EC 1.1.1.209: 3(or 17)alpha-hydroxysteroid dehydrogenase

OxidoreductasesOpen in Browse

CatLog read 265 records for EC 1.1.1.209 from 19 papers, for 3 organisms. Names in these papers: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), 3(17)α-hydroxysteroid dehydrogenase (AKR1C21), 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1), AKR1C1 and 17 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 27 records for EC 1.1.1.209 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.1.1.209 in Browse.

Papers

Papers with records for EC 1.1.1.209
Paper	Organisms	Records
Characterization of two isoforms of mouse 3(17)alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase family	Mus musculus	90
Selective and potent inhibitors of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) that metabolizes neurosteroids derived from progesterone	Homo sapiens	56
Studies on a Tyr residue critical for the binding of coenzyme and substrate in mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21): structure of the Y224D mutant enzyme	Mus musculus	36
Human cytosolic hydroxysteroid dehydrogenases of the aldo-ketoreductase superfamily catalyze reduction of conjugated steroids: implications for phase I and phase II steroid hormone metabolism	Homo sapiens	12
Expression cloning and characterization of oxidative 17beta- and 3alpha-hydroxysteroid dehydrogenases from rat and human prostate	Homo sapiens, Rattus norvegicus	11
Structure of the G225P/G226P mutant of mouse 3(17)alpha-hydroxysteroid dehydrogenase (AKR1C21) ternary complex: implications for the binding of inhibitor and substrate	Mus musculus	10
Characterization of a novel type of human microsomal 3alpha -hydroxysteroid dehydrogenase: unique tissue distribution and catalytic properties	Homo sapiens	7
cDNA cloning and characterization of a new human microsomal NAD+-dependent dehydrogenase that oxidizes all-trans-retinol and 3alpha-hydroxysteroids	Homo sapiens	7
Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone…	Homo sapiens	6
Mouse 17alpha-hydroxysteroid dehydrogenase (AKR1C21) binds steroids differently from other aldo-keto reductases: identification and characterization of amino acid residues critical for substrate…	Homo sapiens, Mus musculus	6
Molecular characterization of a first human 3(alpha-->beta)-hydroxysteroid epimerase	Homo sapiens	5
An indomethacin analogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3alpha-HSD, type 5 17beta-HSD, and prostaglandin F synthase), a potential target…	Homo sapiens	4
Factorizing the role of a critical leucine residue in the binding of substrate to human 20alpha-hydroxysteroid dehydrogenase (AKR1C1): molecular modeling and kinetic studies of the Leu308Val mutant…	Homo sapiens	4
Human 3-alpha hydroxysteroid dehydrogenase type 3 (3α-HSD3): the V54L mutation restricting the steroid alternative binding and enhancing the 20α-HSD activity	Homo sapiens	4
A new branch of mammalian vitamin B₆ metabolism: AKR1C-mediated conversion of pyridoxal to pyridoxine and 4-pyridoxolactone	Homo sapiens	3
Complementary deoxyribonucleic acid cloning and enzymatic characterization of a novel 17beta/3alpha-hydroxysteroid/retinoid short chain dehydrogenase/reductase	Mus musculus	1
Comparative functional analysis of human medium-chain dehydrogenases, short-chain dehydrogenases/reductases and aldo-keto reductases with retinoids	Homo sapiens	1
Kinetic studies of AKR1B10, human aldose reductase-like protein: endogenous substrates and inhibition by steroids	Homo sapiens	1
Substrate specificity and inhibitor sensitivity of rabbit 20α-hydroxysteroid dehydrogenase	Homo sapiens	1

Records

Records for EC 1.1.1.209 read from the paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Paper	Open record
17beta/3alpha-hydroxysteroid/retinoid short chain dehydrogenase/reductase (17bHSD9)	Mus musculus	all-trans-retinol	—	0.0032	—	pH 9, 37 °C	PMID 10537158	Open record: 17beta/3alpha-hydroxysteroid/retinoid short chain dehydrogenase/reductase (17bHSD9), all-trans-retinol
17α-hydroxysteroid dehydrogenase (m17α-HSD, AKR1C21)	Mus musculus	androst-4-ene-3,17-dione	0.3678	0.01926	19.1	pH 7.3, 37 °C	PMID 17442338	Open record: 17α-hydroxysteroid dehydrogenase (m17α-HSD, AKR1C21), androst-4-ene-3,17-dione
17α-hydroxysteroid dehydrogenase (m17α-HSD, AKR1C21)variant A24Y	Mus musculus	androst-4-ene-3,17-dione	0.0368	0.1246	0.3	pH 7.3, 37 °C	PMID 17442338	Open record: 17α-hydroxysteroid dehydrogenase (m17α-HSD, AKR1C21) variant A24Y, androst-4-ene-3,17-dione
17α-hydroxysteroid dehydrogenase (m17α-HSD, AKR1C21)variant K31A	Mus musculus	androst-4-ene-3,17-dione	0.7767	0.02279	34.08	pH 7.3, 37 °C	PMID 17442338	Open record: 17α-hydroxysteroid dehydrogenase (m17α-HSD, AKR1C21) variant K31A, androst-4-ene-3,17-dione
17α-hydroxysteroid dehydrogenase (m17α-HSD, AKR1C21)variant K31M	Mus musculus	androst-4-ene-3,17-dione	0.6623	0.02279	29.07	pH 7.3, 37 °C	PMID 17442338	Open record: 17α-hydroxysteroid dehydrogenase (m17α-HSD, AKR1C21) variant K31M, androst-4-ene-3,17-dione
17β-HSD6 (17β-hydroxysteroid dehydrogenase type 6)	Rattus norvegicus	4-androsten-17beta-ol-3-one	—	0.0011	—	pH 7.5, 37 °C	PMID 9188497	Open record: 17β-HSD6 (17β-hydroxysteroid dehydrogenase type 6), 4-androsten-17beta-ol-3-one
17β-HSD6 (17β-hydroxysteroid dehydrogenase type 6)	Rattus norvegicus	5alpha-androstan-17beta-ol-3-one	—	5 × 10⁻⁴	—	pH 7.5, 37 °C	PMID 9188497	Open record: 17β-HSD6 (17β-hydroxysteroid dehydrogenase type 6), 5alpha-androstan-17beta-ol-3-one
17β-HSD6 (17β-hydroxysteroid dehydrogenase type 6)	Rattus norvegicus	5alpha-androstan-3alpha-ol-17-one	—	2 × 10⁻⁴	—	pH 7.5, 37 °C	PMID 9188497	Open record: 17β-HSD6 (17β-hydroxysteroid dehydrogenase type 6), 5alpha-androstan-3alpha-ol-17-one
17β-HSD6 (17β-hydroxysteroid dehydrogenase type 6)	Rattus norvegicus	5alpha-androstane-3alpha,17beta-diol	—	1 × 10⁻⁴	—	pH 7.5, 37 °C	PMID 9188497	Open record: 17β-HSD6 (17β-hydroxysteroid dehydrogenase type 6), 5alpha-androstane-3alpha,17beta-diol
17β-HSD6 (17β-hydroxysteroid dehydrogenase type 6)	Rattus norvegicus	Estradiol	—	8 × 10⁻⁴	—	pH 7.5, 37 °C	PMID 9188497	Open record: 17β-HSD6 (17β-hydroxysteroid dehydrogenase type 6), Estradiol
17β-HSD6 (17β-hydroxysteroid dehydrogenase type 6)	Rattus norvegicus	NAD+	—	0.003	—	pH 7.5, 37 °C	PMID 9188497	Open record: 17β-HSD6 (17β-hydroxysteroid dehydrogenase type 6), NAD+
17β-HSD6 (17β-hydroxysteroid dehydrogenase type 6)	Rattus norvegicus	NADP+	—	1	—	pH 7.5, 37 °C	PMID 9188497	Open record: 17β-HSD6 (17β-hydroxysteroid dehydrogenase type 6), NADP+
20α-hydroxysteroid dehydrogenase (AKR1C1)	Homo sapiens	β-Ionol	0.053	0.0012	44 calc.	pH 7.4, 25 °C	PMID 23995665	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C1), β-Ionol
