CatLogenzyme kinetics catalog

EC 1.1.1.188: prostaglandin-F synthase

OxidoreductasesOpen in Browse

CatLog read 98 records for EC 1.1.1.188 from 11 papers, for 2 organisms. Names in these papers: bovine liver PGF synthase (prostaglandin F synthase, liver isozyme), liver-type prostaglandin F synthase (PGF synthase), AKR1C3, 3α-hydroxysteroid dehydrogenase type IIBrain (3α-HSD type IIBrain) and 4 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 38 records for EC 1.1.1.188 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.1.1.188 in Browse.

Papers

PaperOrganismsRecords
Purification and characterization of prostaglandin F synthase from bovine liverBos taurus25
cDNA cloning, expression, and mutagenesis study of liver-type prostaglandin F synthaseBos taurus24
Selective and potent inhibitors of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) that metabolizes neurosteroids derived from progesteroneHomo sapiens15
Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymesHomo sapiens12
Enzymatic formation of prostaglandin F2 alpha from prostaglandin H2 and D2. Purification and properties of prostaglandin F synthetase from bovine lungBos taurus8
cDNA cloning, expression and characterization of human prostaglandin F synthaseHomo sapiens6
An indomethacin analogue, N-(4-chlorobenzoyl)-melatonin, is a selective inhibitor of aldo-keto reductase 1C3 (type 2 3alpha-HSD, type 5 17beta-HSD, and prostaglandin F synthase), a potential target…Homo sapiens2
Prostaglandin F2alpha synthase activities of aldo-keto reductase 1B1, 1B3 and 1B7Homo sapiens2
A new branch of mammalian vitamin B6 metabolism: AKR1C-mediated conversion of pyridoxal to pyridoxine and 4-pyridoxolactoneHomo sapiens2
Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone…Homo sapiens1
Molecular characterization of a novel type of prostamide/prostaglandin F synthase, belonging to the thioredoxin-like superfamily—1

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
3α-hydroxysteroid dehydrogenase type IIBrain (3α-HSD type IIBrain)Homo sapiens5α-androstan-17β-ol-3-oneno SSRI added—0.00237—pH 7.3, 37 °CPMID 10557352Open
3α-hydroxysteroid dehydrogenase type IIBrain (3α-HSD type IIBrain)Homo sapiens5α-androstan-17β-ol-3-one—5 × 10⁻⁵—pH 7.3, 37 °CPMID 10557352Open
3α-hydroxysteroid dehydrogenase type IIBrain (3α-HSD type IIBrain)Homo sapiens5α-androstan-17β-ol-3-one—3.9 × 10⁻⁴—pH 7.3, 37 °CPMID 10557352Open
3α-hydroxysteroid dehydrogenase type IIBrain (3α-HSD type IIBrain)Homo sapiens5α-androstan-17β-ol-3-one—0.0178—pH 7.3, 37 °CPMID 10557352Open
3α-hydroxysteroid dehydrogenase type IIBrain (3α-HSD type IIBrain)Homo sapiens5α-androstan-3α,17β-diolno SSRI added—0.001—pH 8.9PMID 10557352Open
3α-hydroxysteroid dehydrogenase type IIBrain (3α-HSD type IIBrain)Homo sapiens5α-androstan-3α,17β-diol—0.0072—pH 8.9PMID 10557352Open
