehydrogenase 2 (17β-HSD2)	Homo sapiens	Estradiol	3.9	3.5 × 10⁻⁴	1.1 × 10⁴	pH 7.4, 37 °C	PMID 11940569	Open record: 17β-hydroxysteroid dehydrogenase 2 (17β-HSD2), Estradiol
17β-hydroxysteroid dehydrogenase 2 (17β-HSD2)	Homo sapiens	NAD10 µM estradiol constant; cosubstrate Estradiol	4.7	0.11	40	pH 7.4, 37 °C	PMID 11940569	Open record: 17β-hydroxysteroid dehydrogenase 2 (17β-HSD2), NAD
17β-hydroxysteroid dehydrogenase 2 (17β-HSD2)	Homo sapiens	NAD10 µM testosterone constant; cosubstrate Testosterone	2.9	0.167	20	pH 7.4, 37 °C	PMID 11940569	Open record: 17β-hydroxysteroid dehydrogenase 2 (17β-HSD2), NAD
17β-hydroxysteroid dehydrogenase 2 (17β-HSD2)	Homo sapiens	NADH10 µM estrone constant; cosubstrate Estrone	0.33	0.0056	60	pH 7.4, 37 °C	PMID 11940569	Open record: 17β-hydroxysteroid dehydrogenase 2 (17β-HSD2), NADH
17β-hydroxysteroid dehydrogenase 2 (17β-HSD2)	Homo sapiens	NADH10 µM androstenedione constant	0.27	0.0053	50	pH 7.4, 37 °C	PMID 11940569	Open record: 17β-hydroxysteroid dehydrogenase 2 (17β-HSD2), NADH
17β-hydroxysteroid dehydrogenase 2 (17β-HSD2)	Homo sapiens	NADP	1.3	9.6	0.1	pH 7.4, 37 °C	PMID 11940569	Open record: 17β-hydroxysteroid dehydrogenase 2 (17β-HSD2), NADP
17β-hydroxysteroid dehydrogenase 2 (17β-HSD2)	Homo sapiens	Testosterone	3.4	6.1 × 10⁻⁴	5.5 × 10³	pH 7.4, 37 °C	PMID 11940569	Open record: 17β-hydroxysteroid dehydrogenase 2 (17β-HSD2), Testosterone
20α-hydroxysteroid dehydrogenase (AKR1C1)	Homo sapiens	β-Ionol	0.053	0.0012	44 calc.	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C1), β-Ionol
20α-hydroxysteroid dehydrogenase (AKR1C1)variant L308A	Homo sapiens	(S)-1,2,3,4-tetrahydronaphthalen-1-ol	—	0.47	0.83	pH 7.4, 25 °C	PMID 20656485	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C1) variant L308A, (S)-1,2,3,4-tetrahydronaphthalen-1-ol
20α-hydroxysteroid dehydrogenase (AKR1C1)variant L308V	Homo sapiens	(S)-1,2,3,4-tetrahydronaphthalen-1-ol	—	0.016	13	pH 7.4, 25 °C	PMID 20656485	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C1) variant L308V, (S)-1,2,3,4-tetrahydronaphthalen-1-ol
20α-hydroxysteroid dehydrogenase (AKR1C1)variant L308V	Homo sapiens	5α-pregnane-3α,20α-diol	—	4 × 10⁻⁴	270	pH 7.4, 25 °C	PMID 20656485	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C1) variant L308V, 5α-pregnane-3α,20α-diol
20α-hydroxysteroid dehydrogenase (AKR1C1)variant L308V	Homo sapiens	5β-pregnan-3α-ol-20-one	—	0.0062	27	pH 7.4, 25 °C	PMID 20656485	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C1) variant L308V, 5β-pregnan-3α-ol-20-one
3-alpha hydroxysteroid dehydrogenase type 3 (3α-HSD3, AKR1C2)	Homo sapiens	5α-dihydrotestosterone	0.0612	0.00218	28	pH 7.4, 37 °C	PMID 24434280	Open record: 3-alpha hydroxysteroid dehydrogenase type 3 (3α-HSD3, AKR1C2), 5α-dihydrotestosterone