20α-hydroxysteroid dehydrogenase (AKR1C1)variant L308A	Homo sapiens	(S)-1,2,3,4-tetrahydronaphthalen-1-ol	—	0.47	0.83	pH 7.4, 25 °C	PMID 20656485	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C1) variant L308A, (S)-1,2,3,4-tetrahydronaphthalen-1-ol
20α-hydroxysteroid dehydrogenase (AKR1C1)variant L308V	Homo sapiens	(S)-1,2,3,4-tetrahydronaphthalen-1-ol	—	0.016	13	pH 7.4, 25 °C	PMID 20656485	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C1) variant L308V, (S)-1,2,3,4-tetrahydronaphthalen-1-ol
20α-hydroxysteroid dehydrogenase (AKR1C1)variant L308V	Homo sapiens	5α-pregnane-3α,20α-diol	—	4 × 10⁻⁴	270	pH 7.4, 25 °C	PMID 20656485	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C1) variant L308V, 5α-pregnane-3α,20α-diol
20α-hydroxysteroid dehydrogenase (AKR1C1)variant L308V	Homo sapiens	5β-pregnan-3α-ol-20-one	—	0.0062	27	pH 7.4, 25 °C	PMID 20656485	Open record: 20α-hydroxysteroid dehydrogenase (AKR1C1) variant L308V, 5β-pregnan-3α-ol-20-one
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	(R)-2,3-dihydro-1H-inden-1-ol	0.45	0.37	1.2	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), (R)-2,3-dihydro-1H-inden-1-ol
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	1-Phenylisatin	0.58	0.0019	300	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), 1-Phenylisatin
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	16-Ketoestrone	0.58	8 × 10⁻⁴	730	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), 16-Ketoestrone
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	17α-Estradiol	0.033	0.0016	17	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), 17α-Estradiol
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	17α-Hydroxy-5α-androstan-3-one	0.17	4 × 10⁻⁴	420	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), 17α-Hydroxy-5α-androstan-3-one
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	17α-Hydroxy-5β-androstan-3-one	0.14	4 × 10⁻⁴	350	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), 17α-Hydroxy-5β-androstan-3-one
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	17α-Hydroxyestr-4-en-3-one	0.127	0.0025	50	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), 17α-Hydroxyestr-4-en-3-one
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	17β-Hydroxy-5β-androstan-3-one	0.62	0.0017	370	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), 17β-Hydroxy-5β-androstan-3-one
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	21-Hydroxy-5α-pregnane-3,20-dione	0.33	0.0013	250	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), 21-Hydroxy-5α-pregnane-3,20-dione
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	21-Hydroxy-5β-pregnane-3,20-dione	0.6	3 × 10⁻⁴	2 × 10³	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), 21-Hydroxy-5β-pregnane-3,20-dione
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	3α,21-Dihydroxy-5α-pregnan-20-one	0.132	0.003	50	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), 3α,21-Dihydroxy-5α-pregnan-20-one
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	3α,21-Dihydroxy-5β-pregnan-20-one	0.22	0.001	220	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), 3α,21-Dihydroxy-5β-pregnan-20-one
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	3α-Hydroxy-5α-pregnan-20-one	0.12	0.0026	50	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), 3α-Hydroxy-5α-pregnan-20-one
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	3α-Hydroxy-5β-androstan-17-one0.25 mM NADP+; NADPH fluorescence (ex 340 nm, em 455 nm)	0.122	4 × 10⁻⁴	300	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), 3α-Hydroxy-5β-androstan-17-one
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	3α-Hydroxy-5β-androstan-17-one0.1 mM NADPH; NADPH absorbance at 340 nm	0.053	3 × 10⁻⁴	170	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), 3α-Hydroxy-5β-androstan-17-one
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	3α-Hydroxy-5β-pregnan-20-one	0.2	7 × 10⁻⁴	280	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), 3α-Hydroxy-5β-pregnan-20-one
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	3α-Hydroxyandrost-4-en-17-one	0.025	6 × 10⁻⁴	50	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), 3α-Hydroxyandrost-4-en-17-one
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	4-Nitroacetophenone	0.2	0.043	5	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), 4-Nitroacetophenone
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	4-Nitrobenzaldehyde	0.5	0.0023	220	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), 4-Nitrobenzaldehyde
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	5α-Androstane-3,17-dione	0.13	0.001	130	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), 5α-Androstane-3,17-dione
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	5α-dihydrotestosterone	0.142	0.0011	130	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), 5α-dihydrotestosterone
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	5α-Pregnane-3,20-dione	0.2	4 × 10⁻⁴	500	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), 5α-Pregnane-3,20-dione
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	5α-Pregnane-3α,20α-diol	0.105	5 × 10⁻⁴	220	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), 5α-Pregnane-3α,20α-diol
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	5β-Androstane-3,17-dione	0.33	7 × 10⁻⁴	480	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), 5β-Androstane-3,17-dione
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	5β-Dihydrocorticosterone	0.18	0.0094	17	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), 5β-Dihydrocorticosterone
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	5β-Dihydrocortisone	0.058	0.0064	8.3	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), 5β-Dihydrocortisone
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	5β-Pregnane-3,20-dione	0.4	6 × 10⁻⁴	670	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), 5β-Pregnane-3,20-dione
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	5β-Pregnane-3α,20α-diol	0.22	6 × 10⁻⁴	370	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), 5β-Pregnane-3α,20α-diol
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	Acenaphthenequinone	0.58	7 × 10⁻⁴	830	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), Acenaphthenequinone
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	Androst-4-ene-3,17-dione	0.17	2 × 10⁻⁴	830	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), Androst-4-ene-3,17-dione
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	Androst-5-ene-3β,17α-diol	0.085	0.0026	33	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), Androst-5-ene-3β,17α-diol
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	cis-cyclohexa-3,5-diene-1,2-diol	1.03	1.24	0.83	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), cis-cyclohexa-3,5-diene-1,2-diol
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	dehydroepiandrosterone	0.09	4 × 10⁻⁴	220	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), dehydroepiandrosterone
