EC 1.1.1.40: malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+)

OxidoreductasesOpen in Browse

CatLog read 351 records for EC 1.1.1.40 from 19 papers, for 9 organisms. Names in these papers: cytosolic NADP+-dependent malic enzyme (c-NADP-ME), cytosolic NADP+-dependent malic enzyme, NADP-malic enzyme pI 4.90 isozyme (type 2), NADP-malic enzyme pI 5.28 isozyme (type 1) and 28 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 140 records for EC 1.1.1.40 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.1.1.40 in Browse.

Papers

Papers with records for EC 1.1.1.40
Paper	Organisms	Records
Determinants of nucleotide-binding selectivity of malic enzyme	Homo sapiens	70
Structural characteristics of the nonallosteric human cytosolic malic enzyme	Homo sapiens	52
Two forms of NADP-dependent malic enzyme in expanding maize leaves	Zea mays	32
Identification of domains involved in tetramerization and malate inhibition of maize C4-NADP-malic enzyme	Zea mays	24
Molecular adaptations of NADP-malic enzyme for its function in C₄ photosynthesis in grasses	Zea mays	24
Critical roles of conserved carboxylic acid residues in pigeon cytosolic NADP+-dependent malic enzyme	pigeon	23
Arabidopsis thaliana NADP-malic enzyme isoforms: high degree of identity but clearly distinct properties	Arabidopsis thaliana	23
Functional roles of the tetramer organization of malic enzyme	Homo sapiens	20
Functional characterization of residues involved in redox modulation of maize photosynthetic NADP-malic enzyme activity	Zea mays	16
Nonidentity of the cDNA sequence of human breast cancer cell malic enzyme to that from the normal human cell	Columba livia (pigeon), Homo sapiens	12
Maize C4 NADP-malic enzyme. Expression in Escherichia coli and characterization of site-directed mutants at the putative nucleoside-binding sites	Zea mays	11
Duck liver 'malic' enzyme. Expression in Escherichia coli and characterization of the wild-type enzyme and site-directed mutants	duck	8
A comprehensive analysis of the NADP-malic enzyme gene family of Arabidopsis	Arabidopsis thaliana	7
Properties of Malic Enzyme from the Aerobic Methanotroph Methylosinus trichosporium	Methylosinus trichosporium	6
Purification and properties of cytosolic and mitochondrial malic enzyme isolated from human brain	Homo sapiens	6
Basic residues play key roles in catalysis and NADP(+)-specificity in maize (Zea mays L.) photosynthetic NADP(+)-dependent malic enzyme	Zea mays	5
Non-photosynthetic 'malic enzyme' from maize: a constituvely expressed enzyme that responds to plant defence inducers	Zea mays	4
Characterization of the NADP malic enzyme gene family in the facultative, single-cell C4 monocot Hydrilla verticillata	Hydrilla verticillata	4
Bifunctional Malic/Malolactic Enzyme Provides a Novel Mechanism for NADPH-Balancing in Bacillus subtilis	Bacillus subtilis	4

Records

Records for EC 1.1.1.40 read from the paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Paper	Open record
C4-NADP-ME (L isoform, photosynthetic plastidic NADP-malic enzyme)	Zea mays	L-malate	202.4	0.22	919.1	pH 8	PMID 17150960	Open record: C4-NADP-ME (L isoform, photosynthetic plastidic NADP-malic enzyme), L-malate
C4-NADP-ME (L isoform, photosynthetic plastidic NADP-malic enzyme)	Zea mays	L-malate	104.4	0.04	2.61 × 10³	pH 7	PMID 17150960	Open record: C4-NADP-ME (L isoform, photosynthetic plastidic NADP-malic enzyme), L-malate
C4-NADP-ME (L isoform, photosynthetic plastidic NADP-malic enzyme)	Zea mays	NADP+	—	0.008	2.53 × 10⁴	pH 8	PMID 17150960	Open record: C4-NADP-ME (L isoform, photosynthetic plastidic NADP-malic enzyme), NADP+
C4-NADP-ME (ZmC4-NADP-ME)	Zea mays	(S)-malate	28.1	0.23	122.2	pH 8, 25 °C	PMID 31235877	Open record: C4-NADP-ME (ZmC4-NADP-ME), (S)-malate
C4-NADP-ME (ZmC4-NADP-ME)	Zea mays	nicotinamide adenine dinucleotide phosphate (oxidized)	—	0.0149	—	pH 8, 25 °C	PMID 31235877	Open record: C4-NADP-ME (ZmC4-NADP-ME), nicotinamide adenine dinucleotide phosphate (oxidized)
C4-NADP-ME (ZmC4-NADP-ME)variant E339A	Zea mays	(S)-malate	28.7	0.47	61.1	pH 8, 25 °C	PMID 31235877	Open record: C4-NADP-ME (ZmC4-NADP-ME) variant E339A, (S)-malate
C4-NADP-ME (ZmC4-NADP-ME)variant E339A	Zea mays	nicotinamide adenine dinucleotide phosphate (oxidized)	—	0.0159	—	pH 8, 25 °C	PMID 31235877	Open record: C4-NADP-ME (ZmC4-NADP-ME) variant E339A, nicotinamide adenine dinucleotide phosphate (oxidized)
C4-NADP-ME (ZmC4-NADP-ME)variant F140I	Zea mays	(S)-malate	3.6	0.47	7.7	pH 8, 25 °C	PMID 31235877	Open record: C4-NADP-ME (ZmC4-NADP-ME) variant F140I, (S)-malate
C4-NADP-ME (ZmC4-NADP-ME)variant F140I	Zea mays	nicotinamide adenine dinucleotide phosphate (oxidized)	—	0.0082	—	pH 8, 25 °C	PMID 31235877	Open record: C4-NADP-ME (ZmC4-NADP-ME) variant F140I, nicotinamide adenine dinucleotide phosphate (oxidized)
C4-NADP-ME (ZmC4-NADP-ME)variant L544F	Zea mays	(S)-malate	27.4	0.58	47.2	pH 8, 25 °C	PMID 31235877	Open record: C4-NADP-ME (ZmC4-NADP-ME) variant L544F, (S)-malate
C4-NADP-ME (ZmC4-NADP-ME)variant L544F	Zea mays	nicotinamide adenine dinucleotide phosphate (oxidized)	—	0.0159	—	pH 8, 25 °C	PMID 31235877	Open record: C4-NADP-ME (ZmC4-NADP-ME) variant L544F, nicotinamide adenine dinucleotide phosphate (oxidized)
C4-NADP-ME (ZmC4-NADP-ME)variant Q503E	Zea mays	(S)-malate	29.8	0.46	64.8	pH 8, 25 °C	PMID 31235877	Open record: C4-NADP-ME (ZmC4-NADP-ME) variant Q503E, (S)-malate
C4-NADP-ME (ZmC4-NADP-ME)variant Q503E	Zea mays	nicotinamide adenine dinucleotide phosphate (oxidized)	—	0.0128	—	pH 8, 25 °C	PMID 31235877	Open record: C4-NADP-ME (ZmC4-NADP-ME) variant Q503E, nicotinamide adenine dinucleotide phosphate (oxidized)
C4-specific NADP-malic enzyme (NADP-ME)	Zea mays	L-malate	—	0.23	—		PMID 12562758	Open record: C4-specific NADP-malic enzyme (NADP-ME), L-malate
C4-specific NADP-malic enzyme (NADP-ME)	Zea mays	L-malate	—	0.084	—	pH 7	PMID 12562758	Open record: C4-specific NADP-malic enzyme (NADP-ME), L-malate
C4-specific NADP-malic enzyme (NADP-ME)	Zea mays	NAD	13.5	8.1	1.7	pH 7	PMID 12562758	Open record: C4-specific NADP-malic enzyme (NADP-ME), NAD
C4-specific NADP-malic enzyme (NADP-ME)	Zea mays	NADP	201.3	0.008	2.52 × 10⁴		PMID 12562758	Open record: C4-specific NADP-malic enzyme (NADP-ME), NADP
C4-specific NADP-malic enzyme (NADP-ME)variant A387G	Zea mays	L-malate	—	1.1	—		PMID 12562758	Open record: C4-specific NADP-malic enzyme (NADP-ME) variant A387G, L-malate
C4-specific NADP-malic enzyme (NADP-ME)variant A387G	Zea mays	NADP	4.2	0.0373	110		PMID 12562758	Open record: C4-specific NADP-malic enzyme (NADP-ME) variant A387G, NADP
C4-specific NADP-malic enzyme (NADP-ME)variant A392G	Zea mays	L-malate	—	0.5	—		PMID 12562758	Open record: C4-specific NADP-malic enzyme (NADP-ME) variant A392G, L-malate
C4-specific NADP-malic enzyme (NADP-ME)variant A392G	Zea mays	NAD	40.6	6	6.8	pH 7	PMID 12562758	Open record: C4-specific NADP-malic enzyme (NADP-ME) variant A392G, NAD
C4-specific NADP-malic enzyme (NADP-ME)variant A392G	Zea mays	NADP	200.3	0.0302	6.7 × 10³		PMID 12562758	Open record: C4-specific NADP-malic enzyme (NADP-ME) variant A392G, NADP
C4-specific NADP-malic enzyme (NADP-ME)variant R237L	Zea mays	L-malate	—	2.9	—		PMID 12562758	Open record: C4-specific NADP-malic enzyme (NADP-ME) variant R237L, L-malate
C4-specific NADP-malic enzyme (NADP-ME)variant R237L	Zea mays	NADP	0.38	0.29	1		PMID 12562758	Open record: C4-specific NADP-malic enzyme (NADP-ME) variant R237L, NADP
C4-specific photosynthetic NADP+-dependent malic enzyme (C4-NADP+-ME)variant K255I	Zea mays	L-malate	—	2.6	—	pH 8, 30 °C	PMID 15245332	Open record: C4-specific photosynthetic NADP+-dependent malic enzyme (C4-NADP+-ME) variant K255I, L-malate
C4-specific photosynthetic NADP+-dependent malic enzyme (C4-NADP+-ME)variant K255I	Zea mays	NADP+	1.1	0.123	8.9 calc.	pH 8, 30 °C	PMID 15245332	Open record: C4-specific photosynthetic NADP+-dependent malic enzyme (C4-NADP+-ME) variant K255I, NADP+
C4-specific photosynthetic NADP+-dependent malic enzyme (C4-NADP+-ME)variant K435L/K436L	Zea mays	L-malate	—	0.31	—	pH 8, 30 °C	PMID 15245332	Open record: C4-specific photosynthetic NADP+-dependent malic enzyme (C4-NADP+-ME) variant K435L/K436L, L-malate
C4-specific photosynthetic NADP+-dependent malic enzyme (C4-NADP+-ME)variant K435L/K436L	Zea mays	NAD+	18.4	1.9	9.7 calc.	pH 7, 30 °C	PMID 15245332	Open record: C4-specific photosynthetic NADP+-dependent malic enzyme (C4-NADP+-ME) variant K435L/K436L, NAD+
C4-specific photosynthetic NADP+-dependent malic enzyme (C4-NADP+-ME)variant K435L/K436L	Zea mays	NADP+	181.1	0.073	2.5 × 10³ calc.	pH 8, 30 °C	PMID 15245332	Open record: C4-specific photosynthetic NADP+-dependent malic enzyme (C4-NADP+-ME) variant K435L/K436L, NADP+
cytosolic malic enzyme	Homo sapiens	nicotinamide adenine dinucleotide (oxidized)	—	4.5	—	37 °C	PMID 7757881	Open record: cytosolic malic enzyme, nicotinamide adenine dinucleotide (oxidized)
cytosolic malic enzyme	Homo sapiens	nicotinamide adenine dinucleotide phosphate (oxidized)	—	0.00139	—	37 °C	PMID 7757881	Open record: cytosolic malic enzyme, nicotinamide adenine dinucleotide phosphate (oxidized)