3-alpha hydroxysteroid dehydrogenase type 3 (3α-HSD3, AKR1C2)	Homo sapiens	progesterone	0.0035	8.4 × 10⁻⁴	4.2	pH 7.4, 37 °C	PMID 24434280	Open record: 3-alpha hydroxysteroid dehydrogenase type 3 (3α-HSD3, AKR1C2), progesterone
3-alpha hydroxysteroid dehydrogenase type 3 (3α-HSD3, AKR1C2)variant V54L	Homo sapiens	5α-dihydrotestosterone	0.1153	0.07103	1.7	pH 7.4, 37 °C	PMID 24434280	Open record: 3-alpha hydroxysteroid dehydrogenase type 3 (3α-HSD3, AKR1C2) variant V54L, 5α-dihydrotestosterone
3-alpha hydroxysteroid dehydrogenase type 3 (3α-HSD3, AKR1C2)variant V54L	Homo sapiens	progesterone	0.0392	0.00213	18.3	pH 7.4, 37 °C	PMID 24434280	Open record: 3-alpha hydroxysteroid dehydrogenase type 3 (3α-HSD3, AKR1C2) variant V54L, progesterone
AKR1C1	Homo sapiens	(S)-1,2,3,4-tetrahydro-1-naphthol	0.43	0.007	62	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, (S)-1,2,3,4-tetrahydro-1-naphthol
AKR1C1	Homo sapiens	17β-hydroxy-5α-androstan-3-one (5α-dihydrotestosterone)	0.0125	—	—	pH 7, 37 °C	PMID 14672942	Open record: AKR1C1, 17β-hydroxy-5α-androstan-3-one (5α-dihydrotestosterone)
AKR1C1	Homo sapiens	4-pregnen-20α-ol-3-one	0.152	0.016	9.5	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 4-pregnen-20α-ol-3-one
AKR1C1	Homo sapiens	5α-pregnan-20α-ol-3-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH	0.01	7 × 10⁻⁴	14.3	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5α-pregnan-20α-ol-3-one
AKR1C1	Homo sapiens	5α-pregnan-20α-ol-3-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+	0.152	0.0027	57	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5α-pregnan-20α-ol-3-one
AKR1C1	Homo sapiens	5α-pregnan-3α-ol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH	0.073	0.002	37	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5α-pregnan-3α-ol-20-one
AKR1C1	Homo sapiens	5α-pregnan-3α-ol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+	0.0013	0.0033	0.33	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5α-pregnan-3α-ol-20-one
AKR1C1	Homo sapiens	5α-pregnane-21-ol-3,20-dione	0.0093	0.0012	7	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5α-pregnane-21-ol-3,20-dione
AKR1C1	Homo sapiens	5α-pregnane-3,20-dione	0.043	0.0011	40	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5α-pregnane-3,20-dione
AKR1C1	Homo sapiens	5α-pregnane-3α,20α-diol	0.037	9 × 10⁻⁴	40	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5α-pregnane-3α,20α-diol
AKR1C1	Homo sapiens	5α-pregnane-3α,21-diol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH	0.0017	—	—	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5α-pregnane-3α,21-diol-20-one
AKR1C1	Homo sapiens	5α-pregnane-3α,21-diol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+	0.0037	0.0026	1.3	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5α-pregnane-3α,21-diol-20-one
AKR1C1	Homo sapiens	5β-pregnan-20α-ol-3-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH	0.037	0.0013	28	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5β-pregnan-20α-ol-3-one