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	dehydroepiandrosterone 3-sulfate	0.08	4 × 10⁻⁴	200	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), dehydroepiandrosterone 3-sulfate
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	Dehydrolithocholic acid	0.25	8 × 10⁻⁴	320	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), Dehydrolithocholic acid
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	Deoxycorticosterone	0.017	0.002	8.3	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), Deoxycorticosterone
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	Epitestosterone	0.3	6 × 10⁻⁴	500	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), Epitestosterone
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	Estrone	0.0067	8 × 10⁻⁴	8.3	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), Estrone
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	Lithocholic acid	0.047	1 × 10⁻⁴	470	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), Lithocholic acid
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	NAD+	—	1.58	0.17	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), NAD+
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	NADH	—	0.28	0.83	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), NADH
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	NADP+	—	0.0018	170	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), NADP+
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	NADPH	—	0.001	180	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), NADPH
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	Phenanthrenequinone	0.78	0.0026	300	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), Phenanthrenequinone
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	R-Camphorquinone	1.1	0.0011	1 × 10³	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), R-Camphorquinone
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	S-Camphorquinone	1.15	8 × 10⁻⁴	1.43 × 10³	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), S-Camphorquinone
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3)	Mus musculus	Testosterone	0.013	5 × 10⁻⁴	33	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21 (DD3), Testosterone
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	(R)-2,3-dihydro-1H-inden-1-ol	0.32	0.37	0.83	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), (R)-2,3-dihydro-1H-inden-1-ol
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	1-Phenylisatin	0.53	0.002	270	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), 1-Phenylisatin
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	16-Ketoestrone	0.5	8 × 10⁻⁴	620	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), 16-Ketoestrone
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	17α-Estradiol	0.027	0.0025	10	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), 17α-Estradiol
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	17α-Hydroxy-5α-androstan-3-one	0.14	4 × 10⁻⁴	350	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), 17α-Hydroxy-5α-androstan-3-one
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	17α-Hydroxy-5β-androstan-3-one	0.042	4 × 10⁻⁴	100	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), 17α-Hydroxy-5β-androstan-3-one
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	17α-Hydroxyestr-4-en-3-one	0.088	0.0033	33	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), 17α-Hydroxyestr-4-en-3-one
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	17β-Hydroxy-5β-androstan-3-one	0.35	0.0012	300	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), 17β-Hydroxy-5β-androstan-3-one
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	21-Hydroxy-5α-pregnane-3,20-dione	0.25	0.001	250	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), 21-Hydroxy-5α-pregnane-3,20-dione
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	21-Hydroxy-5β-pregnane-3,20-dione	0.58	4 × 10⁻⁴	1.47 × 10³	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), 21-Hydroxy-5β-pregnane-3,20-dione
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	3α,21-Dihydroxy-5α-pregnan-20-one	0.058	0.0019	33	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), 3α,21-Dihydroxy-5α-pregnan-20-one
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	3α,21-Dihydroxy-5β-pregnan-20-one	0.147	0.0011	130	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), 3α,21-Dihydroxy-5β-pregnan-20-one
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	3α-Hydroxy-5α-pregnan-20-one	0.063	0.0014	50	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), 3α-Hydroxy-5α-pregnan-20-one
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	3α-Hydroxy-5β-androstan-17-one0.25 mM NADP+; NADPH fluorescence (ex 340 nm, em 455 nm)	0.112	5 × 10⁻⁴	220	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), 3α-Hydroxy-5β-androstan-17-one
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	3α-Hydroxy-5β-androstan-17-one0.1 mM NADPH; NADPH absorbance at 340 nm	0.045	3 × 10⁻⁴	150	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), 3α-Hydroxy-5β-androstan-17-one
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	3α-Hydroxy-5β-pregnan-20-one	0.125	4 × 10⁻⁴	320	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), 3α-Hydroxy-5β-pregnan-20-one
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	3α-Hydroxyandrost-4-en-17-one	0.02	5 × 10⁻⁴	33	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), 3α-Hydroxyandrost-4-en-17-one
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	4-Nitroacetophenone	0.097	0.051	1.7	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), 4-Nitroacetophenone
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	4-Nitrobenzaldehyde	0.43	0.0061	67	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), 4-Nitrobenzaldehyde
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	5α-Androstane-3,17-dione	0.105	6 × 10⁻⁴	170	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), 5α-Androstane-3,17-dione
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	5α-dihydrotestosterone	0.103	0.001	100	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), 5α-dihydrotestosterone
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	5α-Pregnane-3,20-dione	0.148	4 × 10⁻⁴	370	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), 5α-Pregnane-3,20-dione
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	5α-Pregnane-3α,20α-diol	0.077	0.001	83	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), 5α-Pregnane-3α,20α-diol
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	5β-Androstane-3,17-dione	0.28	0.001	280	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), 5β-Androstane-3,17-dione
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	5β-Dihydrocorticosterone	0.12	0.0062	17	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), 5β-Dihydrocorticosterone
