CatLogenzyme kinetics catalog

EC 1.1.1.210: 3beta(or 20alpha)-hydroxysteroid dehydrogenase

OxidoreductasesOpen in Browse

CatLog read 94 records for EC 1.1.1.210 from 10 papers, for 1 organism. Names in these papers: AKR1C1, AKR1C3, AKR1C4, 3α-hydroxysteroid dehydrogenase type IIBrain (3α-HSD type IIBrain) and 5 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 14 records for EC 1.1.1.210 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.1.1.210 in Browse.

Papers

PaperOrganismsRecords
Selective and potent inhibitors of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) that metabolizes neurosteroids derived from progesteroneHomo sapiens54
Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymesHomo sapiens12
Human cytosolic hydroxysteroid dehydrogenases of the aldo-ketoreductase superfamily catalyze reduction of conjugated steroids: implications for phase I and phase II steroid hormone metabolismHomo sapiens8
A new branch of mammalian vitamin B6 metabolism: AKR1C-mediated conversion of pyridoxal to pyridoxine and 4-pyridoxolactoneHomo sapiens5
An indomethacin analogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3alpha-HSD, type 5 17beta-HSD, and prostaglandin F synthase), a potential target…Homo sapiens4
Factorizing the role of a critical leucine residue in the binding of substrate to human 20alpha-hydroxysteroid dehydrogenase (AKR1C1): molecular modeling and kinetic studies of the Leu308Val mutant…Homo sapiens4
Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone…Homo sapiens3
Production, purification, and functional analysis of recombinant human and mouse 17beta-hydroxysteroid dehydrogenase type 7Homo sapiens2
Kinetic studies of AKR1B10, human aldose reductase-like protein: endogenous substrates and inhibition by steroidsHomo sapiens1
Substrate specificity and inhibitor sensitivity of rabbit 20α-hydroxysteroid dehydrogenaseHomo sapiens1

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
17β-hydroxysteroid dehydrogenase type 7 (h17HSD7)Homo sapiens5α-dihydrotestosterone—0.0026—PMID 12732193Open
17β-hydroxysteroid dehydrogenase type 7 (h17HSD7)Homo sapiensestrone—0.00325—PMID 12732193Open
20α-hydroxysteroid dehydrogenase (AKR1C1)Homo sapiensβ-Ionol0.0530.001244 calc.pH 7.4, 25 °CPMID 23995665Open
20α-hydroxysteroid dehydrogenase (AKR1C1)variant L308AHomo sapiens(S)-1,2,3,4-tetrahydronaphthalen-1-ol—0.470.83pH 7.4, 25 °CPMID 20656485Open
20α-hydroxysteroid dehydrogenase (AKR1C1)variant L308VHomo sapiens(S)-1,2,3,4-tetrahydronaphthalen-1-ol—0.01613pH 7.4, 25 °CPMID 20656485Open
20α-hydroxysteroid dehydrogenase (AKR1C1)variant L308VHomo sapiens5α-pregnane-3α,20α-diol—4 × 10⁻⁴270pH 7.4, 25 °CPMID 20656485Open
20α-hydroxysteroid dehydrogenase (AKR1C1)variant L308VHomo sapiens5β-pregnan-3α-ol-20-one—0.006227pH 7.4, 25 °CPMID 20656485Open
3α-hydroxysteroid dehydrogenase type IIBrain (3α-HSD type IIBrain)Homo sapiens5α-androstan-17β-ol-3-oneno SSRI added—0.00237—pH 7.3, 37 °CPMID 10557352Open
3α-hydroxysteroid dehydrogenase type IIBrain (3α-HSD type IIBrain)Homo sapiens5α-androstan-17β-ol-3-one—5 × 10⁻⁵—pH 7.3, 37 °CPMID 10557352Open