AKR1C1	Homo sapiens	5β-pregnan-20α-ol-3-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+	0.093	0.001	93	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5β-pregnan-20α-ol-3-one
AKR1C1	Homo sapiens	5β-pregnan-3α-ol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH	0.18	0.0033	55	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5β-pregnan-3α-ol-20-one
AKR1C1	Homo sapiens	5β-pregnan-3α-ol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+	0.006	0.0045	1.3	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5β-pregnan-3α-ol-20-one
AKR1C1	Homo sapiens	5β-pregnan-3α-ol-20-oneKm from secondary plots; reduction of 3α,5β-THP	—	0.0012	—	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5β-pregnan-3α-ol-20-one
AKR1C1	Homo sapiens	5β-pregnane-3,20-dione	0.05	0.0012	42	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5β-pregnane-3,20-dione
AKR1C1	Homo sapiens	5β-pregnane-3α,20α-dioloxidation direction with 0.25 mM NADP+	0.16	0.0015	107	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5β-pregnane-3α,20α-diol
AKR1C1	Homo sapiens	5β-pregnane-3α,20α-diolKm from secondary plots	—	0.0011	—	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5β-pregnane-3α,20α-diol
AKR1C1	Homo sapiens	9,10-phenanthrenequinone	0.58	7.3 × 10⁻⁴	800	pH 7, 37 °C	PMID 17950253	Open record: AKR1C1, 9,10-phenanthrenequinone
AKR1C1	Homo sapiens	NADP+	—	9 × 10⁻⁴	—	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, NADP+
AKR1C1	Homo sapiens	NADPH	—	0.0021	—	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, NADPH
AKR1C1	Homo sapiens	pregn-4-ene-3,20-dione	0.025	0.0013	20	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, pregn-4-ene-3,20-dione
AKR1C1	Homo sapiens	progesterone	0.0155	0.0057	3.5	pH 7, 37 °C	PMID 17950253	Open record: AKR1C1, progesterone
AKR1C1	Homo sapiens	pyridoxalpyridoxal reductase (PLR) activity; PL -> pyridoxine	0.042	0.363	0.115	pH 7, 37 °C	PMID 41741972	Open record: AKR1C1, pyridoxal
AKR1C1	Homo sapiens	pyridoxalpyridoxal dehydrogenase (PLD) activity; 0.2 mM NADP+	0.057	0.629	0.09	pH 7, 37 °C	PMID 41741972	Open record: AKR1C1, pyridoxal
AKR1C2	Homo sapiens	(S)-1,2,3,4-tetrahydro-1-naphthol	0.27	0.26	1	pH 7, 25 °C	PMID 12604236	Open record: AKR1C2, (S)-1,2,3,4-tetrahydro-1-naphthol
AKR1C2	Homo sapiens	17β-hydroxy-5α-androstan-3-one (5α-dihydrotestosterone)radiometric time courses; apparent kcat	0.0492	—	—	pH 7, 37 °C	PMID 14672942	Open record: AKR1C2, 17β-hydroxy-5α-androstan-3-one (5α-dihydrotestosterone)
AKR1C2	Homo sapiens	17β-hydroxy-5α-androstan-3-one (5α-dihydrotestosterone)radiometric assay; [4-14C]DHT; DHT 1.6-41.25 µM	—	0.0066	—	pH 7, 37 °C	PMID 14672942	Open record: AKR1C2, 17β-hydroxy-5α-androstan-3-one (5α-dihydrotestosterone)
AKR1C2	Homo sapiens	17β-hydroxy-5α-androstan-3-one (5α-dihydrotestosterone)radiometric assay; [4-14C]DHT; DHT 1.6-41.25 µM	—	0.011	—	pH 7, 37 °C	PMID 14672942	Open record: AKR1C2, 17β-hydroxy-5α-androstan-3-one (5α-dihydrotestosterone)