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	5β-Dihydrocortisone	0.058	0.0084	6.7	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), 5β-Dihydrocortisone
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	5β-Pregnane-3,20-dione	0.32	5 × 10⁻⁴	630	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), 5β-Pregnane-3,20-dione
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	5β-Pregnane-3α,20α-diol	0.13	4 × 10⁻⁴	330	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), 5β-Pregnane-3α,20α-diol
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	Acenaphthenequinone	0.37	5 × 10⁻⁴	730	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), Acenaphthenequinone
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	Androst-4-ene-3,17-dione	0.18	3 × 10⁻⁴	620	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), Androst-4-ene-3,17-dione
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	Androst-5-ene-3β,17α-diol	0.062	0.0021	33	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), Androst-5-ene-3β,17α-diol
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	cis-cyclohexa-3,5-diene-1,2-diol	0.63	1.91	0.33	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), cis-cyclohexa-3,5-diene-1,2-diol
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	dehydroepiandrosterone	0.068	4 × 10⁻⁴	170	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), dehydroepiandrosterone
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	dehydroepiandrosterone 3-sulfate	0.06	3 × 10⁻⁴	200	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), dehydroepiandrosterone 3-sulfate
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	Dehydrolithocholic acid	0.17	7 × 10⁻⁴	230	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), Dehydrolithocholic acid
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	Deoxycorticosterone	0.0083	0.0015	5	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), Deoxycorticosterone
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	Epitestosterone	0.22	6 × 10⁻⁴	370	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), Epitestosterone
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	Estrone	0.005	8 × 10⁻⁴	6.7	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), Estrone
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	Lithocholic acid	0.032	1 × 10⁻⁴	320	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), Lithocholic acid
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	Phenanthrenequinone	0.45	0.0027	170	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), Phenanthrenequinone
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	R-Camphorquinone	0.7	7 × 10⁻⁴	1 × 10³	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), R-Camphorquinone
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	S-Camphorquinone	0.7	8 × 10⁻⁴	880	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), S-Camphorquinone
3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1)variant AKR1C21* (DD1)	Mus musculus	Testosterone	0.015	9 × 10⁻⁴	17	pH 7, 25 °C	PMID 15577209	Open record: 3(17)alpha-hydroxysteroid dehydrogenase AKR1C21* (DD1) variant AKR1C21* (DD1), Testosterone
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)	Mus musculus	5α-androstan-3α-ol-17-one	0.073	6 × 10⁻⁴	122	25 °C	PMID 19237748	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21), 5α-androstan-3α-ol-17-one
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)	Mus musculus	NADP+	0.063	5 × 10⁻⁴	130 calc.	pH 7, 25 °C	PMID 20124700	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21), NADP+
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)	Mus musculus	NADPH	0.38	5 × 10⁻⁴	770 calc.	pH 7, 25 °C	PMID 20124700	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21), NADPH
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant G225P/G226P	Mus musculus	4-androstene-3,17-dione	0.137	9 × 10⁻⁴	150	25 °C	PMID 19237748	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant G225P/G226P, 4-androstene-3,17-dione
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant G225P/G226P	Mus musculus	5α-androstan-17α-ol-3-one	0.145	0.0048	30	pH 7, 25 °C	PMID 19237748	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant G225P/G226P, 5α-androstan-17α-ol-3-one
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant G225P/G226P	Mus musculus	5α-androstan-17β-ol-3-one	0.38	0.027	14.2	pH 7, 25 °C	PMID 19237748	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant G225P/G226P, 5α-androstan-17β-ol-3-one
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant G225P/G226P	Mus musculus	5α-androstan-3α-ol-17-one	0.22	0.0097	22	25 °C	PMID 19237748	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant G225P/G226P, 5α-androstan-3α-ol-17-one
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant G225P/G226P	Mus musculus	5α-pregnane-3α,20α-diol	0.15	0.08	1.7	pH 7, 25 °C	PMID 19237748	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant G225P/G226P, 5α-pregnane-3α,20α-diol
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant G225P/G226P	Mus musculus	5β-androstan-17α-ol-3-one	0.055	0.0013	42	pH 7, 25 °C	PMID 19237748	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant G225P/G226P, 5β-androstan-17α-ol-3-one
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant G225P/G226P	Mus musculus	5β-pregnane-3α,20α-diol	0.18	0.0029	63	pH 7, 25 °C	PMID 19237748	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant G225P/G226P, 5β-pregnane-3α,20α-diol
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant G225P/G226P	Mus musculus	epitestosterone (epi-T)	0.25	0.018	13	pH 7, 25 °C	PMID 19237748	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant G225P/G226P, epitestosterone (epi-T)
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant G225P/G226P	Mus musculus	testosterone (TES)	0.04	0.023	1.7	pH 7, 25 °C	PMID 19237748	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant G225P/G226P, testosterone (TES)
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant Q222N	Mus musculus	4-Androstene-3,17-dione	0.62	0.0059	105	pH 7, 25 °C	PMID 20124700	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant Q222N, 4-Androstene-3,17-dione
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant Q222N	Mus musculus	5-Androstene-3β,17β-diol	0.065	0.1	0.65	pH 7, 25 °C	PMID 20124700	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant Q222N, 5-Androstene-3β,17β-diol
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant Q222N	Mus musculus	5α-Androstan-17α-ol-3-one	0.28	0.014	20	pH 7, 25 °C	PMID 20124700	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant Q222N, 5α-Androstan-17α-ol-3-one
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant Q222N	Mus musculus	5α-Androstan-17β-ol-3-one	0.037	0.082	0.45	pH 7, 25 °C	PMID 20124700	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant Q222N, 5α-Androstan-17β-ol-3-one