3α-hydroxysteroid dehydrogenase type IIBrain (3α-HSD type IIBrain)Homo sapiens5α-androstan-17β-ol-3-one—3.9 × 10⁻⁴—pH 7.3, 37 °CPMID 10557352Open
3α-hydroxysteroid dehydrogenase type IIBrain (3α-HSD type IIBrain)Homo sapiens5α-androstan-17β-ol-3-one—0.0178—pH 7.3, 37 °CPMID 10557352Open
3α-hydroxysteroid dehydrogenase type IIBrain (3α-HSD type IIBrain)Homo sapiens5α-androstan-3α,17β-diolno SSRI added—0.001—pH 8.9PMID 10557352Open
3α-hydroxysteroid dehydrogenase type IIBrain (3α-HSD type IIBrain)Homo sapiens5α-androstan-3α,17β-diol—0.0072—pH 8.9PMID 10557352Open
3α-hydroxysteroid dehydrogenase type IIBrain (3α-HSD type IIBrain)Homo sapiens5α-androstan-3α,17β-diol—4.6 × 10⁻⁴—pH 8.9PMID 10557352Open
3α-hydroxysteroid dehydrogenase type IIBrain (3α-HSD type IIBrain)Homo sapiens5α-androstan-3α,17β-diol—2.1 × 10⁻⁴—pH 8.9PMID 10557352Open
3α-hydroxysteroid dehydrogenase type IIBrain (3α-HSD type IIBrain)Homo sapiensprogesteroneno SSRI added—0.1421—pH 7.3, 37 °CPMID 10557352Open
3α-hydroxysteroid dehydrogenase type IIBrain (3α-HSD type IIBrain)Homo sapiensprogesterone—0.238—pH 7.3, 37 °CPMID 10557352Open
3α-hydroxysteroid dehydrogenase type IIBrain (3α-HSD type IIBrain)Homo sapiensprogesterone—0.121—pH 7.3, 37 °CPMID 10557352Open
3α-hydroxysteroid dehydrogenase type IIBrain (3α-HSD type IIBrain)Homo sapiensprogesterone—0.1499—pH 7.3, 37 °CPMID 10557352Open
AKR1C1Homo sapiens(S)-1,2,3,4-tetrahydro-1-naphthol0.430.00762pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens17β-hydroxy-5α-androstan-3-one (5α-dihydrotestosterone)0.0125——pH 7, 37 °CPMID 14672942Open
AKR1C1Homo sapiens4-pregnen-20α-ol-3-one0.1520.0169.5pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5α-pregnan-20α-ol-3-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.017 × 10⁻⁴14.3pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5α-pregnan-20α-ol-3-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.1520.002757pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5α-pregnan-3α-ol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.0730.00237pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5α-pregnan-3α-ol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.00130.00330.33pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5α-pregnane-21-ol-3,20-dione0.00930.00127pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5α-pregnane-3,20-dione0.0430.001140pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5α-pregnane-3α,20α-diol0.0379 × 10⁻⁴40pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5α-pregnane-3α,21-diol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.0017——pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5α-pregnane-3α,21-diol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.00370.00261.3pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5β-pregnan-20α-ol-3-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.0370.001328pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5β-pregnan-20α-ol-3-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.0930.00193pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5β-pregnan-3α-ol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.180.003355pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5β-pregnan-3α-ol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.0060.00451.3pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5β-pregnan-3α-ol-20-oneKm