AKR1C2	Homo sapiens	17β-hydroxy-5α-androstan-3-one (5α-dihydrotestosterone)	0.0517	0.0043	11.9	37 °C	PMID 14672942	Open record: AKR1C2, 17β-hydroxy-5α-androstan-3-one (5α-dihydrotestosterone)
AKR1C2	Homo sapiens	4-pregnen-20α-ol-3-one	0.0022	0.0073	0.33	pH 7, 25 °C	PMID 12604236	Open record: AKR1C2, 4-pregnen-20α-ol-3-one
AKR1C2	Homo sapiens	5α-dihydrotestosterone	0.063	0.0046	13.7	pH 7, 37 °C	PMID 17950253	Open record: AKR1C2, 5α-dihydrotestosterone
AKR1C2	Homo sapiens	5α-pregnan-20α-ol-3-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH	0.008	5 × 10⁻⁴	16	pH 7, 25 °C	PMID 12604236	Open record: AKR1C2, 5α-pregnan-20α-ol-3-one
AKR1C2	Homo sapiens	5α-pregnan-20α-ol-3-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+	0.001	—	—	pH 7, 25 °C	PMID 12604236	Open record: AKR1C2, 5α-pregnan-20α-ol-3-one
AKR1C2	Homo sapiens	5α-pregnan-3α-ol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH	0.0043	0.0031	1.3	pH 7, 25 °C	PMID 12604236	Open record: AKR1C2, 5α-pregnan-3α-ol-20-one
AKR1C2	Homo sapiens	5α-pregnan-3α-ol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+	0.0047	0.028	0.17	pH 7, 25 °C	PMID 12604236	Open record: AKR1C2, 5α-pregnan-3α-ol-20-one
AKR1C2	Homo sapiens	5α-pregnane-21-ol-3,20-dione	0.0082	8 × 10⁻⁴	10.2	pH 7, 25 °C	PMID 12604236	Open record: AKR1C2, 5α-pregnane-21-ol-3,20-dione
AKR1C2	Homo sapiens	5α-pregnane-3,20-dione	0.008	6 × 10⁻⁴	11.7	pH 7, 25 °C	PMID 12604236	Open record: AKR1C2, 5α-pregnane-3,20-dione
AKR1C2	Homo sapiens	5α-pregnane-3α,20α-diol	0.0032	0.0018	1.8	pH 7, 25 °C	PMID 12604236	Open record: AKR1C2, 5α-pregnane-3α,20α-diol
AKR1C2	Homo sapiens	5α-pregnane-3α,21-diol-20-one	0.0022	0.0068	0.33	pH 7, 25 °C	PMID 12604236	Open record: AKR1C2, 5α-pregnane-3α,21-diol-20-one
AKR1C2	Homo sapiens	5β-pregnan-20α-ol-3-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH	0.0108	3 × 10⁻⁴	37	pH 7, 25 °C	PMID 12604236	Open record: AKR1C2, 5β-pregnan-20α-ol-3-one
AKR1C2	Homo sapiens	5β-pregnan-20α-ol-3-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+	0.0012	—	—	pH 7, 25 °C	PMID 12604236	Open record: AKR1C2, 5β-pregnan-20α-ol-3-one
AKR1C2	Homo sapiens	5β-pregnan-3α-ol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH	0.007	0.0045	1.5	pH 7, 25 °C	PMID 12604236	Open record: AKR1C2, 5β-pregnan-3α-ol-20-one
AKR1C2	Homo sapiens	5β-pregnan-3α-ol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+	0.0045	0.0028	1.7	pH 7, 25 °C	PMID 12604236	Open record: AKR1C2, 5β-pregnan-3α-ol-20-one
AKR1C2	Homo sapiens	5β-pregnane-3,20-dione	0.018	7 × 10⁻⁴	27	pH 7, 25 °C	PMID 12604236	Open record: AKR1C2, 5β-pregnane-3,20-dione
AKR1C2	Homo sapiens	5β-pregnane-3α,20α-diol	0.0037	0.001	3.7	pH 7, 25 °C	PMID 12604236	Open record: AKR1C2, 5β-pregnane-3α,20α-diol