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant Q222N	Mus musculus	5α-Androstan-3α-ol-17-one	0.23	0.0034	68	pH 7, 25 °C	PMID 20124700	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant Q222N, 5α-Androstan-3α-ol-17-one
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant Q222N	Mus musculus	5β-Pregnan-20α-ol-3-one	2.83	7 × 10⁻⁴	4 × 10³	pH 7, 25 °C	PMID 20124700	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant Q222N, 5β-Pregnan-20α-ol-3-one
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant Q222N	Mus musculus	5β-Pregnane-3,20-dione	4.8	4 × 10⁻⁴	1.2 × 10⁴	pH 7, 25 °C	PMID 20124700	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant Q222N, 5β-Pregnane-3,20-dione
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant Q222N	Mus musculus	5β-Pregnane-3α,20α-diol	0.25	0.0038	65	pH 7, 25 °C	PMID 20124700	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant Q222N, 5β-Pregnane-3α,20α-diol
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant Q222N	Mus musculus	epitestosterone	0.23	0.02	11.7	pH 7, 25 °C	PMID 20124700	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant Q222N, epitestosterone
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant Q222N	Mus musculus	Lithocholic acid	0.105	6 × 10⁻⁴	180	pH 7, 25 °C	PMID 20124700	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant Q222N, Lithocholic acid
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant Q222N	Mus musculus	NADP+	0.132	0.015	8.8 calc.	pH 7, 25 °C	PMID 20124700	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant Q222N, NADP+
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant Q222N	Mus musculus	NADPH	5.17	0.005	1.0 × 10³ calc.	pH 7, 25 °C	PMID 20124700	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant Q222N, NADPH
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant Y224D	Mus musculus	4-Androstene-3,17-dione	0.022	0.0078	3.3	pH 7, 25 °C	PMID 20124700	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant Y224D, 4-Androstene-3,17-dione
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant Y224D	Mus musculus	5-Androstene-3β,17β-diol	0.0017	0.035	0.05	pH 7, 25 °C	PMID 20124700	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant Y224D, 5-Androstene-3β,17β-diol
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant Y224D	Mus musculus	5α-Androstan-17β-ol-3-one	0.0025	0.096	0.033	pH 7, 25 °C	PMID 20124700	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant Y224D, 5α-Androstan-17β-ol-3-one
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant Y224D	Mus musculus	5α-Androstan-3α-ol-17-one	0.022	0.015	1.5	pH 7, 25 °C	PMID 20124700	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant Y224D, 5α-Androstan-3α-ol-17-one
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant Y224D	Mus musculus	5β-Pregnan-20α-ol-3-one	1.25	0.015	83	pH 7, 25 °C	PMID 20124700	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant Y224D, 5β-Pregnan-20α-ol-3-one
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant Y224D	Mus musculus	5β-Pregnane-3,20-dione	0.35	0.0059	60	pH 7, 25 °C	PMID 20124700	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant Y224D, 5β-Pregnane-3,20-dione
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant Y224D	Mus musculus	5β-Pregnane-3α,20α-diol	0.0037	0.018	1.7	pH 7, 25 °C	PMID 20124700	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant Y224D, 5β-Pregnane-3α,20α-diol
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant Y224D	Mus musculus	Lithocholic acid	0.0073	0.0067	1.2	pH 7, 25 °C	PMID 20124700	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant Y224D, Lithocholic acid
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant Y224D	Mus musculus	NADP+	0.0048	0.04	0.12 calc.	pH 7, 25 °C	PMID 20124700	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant Y224D, NADP+
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant Y224D	Mus musculus	NADPH	0.35	0.024	15 calc.	pH 7, 25 °C	PMID 20124700	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant Y224D, NADPH
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant Y224F	Mus musculus	4-Androstene-3,17-dione	0.32	0.0015	220	pH 7, 25 °C	PMID 20124700	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant Y224F, 4-Androstene-3,17-dione
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant Y224F	Mus musculus	5-Androstene-3β,17β-diol	0.0022	0.013	0.17	pH 7, 25 °C	PMID 20124700	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant Y224F, 5-Androstene-3β,17β-diol
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant Y224F	Mus musculus	5α-Androstan-17α-ol-3-one	0.87	0.0054	160	pH 7, 25 °C	PMID 20124700	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant Y224F, 5α-Androstan-17α-ol-3-one
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant Y224F	Mus musculus	5α-Androstan-17β-ol-3-one	0.0027	0.0047	0.5	pH 7, 25 °C	PMID 20124700	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant Y224F, 5α-Androstan-17β-ol-3-one
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant Y224F	Mus musculus	5α-Androstan-3α-ol-17-one	0.127	0.0018	70	pH 7, 25 °C	PMID 20124700	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant Y224F, 5α-Androstan-3α-ol-17-one
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant Y224F	Mus musculus	5β-Pregnan-20α-ol-3-one	4.83	6 × 10⁻⁴	8 × 10³	pH 7, 25 °C	PMID 20124700	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant Y224F, 5β-Pregnan-20α-ol-3-one
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant Y224F	Mus musculus	5β-Pregnane-3,20-dione	4	5 × 10⁻⁴	8 × 10³	pH 7, 25 °C	PMID 20124700	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant Y224F, 5β-Pregnane-3,20-dione
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant Y224F	Mus musculus	5β-Pregnane-3α,20α-diol	0.4	0.0032	125	pH 7, 25 °C	PMID 20124700	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant Y224F, 5β-Pregnane-3α,20α-diol
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant Y224F	Mus musculus	epitestosterone	0.57	0.014	40	pH 7, 25 °C	PMID 20124700	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant Y224F, epitestosterone
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant Y224F	Mus musculus	Lithocholic acid	0.082	2 × 10⁻⁴	400	pH 7, 25 °C	PMID 20124700	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant Y224F, Lithocholic acid
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant Y224F	Mus musculus	NADP+	0.092	0.0082	11 calc.	pH 7, 25 °C	PMID 20124700	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant Y224F, NADP+
3(17)α-hydroxysteroid dehydrogenase (AKR1C21)variant Y224F	Mus musculus	NADPH	4.17	0.0034	1.2 × 10³ calc.	pH 7, 25 °C	PMID 20124700	Open record: 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) variant Y224F, NADPH