3α-hydroxysteroid dehydrogenase type IIBrain (3α-HSD type IIBrain)Homo sapiens5α-androstan-3α,17β-diol—4.6 × 10⁻⁴—pH 8.9PMID 10557352Open
3α-hydroxysteroid dehydrogenase type IIBrain (3α-HSD type IIBrain)Homo sapiens5α-androstan-3α,17β-diol—2.1 × 10⁻⁴—pH 8.9PMID 10557352Open
3α-hydroxysteroid dehydrogenase type IIBrain (3α-HSD type IIBrain)Homo sapiensprogesteroneno SSRI added—0.1421—pH 7.3, 37 °CPMID 10557352Open
3α-hydroxysteroid dehydrogenase type IIBrain (3α-HSD type IIBrain)Homo sapiensprogesterone—0.238—pH 7.3, 37 °CPMID 10557352Open
3α-hydroxysteroid dehydrogenase type IIBrain (3α-HSD type IIBrain)Homo sapiensprogesterone—0.121—pH 7.3, 37 °CPMID 10557352Open
3α-hydroxysteroid dehydrogenase type IIBrain (3α-HSD type IIBrain)Homo sapiensprogesterone—0.1499—pH 7.3, 37 °CPMID 10557352Open
AKR1C3Homo sapiens(S)-1,2,3,4-tetrahydro-1-naphthol0.581.40.5pH 7, 25 °CPMID 12604236Open
AKR1C3Homo sapiens17β-hydroxy-5α-androstan-3-one (5α-dihydrotestosterone)0.0038——pH 7, 37 °CPMID 14672942Open
AKR1C3Homo sapiens4-pregnen-20α-ol-3-one5 × 10⁻⁴——pH 7, 25 °CPMID 12604236Open
AKR1C3Homo sapiens5α-pregnan-20α-ol-3-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.00870.00214.2pH 7, 25 °CPMID 12604236Open
AKR1C3Homo sapiens5α-pregnan-20α-ol-3-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+1.7 × 10⁻⁴——pH 7, 25 °CPMID 12604236Open
AKR1C3Homo sapiens5α-pregnan-3α-ol-20-one0.0013——pH 7, 25 °CPMID 12604236Open
AKR1C3Homo sapiens5α-pregnane-21-ol-3,20-dione0.001——pH 7, 25 °CPMID 12604236Open
AKR1C3Homo sapiens5α-pregnane-3,20-dione0.001——pH 7, 25 °CPMID 12604236Open
AKR1C3Homo sapiens5α-pregnane-3α,20α-diol0.001——pH 7, 25 °CPMID 12604236Open
AKR1C3Homo sapiens5α-pregnane-3α,21-diol-20-one1.7 × 10⁻⁴——pH 7, 25 °CPMID 12604236Open
AKR1C3Homo sapiens5β-pregnan-20α-ol-3-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.0189 × 10⁻⁴20pH 7, 25 °CPMID 12604236Open
AKR1C3Homo sapiens5β-pregnan-20α-ol-3-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+5 × 10⁻⁴——pH 7, 25 °CPMID 12604236Open
AKR1C3Homo sapiens5β-pregnan-3α-ol-20-onereduction direction with 0.1 mM NADPH; cosubstrate NADPH0.001——pH 7, 25 °CPMID 12604236Open
AKR1C3Homo sapiens5β-pregnan-3α-ol-20-oneoxidation direction with 0.25 mM NADP+; cosubstrate NADP+0.001——pH 7, 25 °CPMID 12604236Open
AKR1C3Homo sapiens5β-pregnane-3,20-dione0.0032——pH 7, 25 °CPMID 12604236Open
AKR1C3Homo sapiens5β-pregnane-3α,20α-diol0.0280.0271pH 7, 25 °CPMID 12604236Open
AKR1C3Homo sapiens9,10-phenanthrenequinone1.40.0015920pH 7, 37 °CPMID 17950253Open
AKR1C3Homo sapiensandrost-4-ene-3,17-dione0.00270.00660.4pH 7, 37 °CPMID 17950253Open
AKR1C3Homo sapienspyridoxalpyridoxal reductase (PLR) activity; PL -> pyridoxine0.00530.2980.018pH 7, 37 °CPMID 41741972Open
AKR1C3Homo sapienspyridoxalpyridoxal dehydrogenase (PLD) activity; 0.2 mM NADP+0.01271.020.013pH 7, 37 °CPMID 41741972Open
AKR1C3 (human lung prostaglandin F synthase)Homo sapiens4-nitrobenzaldehyde—0.0091—PMID 19010934Open