cytosolic malic enzyme	Homo sapiens	pyruvate	—	7.2	—	37 °C	PMID 7757881	Open record: cytosolic malic enzyme, pyruvate
cytosolic malic enzyme	Homo sapiens	sodium bicarbonate	—	23	—	37 °C	PMID 7757881	Open record: cytosolic malic enzyme, sodium bicarbonate
cytosolic NADP+-dependent malic enzyme	pigeon	L-malatemetal Mn2+	31.34	0.08	390 calc.	pH 7.4, 25 °C	PMID 16889632	Open record: cytosolic NADP+-dependent malic enzyme, L-malate
cytosolic NADP+-dependent malic enzyme	pigeon	L-malatemetal Mg2+ (replaces Mn2+)	34.83	0.27	130 calc.	pH 7.4, 25 °C	PMID 16889632	Open record: cytosolic NADP+-dependent malic enzyme, L-malate
cytosolic NADP+-dependent malic enzyme	pigeon	L-malatewith 50 mM sodium azide; metal Mn2+	27.8	0.18	150 calc.	pH 7.4, 25 °C	PMID 16889632	Open record: cytosolic NADP+-dependent malic enzyme, L-malate
cytosolic NADP+-dependent malic enzyme	pigeon	nicotinamide adenine dinucleotide phosphate (oxidized)	—	0.00207	—	pH 7.4, 25 °C	PMID 16889632	Open record: cytosolic NADP+-dependent malic enzyme, nicotinamide adenine dinucleotide phosphate (oxidized)
cytosolic NADP+-dependent malic enzyme	pigeon	oxaloacetate	33.41	0.17	200 calc.	pH 4.5	PMID 16889632	Open record: cytosolic NADP+-dependent malic enzyme, oxaloacetate
cytosolic NADP+-dependent malic enzyme	pigeon	pyruvate1-50 mM pyruvate	0.8	6.05	0.13 calc.	pH 7.4, 25 °C	PMID 16889632	Open record: cytosolic NADP+-dependent malic enzyme, pyruvate
cytosolic NADP+-dependent malic enzyme	pigeon	pyruvatewith 50 mM sodium azide	0.87	0.65	1.3 calc.	pH 7.4, 25 °C	PMID 16889632	Open record: cytosolic NADP+-dependent malic enzyme, pyruvate
cytosolic NADP+-dependent malic enzymevariant D235A	pigeon	L-malate	0.004	0.1	0.040 calc.	pH 7.4, 25 °C	PMID 16889632	Open record: cytosolic NADP+-dependent malic enzyme variant D235A, L-malate
cytosolic NADP+-dependent malic enzymevariant D235A	pigeon	nicotinamide adenine dinucleotide phosphate (oxidized)	—	0.00179	—	pH 7.4, 25 °C	PMID 16889632	Open record: cytosolic NADP+-dependent malic enzyme variant D235A, nicotinamide adenine dinucleotide phosphate (oxidized)
cytosolic NADP+-dependent malic enzymevariant D235A	pigeon	oxaloacetate	0.09	0.91	0.099 calc.	pH 4.5	PMID 16889632	Open record: cytosolic NADP+-dependent malic enzyme variant D235A, oxaloacetate
cytosolic NADP+-dependent malic enzymevariant D235A	pigeon	pyruvate	0.001	6.11	1.6 × 10⁻⁴ calc.	pH 7.4, 25 °C	PMID 16889632	Open record: cytosolic NADP+-dependent malic enzyme variant D235A, pyruvate
cytosolic NADP+-dependent malic enzymevariant D257A	pigeon	L-malate	1.1	0.1	11 calc.	pH 7.4, 25 °C	PMID 16889632	Open record: cytosolic NADP+-dependent malic enzyme variant D257A, L-malate
cytosolic NADP+-dependent malic enzymevariant D257A	pigeon	nicotinamide adenine dinucleotide phosphate (oxidized)	—	0.00283	—	pH 7.4, 25 °C	PMID 16889632	Open record: cytosolic NADP+-dependent malic enzyme variant D257A, nicotinamide adenine dinucleotide phosphate (oxidized)
cytosolic NADP+-dependent malic enzymevariant D257A	pigeon	oxaloacetate	76.72	0.07	1.1 × 10³ calc.	pH 4.5	PMID 16889632	Open record: cytosolic NADP+-dependent malic enzyme variant D257A, oxaloacetate
cytosolic NADP+-dependent malic enzymevariant D257A	pigeon	pyruvate	0.18	1.42	0.13 calc.	pH 7.4, 25 °C	PMID 16889632	Open record: cytosolic NADP+-dependent malic enzyme variant D257A, pyruvate
cytosolic NADP+-dependent malic enzymevariant D258A	pigeon	L-malate	0.006	0.05	0.12 calc.	pH 7.4, 25 °C	PMID 16889632	Open record: cytosolic NADP+-dependent malic enzyme variant D258A, L-malate
cytosolic NADP+-dependent malic enzymevariant D258A	pigeon	L-malatewith 50 mM sodium azide	11.76	3.2	3.7 calc.	pH 7.4, 25 °C	PMID 16889632	Open record: cytosolic NADP+-dependent malic enzyme variant D258A, L-malate
cytosolic NADP+-dependent malic enzymevariant D258A	pigeon	nicotinamide adenine dinucleotide phosphate (oxidized)	—	0.00296	—	pH 7.4, 25 °C	PMID 16889632	Open record: cytosolic NADP+-dependent malic enzyme variant D258A, nicotinamide adenine dinucleotide phosphate (oxidized)
cytosolic NADP+-dependent malic enzymevariant D258A	pigeon	oxaloacetate	0.22	2.37	0.093 calc.	pH 4.5	PMID 16889632	Open record: cytosolic NADP+-dependent malic enzyme variant D258A, oxaloacetate
cytosolic NADP+-dependent malic enzymevariant D258A	pigeon	pyruvate1-50 mM pyruvate	0.0014	1.9	7.4 × 10⁻⁴ calc.	pH 7.4, 25 °C	PMID 16889632	Open record: cytosolic NADP+-dependent malic enzyme variant D258A, pyruvate
cytosolic NADP+-dependent malic enzymevariant D258A	pigeon	pyruvatewith 50 mM sodium azide	0.84	5.69	0.15 calc.	pH 7.4, 25 °C	PMID 16889632	Open record: cytosolic NADP+-dependent malic enzyme variant D258A, pyruvate
cytosolic NADP+-dependent malic enzymevariant E234A	pigeon	L-malate	46.44	13.33	3.484 calc.	pH 7.4, 25 °C	PMID 16889632	Open record: cytosolic NADP+-dependent malic enzyme variant E234A, L-malate
cytosolic NADP+-dependent malic enzymevariant E234A	pigeon	nicotinamide adenine dinucleotide phosphate (oxidized)	—	0.0018	—	pH 7.4, 25 °C	PMID 16889632	Open record: cytosolic NADP+-dependent malic enzyme variant E234A, nicotinamide adenine dinucleotide phosphate (oxidized)
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)	Homo sapiens	L-malate	110.9	0.49	230 calc.	pH 7.4, 30 °C	PMID 19416979	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME), L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)	Homo sapiens	L-malate1 mM NADP+; NADPH formation at 340 nm; cosubstrate NADP+	—	0.9	—	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME), L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)	Homo sapiens	L-malate1 mM NAD+; NADH formation at 340 nm; cosubstrate NAD+	—	5	—	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME), L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)	Homo sapiens	L-malatewithout fumarate	30	1.2	25 calc.	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME), L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)	Homo sapiens	L-malatewith 5 mM fumarate	30	1.2	25 calc.	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME), L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)	Homo sapiens	NAD+kcat per tetramer; apparent Km	51	19	2.7 calc.	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME), NAD+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)	Homo sapiens	NAD+	—	—	2.8	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME), NAD+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)	Homo sapiens	NADP+	—	0.009	—	pH 7.4, 30 °C	PMID 19416979	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME), NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)	Homo sapiens	NADP+kcat per tetramer; apparent Km	146	0.005	2.9 × 10⁴ calc.	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME), NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)	Homo sapiens	NADP+	—	—	3.6 × 10⁴	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME), NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)	Homo sapiens	NADP+without fumarate	—	0.0019	—	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME), NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)	Homo sapiens	NADP+with 5 mM fumarate	—	0.0022	—	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME), NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant D139A	Homo sapiens	L-malate	95.53	0.95	100 calc.	pH 7.4, 30 °C	PMID 19416979	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant D139A, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant D139A	Homo sapiens	NADP+	—	0.0048	—	pH 7.4, 30 °C	PMID 19416979	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant D139A, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant D568A	Homo sapiens	L-malate	136.9	0.97	140 calc.	pH 7.4, 30 °C	PMID 19416979	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant D568A, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant D568A	Homo sapiens	NADP+	—	0.005	—	pH 7.4, 30 °C	PMID 19416979	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant D568A, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant D90A	Homo sapiens	L-malate	94.57	0.68	140 calc.	pH 7.4, 30 °C	PMID 19416979	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant D90A, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant D90A	Homo sapiens	NADP+	—	0.0039	—	pH 7.4, 30 °C	PMID 19416979	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant D90A, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant E314A	Homo sapiens	L-malate1 mM NADP+; NADPH formation at 340 nm; cosubstrate NADP+	—	0.4	—	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant E314A, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant E314A	Homo sapiens	L-malate1 mM NAD+; NADH formation at 340 nm; cosubstrate NAD+	—	4	—	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant E314A, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant E314A	Homo sapiens	NAD+	113	1.6	71 calc.	