AKR1C2	Homo sapiens	9,10-phenanthrenequinone	1.83	0.0011	1.7 × 10³	pH 7, 37 °C	PMID 17950253	Open record: AKR1C2, 9,10-phenanthrenequinone
AKR1C2	Homo sapiens	pregn-4-ene-3,20-dione	6.7 × 10⁻⁴	—	—	pH 7, 25 °C	PMID 12604236	Open record: AKR1C2, pregn-4-ene-3,20-dione
AKR1C4	Homo sapiens	(S)-1,2,3,4-tetrahydro-1-naphthol	0.2	0.11	1.8	pH 7, 25 °C	PMID 12604236	Open record: AKR1C4, (S)-1,2,3,4-tetrahydro-1-naphthol
AKR1C4	Homo sapiens	17β-hydroxy-5α-androstan-3-one (5α-dihydrotestosterone)	0.0938	—	—	pH 7, 37 °C	PMID 14672942	Open record: AKR1C4, 17β-hydroxy-5α-androstan-3-one (5α-dihydrotestosterone)
AKR1C4	Homo sapiens	4-pregnen-20α-ol-3-one	0.0057	3 × 10⁻⁴	18	pH 7, 25 °C	PMID 12604236	Open record: AKR1C4, 4-pregnen-20α-ol-3-one
AKR1C4	Homo sapiens	5α-pregnan-20α-ol-3-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH	0.022	0.0011	20	pH 7, 25 °C	PMID 12604236	Open record: AKR1C4, 5α-pregnan-20α-ol-3-one
AKR1C4	Homo sapiens	5α-pregnan-20α-ol-3-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+	0.0107	2 × 10⁻⁴	53	pH 7, 25 °C	PMID 12604236	Open record: AKR1C4, 5α-pregnan-20α-ol-3-one
AKR1C4	Homo sapiens	5α-pregnan-3α-ol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH	0.01	9 × 10⁻⁴	11.2	pH 7, 25 °C	PMID 12604236	Open record: AKR1C4, 5α-pregnan-3α-ol-20-one
AKR1C4	Homo sapiens	5α-pregnan-3α-ol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+	0.067	2 × 10⁻⁴	330	pH 7, 25 °C	PMID 12604236	Open record: AKR1C4, 5α-pregnan-3α-ol-20-one
AKR1C4	Homo sapiens	5α-pregnane-21-ol-3,20-dione	0.035	0.0017	20	pH 7, 25 °C	PMID 12604236	Open record: AKR1C4, 5α-pregnane-21-ol-3,20-dione
AKR1C4	Homo sapiens	5α-pregnane-3,20-dione	0.02	6 × 10⁻⁴	33	pH 7, 25 °C	PMID 12604236	Open record: AKR1C4, 5α-pregnane-3,20-dione
AKR1C4	Homo sapiens	5α-pregnane-3α,20α-diol	0.067	2 × 10⁻⁴	330	pH 7, 25 °C	PMID 12604236	Open record: AKR1C4, 5α-pregnane-3α,20α-diol
AKR1C4	Homo sapiens	5α-pregnane-3α,21-diol-20-one	0.07	3 × 10⁻⁴	230	pH 7, 25 °C	PMID 12604236	Open record: AKR1C4, 5α-pregnane-3α,21-diol-20-one
AKR1C4	Homo sapiens	5β-pregnan-20α-ol-3-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH	0.023	0.0015	15.5	pH 7, 25 °C	PMID 12604236	Open record: AKR1C4, 5β-pregnan-20α-ol-3-one
AKR1C4	Homo sapiens	5β-pregnan-20α-ol-3-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+	0.0083	3 × 10⁻⁴	28	pH 7, 25 °C	PMID 12604236	Open record: AKR1C4, 5β-pregnan-20α-ol-3-one
AKR1C4	Homo sapiens	5β-pregnan-3α-ol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH	0.0122	5 × 10⁻⁴	25	pH 7, 25 °C	PMID 12604236	Open record: AKR1C4, 5β-pregnan-3α-ol-20-one
AKR1C4	Homo sapiens	5β-pregnan-3α-ol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+	0.027	4 × 10⁻⁴	67	pH 7, 25 °C	PMID 12604236	Open record: AKR1C4, 5β-pregnan-3α-ol-20-one
AKR1C4	Homo sapiens	5β-pregnane-3,20-dione	0.057	7 × 10⁻⁴	82	pH 7, 25 °C	PMID 12604236	Open record: AKR1C4, 5β-pregnane-3,20-dione