AKR1C3 (human lung prostaglandin F synthase)Homo sapiensprostaglandin H2—0.0175—pH 7, 37 °CPMID 19010934Open
bovine liver PGF synthase (prostaglandin F synthase, liver isozyme)Bos taurus4-nitrobenzaldehyde—0.0143—pH 6.5, 37 °CPMID 1605628Open
bovine liver PGF synthase (prostaglandin F synthase, liver isozyme)Bos taurus5beta-Dihydrotestosterone—0.0175—pH 6.5, 37 °CPMID 1605628Open
bovine liver PGF synthase (prostaglandin F synthase, liver isozyme)Bos taurus9,10-Phenanthrenequinone—0.002—pH 6.5, 37 °CPMID 1605628Open
bovine liver PGF synthase (prostaglandin F synthase, liver isozyme)Bos taurusCyclohexanone—0.053—pH 6.5, 37 °CPMID 1605628Open
bovine liver PGF synthase (prostaglandin F synthase, liver isozyme)Bos taurusD-Xylose—135—pH 6.5, 37 °CPMID 1605628Open
bovine liver PGF synthase (prostaglandin F synthase, liver isozyme)Bos taurusDL-Glyceraldehyde—0.143—pH 6.5, 37 °CPMID 1605628Open
bovine liver PGF synthase (prostaglandin F synthase, liver isozyme)Bos taurusHydrindantin—0.0031—pH 6.5, 37 °CPMID 1605628Open
bovine liver PGF synthase (prostaglandin F synthase, liver isozyme)Bos taurusNADHp-nitrobenzaldehyde (Table 3 concentration column: 0.5 mM)—4—pH 6.5, 37 °CPMID 1605628Open
bovine liver PGF synthase (prostaglandin F synthase, liver isozyme)Bos taurusNADHcosubstrate 9,10-phenanthrenequinone—0.8—pH 6.5, 37 °CPMID 1605628Open
bovine liver PGF synthase (prostaglandin F synthase, liver isozyme)Bos taurusNADHphenylglyoxal (Table 3 concentration column: 1.0 mM)—1—pH 6.5, 37 °CPMID 1605628Open
bovine liver PGF synthase (prostaglandin F synthase, liver isozyme)Bos taurusNADHp-nitroacetophenone (Table 3 concentration column: 0.5 mM)—0.4—pH 6.5, 37 °CPMID 1605628Open
bovine liver PGF synthase (prostaglandin F synthase, liver isozyme)Bos taurusNADHhydrindantin (Table 3 concentration column: 0.1 mM)—2—pH 6.5, 37 °CPMID 1605628Open
bovine liver PGF synthase (prostaglandin F synthase, liver isozyme)Bos taurusNADHmenadione (Table 3 concentration column: 0.25 mM)—1—pH 6.5, 37 °CPMID 1605628Open
bovine liver PGF synthase (prostaglandin F synthase, liver isozyme)Bos taurusNADPHp-nitrobenzaldehyde (Table 3 concentration column: 0.5 mM)—0.0069—pH 6.5, 37 °CPMID 1605628Open
bovine liver PGF synthase (prostaglandin F synthase, liver isozyme)Bos taurusNADPHcosubstrate 9,10-phenanthrenequinone—0.0029—pH 6.5, 37 °CPMID 1605628Open
bovine liver PGF synthase (prostaglandin F synthase, liver isozyme)Bos taurusNADPHphenylglyoxal (Table 3 concentration column: 1.0 mM)—0.0067—pH 6.5, 37 °CPMID 1605628Open
bovine liver PGF synthase (prostaglandin F synthase, liver isozyme)Bos taurusNADPHp-nitroacetophenone (Table 3 concentration column: 0.5 mM)—0.0054—pH 6.5, 37 °CPMID 1605628Open
bovine liver PGF synthase (prostaglandin F synthase, liver isozyme)Bos taurusNADPHhydrindantin (Table 3 concentration column: 0.1 mM)—0.0057—pH 6.5, 37 °CPMID 1605628Open