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant E314A, NAD+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant E314A	Homo sapiens	NADP+	110	0.002	5.5 × 10⁴ calc.	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant E314A, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant E314A/S346I/K347D/K362H	Homo sapiens	L-malate1 mM NADP+; NADPH formation at 340 nm; cosubstrate NADP+	—	21	—	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant E314A/S346I/K347D/K362H, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant E314A/S346I/K347D/K362H	Homo sapiens	L-malate1 mM NAD+; NADH formation at 340 nm; cosubstrate NAD+	—	3	—	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant E314A/S346I/K347D/K362H, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant E314A/S346I/K347D/K362H	Homo sapiens	NAD+	166	0.9	180 calc.	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant E314A/S346I/K347D/K362H, NAD+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant E314A/S346I/K347D/K362H	Homo sapiens	NADP+	15	29	0.52 calc.	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant E314A/S346I/K347D/K362H, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant E314A/S346K	Homo sapiens	L-malate1 mM NADP+; NADPH formation at 340 nm; cosubstrate NADP+	—	1	—	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant E314A/S346K, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant E314A/S346K	Homo sapiens	L-malate1 mM NAD+; NADH formation at 340 nm; cosubstrate NAD+	—	4	—	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant E314A/S346K, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant E314A/S346K	Homo sapiens	NAD+	145	5	29 calc.	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant E314A/S346K, NAD+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant E314A/S346K	Homo sapiens	NADP+	137	0.003	4.6 × 10⁴ calc.	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant E314A/S346K, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant E314A/S346K/K347Y/K362H	Homo sapiens	L-malate1 mM NADP+; NADPH formation at 340 nm; cosubstrate NADP+	—	7	—	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant E314A/S346K/K347Y/K362H, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant E314A/S346K/K347Y/K362H	Homo sapiens	L-malate1 mM NAD+; NADH formation at 340 nm; cosubstrate NAD+	—	1	—	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant E314A/S346K/K347Y/K362H, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant E314A/S346K/K347Y/K362H	Homo sapiens	NAD+	258	0.9	290 calc.	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant E314A/S346K/K347Y/K362H, NAD+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant E314A/S346K/K347Y/K362H	Homo sapiens	NADP+	26	3	8.7 calc.	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant E314A/S346K/K347Y/K362H, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant E314A/S346K/K347Y/K362Q	Homo sapiens	L-malate1 mM NADP+; NADPH formation at 340 nm; cosubstrate NADP+	—	5	—	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant E314A/S346K/K347Y/K362Q, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant E314A/S346K/K347Y/K362Q	Homo sapiens	L-malate1 mM NAD+; NADH formation at 340 nm; cosubstrate NAD+	—	2	—	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant E314A/S346K/K347Y/K362Q, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant E314A/S346K/K347Y/K362Q	Homo sapiens	NAD+	208	1.5	140 calc.	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant E314A/S346K/K347Y/K362Q, NAD+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant E314A/S346K/K347Y/K362Q	Homo sapiens	NADP+	51	5	10 calc.	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant E314A/S346K/K347Y/K362Q, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant E73K	Homo sapiens	L-malatewithout fumarate	30	1.3	23 calc.	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant E73K, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant E73K	Homo sapiens	L-malatewith 5 mM fumarate	30	1.5	20 calc.	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant E73K, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant E73K	Homo sapiens	NADP+without fumarate	—	0.0125	—	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant E73K, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant E73K	Homo sapiens	NADP+with 5 mM fumarate	—	0.0119	—	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant E73K, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant H142A	Homo sapiens	L-malate	122.7	0.89	140 calc.	pH 7.4, 30 °C	PMID 19416979	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant H142A, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant H142A	Homo sapiens	NADP+	—	0.004	—	pH 7.4, 30 °C	PMID 19416979	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant H142A, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant H142A/D568A	Homo sapiens	L-malate	98.03	0.92	110 calc.	pH 7.4, 30 °C	PMID 19416979	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant H142A/D568A, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant H142A/D568A	Homo sapiens	NADP+	—	0.0042	—	pH 7.4, 30 °C	PMID 19416979	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant H142A/D568A, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant H51A	Homo sapiens	L-malate	109.5	1.1	100 calc.	pH 7.4, 30 °C	PMID 19416979	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant H51A, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant H51A	Homo sapiens	NADP+	—	0.0072	—	pH 7.4, 30 °C	PMID 19416979	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant H51A, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant H51A/D139A	Homo sapiens	L-malate	105.3	1.03	102 calc.	pH 7.4, 30 °C	PMID 19416979	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant H51A/D139A, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant H51A/D139A	Homo sapiens	NADP+	—	0.004	—	pH 7.4, 30 °C	PMID 19416979	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant H51A/D139A, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant H51A/D90A	Homo sapiens	L-malate	84.83	0.84	100 calc.	pH 7.4, 30 °C	PMID 19416979	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant H51A/D90A, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant H51A/D90A	Homo sapiens	NADP+	—	0.0037	—	pH 7.4, 30 °C	PMID 19416979	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant H51A/D90A, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant H51Q/S57K/F58I/N59E/S60T/E62D/V65A/V68F/V69H/K70R/F72L/E73K/H74K/L75M/N76T/D78P/F79L/D80E/R81K/L83I/L84Y/L85I/D87G/L88I/D90E/V99I/T101Q/S102D	Homo sapiens	L-malatewithout fumarate	36	0.8	45 calc.	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant H51Q/S57K/F58I/N59E/S60T/E62D/V65A/V68F/V69H/K70R/F72L/E73K/H74K/L75M/N76T/D78P/F79L/D80E/R81K/L83I/L84Y/L85I/D87G/L88I/D90E/V99I/T101Q/S102D, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant H51Q/S57K/F58I/N59E/S60T/E62D/V65A/V68F/V69H/K70R/F72L/E73K/H74K/L75M/N76T/D78P/F79L/D80E/R81K/L83I/L84Y/L85I/D87G/L88I/D90E/V99I/T101Q/S102D	Homo sapiens	L-malatewith 5 mM fumarate	36	1	36 calc.	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant H51Q/S57K/F58I/N59E/S60T/E62D/V65A/V68F/V69H/K70R/F72L/E73K/H74K/L75M/N76T/D78P/F79L/D80E/R81K/L83I/L84Y/L85I/D87G/L88I/D90E/V99I/T101Q/S102D, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant H51Q/S57K/F58I/N59E/S60T/E62D/V65A/V68F/V69H/K70R/F72L/E73K/H74K/L75M/N76T/D78P/F79L/D80E/R81K/L83I/L84Y/L85I/D87G/L88I/D90E/V99I/T101Q/S102D	Homo sapiens	NADP+without fumarate	—	0.0027	—	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant H51Q/S57K/F58I/N59E/S60T/E62D/V65A/V68F/V69H/K70R/F72L/E73K/H74K/L75M/N76T/D78P/F79L/D80E/R81K/L83I/L84Y/L85I/D87G/L88I/D90E/V99I/T101Q/S102D, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant H51Q/S57K/F58I/N59E/S60T/E62D/V65A/V68F/V69H/K70R/F72L/E73K/H74K/L75M/N76T/D78P/F79L/D80E/R81K/L83I/L84Y/L85I/D87G/L88I/D90E/V99I/T101Q/S102D	Homo sapiens	NADP+with 5 mM fumarate	—	0.0033	—	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant H51Q/S57K/F58I/N59E/S60T/E62D/V65A/V68F/V69H/K70R/F72L/E73K/H74K/L75M/N76T/D78P/F79L/D80E/R81K/L83I/L84Y/L85I/D87G/L88I/D90E/V99I/T101Q/S102D, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant K347Y	Homo sapiens	L-malate1 mM NADP+; NADPH formation at 340 nm; cosubstrate NADP+	—	2	—	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant K347Y, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant K347Y	Homo sapiens	L-malate1 mM NAD+; NADH formation at 340 nm; cosubstrate NAD+	—	5	—	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant K347Y, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant K347Y	Homo sapiens	NAD+	40	11	3.6 calc.	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant K347Y, NAD+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant K347Y	Homo sapiens	NADP+	121	0.03	4.0 × 10³ calc.	