3(α→β)-hydroxysteroid epimerase (3(α→β)-HSE)	Homo sapiens	5α-androstane-3,17-dioneproduct: ADT (androsterone)	—	4 × 10⁻⁴	—	pH 7.4, 37 °C	PMID 10896656	Open record: 3(α→β)-hydroxysteroid epimerase (3(α→β)-HSE), 5α-androstane-3,17-dione
3(α→β)-hydroxysteroid epimerase (3(α→β)-HSE)	Homo sapiens	5α-androstane-3,17-dioneproduct: epi-ADT (epi-androsterone)	—	2 × 10⁻⁴	—	pH 7.4, 37 °C	PMID 10896656	Open record: 3(α→β)-hydroxysteroid epimerase (3(α→β)-HSE), 5α-androstane-3,17-dione
3(α→β)-hydroxysteroid epimerase (3(α→β)-HSE)	Homo sapiens	5α-androstane-3β-ol-17-one	—	0.0017	—	pH 7.4, 37 °C	PMID 10896656	Open record: 3(α→β)-hydroxysteroid epimerase (3(α→β)-HSE), 5α-androstane-3β-ol-17-one
3(α→β)-hydroxysteroid epimerase (3(α→β)-HSE)	Homo sapiens	5α-pregnane-3α-ol-20-one	—	0.003	—	pH 7.4, 37 °C	PMID 10896656	Open record: 3(α→β)-hydroxysteroid epimerase (3(α→β)-HSE), 5α-pregnane-3α-ol-20-one
3(α→β)-hydroxysteroid epimerase (3(α→β)-HSE)	Homo sapiens	androsterone	—	4 × 10⁻⁴	—	pH 7.4, 37 °C	PMID 10896656	Open record: 3(α→β)-hydroxysteroid epimerase (3(α→β)-HSE), androsterone
3-alpha hydroxysteroid dehydrogenase type 3 (3α-HSD3, AKR1C2)	Homo sapiens	5α-dihydrotestosterone	0.0612	0.00218	28	pH 7.4, 37 °C	PMID 24434280	Open record: 3-alpha hydroxysteroid dehydrogenase type 3 (3α-HSD3, AKR1C2), 5α-dihydrotestosterone
3-alpha hydroxysteroid dehydrogenase type 3 (3α-HSD3, AKR1C2)	Homo sapiens	progesterone	0.0035	8.4 × 10⁻⁴	4.2	pH 7.4, 37 °C	PMID 24434280	Open record: 3-alpha hydroxysteroid dehydrogenase type 3 (3α-HSD3, AKR1C2), progesterone
3-alpha hydroxysteroid dehydrogenase type 3 (3α-HSD3, AKR1C2)variant V54L	Homo sapiens	5α-dihydrotestosterone	0.1153	0.07103	1.7	pH 7.4, 37 °C	PMID 24434280	Open record: 3-alpha hydroxysteroid dehydrogenase type 3 (3α-HSD3, AKR1C2) variant V54L, 5α-dihydrotestosterone
3-alpha hydroxysteroid dehydrogenase type 3 (3α-HSD3, AKR1C2)variant V54L	Homo sapiens	progesterone	0.0392	0.00213	18.3	pH 7.4, 37 °C	PMID 24434280	Open record: 3-alpha hydroxysteroid dehydrogenase type 3 (3α-HSD3, AKR1C2) variant V54L, progesterone
AKR1C1	Homo sapiens	(S)-1,2,3,4-tetrahydro-1-naphthol	0.43	0.007	62	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, (S)-1,2,3,4-tetrahydro-1-naphthol
AKR1C1	Homo sapiens	17β-hydroxy-5α-androstan-3-one (5α-dihydrotestosterone)	0.0125	—	—	pH 7, 37 °C	PMID 14672942	Open record: AKR1C1, 17β-hydroxy-5α-androstan-3-one (5α-dihydrotestosterone)
AKR1C1	Homo sapiens	4-pregnen-20α-ol-3-one	0.152	0.016	9.5	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 4-pregnen-20α-ol-3-one
AKR1C1	Homo sapiens	5α-pregnan-20α-ol-3-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH	0.01	7 × 10⁻⁴	14.3	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5α-pregnan-20α-ol-3-one
AKR1C1	Homo sapiens	5α-pregnan-20α-ol-3-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+	0.152	0.0027	57	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5α-pregnan-20α-ol-3-one
AKR1C1	Homo sapiens	5α-pregnan-3α-ol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH	0.073	0.002	37	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5α-pregnan-3α-ol-20-one
AKR1C1	Homo sapiens	5α-pregnan-3α-ol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+	0.0013	0.0033	0.33	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5α-pregnan-3α-ol-20-one
AKR1C1	Homo sapiens	5α-pregnane-21-ol-3,20-dione	0.0093	0.0012	7	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5α-pregnane-21-ol-3,20-dione
AKR1C1	Homo sapiens	5α-pregnane-3,20-dione	0.043	0.0011	40	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5α-pregnane-3,20-dione
AKR1C1	Homo sapiens	5α-pregnane-3α,20α-diol	0.037	9 × 10⁻⁴	40	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5α-pregnane-3α,20α-diol
AKR1C1	Homo sapiens	5α-pregnane-3α,21-diol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH	0.0017	—	—	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5α-pregnane-3α,21-diol-20-one
AKR1C1	Homo sapiens	5α-pregnane-3α,21-diol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+	0.0037	0.0026	1.3	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5α-pregnane-3α,21-diol-20-one
AKR1C1	Homo sapiens	5β-pregnan-20α-ol-3-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH	0.037	0.0013	28	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5β-pregnan-20α-ol-3-one
AKR1C1	Homo sapiens	5β-pregnan-20α-ol-3-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+	0.093	0.001	93	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5β-pregnan-20α-ol-3-one
AKR1C1	Homo sapiens	5β-pregnan-3α-ol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH	0.18	0.0033	55	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5β-pregnan-3α-ol-20-one
AKR1C1	Homo sapiens	5β-pregnan-3α-ol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+	0.006	0.0045	1.3	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5β-pregnan-3α-ol-20-one
AKR1C1	Homo sapiens	5β-pregnan-3α-ol-20-oneKm from secondary plots; reduction of 3α,5β-THP	—	0.0012	—	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5β-pregnan-3α-ol-20-one
AKR1C1	Homo sapiens	5β-pregnane-3,20-dione	0.05	0.0012	42	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5β-pregnane-3,20-dione
AKR1C1	Homo sapiens	5β-pregnane-3α,20α-dioloxidation direction with 0.25 mM NADP+	0.16	0.0015	107	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5β-pregnane-3α,20α-diol
AKR1C1	Homo sapiens	5β-pregnane-3α,20α-diolKm from secondary plots	—	0.0011	—	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, 5β-pregnane-3α,20α-diol
AKR1C1	Homo sapiens	9,10-phenanthrenequinone	0.58	7.3 × 10⁻⁴	800	pH 7, 37 °C	PMID 17950253	Open record: AKR1C1, 9,10-phenanthrenequinone
AKR1C1	Homo sapiens	NADP+	—	9 × 10⁻⁴	—	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, NADP+
AKR1C1	Homo sapiens	NADPH	—	0.0021	—	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, NADPH
AKR1C1	Homo sapiens	pregn-4-ene-3,20-dione	0.025	0.0013	20	pH 7, 25 °C	PMID 12604236	Open record: AKR1C1, pregn-4-ene-3,20-dione
AKR1C1	Homo sapiens	progesterone	0.0155	0.0057	3.5	pH 7, 37 °C	PMID 17950253	Open record: AKR1C1, progesterone
AKR1C1	Homo sapiens	pyridoxalpyridoxal reductase (PLR) activity; PL -> pyridoxine	0.042	0.363	0.115	pH 7, 37 °C	PMID 41741972	Open record: AKR1C1, pyridoxal
AKR1C1	Homo sapiens	pyridoxalpyridoxal dehydrogenase (PLD) activity; 0.2 mM NADP+	0.057	0.629	0.09	pH 7, 37 °C	PMID 41741972	Open record: AKR1C1, pyridoxal
AKR1C2	Homo sapiens	(S)-1,2,3,4-tetrahydro-1-naphthol	0.27	0.26	1	pH 7, 25 °C	PMID 12604236	Open record: AKR1C2, (S)-1,2,3,4-tetrahydro-1-naphthol
AKR1C2	Homo sapiens	17β-hydroxy-5α-androstan-3-one (5α-dihydrotestosterone)radiometric time courses; apparent kcat	0.0492	—	—	pH 7, 37 °C	PMID 14672942	Open record: AKR1C2, 17β-hydroxy-5α-androstan-3-one (5α-dihydrotestosterone)