bovine liver PGF synthase (prostaglandin F synthase, liver isozyme)Bos taurusNADPHmenadione (Table 3 concentration column: 0.25 mM)—0.0067—pH 6.5, 37 °CPMID 1605628Open
bovine liver PGF synthase (prostaglandin F synthase, liver isozyme)Bos taurusNADPHcosubstrate 5beta-dihydrotestosterone—0.008—pH 6.5, 37 °CPMID 1605628Open
bovine liver PGF synthase (prostaglandin F synthase, liver isozyme)Bos taurusNADPHcosubstrate PGD2 (prostaglandin D2)—0.0033—pH 6.5, 37 °CPMID 1605628Open
bovine liver PGF synthase (prostaglandin F synthase, liver isozyme)Bos taurusprostaglandin D1—0.007—pH 6.5, 37 °CPMID 1605628Open
bovine liver PGF synthase (prostaglandin F synthase, liver isozyme)Bos taurusprostaglandin D2—0.01—pH 6.5, 37 °CPMID 1605628Open
bovine liver PGF synthase (prostaglandin F synthase, liver isozyme)Bos taurusprostaglandin D3—0.0056—pH 6.5, 37 °CPMID 1605628Open
bovine liver PGF synthase (prostaglandin F synthase, liver isozyme)Bos taurusprostaglandin H2—0.025—PMID 1605628Open
liver-type prostaglandin F synthase (PGF synthase)Bos taurus9,10-phenanthrenequinone0.11380.0011103.5pH 6.5, 37 °CPMID 9867836Open
liver-type prostaglandin F synthase (PGF synthase)Bos taurusprostaglandin D20.01420.0150.95pH 6.5, 37 °CPMID 9867836Open
liver-type prostaglandin F synthase (PGF synthase)Bos taurusprostaglandin H20.00570.0250.23pH 6.5, 37 °CPMID 9867836Open
liver-type prostaglandin F synthase (PGF synthase)variant H170CBos taurus9,10-phenanthrenequinone0.0635.1 × 10⁻⁴123.5pH 6.5, 37 °CPMID 9867836Open
liver-type prostaglandin F synthase (PGF synthase)variant H170CBos taurusprostaglandin D20.0110.0750.15pH 6.5, 37 °CPMID 9867836Open
liver-type prostaglandin F synthase (PGF synthase)variant H170CBos taurusprostaglandin H20.00430.0031.45pH 6.5, 37 °CPMID 9867836Open
liver-type prostaglandin F synthase (PGF synthase)variant K225SBos taurus9,10-phenanthrenequinone0.1613.6 × 10⁻⁴447.2pH 6.5, 37 °CPMID 9867836Open
liver-type prostaglandin F synthase (PGF synthase)variant K225SBos taurusprostaglandin D20.02820.050.57pH 6.5, 37 °CPMID 9867836Open
liver-type prostaglandin F synthase (PGF synthase)variant K225SBos taurusprostaglandin H20.00420.0280.15pH 6.5, 37 °CPMID 9867836Open
liver-type prostaglandin F synthase (PGF synthase)variant N306YBos taurus9,10-phenanthrenequinone0.05526.7 × 10⁻⁴82.3pH 6.5, 37 °CPMID 9867836Open
liver-type prostaglandin F synthase (PGF synthase)variant N306YBos taurusprostaglandin D20.00850.10.083pH 6.5, 37 °CPMID 9867836Open
liver-type prostaglandin F synthase (PGF synthase)variant N306YBos taurusprostaglandin H20.01220.011.22pH 6.5, 37 °CPMID 9867836Open
liver-type prostaglandin F synthase (PGF synthase)variant R223LBos taurus9,10-phenanthrenequinone0.181.2 × 10⁻⁴1.5 × 10³pH 6.5, 37 °CPMID 9867836Open
liver-type prostaglandin F synthase (PGF synthase)variant R223LBos taurusprostaglandin D20.06870.180.38pH 6.5, 37 °CPMID 9867836Open