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant K347Y, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant K347Y/K362Q	Homo sapiens	L-malate1 mM NADP+; NADPH formation at 340 nm; cosubstrate NADP+	—	5	—	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant K347Y/K362Q, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant K347Y/K362Q	Homo sapiens	L-malate1 mM NAD+; NADH formation at 340 nm; cosubstrate NAD+	—	8	—	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant K347Y/K362Q, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant K347Y/K362Q	Homo sapiens	NAD+	53	20	2.6 calc.	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant K347Y/K362Q, NAD+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant K347Y/K362Q	Homo sapiens	NADP+	78	12	6.5 calc.	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant K347Y/K362Q, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant K362H	Homo sapiens	L-malate1 mM NADP+; NADPH formation at 340 nm; cosubstrate NADP+	—	4	—	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant K362H, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant K362H	Homo sapiens	L-malate1 mM NAD+; NADH formation at 340 nm; cosubstrate NAD+	—	8	—	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant K362H, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant K362H	Homo sapiens	NAD+	108	14	7.7 calc.	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant K362H, NAD+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant K362H	Homo sapiens	NADP+	149	0.3	500 calc.	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant K362H, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant K362Q	Homo sapiens	L-malate1 mM NADP+; NADPH formation at 340 nm; cosubstrate NADP+	—	2	—	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant K362Q, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant K362Q	Homo sapiens	L-malate1 mM NAD+; NADH formation at 340 nm; cosubstrate NAD+	—	5	—	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant K362Q, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant K362Q	Homo sapiens	NAD+	60	13	4.6 calc.	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant K362Q, NAD+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant K362Q	Homo sapiens	NADP+	132	0.7	190 calc.	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant K362Q, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant N59E	Homo sapiens	L-malatewithout fumarate	27	0.9	30 calc.	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant N59E, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant N59E	Homo sapiens	L-malatewith 5 mM fumarate	28	1	28 calc.	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant N59E, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant N59E	Homo sapiens	NADP+without fumarate	—	0.0089	—	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant N59E, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant N59E	Homo sapiens	NADP+with 5 mM fumarate	—	0.0091	—	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant N59E, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant N59E/E73K	Homo sapiens	L-malatewithout fumarate	28	1.2	23 calc.	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant N59E/E73K, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant N59E/E73K	Homo sapiens	L-malatewith 5 mM fumarate	27	1.3	21 calc.	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant N59E/E73K, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant N59E/E73K	Homo sapiens	NADP+without fumarate	—	0.0046	—	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant N59E/E73K, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant N59E/E73K	Homo sapiens	NADP+with 5 mM fumarate	—	0.003	—	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant N59E/E73K, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant N59E/E73K/S102D	Homo sapiens	L-malatewithout fumarate	28	1.4	20 calc.	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant N59E/E73K/S102D, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant N59E/E73K/S102D	Homo sapiens	L-malatewith 5 mM fumarate	29	1.9	15 calc.	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant N59E/E73K/S102D, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant N59E/E73K/S102D	Homo sapiens	NADP+without fumarate	—	0.0045	—	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant N59E/E73K/S102D, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant N59E/E73K/S102D	Homo sapiens	NADP+with 5 mM fumarate	—	0.0067	—	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant N59E/E73K/S102D, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S102D	Homo sapiens	L-malatewithout fumarate	29	1.6	18 calc.	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S102D, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S102D	Homo sapiens	L-malatewith 5 mM fumarate	27	1.9	14 calc.	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S102D, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S102D	Homo sapiens	NADP+without fumarate	—	0.0049	—	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S102D, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S102D	Homo sapiens	NADP+with 5 mM fumarate	—	0.0058	—	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S102D, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S346I/K347D/K362H	Homo sapiens	L-malate1 mM NADP+; NADPH formation at 340 nm; cosubstrate NADP+	—	32	—	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S346I/K347D/K362H, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S346I/K347D/K362H	Homo sapiens	L-malate1 mM NAD+; NADH formation at 340 nm; cosubstrate NAD+	—	7	—	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S346I/K347D/K362H, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S346I/K347D/K362H	Homo sapiens	NAD+kcat per tetramer; apparent Km	131	6.5	20 calc.	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S346I/K347D/K362H, NAD+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S346I/K347D/K362H	Homo sapiens	NAD+	—	—	29	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S346I/K347D/K362H, NAD+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S346I/K347D/K362H	Homo sapiens	NADP+kcat per tetramer; apparent Km	1.3	116	0.011 calc.	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S346I/K347D/K362H, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S346I/K347D/K362H	Homo sapiens	NADP+	—	—	0.0112	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S346I/K347D/K362H, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S346K	Homo sapiens	L-malate1 mM NADP+; NADPH formation at 340 nm; cosubstrate NADP+	—	0.8	—	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S346K, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S346K	Homo sapiens	L-malate1 mM NAD+; NADH formation at 340 nm; cosubstrate NAD+	—	4	—	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S346K, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S346K	Homo sapiens	NAD+	22	17	1.3 calc.	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S346K, NAD+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S346K	Homo sapiens	NADP+	129	0.013	9.9 × 10³ calc.	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S346K, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S346K/K347Y	Homo sapiens	L-malate1 mM NADP+; NADPH formation at 340 nm; cosubstrate NADP+	—	1	—	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S346K/K347Y, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S346K/K347Y	Homo sapiens	L-malate1 mM NAD+; NADH formation at 340 nm; cosubstrate NAD+	—	5	—	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S346K/K347Y, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S346K/K347Y	Homo sapiens	NAD+	65	18	3.6 calc.	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S346K/K347Y, NAD+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S346K/K347Y	Homo sapiens	NADP+	102	0.14	730 calc.	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S346K/K347Y, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S346K/K347Y/K362H	Homo sapiens	L-malate1 mM NADP+; NADPH formation at 340 nm; cosubstrate NADP+	—	10	—	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S346K/K347Y/K362H, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S346K/K347Y/K362H	Homo sapiens	L-malate1 mM NAD+; NADH formation at 340 nm; cosubstrate NAD+	—	6	—	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S346K/K347Y/K362H, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S346K/K347Y/K362H	Homo sapiens	NAD+	219	7.1	31 calc.	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S346K/K347Y/K362H, NAD+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S346K/K347Y/K362H	Homo sapiens	NADP+	8	29	0.28 calc.	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S346K/K347Y/K362H, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S346K/K347Y/K362Q	Homo sapiens	L-malate1 mM NADP+; NADPH formation at 340 nm; cosubstrate NADP+	—	9	—	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S346K/K347Y/K362Q, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S346K/K347Y/K362Q	Homo sapiens	L-malate1 mM NAD+; NADH formation at 340 nm; cosubstrate NAD+	—	4	—	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S346K/K347Y/K362Q, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S346K/K347Y/K362Q	Homo sapiens	NAD+kcat per tetramer; apparent Km	124	10	12 calc.	