from secondary plots; reduction of 3α,5β-THP—0.0012—pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5β-pregnane-3,20-dione0.050.001242pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5β-pregnane-3α,20α-dioloxidation direction with 0.25 mM NADP+0.160.0015107pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens5β-pregnane-3α,20α-diolKm from secondary plots—0.0011—pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiens9,10-phenanthrenequinone0.587.3 × 10⁻⁴800pH 7, 37 °CPMID 17950253Open
AKR1C1Homo sapiensNADP+—9 × 10⁻⁴—pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiensNADPH—0.0021—pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapienspregn-4-ene-3,20-dione0.0250.001320pH 7, 25 °CPMID 12604236Open
AKR1C1Homo sapiensprogesterone0.01550.00573.5pH 7, 37 °CPMID 17950253Open
AKR1C1Homo sapienspyridoxalpyridoxal reductase (PLR) activity; PL -> pyridoxine0.0420.3630.115pH 7, 37 °CPMID 41741972Open
AKR1C1Homo sapienspyridoxalpyridoxal dehydrogenase (PLD) activity; 0.2 mM NADP+0.0570.6290.09pH 7, 37 °CPMID 41741972Open
AKR1C3Homo sapiens(S)-1,2,3,4-tetrahydro-1-naphthol0.581.40.5pH 7, 25 °CPMID 12604236Open
AKR1C3Homo sapiens17β-hydroxy-5α-androstan-3-one (5α-dihydrotestosterone)0.0038——pH 7, 37 °CPMID 14672942Open
AKR1C3Homo sapiens4-pregnen-20α-ol-3-one5 × 10⁻⁴——pH 7, 25 °CPMID 12604236Open
AKR1C3Homo sapiens5α-pregnan-20α-ol-3-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.00870.00214.2pH 7, 25 °CPMID 12604236Open
AKR1C3Homo sapiens5α-pregnan-20α-ol-3-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+1.7 × 10⁻⁴——pH 7, 25 °CPMID 12604236Open
AKR1C3Homo sapiens5α-pregnan-3α-ol-20-one0.0013——pH 7, 25 °CPMID 12604236Open
AKR1C3Homo sapiens5α-pregnane-21-ol-3,20-dione0.001——pH 7, 25 °CPMID 12604236Open
AKR1C3Homo sapiens5α-pregnane-3,20-dione0.001——pH 7, 25 °CPMID 12604236Open
AKR1C3Homo sapiens5α-pregnane-3α,20α-diol0.001——pH 7, 25 °CPMID 12604236Open
AKR1C3Homo sapiens5α-pregnane-3α,21-diol-20-one1.7 × 10⁻⁴——pH 7, 25 °CPMID 12604236Open
AKR1C3Homo sapiens5β-pregnan-20α-ol-3-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.0189 × 10⁻⁴20pH 7, 25 °CPMID 12604236Open
AKR1C3Homo sapiens5β-pregnan-20α-ol-3-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+5 × 10⁻⁴——pH 7, 25 °CPMID 12604236Open
AKR1C3Homo sapiens5β-pregnan-3α-ol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.001——pH 7, 25 °CPMID 12604236Open
AKR1C3Homo sapiens5β-pregnan-3α-ol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.001——pH 7, 25 °CPMID 12604236Open
AKR1C3Homo sapiens5β-pregnane-3,20-dione0.0032——pH 7, 25 °CPMID 12604236Open
AKR1C3Homo sapiens5β-pregnane-3α,20α-diol0.0280.0271pH 7, 25 °CPMID 12604236Open
AKR1C3Homo sapiens9,10-phenanthrenequinone1.40.0015920pH 7, 37 °CPMID 17950253Open
AKR1C3Homo sapiensandrost-4-ene-3,17-dione0.00270.00660.4pH 7, 37 °CPMID 17950253Open
AKR1C3Homo sapienspyridoxalpyridoxal reductase (PLR) activity; PL -> pyridoxine0.00530.2980.018pH 7, 37 °CPMID 41741972Open