AKR1C2	Homo sapiens	17β-hydroxy-5α-androstan-3-one (5α-dihydrotestosterone)radiometric assay; [4-14C]DHT; DHT 1.6-41.25 µM	—	0.0066	—	pH 7, 37 °C	PMID 14672942	Open record: AKR1C2, 17β-hydroxy-5α-androstan-3-one (5α-dihydrotestosterone)
AKR1C2	Homo sapiens	17β-hydroxy-5α-androstan-3-one (5α-dihydrotestosterone)radiometric assay; [4-14C]DHT; DHT 1.6-41.25 µM	—	0.011	—	pH 7, 37 °C	PMID 14672942	Open record: AKR1C2, 17β-hydroxy-5α-androstan-3-one (5α-dihydrotestosterone)
AKR1C2	Homo sapiens	17β-hydroxy-5α-androstan-3-one (5α-dihydrotestosterone)	0.0517	0.0043	11.9	37 °C	PMID 14672942	Open record: AKR1C2, 17β-hydroxy-5α-androstan-3-one (5α-dihydrotestosterone)
AKR1C2	Homo sapiens	4-pregnen-20α-ol-3-one	0.0022	0.0073	0.33	pH 7, 25 °C	PMID 12604236	Open record: AKR1C2, 4-pregnen-20α-ol-3-one
AKR1C2	Homo sapiens	5α-dihydrotestosterone	0.063	0.0046	13.7	pH 7, 37 °C	PMID 17950253	Open record: AKR1C2, 5α-dihydrotestosterone
AKR1C2	Homo sapiens	5α-pregnan-20α-ol-3-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH	0.008	5 × 10⁻⁴	16	pH 7, 25 °C	PMID 12604236	Open record: AKR1C2, 5α-pregnan-20α-ol-3-one
AKR1C2	Homo sapiens	5α-pregnan-20α-ol-3-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+	0.001	—	—	pH 7, 25 °C	PMID 12604236	Open record: AKR1C2, 5α-pregnan-20α-ol-3-one
AKR1C2	Homo sapiens	5α-pregnan-3α-ol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH	0.0043	0.0031	1.3	pH 7, 25 °C	PMID 12604236	Open record: AKR1C2, 5α-pregnan-3α-ol-20-one
AKR1C2	Homo sapiens	5α-pregnan-3α-ol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+	0.0047	0.028	0.17	pH 7, 25 °C	PMID 12604236	Open record: AKR1C2, 5α-pregnan-3α-ol-20-one
AKR1C2	Homo sapiens	5α-pregnane-21-ol-3,20-dione	0.0082	8 × 10⁻⁴	10.2	pH 7, 25 °C	PMID 12604236	Open record: AKR1C2, 5α-pregnane-21-ol-3,20-dione
AKR1C2	Homo sapiens	5α-pregnane-3,20-dione	0.008	6 × 10⁻⁴	11.7	pH 7, 25 °C	PMID 12604236	Open record: AKR1C2, 5α-pregnane-3,20-dione
AKR1C2	Homo sapiens	5α-pregnane-3α,20α-diol	0.0032	0.0018	1.8	pH 7, 25 °C	PMID 12604236	Open record: AKR1C2, 5α-pregnane-3α,20α-diol
AKR1C2	Homo sapiens	5α-pregnane-3α,21-diol-20-one	0.0022	0.0068	0.33	pH 7, 25 °C	PMID 12604236	Open record: AKR1C2, 5α-pregnane-3α,21-diol-20-one
AKR1C2	Homo sapiens	5β-pregnan-20α-ol-3-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH	0.0108	3 × 10⁻⁴	37	pH 7, 25 °C	PMID 12604236	Open record: AKR1C2, 5β-pregnan-20α-ol-3-one
AKR1C2	Homo sapiens	5β-pregnan-20α-ol-3-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+	0.0012	—	—	pH 7, 25 °C	PMID 12604236	Open record: AKR1C2, 5β-pregnan-20α-ol-3-one
AKR1C2	Homo sapiens	5β-pregnan-3α-ol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH	0.007	0.0045	1.5	pH 7, 25 °C	PMID 12604236	Open record: AKR1C2, 5β-pregnan-3α-ol-20-one
AKR1C2	Homo sapiens	5β-pregnan-3α-ol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+	0.0045	0.0028	1.7	pH 7, 25 °C	PMID 12604236	Open record: AKR1C2, 5β-pregnan-3α-ol-20-one
AKR1C2	Homo sapiens	5β-pregnane-3,20-dione	0.018	7 × 10⁻⁴	27	pH 7, 25 °C	PMID 12604236	Open record: AKR1C2, 5β-pregnane-3,20-dione
AKR1C2	Homo sapiens	5β-pregnane-3α,20α-diol	0.0037	0.001	3.7	pH 7, 25 °C	PMID 12604236	Open record: AKR1C2, 5β-pregnane-3α,20α-diol
AKR1C2	Homo sapiens	9,10-phenanthrenequinone	1.83	0.0011	1.7 × 10³	pH 7, 37 °C	PMID 17950253	Open record: AKR1C2, 9,10-phenanthrenequinone
AKR1C2	Homo sapiens	pregn-4-ene-3,20-dione	6.7 × 10⁻⁴	—	—	pH 7, 25 °C	PMID 12604236	Open record: AKR1C2, pregn-4-ene-3,20-dione
AKR1C4	Homo sapiens	(S)-1,2,3,4-tetrahydro-1-naphthol	0.2	0.11	1.8	pH 7, 25 °C	PMID 12604236	Open record: AKR1C4, (S)-1,2,3,4-tetrahydro-1-naphthol
AKR1C4	Homo sapiens	17β-hydroxy-5α-androstan-3-one (5α-dihydrotestosterone)	0.0938	—	—	pH 7, 37 °C	PMID 14672942	Open record: AKR1C4, 17β-hydroxy-5α-androstan-3-one (5α-dihydrotestosterone)
AKR1C4	Homo sapiens	4-pregnen-20α-ol-3-one	0.0057	3 × 10⁻⁴	18	pH 7, 25 °C	PMID 12604236	Open record: AKR1C4, 4-pregnen-20α-ol-3-one
AKR1C4	Homo sapiens	5α-pregnan-20α-ol-3-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH	0.022	0.0011	20	pH 7, 25 °C	PMID 12604236	Open record: AKR1C4, 5α-pregnan-20α-ol-3-one
AKR1C4	Homo sapiens	5α-pregnan-20α-ol-3-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+	0.0107	2 × 10⁻⁴	53	pH 7, 25 °C	PMID 12604236	Open record: AKR1C4, 5α-pregnan-20α-ol-3-one
AKR1C4	Homo sapiens	5α-pregnan-3α-ol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH	0.01	9 × 10⁻⁴	11.2	pH 7, 25 °C	PMID 12604236	Open record: AKR1C4, 5α-pregnan-3α-ol-20-one
AKR1C4	Homo sapiens	5α-pregnan-3α-ol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+	0.067	2 × 10⁻⁴	330	pH 7, 25 °C	PMID 12604236	Open record: AKR1C4, 5α-pregnan-3α-ol-20-one
AKR1C4	Homo sapiens	5α-pregnane-21-ol-3,20-dione	0.035	0.0017	20	pH 7, 25 °C	PMID 12604236	Open record: AKR1C4, 5α-pregnane-21-ol-3,20-dione
AKR1C4	Homo sapiens	5α-pregnane-3,20-dione	0.02	6 × 10⁻⁴	33	pH 7, 25 °C	PMID 12604236	Open record: AKR1C4, 5α-pregnane-3,20-dione
AKR1C4	Homo sapiens	5α-pregnane-3α,20α-diol	0.067	2 × 10⁻⁴	330	pH 7, 25 °C	PMID 12604236	Open record: AKR1C4, 5α-pregnane-3α,20α-diol
AKR1C4	Homo sapiens	5α-pregnane-3α,21-diol-20-one	0.07	3 × 10⁻⁴	230	pH 7, 25 °C	PMID 12604236	Open record: AKR1C4, 5α-pregnane-3α,21-diol-20-one
AKR1C4	Homo sapiens	5β-pregnan-20α-ol-3-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH	0.023	0.0015	15.5	pH 7, 25 °C	PMID 12604236	Open record: AKR1C4, 5β-pregnan-20α-ol-3-one
AKR1C4	Homo sapiens	5β-pregnan-20α-ol-3-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+	0.0083	3 × 10⁻⁴	28	pH 7, 25 °C	PMID 12604236	Open record: AKR1C4, 5β-pregnan-20α-ol-3-one
AKR1C4	Homo sapiens	5β-pregnan-3α-ol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH	0.0122	5 × 10⁻⁴	25	pH 7, 25 °C	PMID 12604236	Open record: AKR1C4, 5β-pregnan-3α-ol-20-one
AKR1C4	Homo sapiens	5β-pregnan-3α-ol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+	0.027	4 × 10⁻⁴	67	pH 7, 25 °C	PMID 12604236	Open record: AKR1C4, 5β-pregnan-3α-ol-20-one
AKR1C4	Homo sapiens	5β-pregnane-3,20-dione	0.057	7 × 10⁻⁴	82	pH 7, 25 °C	PMID 12604236	Open record: AKR1C4, 5β-pregnane-3,20-dione
AKR1C4	Homo sapiens	5β-pregnane-3α,20α-diol	0.02	2 × 10⁻⁴	100	pH 7, 25 °C	PMID 12604236	Open record: AKR1C4, 5β-pregnane-3α,20α-diol
AKR1C4	Homo sapiens	pregn-4-ene-3,20-dione	8.3 × 10⁻⁴	—	—	pH 7, 25 °C	PMID 12604236	Open record: AKR1C4, pregn-4-ene-3,20-dione
AKR1C4	Homo sapiens	pyridoxal	0.006	0.304	0.02	pH 7, 37 °C	PMID 41741972	Open record: AKR1C4, pyridoxal
AKR1C4 (hydroxysteroid dehydrogenase isoform)	Homo sapiens	(2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenal (all-trans-geranylgeranial)	—	—	13		PMID 19464995	Open record: AKR1C4 (hydroxysteroid dehydrogenase isoform), (2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenal (all-trans-geranylgeranial)