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S346K/K347Y/K362Q, NAD+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S346K/K347Y/K362Q	Homo sapiens	NAD+	—	—	12	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S346K/K347Y/K362Q, NAD+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S346K/K347Y/K362Q	Homo sapiens	NADP+kcat per tetramer; apparent Km	15	17	0.88 calc.	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S346K/K347Y/K362Q, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S346K/K347Y/K362Q	Homo sapiens	NADP+	—	—	0.88	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S346K/K347Y/K362Q, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S346K/K362Q	Homo sapiens	L-malate1 mM NADP+; NADPH formation at 340 nm; cosubstrate NADP+	—	3	—	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S346K/K362Q, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S346K/K362Q	Homo sapiens	L-malate1 mM NAD+; NADH formation at 340 nm; cosubstrate NAD+	—	4	—	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S346K/K362Q, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S346K/K362Q	Homo sapiens	NAD+	110	14	7.9 calc.	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S346K/K362Q, NAD+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S346K/K362Q	Homo sapiens	NADP+	112	6	19 calc.	pH 7.4, 30 °C	PMID 21980421	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S346K/K362Q, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S57K	Homo sapiens	L-malatewithout fumarate	32	1.7	19 calc.	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S57K, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S57K	Homo sapiens	L-malatewith 5 mM fumarate	29	1.7	17 calc.	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S57K, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S57K	Homo sapiens	NADP+without fumarate	—	0.0045	—	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S57K, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S57K	Homo sapiens	NADP+with 5 mM fumarate	—	0.0056	—	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S57K, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S57K/N59E/E73K	Homo sapiens	L-malatewithout fumarate	30	1	30 calc.	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S57K/N59E/E73K, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S57K/N59E/E73K	Homo sapiens	L-malatewith 5 mM fumarate	31	1.2	26 calc.	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S57K/N59E/E73K, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S57K/N59E/E73K	Homo sapiens	NADP+without fumarate	—	0.0069	—	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S57K/N59E/E73K, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S57K/N59E/E73K	Homo sapiens	NADP+with 5 mM fumarate	—	0.0054	—	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S57K/N59E/E73K, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S57K/N59E/E73K/S102D	Homo sapiens	L-malatewithout fumarate	31	1.2	26 calc.	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S57K/N59E/E73K/S102D, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S57K/N59E/E73K/S102D	Homo sapiens	L-malatewith 5 mM fumarate	31	1.3	24 calc.	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S57K/N59E/E73K/S102D, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S57K/N59E/E73K/S102D	Homo sapiens	NADP+without fumarate	—	0.0031	—	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S57K/N59E/E73K/S102D, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S57K/N59E/E73K/S102D	Homo sapiens	NADP+with 5 mM fumarate	—	0.003	—	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S57K/N59E/E73K/S102D, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S57K/N59E/E73K/S102D/H74K/D78P/D80E/D87G	Homo sapiens	L-malatewithout fumarate	22	0.8	28 calc.	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S57K/N59E/E73K/S102D/H74K/D78P/D80E/D87G, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S57K/N59E/E73K/S102D/H74K/D78P/D80E/D87G	Homo sapiens	L-malatewith 5 mM fumarate	21	1.1	19 calc.	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S57K/N59E/E73K/S102D/H74K/D78P/D80E/D87G, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S57K/N59E/E73K/S102D/H74K/D78P/D80E/D87G	Homo sapiens	NADP+without fumarate	—	0.0019	—	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S57K/N59E/E73K/S102D/H74K/D78P/D80E/D87G, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S57K/N59E/E73K/S102D/H74K/D78P/D80E/D87G	Homo sapiens	NADP+with 5 mM fumarate	—	0.0021	—	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S57K/N59E/E73K/S102D/H74K/D78P/D80E/D87G, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S57K/N59E/E73K/S102D/H74K/D78P/D80E/D87G/D90E/K106S/Q121S/L125H	Homo sapiens	L-malatewithout fumarate	21	1	21 calc.	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S57K/N59E/E73K/S102D/H74K/D78P/D80E/D87G/D90E/K106S/Q121S/L125H, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S57K/N59E/E73K/S102D/H74K/D78P/D80E/D87G/D90E/K106S/Q121S/L125H	Homo sapiens	L-malatewith 5 mM fumarate	21	1.3	16 calc.	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S57K/N59E/E73K/S102D/H74K/D78P/D80E/D87G/D90E/K106S/Q121S/L125H, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S57K/N59E/E73K/S102D/H74K/D78P/D80E/D87G/D90E/K106S/Q121S/L125H	Homo sapiens	NADP+without fumarate	—	0.0018	—	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S57K/N59E/E73K/S102D/H74K/D78P/D80E/D87G/D90E/K106S/Q121S/L125H, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S57K/N59E/E73K/S102D/H74K/D78P/D80E/D87G/D90E/K106S/Q121S/L125H	Homo sapiens	NADP+with 5 mM fumarate	—	0.0032	—	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S57K/N59E/E73K/S102D/H74K/D78P/D80E/D87G/D90E/K106S/Q121S/L125H, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S57K/N59E/E73K/S102D/H74K/D78P/D80E/D87G/K106S/Q121S/L125H	Homo sapiens	L-malatewithout fumarate	23	0.8	29 calc.	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S57K/N59E/E73K/S102D/H74K/D78P/D80E/D87G/K106S/Q121S/L125H, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S57K/N59E/E73K/S102D/H74K/D78P/D80E/D87G/K106S/Q121S/L125H	Homo sapiens	L-malatewith 5 mM fumarate	24	1.3	18 calc.	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S57K/N59E/E73K/S102D/H74K/D78P/D80E/D87G/K106S/Q121S/L125H, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S57K/N59E/E73K/S102D/H74K/D78P/D80E/D87G/K106S/Q121S/L125H	Homo sapiens	NADP+without fumarate	—	0.0023	—	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S57K/N59E/E73K/S102D/H74K/D78P/D80E/D87G/K106S/Q121S/L125H, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant S57K/N59E/E73K/S102D/H74K/D78P/D80E/D87G/K106S/Q121S/L125H	Homo sapiens	NADP+with 5 mM fumarate	—	0.0025	—	pH 7.4, 30 °C	PMID 24998673	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant S57K/N59E/E73K/S102D/H74K/D78P/D80E/D87G/K106S/Q121S/L125H, NADP+
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant W572A	Homo sapiens	L-malate	106.0	0.98	110 calc.	pH 7.4, 30 °C	PMID 19416979	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant W572A, L-malate
cytosolic NADP+-dependent malic enzyme (c-NADP-ME)variant W572A	Homo sapiens	NADP+	—	0.005	—	pH 7.4, 30 °C	PMID 19416979	Open record: cytosolic NADP+-dependent malic enzyme (c-NADP-ME) variant W572A, NADP+
cytosolic NADP+-dependent malic enzyme (human breast cancer cell)	Homo sapiens	L-malate	—	0.29	—		PMID 8804575	Open record: cytosolic NADP+-dependent malic enzyme (human breast cancer cell), L-malate
cytosolic NADP+-dependent malic enzyme (human breast cancer cell)	Homo sapiens	L-malatefull-length recombinant enzyme (expression host not stated)	—	1.06	—		PMID 8804575	Open record: cytosolic NADP+-dependent malic enzyme (human breast cancer cell), L-malate
cytosolic NADP+-dependent malic enzyme (human breast cancer cell)	Homo sapiens	NADP+	—	0.0019	—		PMID 8804575	Open record: cytosolic NADP+-dependent malic enzyme (human breast cancer cell), NADP+
cytosolic NADP+-dependent malic enzyme (human breast cancer cell)	Homo sapiens	NADP+full-length recombinant enzyme (expression host not stated)	—	4.4 × 10⁻⁴	—		PMID 8804575	Open record: cytosolic NADP+-dependent malic enzyme (human breast cancer cell), NADP+
cytosolic NADP+-dependent malic enzyme (human breast cancer cell)ΔN28 (truncated at the 28th amino acid)	Homo sapiens	L-malate	0.04	1.21	0.033 calc.		PMID 8804575	Open record: cytosolic NADP+-dependent malic enzyme (human breast cancer cell) ΔN28 (truncated at the 28th amino acid), L-malate
cytosolic NADP+-dependent malic enzyme (human breast cancer cell)ΔN28 (truncated at the 28th amino acid)	Homo sapiens	NADP+	—	9.7 × 10⁻⁴	—		PMID 8804575	Open record: cytosolic NADP+-dependent malic enzyme (human breast cancer cell) ΔN28 (truncated at the 28th amino acid), NADP+