AKR1C4	Homo sapiens	5β-pregnane-3α,20α-diol	0.02	2 × 10⁻⁴	100	pH 7, 25 °C	PMID 12604236	Open record: AKR1C4, 5β-pregnane-3α,20α-diol
AKR1C4	Homo sapiens	pregn-4-ene-3,20-dione	8.3 × 10⁻⁴	—	—	pH 7, 25 °C	PMID 12604236	Open record: AKR1C4, pregn-4-ene-3,20-dione
AKR1C4	Homo sapiens	pyridoxal	0.006	0.304	0.02	pH 7, 37 °C	PMID 41741972	Open record: AKR1C4, pyridoxal
AKR1C4 (hydroxysteroid dehydrogenase isoform)	Homo sapiens	(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenal (all-trans-geranylgeranial)	—	—	13		PMID 19464995	Open record: AKR1C4 (hydroxysteroid dehydrogenase isoform), (2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenal (all-trans-geranylgeranial)
aldo-keto reductase AKR1C1 (human 20α-HSD)	Homo sapiens	5α-dihydrotestosterone	0.0123	0.0042	3		PMID 19218247	Open record: aldo-keto reductase AKR1C1 (human 20α-HSD), 5α-dihydrotestosterone
aldo-keto reductase AKR1C1 (human 20α-HSD)	Homo sapiens	5α-dihydrotestosterone-17β-glucuronide	0.0088	0.0161	0.55		PMID 19218247	Open record: aldo-keto reductase AKR1C1 (human 20α-HSD), 5α-dihydrotestosterone-17β-glucuronide
aldo-keto reductase AKR1C1 (human 20α-HSD)	Homo sapiens	5α-dihydrotestosterone-17β-sulfate	0.0125	0.0052	2.3		PMID 19218247	Open record: aldo-keto reductase AKR1C1 (human 20α-HSD), 5α-dihydrotestosterone-17β-sulfate
aldo-keto reductase AKR1C1 (human 20α-HSD)	Homo sapiens	tibolone-17β-sulfate	0.032	0.0025	12.7		PMID 19218247	Open record: aldo-keto reductase AKR1C1 (human 20α-HSD), tibolone-17β-sulfate
aldo-keto reductase AKR1C2 (human type 3 3α-HSD)	Homo sapiens	5α-dihydrotestosterone	0.033	0.0029	11.3		PMID 19218247	Open record: aldo-keto reductase AKR1C2 (human type 3 3α-HSD), 5α-dihydrotestosterone
aldo-keto reductase AKR1C2 (human type 3 3α-HSD)	Homo sapiens	5α-dihydrotestosterone-17β-glucuronide	0.004	0.0041	0.98		PMID 19218247	Open record: aldo-keto reductase AKR1C2 (human type 3 3α-HSD), 5α-dihydrotestosterone-17β-glucuronide
aldo-keto reductase AKR1C2 (human type 3 3α-HSD)	Homo sapiens	5α-dihydrotestosterone-17β-sulfate	0.017	0.0042	4		PMID 19218247	Open record: aldo-keto reductase AKR1C2 (human type 3 3α-HSD), 5α-dihydrotestosterone-17β-sulfate
aldo-keto reductase AKR1C2 (human type 3 3α-HSD)	Homo sapiens	tibolone-17β-sulfate	0.202	0.0012	170		PMID 19218247	Open record: aldo-keto reductase AKR1C2 (human type 3 3α-HSD), tibolone-17β-sulfate
aldo-keto reductase AKR1C4 (human type 1 3α-HSD)	Homo sapiens	5α-dihydrotestosterone	0.0513	—	—		PMID 19218247	Open record: aldo-keto reductase AKR1C4 (human type 1 3α-HSD), 5α-dihydrotestosterone
aldo-keto reductase AKR1C4 (human type 1 3α-HSD)	Homo sapiens	5α-dihydrotestosterone-17β-glucuronide	0.0547	—	—		PMID 19218247	Open record: aldo-keto reductase AKR1C4 (human type 1 3α-HSD), 5α-dihydrotestosterone-17β-glucuronide