aldo-keto reductase AKR1C1 (human 20α-HSD)	Homo sapiens	5α-dihydrotestosterone	0.0123	0.0042	3		PMID 19218247	Open record: aldo-keto reductase AKR1C1 (human 20α-HSD), 5α-dihydrotestosterone
aldo-keto reductase AKR1C1 (human 20α-HSD)	Homo sapiens	5α-dihydrotestosterone-17β-glucuronide	0.0088	0.0161	0.55		PMID 19218247	Open record: aldo-keto reductase AKR1C1 (human 20α-HSD), 5α-dihydrotestosterone-17β-glucuronide
aldo-keto reductase AKR1C1 (human 20α-HSD)	Homo sapiens	5α-dihydrotestosterone-17β-sulfate	0.0125	0.0052	2.3		PMID 19218247	Open record: aldo-keto reductase AKR1C1 (human 20α-HSD), 5α-dihydrotestosterone-17β-sulfate
aldo-keto reductase AKR1C1 (human 20α-HSD)	Homo sapiens	tibolone-17β-sulfate	0.032	0.0025	12.7		PMID 19218247	Open record: aldo-keto reductase AKR1C1 (human 20α-HSD), tibolone-17β-sulfate
aldo-keto reductase AKR1C2 (human type 3 3α-HSD)	Homo sapiens	5α-dihydrotestosterone	0.033	0.0029	11.3		PMID 19218247	Open record: aldo-keto reductase AKR1C2 (human type 3 3α-HSD), 5α-dihydrotestosterone
aldo-keto reductase AKR1C2 (human type 3 3α-HSD)	Homo sapiens	5α-dihydrotestosterone-17β-glucuronide	0.004	0.0041	0.98		PMID 19218247	Open record: aldo-keto reductase AKR1C2 (human type 3 3α-HSD), 5α-dihydrotestosterone-17β-glucuronide
aldo-keto reductase AKR1C2 (human type 3 3α-HSD)	Homo sapiens	5α-dihydrotestosterone-17β-sulfate	0.017	0.0042	4		PMID 19218247	Open record: aldo-keto reductase AKR1C2 (human type 3 3α-HSD), 5α-dihydrotestosterone-17β-sulfate
aldo-keto reductase AKR1C2 (human type 3 3α-HSD)	Homo sapiens	tibolone-17β-sulfate	0.202	0.0012	170		PMID 19218247	Open record: aldo-keto reductase AKR1C2 (human type 3 3α-HSD), tibolone-17β-sulfate
aldo-keto reductase AKR1C4 (human type 1 3α-HSD)	Homo sapiens	5α-dihydrotestosterone	0.0513	—	—		PMID 19218247	Open record: aldo-keto reductase AKR1C4 (human type 1 3α-HSD), 5α-dihydrotestosterone
aldo-keto reductase AKR1C4 (human type 1 3α-HSD)	Homo sapiens	5α-dihydrotestosterone-17β-glucuronide	0.0547	—	—		PMID 19218247	Open record: aldo-keto reductase AKR1C4 (human type 1 3α-HSD), 5α-dihydrotestosterone-17β-glucuronide
aldo-keto reductase AKR1C4 (human type 1 3α-HSD)	Homo sapiens	5α-dihydrotestosterone-17β-sulfate	0.0512	—	—		PMID 19218247	Open record: aldo-keto reductase AKR1C4 (human type 1 3α-HSD), 5α-dihydrotestosterone-17β-sulfate
aldo-keto reductase AKR1C4 (human type 1 3α-HSD)	Homo sapiens	tibolone-17β-sulfate	0.02	5 × 10⁻⁴	40		PMID 19218247	Open record: aldo-keto reductase AKR1C4 (human type 1 3α-HSD), tibolone-17β-sulfate
human type 3 3α-hydroxysteroid dehydrogenase (h3α-HSD3)variant Y24A	Homo sapiens	androst-4-ene-3,17-dione17α-HSD activity (17α-reduction of Δ4)	3.3 × 10⁻⁴	0.02094	0.017	pH 7.3, 37 °C	PMID 17442338	Open record: human type 3 3α-hydroxysteroid dehydrogenase (h3α-HSD3) variant Y24A, androst-4-ene-3,17-dione
human type 3 3α-hydroxysteroid dehydrogenase (h3α-HSD3)variant Y24A	Homo sapiens	androst-4-ene-3,17-dione17β-HSD activity (17β-reduction of Δ4 to testosterone)	0.0215	0.02957	0.73	pH 7.3, 37 °C	PMID 17442338	Open record: human type 3 3α-hydroxysteroid dehydrogenase (h3α-HSD3) variant Y24A, androst-4-ene-3,17-dione
microsomal 3α-hydroxysteroid dehydrogenase (3α-HSD)	Homo sapiens	17beta-hydroxy-5alpha-androstan-3-one	—	0.012	—	pH 7.4, 37 °C	PMID 11294878	Open record: microsomal 3α-hydroxysteroid dehydrogenase (3α-HSD), 17beta-hydroxy-5alpha-androstan-3-one
microsomal 3α-hydroxysteroid dehydrogenase (3α-HSD)	Homo sapiens	3alpha-hydroxy-5alpha-androstan-17-one	—	0.024	—	pH 7.4, 37 °C	PMID 11294878	Open record: microsomal 3α-hydroxysteroid dehydrogenase (3α-HSD), 3alpha-hydroxy-5alpha-androstan-17-one
microsomal 3α-hydroxysteroid dehydrogenase (3α-HSD)	Homo sapiens	3alpha-hydroxy-5alpha-pregnan-20-one	—	0.005	—	pH 7.4, 37 °C	PMID 11294878	Open record: microsomal 3α-hydroxysteroid dehydrogenase (3α-HSD), 3alpha-hydroxy-5alpha-pregnan-20-one
microsomal 3α-hydroxysteroid dehydrogenase (3α-HSD)	Homo sapiens	3beta-hydroxyandrost-5-en-17-one	—	0.014	—	pH 7.4, 37 °C	PMID 11294878	Open record: microsomal 3α-hydroxysteroid dehydrogenase (3α-HSD), 3beta-hydroxyandrost-5-en-17-one
microsomal 3α-hydroxysteroid dehydrogenase (3α-HSD)	Homo sapiens	5alpha-androstane-3alpha,17beta-diol	—	0.0075	—	pH 7.4, 37 °C	PMID 11294878	Open record: microsomal 3α-hydroxysteroid dehydrogenase (3α-HSD), 5alpha-androstane-3alpha,17beta-diol
microsomal 3α-hydroxysteroid dehydrogenase (3α-HSD)	Homo sapiens	NAD+	—	0.072	—	pH 7.4, 37 °C	PMID 11294878	Open record: microsomal 3α-hydroxysteroid dehydrogenase (3α-HSD), NAD+
microsomal 3α-hydroxysteroid dehydrogenase (3α-HSD)	Homo sapiens	NADH	—	0.009	—	pH 7.4, 37 °C	PMID 11294878	Open record: microsomal 3α-hydroxysteroid dehydrogenase (3α-HSD), NADH
retinol dehydrogenase 4 (RoDH-4)	Homo sapiens	5alpha-androstan-17beta-ol-3-one	—	8 × 10⁻⁴	—	pH 7.3, 25 °C	PMID 9677409	Open record: retinol dehydrogenase 4 (RoDH-4), 5alpha-androstan-17beta-ol-3-one
retinol dehydrogenase 4 (RoDH-4)	Homo sapiens	5alpha-androstan-3alpha,17beta-diol	—	2.2 × 10⁻⁴	—	pH 7.3, 25 °C	PMID 9677409	Open record: retinol dehydrogenase 4 (RoDH-4), 5alpha-androstan-3alpha,17beta-diol
retinol dehydrogenase 4 (RoDH-4)	Homo sapiens	5alpha-androstan-3alpha-ol-17-one	—	1.4 × 10⁻⁴	—	pH 7.3, 25 °C	PMID 9677409	Open record: retinol dehydrogenase 4 (RoDH-4), 5alpha-androstan-3alpha-ol-17-one
retinol dehydrogenase 4 (RoDH-4)	Homo sapiens	NAD+	—	1.3 × 10⁻⁴	—	pH 7.3, 25 °C	PMID 9677409	Open record: retinol dehydrogenase 4 (RoDH-4), NAD+
retinol dehydrogenase 4 (RoDH-4)	Homo sapiens	NADH	—	1 × 10⁻⁴	—	pH 7.3, 25 °C	PMID 9677409	Open record: retinol dehydrogenase 4 (RoDH-4), NADH
retinol dehydrogenase 4 (RoDH-4)	Homo sapiens	NADP+	—	0.19	—	pH 7.3, 25 °C	PMID 9677409	Open record: retinol dehydrogenase 4 (RoDH-4), NADP+
retinol dehydrogenase 4 (RoDH-4)	Homo sapiens	NADPH	—	0.025	—	pH 7.3, 25 °C	PMID 9677409	Open record: retinol dehydrogenase 4 (RoDH-4), NADPH
RoDH (retinol dehydrogenase), human	Homo sapiens	4-androsten-17beta-ol-3-one	—	0.0033	—	pH 7.5, 37 °C	PMID 9188497	Open record: RoDH (retinol dehydrogenase), human, 4-androsten-17beta-ol-3-one
RoDH (retinol dehydrogenase), human	Homo sapiens	5alpha-androstan-17beta-ol-3-one	—	1 × 10⁻⁴	—	pH 7.5, 37 °C	PMID 9188497	Open record: RoDH (retinol dehydrogenase), human, 5alpha-androstan-17beta-ol-3-one
RoDH (retinol dehydrogenase), human	Homo sapiens	5alpha-androstan-3alpha-ol-17-one	—	1 × 10⁻⁴	—	pH 7.5, 37 °C	PMID 9188497	Open record: RoDH (retinol dehydrogenase), human, 5alpha-androstan-3alpha-ol-17-one
RoDH (retinol dehydrogenase), human	Homo sapiens	5alpha-androstane-3alpha,17beta-diol	—	1 × 10⁻⁴	—	pH 7.5, 37 °C	PMID 9188497	Open record: RoDH (retinol dehydrogenase), human, 5alpha-androstane-3alpha,17beta-diol
RoDH-4 (retinol dehydrogenase 4)	Homo sapiens	all-trans-retinol	0.02	0.0011	18.3	pH 7.4, 37 °C	PMID 16787387	Open record: RoDH-4 (retinol dehydrogenase 4), all-trans-retinol