cytosolic NADP+-dependent malic enzyme (pigeon liver)	Columba livia (pigeon)	L-malatenatural enzyme purified from pigeon liver	94.5	0.21	450 calc.		PMID 8804575	Open record: cytosolic NADP+-dependent malic enzyme (pigeon liver), L-malate
cytosolic NADP+-dependent malic enzyme (pigeon liver)	Columba livia (pigeon)	L-malate	123.9	0.25	500 calc.		PMID 8804575	Open record: cytosolic NADP+-dependent malic enzyme (pigeon liver), L-malate
cytosolic NADP+-dependent malic enzyme (pigeon liver)	Columba livia (pigeon)	NADP+natural enzyme purified from pigeon liver	—	0.00777	—		PMID 8804575	Open record: cytosolic NADP+-dependent malic enzyme (pigeon liver), NADP+
cytosolic NADP+-dependent malic enzyme (pigeon liver)	Columba livia (pigeon)	NADP+	—	0.00535	—		PMID 8804575	Open record: cytosolic NADP+-dependent malic enzyme (pigeon liver), NADP+
cytosolic NADP+-dependent malic enzyme (pigeon liver)ΔN13 (truncated at the 13th amino acid)	Columba livia (pigeon)	L-malate	100.7	11.2	8.99 calc.		PMID 8804575	Open record: cytosolic NADP+-dependent malic enzyme (pigeon liver) ΔN13 (truncated at the 13th amino acid), L-malate
cytosolic NADP+-dependent malic enzyme (pigeon liver)ΔN13 (truncated at the 13th amino acid)	Columba livia (pigeon)	NADP+	—	0.0082	—		PMID 8804575	Open record: cytosolic NADP+-dependent malic enzyme (pigeon liver) ΔN13 (truncated at the 13th amino acid), NADP+
LpR-NADP-ME (chimera of maize C4- and non-C4-NADP-malic enzyme)chimera LpR-NADP-ME	Zea mays	L-malate	107.8	0.51	211.3	pH 8	PMID 17150960	Open record: LpR-NADP-ME (chimera of maize C4- and non-C4-NADP-malic enzyme) chimera LpR-NADP-ME, L-malate
LpR-NADP-ME (chimera of maize C4- and non-C4-NADP-malic enzyme)chimera LpR-NADP-ME	Zea mays	L-malate	55.4	0.42	131	pH 7	PMID 17150960	Open record: LpR-NADP-ME (chimera of maize C4- and non-C4-NADP-malic enzyme) chimera LpR-NADP-ME, L-malate
LpR-NADP-ME (chimera of maize C4- and non-C4-NADP-malic enzyme)chimera LpR-NADP-ME	Zea mays	NADP+	—	0.0207	5.2 × 10³	pH 8	PMID 17150960	Open record: LpR-NADP-ME (chimera of maize C4- and non-C4-NADP-malic enzyme) chimera LpR-NADP-ME, NADP+
LR-NADP-ME (chimera of maize C4- and non-C4-NADP-malic enzyme)chimera LR-NADP-ME	Zea mays	L-malate	0.24	0.59	0.42	pH 8	PMID 17150960	Open record: LR-NADP-ME (chimera of maize C4- and non-C4-NADP-malic enzyme) chimera LR-NADP-ME, L-malate
LR-NADP-ME (chimera of maize C4- and non-C4-NADP-malic enzyme)chimera LR-NADP-ME	Zea mays	L-malate	0.16	0.51	0.3	pH 7	PMID 17150960	Open record: LR-NADP-ME (chimera of maize C4- and non-C4-NADP-malic enzyme) chimera LR-NADP-ME, L-malate
LR-NADP-ME (chimera of maize C4- and non-C4-NADP-malic enzyme)chimera LR-NADP-ME	Zea mays	NADP+	—	0.0312	—	pH 8	PMID 17150960	Open record: LR-NADP-ME (chimera of maize C4- and non-C4-NADP-malic enzyme) chimera LR-NADP-ME, NADP+
LRL-NADP-ME (chimera of maize C4- and non-C4-NADP-malic enzyme)chimera LRL-NADP-ME	Zea mays	L-malate	3.3	0.73	4.5	pH 8	PMID 17150960	Open record: LRL-NADP-ME (chimera of maize C4- and non-C4-NADP-malic enzyme) chimera LRL-NADP-ME, L-malate
LRL-NADP-ME (chimera of maize C4- and non-C4-NADP-malic enzyme)chimera LRL-NADP-ME	Zea mays	L-malate	2.8	0.13	21	pH 7	PMID 17150960	Open record: LRL-NADP-ME (chimera of maize C4- and non-C4-NADP-malic enzyme) chimera LRL-NADP-ME, L-malate
LRL-NADP-ME (chimera of maize C4- and non-C4-NADP-malic enzyme)chimera LRL-NADP-ME	Zea mays	NADP+	—	0.0312	100	pH 8	PMID 17150960	Open record: LRL-NADP-ME (chimera of maize C4- and non-C4-NADP-malic enzyme) chimera LRL-NADP-ME, NADP+
malic enzyme	duck	L-malatepurified from duck liver (natural enzyme)	160	0.073	2.2 × 10³ calc.	pH 7, 30 °C	PMID 1622402	Open record: malic enzyme, L-malate
malic enzyme	duck	L-malateexpressed from pUC-8 in E. coli TG-2	169	0.081	2.1 × 10³ calc.	pH 7, 30 °C	PMID 1622402	Open record: malic enzyme, L-malate
malic enzyme	duck	NADP+purified from duck liver (natural enzyme)	—	0.0046	—	pH 7, 30 °C	PMID 1622402	Open record: malic enzyme, NADP+
malic enzyme	duck	NADP+expressed from pUC-8 in E. coli TG-2	—	0.005	—	pH 7, 30 °C	PMID 1622402	Open record: malic enzyme, NADP+
malic enzymevariant C99S	duck	L-malate	56	0.292	190 calc.	pH 7, 30 °C	PMID 1622402	Open record: malic enzyme variant C99S, L-malate
malic enzymevariant C99S	duck	NADP+	—	0.0047	—	pH 7, 30 °C	PMID 1622402	Open record: malic enzyme variant C99S, NADP+
malic enzymevariant R70Q	duck	L-malate	113	0.126	897 calc.	pH 7, 30 °C	PMID 1622402	Open record: malic enzyme variant R70Q, L-malate
malic enzymevariant R70Q	duck	NADP+	—	0.0036	—	pH 7, 30 °C	PMID 1622402	Open record: malic enzyme variant R70Q, NADP+
malic enzyme (NADP+-dependent, ME)	Methylosinus trichosporium	malate	0.3	3	0.12	30 °C	PMID 31228930	Open record: malic enzyme (NADP+-dependent, ME), malate
malic enzyme (NADP+-dependent, ME)	Methylosinus trichosporium	NADP+	—	0.064	—	30 °C	PMID 31228930	Open record: malic enzyme (NADP+-dependent, ME), NADP+
malic enzyme (NADP+-dependent, ME)	Methylosinus trichosporium	NADPH	—	0.047	—	30 °C	PMID 31228930	Open record: malic enzyme (NADP+-dependent, ME), NADPH
malic enzyme (NADP+-dependent, ME)	Methylosinus trichosporium	pyruvate	0.067	6	0.01	30 °C	PMID 31228930	Open record: malic enzyme (NADP+-dependent, ME), pyruvate
malic enzyme (NADP+-dependent, ME)ME1 (N-terminal fragment)	Methylosinus trichosporium	malate	0.017	4	0.005	30 °C	PMID 31228930	Open record: malic enzyme (NADP+-dependent, ME) ME1 (N-terminal fragment), malate
malic enzyme (NADP+-dependent, ME)ME1 (N-terminal fragment)	Methylosinus trichosporium	pyruvate	0.0017	11	1.7 × 10⁻⁴	30 °C	PMID 31228930	Open record: malic enzyme (NADP+-dependent, ME) ME1 (N-terminal fragment), pyruvate
malic enzyme YtsJ	Bacillus subtilis	NADPH	—	0.8	—	pH 7.8, 37 °C	PMID 33824210	Open record: malic enzyme YtsJ, NADPH
malic enzyme YtsJ	Bacillus subtilis	pyruvate	—	5.3	—	pH 7.8, 37 °C	PMID 33824210	Open record: malic enzyme YtsJ, pyruvate
mitochondrial malic enzyme	Homo sapiens	nicotinamide adenine dinucleotide (oxidized)	—	45	—	37 °C	PMID 7757881	Open record: mitochondrial malic enzyme, nicotinamide adenine dinucleotide (oxidized)
mitochondrial malic enzyme	Homo sapiens	nicotinamide adenine dinucleotide phosphate (oxidized)	—	0.00283	—	37 °C	PMID 7757881	Open record: mitochondrial malic enzyme, nicotinamide adenine dinucleotide phosphate (oxidized)
NADP-malic enzyme HVME1 (chloroplastic isoform; recombinant rHVME1m)	Hydrilla verticillata	malate	46.1	0.6	76.9	pH 7.5	PMID 17638114	Open record: NADP-malic enzyme HVME1 (chloroplastic isoform; recombinant rHVME1m), malate
NADP-malic enzyme HVME1 (chloroplastic isoform; recombinant rHVME1m)	Hydrilla verticillata	NADP+	39.8	0.05	797	pH 7.5	PMID 17638114	Open record: NADP-malic enzyme HVME1 (chloroplastic isoform; recombinant rHVME1m), NADP+
NADP-malic enzyme HVME3 (cytosolic isoform; recombinant rHVME3)	Hydrilla verticillata	malate	17	—	—	pH 7.5	PMID 17638114	Open record: NADP-malic enzyme HVME3 (cytosolic isoform; recombinant rHVME3), malate
NADP-malic enzyme HVME3 (cytosolic isoform; recombinant rHVME3)	Hydrilla verticillata	NADP+	17.8	0.03	596	pH 7.5	PMID 17638114	Open record: NADP-malic enzyme HVME3 (cytosolic isoform; recombinant rHVME3), NADP+
NADP-malic enzyme pI 4.90 isozyme (type 2)	Zea mays	L-malate2 mM MnCl2	—	0.07	—	pH 6.4, 25 °C	PMID 24407260	Open record: NADP-malic enzyme pI 4.90 isozyme (type 2), L-malate
NADP-malic enzyme pI 4.90 isozyme (type 2)	Zea mays	L-malate2 mM MnCl2	—	0.15	—	pH 7.4, 25 °C	PMID 24407260	Open record: NADP-malic enzyme pI 4.90 isozyme (type 2), L-malate
NADP-malic enzyme pI 4.90 isozyme (type 2)	Zea mays	L-malate2 mM MnCl2	—	0.67	—	pH 8.4, 25 °C	PMID 24407260	Open record: NADP-malic enzyme pI 4.90 isozyme (type 2), L-malate
NADP-malic enzyme pI 4.90 isozyme (type 2)	Zea mays	L-malate2 mM MgCl2	—	0.38	—	pH 6.4, 25 °C	PMID 24407260	Open record: NADP-malic enzyme pI 4.90 isozyme (type 2), L-malate
NADP-malic enzyme pI 4.90 isozyme (type 2)	Zea mays	L-malate2 mM MgCl2	—	1.14	—	pH 7.4, 25 °C	PMID 24407260	Open record: NADP-malic enzyme pI 4.90 isozyme (type 2), L-malate
NADP-malic enzyme pI 4.90 isozyme (type 2)	Zea mays	L-malate2 mM MgCl2	—	1.79	—	pH 8.4, 25 °C	PMID 24407260	Open record: NADP-malic enzyme pI 4.90 isozyme (type 2), L-malate
NADP-malic enzyme pI 4.90 isozyme (type 2)	Zea mays	L-malatetris-HCl 100 mM; NADP+ non-varied (2.7-230 µM)	—	0.091	—	pH 7.45, 25 °C	PMID 24407260	Open record: NADP-malic enzyme pI 4.90 isozyme (type 2), L-malate
NADP-malic enzyme pI 4.90 isozyme (type 2)	Zea mays	L-malateNAD+-linked activity (instead of NADP+); cosubstrate NAD+	—	3.7	—	pH 7.45, 25 °C	PMID 24407260	Open record: NADP-malic enzyme pI 4.90 isozyme (type 2), L-malate
NADP-malic enzyme pI 4.90 isozyme (type 2)	Zea mays	NAD+	—	0.35	—	pH 7.45, 25 °C	PMID 24407260	Open record: NADP-malic enzyme pI 4.90 isozyme (type 2), NAD+
NADP-malic enzyme pI 4.90 isozyme (type 2)	Zea mays	NADP+2 mM MnCl2	—	0.0075	—	pH 6.4, 25 °C	PMID 24407260	Open record: NADP-malic enzyme pI 4.90 isozyme (type 2), NADP+
NADP-malic enzyme pI 4.90 isozyme (type 2)	Zea mays	NADP+2 mM MnCl2	—	0.0123	—	pH 7.4, 25 °C	PMID 24407260	Open record: NADP-malic enzyme pI 4.90 isozyme (type 2), NADP+