aldo-keto reductase AKR1C4 (human type 1 3α-HSD)	Homo sapiens	5α-dihydrotestosterone-17β-sulfate	0.0512	—	—		PMID 19218247	Open record: aldo-keto reductase AKR1C4 (human type 1 3α-HSD), 5α-dihydrotestosterone-17β-sulfate
aldo-keto reductase AKR1C4 (human type 1 3α-HSD)	Homo sapiens	tibolone-17β-sulfate	0.02	5 × 10⁻⁴	40		PMID 19218247	Open record: aldo-keto reductase AKR1C4 (human type 1 3α-HSD), tibolone-17β-sulfate
human type 3 3α-hydroxysteroid dehydrogenase (h3α-HSD3)variant Y24A	Homo sapiens	androst-4-ene-3,17-dione17α-HSD activity (17α-reduction of Δ4)	3.3 × 10⁻⁴	0.02094	0.017	pH 7.3, 37 °C	PMID 17442338	Open record: human type 3 3α-hydroxysteroid dehydrogenase (h3α-HSD3) variant Y24A, androst-4-ene-3,17-dione
human type 3 3α-hydroxysteroid dehydrogenase (h3α-HSD3)variant Y24A	Homo sapiens	androst-4-ene-3,17-dione17β-HSD activity (17β-reduction of Δ4 to testosterone)	0.0215	0.02957	0.73	pH 7.3, 37 °C	PMID 17442338	Open record: human type 3 3α-hydroxysteroid dehydrogenase (h3α-HSD3) variant Y24A, androst-4-ene-3,17-dione
Δ5-3β-hydroxysteroid dehydrogenase (3βHSD; recombinant pQ3βHSD)	Digitalis lanata	5-Androsten-3β-ol-17-one	—	0.642	—	pH 7.8, 50 °C	PMID 17564944	Open record: Δ5-3β-hydroxysteroid dehydrogenase (3βHSD; recombinant pQ3βHSD), 5-Androsten-3β-ol-17-one
Δ5-3β-hydroxysteroid dehydrogenase (3βHSD; recombinant pQ3βHSD)	Digitalis lanata	5-pregnen-3β-ol-20-one	—	0.09	—	pH 7.8, 50 °C	PMID 17564944	Open record: Δ5-3β-hydroxysteroid dehydrogenase (3βHSD; recombinant pQ3βHSD), 5-pregnen-3β-ol-20-one
Δ5-3β-hydroxysteroid dehydrogenase (3βHSD; recombinant pQ3βHSD)	Digitalis lanata	5α-Pregnan-3β-ol-20-one	—	0.116	—	pH 7.8, 50 °C	PMID 17564944	Open record: Δ5-3β-hydroxysteroid dehydrogenase (3βHSD; recombinant pQ3βHSD), 5α-Pregnan-3β-ol-20-one
Δ5-3β-hydroxysteroid dehydrogenase (3βHSD; recombinant pQ3βHSD)	Digitalis lanata	5α-Pregnane-3,20-dione	—	0.106	—	pH 7.8, 50 °C	PMID 17564944	Open record: Δ5-3β-hydroxysteroid dehydrogenase (3βHSD; recombinant pQ3βHSD), 5α-Pregnane-3,20-dione
Δ5-3β-hydroxysteroid dehydrogenase (3βHSD; recombinant pQ3βHSD)	Digitalis lanata	5β-Pregnan-3β-ol-20-one	—	0.314	—	pH 7.8, 50 °C	PMID 17564944	Open record: Δ5-3β-hydroxysteroid dehydrogenase (3βHSD; recombinant pQ3βHSD), 5β-Pregnan-3β-ol-20-one
Δ5-3β-hydroxysteroid dehydrogenase (3βHSD; recombinant pQ3βHSD)	Digitalis lanata	5β-Pregnane-3,20-dione	—	1.725	—	pH 7.8, 50 °C	PMID 17564944	Open record: Δ5-3β-hydroxysteroid dehydrogenase (3βHSD; recombinant pQ3βHSD), 5β-Pregnane-3,20-dione
Δ5-3β-hydroxysteroid dehydrogenase (3βHSD; recombinant pQ3βHSD)	Digitalis lanata	NAD+	—	0.26	—	pH 7.8, 50 °C	PMID 17564944	Open record: Δ5-3β-hydroxysteroid dehydrogenase (3βHSD; recombinant pQ3βHSD), NAD+
Δ5-3β-hydroxysteroid dehydrogenase (3βHSD; recombinant pQ3βHSD)	Digitalis lanata	NADH	—	0.642	—	pH 7.8, 50 °C	PMID 17564944	Open record: Δ5-3β-hydroxysteroid dehydrogenase (3βHSD; recombinant pQ3βHSD), NADH