AKR1C3Homo sapienspyridoxalpyridoxal dehydrogenase (PLD) activity; 0.2 mM NADP+0.01271.020.013pH 7, 37 °CPMID 41741972Open
AKR1C4Homo sapiens(S)-1,2,3,4-tetrahydro-1-naphthol0.20.111.8pH 7, 25 °CPMID 12604236Open
AKR1C4Homo sapiens17β-hydroxy-5α-androstan-3-one (5α-dihydrotestosterone)0.0938——pH 7, 37 °CPMID 14672942Open
AKR1C4Homo sapiens4-pregnen-20α-ol-3-one0.00573 × 10⁻⁴18pH 7, 25 °CPMID 12604236Open
AKR1C4Homo sapiens5α-pregnan-20α-ol-3-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.0220.001120pH 7, 25 °CPMID 12604236Open
AKR1C4Homo sapiens5α-pregnan-20α-ol-3-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.01072 × 10⁻⁴53pH 7, 25 °CPMID 12604236Open
AKR1C4Homo sapiens5α-pregnan-3α-ol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.019 × 10⁻⁴11.2pH 7, 25 °CPMID 12604236Open
AKR1C4Homo sapiens5α-pregnan-3α-ol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.0672 × 10⁻⁴330pH 7, 25 °CPMID 12604236Open
AKR1C4Homo sapiens5α-pregnane-21-ol-3,20-dione0.0350.001720pH 7, 25 °CPMID 12604236Open
AKR1C4Homo sapiens5α-pregnane-3,20-dione0.026 × 10⁻⁴33pH 7, 25 °CPMID 12604236Open
AKR1C4Homo sapiens5α-pregnane-3α,20α-diol0.0672 × 10⁻⁴330pH 7, 25 °CPMID 12604236Open
AKR1C4Homo sapiens5α-pregnane-3α,21-diol-20-one0.073 × 10⁻⁴230pH 7, 25 °CPMID 12604236Open
AKR1C4Homo sapiens5β-pregnan-20α-ol-3-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.0230.001515.5pH 7, 25 °CPMID 12604236Open
AKR1C4Homo sapiens5β-pregnan-20α-ol-3-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.00833 × 10⁻⁴28pH 7, 25 °CPMID 12604236Open
AKR1C4Homo sapiens5β-pregnan-3α-ol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.01225 × 10⁻⁴25pH 7, 25 °CPMID 12604236Open
AKR1C4Homo sapiens5β-pregnan-3α-ol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.0274 × 10⁻⁴67pH 7, 25 °CPMID 12604236Open
AKR1C4Homo sapiens5β-pregnane-3,20-dione0.0577 × 10⁻⁴82pH 7, 25 °CPMID 12604236Open
AKR1C4Homo sapiens5β-pregnane-3α,20α-diol0.022 × 10⁻⁴100pH 7, 25 °CPMID 12604236Open
AKR1C4Homo sapienspregn-4-ene-3,20-dione8.3 × 10⁻⁴——pH 7, 25 °CPMID 12604236Open
AKR1C4Homo sapienspyridoxal0.0060.3040.02pH 7, 37 °CPMID 41741972Open
AKR1C4 (hydroxysteroid dehydrogenase isoform)Homo sapiens(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenal (all-trans-geranylgeranial)——13PMID 19464995Open
aldo-keto reductase AKR1C1 (human 20α-HSD)Homo sapiens5α-dihydrotestosterone0.01230.00423PMID 19218247Open
aldo-keto reductase AKR1C1 (human 20α-HSD)Homo sapiens5α-dihydrotestosterone-17β-glucuronide0.00880.01610.55PMID 19218247Open
aldo-keto reductase AKR1C1 (human 20α-HSD)Homo sapiens5α-dihydrotestosterone-17β-sulfate0.01250.00522.3PMID 19218247Open
aldo-keto reductase AKR1C1 (human 20α-HSD)Homo sapienstibolone-17β-sulfate0.0320.002512.7PMID 19218247Open
aldo-keto reductase AKR1C4 (human type 1 3α-HSD)Homo sapiens5α-dihydrotestosterone0.0513——PMID 19218247Open
aldo-keto reductase AKR1C4 (human type 1 3α-HSD)Homo sapiens5α-dihydrotestosterone-17β-glucuronide0.0547——PMID 19218247Open
aldo-keto reductase AKR1C4 (human type 1 3α-HSD)Homo sapiens5α-dihydrotestosterone-17β-sulfate0.0512——PMID 19218247Open
aldo-keto reductase AKR1C4 (human type 1 3α-HSD)Homo sapienstibolone-17β-sulfate0.025 × 10⁻⁴40PMID 19218247Open