NADP-malic enzyme pI 4.90 isozyme (type 2)	Zea mays	NADP+2 mM MnCl2	—	0.007	—	pH 8.4, 25 °C	PMID 24407260	Open record: NADP-malic enzyme pI 4.90 isozyme (type 2), NADP+
NADP-malic enzyme pI 4.90 isozyme (type 2)	Zea mays	NADP+2 mM MgCl2	—	0.0066	—	pH 6.4, 25 °C	PMID 24407260	Open record: NADP-malic enzyme pI 4.90 isozyme (type 2), NADP+
NADP-malic enzyme pI 4.90 isozyme (type 2)	Zea mays	NADP+2 mM MgCl2	—	0.0125	—	pH 7.4, 25 °C	PMID 24407260	Open record: NADP-malic enzyme pI 4.90 isozyme (type 2), NADP+
NADP-malic enzyme pI 4.90 isozyme (type 2)	Zea mays	NADP+2 mM MgCl2	—	0.0193	—	pH 8.4, 25 °C	PMID 24407260	Open record: NADP-malic enzyme pI 4.90 isozyme (type 2), NADP+
NADP-malic enzyme pI 4.90 isozyme (type 2)	Zea mays	NADP+	—	0.0174	—	pH 7.45, 25 °C	PMID 24407260	Open record: NADP-malic enzyme pI 4.90 isozyme (type 2), NADP+
NADP-malic enzyme pI 5.28 isozyme (type 1)	Zea mays	L-malate2 mM MnCl2	—	0.18	—	pH 6.4, 25 °C	PMID 24407260	Open record: NADP-malic enzyme pI 5.28 isozyme (type 1), L-malate
NADP-malic enzyme pI 5.28 isozyme (type 1)	Zea mays	L-malate2 mM MnCl2	—	0.31	—	pH 7.4, 25 °C	PMID 24407260	Open record: NADP-malic enzyme pI 5.28 isozyme (type 1), L-malate
NADP-malic enzyme pI 5.28 isozyme (type 1)	Zea mays	L-malate2 mM MnCl2	—	1.01	—	pH 8.4, 25 °C	PMID 24407260	Open record: NADP-malic enzyme pI 5.28 isozyme (type 1), L-malate
NADP-malic enzyme pI 5.28 isozyme (type 1)	Zea mays	L-malate2 mM MgCl2	—	0.42	—	pH 6.4, 25 °C	PMID 24407260	Open record: NADP-malic enzyme pI 5.28 isozyme (type 1), L-malate
NADP-malic enzyme pI 5.28 isozyme (type 1)	Zea mays	L-malate2 mM MgCl2	—	0.7	—	pH 7.4, 25 °C	PMID 24407260	Open record: NADP-malic enzyme pI 5.28 isozyme (type 1), L-malate
NADP-malic enzyme pI 5.28 isozyme (type 1)	Zea mays	L-malate2 mM MgCl2	—	1.62	—	pH 8.4, 25 °C	PMID 24407260	Open record: NADP-malic enzyme pI 5.28 isozyme (type 1), L-malate
NADP-malic enzyme pI 5.28 isozyme (type 1)	Zea mays	L-malatetris-HCl 100 mM; 1.0 ml (Fig. 4 legend); cosubstrate NADP+	—	0.52	—	pH 7.45, 25 °C	PMID 24407260	Open record: NADP-malic enzyme pI 5.28 isozyme (type 1), L-malate
NADP-malic enzyme pI 5.28 isozyme (type 1)	Zea mays	L-malateNAD+-linked activity (instead of NADP+); cosubstrate NAD+	—	3.1	—	pH 7.45, 25 °C	PMID 24407260	Open record: NADP-malic enzyme pI 5.28 isozyme (type 1), L-malate
NADP-malic enzyme pI 5.28 isozyme (type 1)	Zea mays	NAD+	—	0.33	—	pH 7.45, 25 °C	PMID 24407260	Open record: NADP-malic enzyme pI 5.28 isozyme (type 1), NAD+
NADP-malic enzyme pI 5.28 isozyme (type 1)	Zea mays	NADP+2 mM MnCl2	—	0.0069	—	pH 6.4, 25 °C	PMID 24407260	Open record: NADP-malic enzyme pI 5.28 isozyme (type 1), NADP+
NADP-malic enzyme pI 5.28 isozyme (type 1)	Zea mays	NADP+2 mM MnCl2	—	0.013	—	pH 7.4, 25 °C	PMID 24407260	Open record: NADP-malic enzyme pI 5.28 isozyme (type 1), NADP+
NADP-malic enzyme pI 5.28 isozyme (type 1)	Zea mays	NADP+2 mM MnCl2	—	0.01	—	pH 8.4, 25 °C	PMID 24407260	Open record: NADP-malic enzyme pI 5.28 isozyme (type 1), NADP+
NADP-malic enzyme pI 5.28 isozyme (type 1)	Zea mays	NADP+2 mM MgCl2	—	0.008	—	pH 6.4, 25 °C	PMID 24407260	Open record: NADP-malic enzyme pI 5.28 isozyme (type 1), NADP+
NADP-malic enzyme pI 5.28 isozyme (type 1)	Zea mays	NADP+2 mM MgCl2	—	0.0121	—	pH 7.4, 25 °C	PMID 24407260	Open record: NADP-malic enzyme pI 5.28 isozyme (type 1), NADP+
NADP-malic enzyme pI 5.28 isozyme (type 1)	Zea mays	NADP+2 mM MgCl2	—	0.0115	—	pH 8.4, 25 °C	PMID 24407260	Open record: NADP-malic enzyme pI 5.28 isozyme (type 1), NADP+
NADP-malic enzyme pI 5.28 isozyme (type 1)	Zea mays	NADP+	—	0.0142	—	pH 7.45, 25 °C	PMID 24407260	Open record: NADP-malic enzyme pI 5.28 isozyme (type 1), NADP+
NADP-malic enzyme, non-photosynthetic root isoform	Zea mays	L-malate	—	0.26	—	pH 7, 30 °C	PMID 11352460	Open record: NADP-malic enzyme, non-photosynthetic root isoform, L-malate
NADP-malic enzyme, non-photosynthetic root isoform	Zea mays	L-malate	—	0.68	—	pH 8, 30 °C	PMID 11352460	Open record: NADP-malic enzyme, non-photosynthetic root isoform, L-malate
NADP-malic enzyme, non-photosynthetic root isoform	Zea mays	NADP+	—	0.006	—	pH 7, 30 °C	PMID 11352460	Open record: NADP-malic enzyme, non-photosynthetic root isoform, NADP+
NADP-malic enzyme, non-photosynthetic root isoform	Zea mays	NADP+	—	0.02	—	pH 8, 30 °C	PMID 11352460	Open record: NADP-malic enzyme, non-photosynthetic root isoform, NADP+
NADP-ME1	Arabidopsis thaliana	L-malate	1.2	—	—	pH 7.5, 30 °C	PMID 18288573	Open record: NADP-ME1, L-malate
NADP-ME1	Arabidopsis thaliana	NADP+	38.7	0.2051	189 calc.	pH 7.5	PMID 16113210	Open record: NADP-ME1, NADP+
NADP-ME1	Arabidopsis thaliana	oxaloacetate	7.7	—	—	pH 5.5, 30 °C	PMID 18288573	Open record: NADP-ME1, oxaloacetate
NADP-ME1	Arabidopsis thaliana	pyruvate	16.5	16.9	0.98	pH 7, 30 °C	PMID 18288573	Open record: NADP-ME1, pyruvate
NADP-ME1	Arabidopsis thaliana	pyruvate	1	—	—	pH 5.5, 30 °C	PMID 18288573	Open record: NADP-ME1, pyruvate
NADP-ME2	Arabidopsis thaliana	L-malate	—	3.33	—	pH 7.5	PMID 16113210	Open record: NADP-ME2, L-malate
NADP-ME2	Arabidopsis thaliana	L-malate	13.1	—	—	pH 7.5, 30 °C	PMID 18288573	Open record: NADP-ME2, L-malate
NADP-ME2	Arabidopsis thaliana	NADP+	324.1	0.0721	4.50 × 10³ calc.	pH 7.5	PMID 16113210	Open record: NADP-ME2, NADP+
NADP-ME2	Arabidopsis thaliana	oxaloacetate	12.2	—	—	pH 5.5, 30 °C	PMID 18288573	Open record: NADP-ME2, oxaloacetate
NADP-ME2	Arabidopsis thaliana	pyruvate	75	0.54	138.9	pH 7, 30 °C	PMID 18288573	Open record: NADP-ME2, pyruvate
NADP-ME2	Arabidopsis thaliana	pyruvate	6.1	—	—	pH 5.5, 30 °C	PMID 18288573	Open record: NADP-ME2, pyruvate
NADP-ME2variant ME2-del1	Arabidopsis thaliana	L-malate	277.2	2.6	110 calc.	pH 7.5, 30 °C	PMID 18288573	Open record: NADP-ME2 variant ME2-del1, L-malate
NADP-ME2variant ME2-del1	Arabidopsis thaliana	NADP+	—	0.05	—	pH 7.5, 30 °C	PMID 18288573	Open record: NADP-ME2 variant ME2-del1, NADP+
NADP-ME2variant ME2-del1	Arabidopsis thaliana	pyruvate	34.6	8.6	4.1	pH 7, 30 °C	PMID 18288573	Open record: NADP-ME2 variant ME2-del1, pyruvate
NADP-ME2variant ME2-del2	Arabidopsis thaliana	L-malate	164.7	—	—	pH 7.5, 30 °C	PMID 18288573	Open record: NADP-ME2 variant ME2-del2, L-malate
NADP-ME2variant R115A	Arabidopsis thaliana	L-malate	234	2.4	98 calc.	pH 7.5, 30 °C	PMID 18288573	Open record: NADP-ME2 variant R115A, L-malate
NADP-ME2variant R115A	Arabidopsis thaliana	NADP+	—	0.05	—	pH 7.5, 30 °C	PMID 18288573	Open record: NADP-ME2 variant R115A, NADP+
NADP-ME2variant R115A	Arabidopsis thaliana	pyruvate	64.1	0.8	82	pH 7, 30 °C	PMID 18288573	Open record: NADP-ME2 variant R115A, pyruvate
NADP-ME3	Arabidopsis thaliana	L-malate	—	0.83	—	pH 7.5	PMID 16113210	Open record: NADP-ME3, L-malate
NADP-ME3	Arabidopsis thaliana	L-malate	67.5	—	—	pH 7.5, 30 °C	PMID 18288573	Open record: NADP-ME3, L-malate
NADP-ME3	Arabidopsis thaliana	NADP+	268.1	0.0065	4.1 × 10⁴ calc.	pH 7.5	PMID 16113210	Open record: NADP-ME3, NADP+
NADP-ME3	Arabidopsis thaliana	oxaloacetate	45.1	—	—	pH 5.5, 30 °C	PMID 18288573	Open record: NADP-ME3, oxaloacetate
NADP-ME3	Arabidopsis thaliana	pyruvate	237	4.92	48.2	pH 7, 30 °C	PMID 18288573	Open record: NADP-ME3, pyruvate
NADP-ME3	Arabidopsis thaliana	pyruvate	10	—	—	pH 5.5, 30 °C	PMID 18288573	Open record: NADP-ME3, pyruvate
NADP-ME4	Arabidopsis thaliana	L-malate	—	0.23	—	pH 7.5	PMID 16113210	Open record: NADP-ME4, L-malate
NADP-ME4	Arabidopsis thaliana	L-malate	7.8	—	—	pH 7.5, 30 °C	PMID 18288573	Open record: NADP-ME4, L-malate
NADP-ME4	Arabidopsis thaliana	NADP+	151.3	0.0102	1.48 × 10⁴ calc.	pH 7.5	PMID 16113210	Open record: NADP-ME4, NADP+
NADP-ME4	Arabidopsis thaliana	oxaloacetate	11.8	—	—	pH 5.5, 30 °C	PMID 18288573	Open record: NADP-ME4, oxaloacetate
NADP-ME4	Arabidopsis thaliana	pyruvate	284.1	10.8	26.3	pH 7, 30 °C	PMID 18288573	Open record: NADP-ME4, pyruvate
NADP-ME4	Arabidopsis thaliana	pyruvate	3.6	—	—	pH 5.5, 30 °C	PMID 18288573	Open record: NADP-ME4, pyruvate
non-C4-NADP-ME (R isoform, non-photosynthetic plastidic NADP-malic enzyme)	Zea mays	L-malate	199.5	0.43	417.5	pH 8	PMID 17150960	Open record: non-C4-NADP-ME (R isoform, non-photosynthetic plastidic NADP-malic enzyme), L-malate
non-C4-NADP-ME (R isoform, non-photosynthetic plastidic NADP-malic enzyme)	Zea mays	L-malate	151.7	0.51	297	pH 7	PMID 17150960	Open record: non-C4-NADP-ME (R isoform, non-photosynthetic plastidic NADP-malic enzyme), L-malate
non-C4-NADP-ME (R isoform, non-photosynthetic plastidic NADP-malic enzyme)	Zea mays	NADP+	—	0.0702	2.5 × 10³	pH 8	PMID 17150960	Open record: non-C4-NADP-ME (R isoform, non-photosynthetic plastidic NADP-malic enzyme), NADP+
nonC4-NADP-ME (ZmnonC4-NADP-ME)	Zea mays	(S)-malate(cDNA coding the mature protein)	26.3	0.43	62.6	pH 8, 25 °C	PMID 31235877	Open record: nonC4-NADP-ME (ZmnonC4-NADP-ME), (S)-malate
nonC4-NADP-ME (ZmnonC4-NADP-ME)	Zea mays	(S)-malatewith N-terminal deletion (DelN)	22	0.95	23.2	pH 8, 25 °C	PMID 31235877	Open record: nonC4-NADP-ME (ZmnonC4-NADP-ME), (S)-malate