liver-type prostaglandin F synthase (PGF synthase)variant R223LBos taurusprostaglandin H20.00180.010.18pH 6.5, 37 °CPMID 9867836Open
liver-type prostaglandin F synthase (PGF synthase)variant R27EBos taurus9,10-phenanthrenequinone0.05520.0010751.5pH 6.5, 37 °CPMID 9867836Open
liver-type prostaglandin F synthase (PGF synthase)variant R27EBos taurusprostaglandin D20.01350.110.12pH 6.5, 37 °CPMID 9867836Open
liver-type prostaglandin F synthase (PGF synthase)variant R27EBos taurusprostaglandin H20.00350.0140.25pH 6.5, 37 °CPMID 9867836Open
liver-type prostaglandin F synthase (PGF synthase)variant R91QBos taurus9,10-phenanthrenequinone0.04238 × 10⁻⁴53pH 6.5, 37 °CPMID 9867836Open
liver-type prostaglandin F synthase (PGF synthase)variant R91QBos taurusprostaglandin D20.0110.1450.083pH 6.5, 37 °CPMID 9867836Open
liver-type prostaglandin F synthase (PGF synthase)variant R91QBos taurusprostaglandin H20.00280.010.28pH 6.5, 37 °CPMID 9867836Open
liver-type prostaglandin F synthase (PGF synthase)variant S301RBos taurus9,10-phenanthrenequinone0.12374.6 × 10⁻⁴268.8pH 6.5, 37 °CPMID 9867836Open
liver-type prostaglandin F synthase (PGF synthase)variant S301RBos taurusprostaglandin D20.03370.040.85pH 6.5, 37 °CPMID 9867836Open
liver-type prostaglandin F synthase (PGF synthase)variant S301RBos taurusprostaglandin H20.00350.030.12pH 6.5, 37 °CPMID 9867836Open
prostaglandin F synthase (PGF synthase, aldo-keto reductase family)—prostaglandin H2 ethanolamide—0.01—PMID 18006499Open
prostaglandin F synthase (PGFS)Homo sapiens5β-Androstan-3α-ol,17-one0.0050.0015.2pH 10, 37 °CPMID 10622721Open
prostaglandin F synthase (PGFS)Homo sapiens5β-Androstane-3,17-dione0.0320.003110.7pH 8.5PMID 10622721Open
prostaglandin F synthase (PGFS)Homo sapiens9alpha,11beta-prostaglandin F24.030.13430.2pH 10, 37 °CPMID 10622721Open
prostaglandin F synthase (PGFS)Homo sapiensp-nitrobenzaldehyde1.080.077414pH 8.5PMID 10622721Open
prostaglandin F synthase (PGFS)Homo sapiensphenanthrenequinone1.858 × 10⁻⁴2.3 × 10³pH 8.5PMID 10622721Open
prostaglandin F synthase (PGFS)Homo sapiensprostaglandin D21.20.0034353pH 8.5PMID 10622721Open
prostaglandin F synthetaseBos taurus4-nitrobenzaldehyde—0.125—pH 6.5, 37 °CPMID 3858278Open
prostaglandin F synthetaseBos taurus9,10-phenanthrenequinone—7 × 10⁻⁴—pH 6.5, 37 °CPMID 3858278Open
prostaglandin F synthetaseBos taurusNADPH—0.01—37 °CPMID 3858278Open
prostaglandin F synthetaseBos taurusprostaglandin A2—0.25—pH 6.5, 37 °CPMID 3858278Open
prostaglandin F synthetaseBos taurusprostaglandin D2—0.12—pH 6.5, 37 °CPMID 3858278Open
prostaglandin F synthetaseBos taurusprostaglandin H2—0.01—pH 6.5, 37 °CPMID 3858278Open
prostaglandin F synthetaseBos taurusprostaglandin J2—0.23—pH 6.5, 37 °CPMID 3858278Open
prostaglandin F synthetaseBos taurusΔ12-prostaglandin J2—0.67—pH 6.5, 37 °CPMID 3858278Open