nonC4-NADP-ME (ZmnonC4-NADP-ME)	Zea mays	nicotinamide adenine dinucleotide phosphate (oxidized)(cDNA coding the mature protein)	—	0.023	—	pH 8, 25 °C	PMID 31235877	Open record: nonC4-NADP-ME (ZmnonC4-NADP-ME), nicotinamide adenine dinucleotide phosphate (oxidized)
nonC4-NADP-ME (ZmnonC4-NADP-ME)	Zea mays	nicotinamide adenine dinucleotide phosphate (oxidized)with N-terminal deletion (DelN)	—	0.023	—	pH 8, 25 °C	PMID 31235877	Open record: nonC4-NADP-ME (ZmnonC4-NADP-ME), nicotinamide adenine dinucleotide phosphate (oxidized)
nonC4-NADP-ME (ZmnonC4-NADP-ME)variant A339E	Zea mays	(S)-malate(cDNA coding the mature protein)	32.1	0.27	118.9	pH 8, 25 °C	PMID 31235877	Open record: nonC4-NADP-ME (ZmnonC4-NADP-ME) variant A339E, (S)-malate
nonC4-NADP-ME (ZmnonC4-NADP-ME)variant A339E	Zea mays	(S)-malatewith N-terminal deletion (DelN)	4	0.4	10	pH 8, 25 °C	PMID 31235877	Open record: nonC4-NADP-ME (ZmnonC4-NADP-ME) variant A339E, (S)-malate
nonC4-NADP-ME (ZmnonC4-NADP-ME)variant A339E	Zea mays	nicotinamide adenine dinucleotide phosphate (oxidized)(cDNA coding the mature protein)	—	0.015	—	pH 8, 25 °C	PMID 31235877	Open record: nonC4-NADP-ME (ZmnonC4-NADP-ME) variant A339E, nicotinamide adenine dinucleotide phosphate (oxidized)
nonC4-NADP-ME (ZmnonC4-NADP-ME)variant A339E	Zea mays	nicotinamide adenine dinucleotide phosphate (oxidized)with N-terminal deletion (DelN)	—	0.0131	—	pH 8, 25 °C	PMID 31235877	Open record: nonC4-NADP-ME (ZmnonC4-NADP-ME) variant A339E, nicotinamide adenine dinucleotide phosphate (oxidized)
nonC4-NADP-ME (ZmnonC4-NADP-ME)variant I140F	Zea mays	(S)-malate	39.6	0.85	46.6	pH 8, 25 °C	PMID 31235877	Open record: nonC4-NADP-ME (ZmnonC4-NADP-ME) variant I140F, (S)-malate
nonC4-NADP-ME (ZmnonC4-NADP-ME)variant I140F	Zea mays	nicotinamide adenine dinucleotide phosphate (oxidized)	—	0.038	—	pH 8, 25 °C	PMID 31235877	Open record: nonC4-NADP-ME (ZmnonC4-NADP-ME) variant I140F, nicotinamide adenine dinucleotide phosphate (oxidized)
nonC4-NADP-ME (ZmnonC4-NADP-ME)variant I140F/A339E	Zea mays	(S)-malate(cDNA coding the mature protein)	36.7	1.12	32.8	pH 8, 25 °C	PMID 31235877	Open record: nonC4-NADP-ME (ZmnonC4-NADP-ME) variant I140F/A339E, (S)-malate
nonC4-NADP-ME (ZmnonC4-NADP-ME)variant I140F/A339E	Zea mays	(S)-malatewith N-terminal deletion (DelN)	85.8	1.05	81.7	pH 8, 25 °C	PMID 31235877	Open record: nonC4-NADP-ME (ZmnonC4-NADP-ME) variant I140F/A339E, (S)-malate
nonC4-NADP-ME (ZmnonC4-NADP-ME)variant I140F/A339E	Zea mays	nicotinamide adenine dinucleotide phosphate (oxidized)(cDNA coding the mature protein)	—	0.0412	—	pH 8, 25 °C	PMID 31235877	Open record: nonC4-NADP-ME (ZmnonC4-NADP-ME) variant I140F/A339E, nicotinamide adenine dinucleotide phosphate (oxidized)
nonC4-NADP-ME (ZmnonC4-NADP-ME)variant I140F/A339E	Zea mays	nicotinamide adenine dinucleotide phosphate (oxidized)with N-terminal deletion (DelN)	—	0.0503	—	pH 8, 25 °C	PMID 31235877	Open record: nonC4-NADP-ME (ZmnonC4-NADP-ME) variant I140F/A339E, nicotinamide adenine dinucleotide phosphate (oxidized)
RL-NADP-ME (chimera of maize non-C4- and C4-NADP-malic enzyme)chimera RL-NADP-ME	Zea mays	L-malate	72.7	0.58	125.4	pH 8	PMID 17150960	Open record: RL-NADP-ME (chimera of maize non-C4- and C4-NADP-malic enzyme) chimera RL-NADP-ME, L-malate
RL-NADP-ME (chimera of maize non-C4- and C4-NADP-malic enzyme)chimera RL-NADP-ME	Zea mays	L-malate	51.7	0.21	271	pH 7	PMID 17150960	Open record: RL-NADP-ME (chimera of maize non-C4- and C4-NADP-malic enzyme) chimera RL-NADP-ME, L-malate
RL-NADP-ME (chimera of maize non-C4- and C4-NADP-malic enzyme)chimera RL-NADP-ME	Zea mays	NADP+	—	0.0421	1.7 × 10³	pH 8	PMID 17150960	Open record: RL-NADP-ME (chimera of maize non-C4- and C4-NADP-malic enzyme) chimera RL-NADP-ME, NADP+
RLR-NADP-ME (chimera of maize non-C4- and C4-NADP-malic enzyme)chimera RLR-NADP-ME	Zea mays	L-malate	25	0.47	53.1	pH 8	PMID 17150960	Open record: RLR-NADP-ME (chimera of maize non-C4- and C4-NADP-malic enzyme) chimera RLR-NADP-ME, L-malate
RLR-NADP-ME (chimera of maize non-C4- and C4-NADP-malic enzyme)chimera RLR-NADP-ME	Zea mays	L-malate	12.9	0.55	23	pH 7	PMID 17150960	Open record: RLR-NADP-ME (chimera of maize non-C4- and C4-NADP-malic enzyme) chimera RLR-NADP-ME, L-malate
RLR-NADP-ME (chimera of maize non-C4- and C4-NADP-malic enzyme)chimera RLR-NADP-ME	Zea mays	NADP+	—	0.042	600	pH 8	PMID 17150960	Open record: RLR-NADP-ME (chimera of maize non-C4- and C4-NADP-malic enzyme) chimera RLR-NADP-ME, NADP+
RpL-NADP-ME (chimera of maize non-C4- and C4-NADP-malic enzyme)chimera RpL-NADP-ME	Zea mays	L-malate	71.6	0.34	238.8	pH 8	PMID 17150960	Open record: RpL-NADP-ME (chimera of maize non-C4- and C4-NADP-malic enzyme) chimera RpL-NADP-ME, L-malate
RpL-NADP-ME (chimera of maize non-C4- and C4-NADP-malic enzyme)chimera RpL-NADP-ME	Zea mays	L-malate	73.7	0.04	1842	pH 7	PMID 17150960	Open record: RpL-NADP-ME (chimera of maize non-C4- and C4-NADP-malic enzyme) chimera RpL-NADP-ME, L-malate
RpL-NADP-ME (chimera of maize non-C4- and C4-NADP-malic enzyme)chimera RpL-NADP-ME	Zea mays	NADP+	—	0.0256	2.7 × 10³	pH 8	PMID 17150960	Open record: RpL-NADP-ME (chimera of maize non-C4- and C4-NADP-malic enzyme) chimera RpL-NADP-ME, NADP+
YtsJ (NADP-dependent malic enzyme)	Bacillus subtilis	NADPH	7.8	—	—	pH 7.8, 37 °C	PMID 33824210	Open record: YtsJ (NADP-dependent malic enzyme), NADPH
YtsJ (NADP-dependent malic enzyme)	Bacillus subtilis	pyruvate	4.3	—	—	pH 7.8, 37 °C	PMID 33824210	Open record: YtsJ (NADP-dependent malic enzyme), pyruvate
ZmC4-NADP-ME (maize photosynthetic plastidic NADP-malic enzyme)	Zea mays	L-malateTable 1	91	0.17	540 calc.	pH 8, 30 °C	PMID 22514092	Open record: ZmC4-NADP-ME (maize photosynthetic plastidic NADP-malic enzyme), L-malate
ZmC4-NADP-ME (maize photosynthetic plastidic NADP-malic enzyme)	Zea mays	L-malate	8.35	0.15	56 calc.	pH 7, 30 °C	PMID 22514092	Open record: ZmC4-NADP-ME (maize photosynthetic plastidic NADP-malic enzyme), L-malate
ZmC4-NADP-ME (maize photosynthetic plastidic NADP-malic enzyme)	Zea mays	L-malate	3.55	0.08	44 calc.	pH 7, 30 °C	PMID 22514092	Open record: ZmC4-NADP-ME (maize photosynthetic plastidic NADP-malic enzyme), L-malate
ZmC4-NADP-ME (maize photosynthetic plastidic NADP-malic enzyme)	Zea mays	L-malateTable 2	269	0.39	690	pH 8, 30 °C	PMID 22514092	Open record: ZmC4-NADP-ME (maize photosynthetic plastidic NADP-malic enzyme), L-malate
ZmC4-NADP-ME (maize photosynthetic plastidic NADP-malic enzyme)	Zea mays	NADP+Table 1	—	0.0088	—	pH 8, 30 °C	PMID 22514092	Open record: ZmC4-NADP-ME (maize photosynthetic plastidic NADP-malic enzyme), NADP+
ZmC4-NADP-ME (maize photosynthetic plastidic NADP-malic enzyme)	Zea mays	NADP+	—	0.0147	—	pH 7, 30 °C	PMID 22514092	Open record: ZmC4-NADP-ME (maize photosynthetic plastidic NADP-malic enzyme), NADP+
ZmC4-NADP-ME (maize photosynthetic plastidic NADP-malic enzyme)	Zea mays	NADP+	—	0.0036	—	pH 7, 30 °C	PMID 22514092	Open record: ZmC4-NADP-ME (maize photosynthetic plastidic NADP-malic enzyme), NADP+
ZmC4-NADP-ME (maize photosynthetic plastidic NADP-malic enzyme)	Zea mays	NADP+Table 2	—	0.0276	9.7 × 10³	pH 8, 30 °C	PMID 22514092	Open record: ZmC4-NADP-ME (maize photosynthetic plastidic NADP-malic enzyme), NADP+
ZmC4-NADP-ME (maize photosynthetic plastidic NADP-malic enzyme)variant C192A	Zea mays	L-malate	5.6	3	1.9	pH 8, 30 °C	PMID 22514092	Open record: ZmC4-NADP-ME (maize photosynthetic plastidic NADP-malic enzyme) variant C192A, L-malate
ZmC4-NADP-ME (maize photosynthetic plastidic NADP-malic enzyme)variant C192A	Zea mays	NADP+	—	0.0154	360	pH 8, 30 °C	PMID 22514092	Open record: ZmC4-NADP-ME (maize photosynthetic plastidic NADP-malic enzyme) variant C192A, NADP+
ZmC4-NADP-ME (maize photosynthetic plastidic NADP-malic enzyme)variant C231A	Zea mays	L-malate	23.2	1.7	13.6	pH 8, 30 °C	PMID 22514092	Open record: ZmC4-NADP-ME (maize photosynthetic plastidic NADP-malic enzyme) variant C231A, L-malate
ZmC4-NADP-ME (maize photosynthetic plastidic NADP-malic enzyme)variant C231A	Zea mays	NADP+	—	0.015	1.5 × 10³	pH 8, 30 °C	PMID 22514092	Open record: ZmC4-NADP-ME (maize photosynthetic plastidic NADP-malic enzyme) variant C231A, NADP+
ZmC4-NADP-ME (maize photosynthetic plastidic NADP-malic enzyme)variant C246A	Zea mays	L-malate	1.1	0.14	7.8	pH 8, 30 °C	PMID 22514092	Open record: ZmC4-NADP-ME (maize photosynthetic plastidic NADP-malic enzyme) variant C246A, L-malate
ZmC4-NADP-ME (maize photosynthetic plastidic NADP-malic enzyme)variant C246A	Zea mays	NADP+	—	0.0053	210	pH 8, 30 °C	PMID 22514092	Open record: ZmC4-NADP-ME (maize photosynthetic plastidic NADP-malic enzyme) variant C246A, NADP+
ZmC4-NADP-ME (maize photosynthetic plastidic NADP-malic enzyme)variant C270A	Zea mays	L-malate	1.6	4.3	0.37	pH 8, 30 °C	PMID 22514092	Open record: ZmC4-NADP-ME (maize photosynthetic plastidic NADP-malic enzyme) variant C270A, L-malate
ZmC4-NADP-ME (maize photosynthetic plastidic NADP-malic enzyme)variant C270A	Zea mays	NADP+	—	0.0135	120	pH 8, 30 °C	PMID 22514092	Open record: ZmC4-NADP-ME (maize photosynthetic plastidic NADP-malic enzyme) variant C270A, NADP+