CatLogenzyme kinetics catalog

EC 3.1.1.8: cholinesterase

HydrolasesOpen in Browse

CatLog read 62 records for EC 3.1.1.8 from 9 papers, for 2 organisms. Names in these papers: butyrylcholinesterase (BuChE), butyrylcholinesterase, butyrylcholinesterase (BChE), BChE (butyrylcholinesterase) and 3 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 72 records for EC 3.1.1.8 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.1.1.8 in Browse.

Papers

PaperOrganismsRecords
Effects of mutations of active site residues and amino acids interacting with the Omega loop on substrate activation of butyrylcholinesteraseHomo sapiens27
On the active site for hydrolysis of aryl amides and choline esters by human cholinesterasesHomo sapiens12
Characterization of butyrylcholinesterase from porcine milkHomo sapiens, Sus scrofa6
Characterization of a high-activity mutant of human butyrylcholinesterase against (-)-cocaineHomo sapiens5
Design, preparation, and characterization of high-activity mutants of human butyrylcholinesterase specific for detoxification of cocaineHomo sapiens4
Kinetic characterization of cholinesterases and a therapeutically valuable cocaine hydrolase for their catalytic activities against heroin and its metabolite 6-monoacetylmorphineHomo sapiens4
Dissection of the human acetylcholinesterase active center determinants of substrate specificity. Identification of residues constituting the anionic site, the hydrophobic site, and the acyl pocketHomo sapiens2
Hydrolytic metabolism of pyrethroids by human and other mammalian carboxylesterasesHomo sapiens1
Catalytic activities of cocaine hydrolases against the most toxic cocaine metabolite norcocaethyleneHomo sapiens1

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
BChE (butyrylcholinesterase)Homo sapiens3,6-diacetylmorphine30.670.12255pH 7.4, 37 °CPMID 30080993Open
BChE (butyrylcholinesterase)Homo sapiens6-monoacetylmorphine0.001080.0240.0452pH 7.4, 37 °CPMID 30080993Open
butyrylcholinesteraseHomo sapiensacetylcholine1.43 × 10³0.1489.7 × 10³25 °CPMID 20971807Open
butyrylcholinesteraseHomo sapiensacetylthiocholine iodide3800.0311.162 × 10⁴pH 8, 22 °CPMID 29908755Open
butyrylcholinesteraseHomo sapiensbutyrylthiocholine iodide5000.0153.238 × 10⁴pH 8, 22 °CPMID 29908755Open
butyrylcholinesteraseHomo sapienspropionylthiocholine iodide5300.0172.517 × 10⁴pH 8, 22 °CPMID 29908755Open
butyrylcholinesterasevariant A199S/F227A/S287G/A328W/E441DHomo sapiensacetylcholine2430.0279 × 10³25 °CPMID 20971807Open
butyrylcholinesterasevariant A199S/F227A/S287G/A328W/Y332G/E441DHomo sapiensacetylcholine2300.0753 × 10³25 °CPMID 20971807Open
butyrylcholinesterasevariant A199S/S287G/A328W/Y332GHomo sapiensacetylcholine1250.0363.5 × 10³25 °CPMID 20971807Open
butyrylcholinesteraseSus scrofaacetylthiocholine iodide1.03 × 10³0.372.58 × 10³pH 8, 22 °CPMID 29908755Open
butyrylcholinesteraseSus scrofabutyrylthiocholine iodide7200.232.87 × 10³pH 8, 22 °CPMID 29908755Open
butyrylcholinesteraseSus scrofapropionylthiocholine iodide7700.253.08 × 10³pH 8, 22 °CPMID 29908755Open
butyrylcholinesterase (BChE)Homo sapiensacetylthiocholine—0.029—pH 7.5, 25 °CPMID 20060817Open
butyrylcholinesterase (BChE)Homo sapiensbutyrylthiocholine—0.021—pH 7.5, 25 °CPMID 20060817Open
butyrylcholinesterase (BChE)Homo sapiensnorcocaethylene0.1580.011713.53pH 7.4, 25 °CPMID 32101217Open
butyrylcholinesterase (BChE)variant A199S/S287G/A328W/Y332GHomo sapiens(-)-cocaine510.00311.65 × 10⁴25 °CPMID 20060817Open
butyrylcholinesterase (BChE)variant A199S/S287G/A328W/Y332GHomo sapiensacetylthiocholine160.20.0374.3 × 10³pH 7.5, 25 °CPMID 20060817Open
butyrylcholinesterase (BChE)variant A199S/S287G/A328W/Y332GHomo sapiensbutyrylthiocholine470.00835.7 × 10³pH 7.5, 25 °CPMID 20060817Open
butyrylcholinesterase (BuChE)Homo sapiensAcetylthiocholine7500.05071.5 × 10⁴ calc.pH 8, 23 °CPMID 16504521Open
butyrylcholinesterase (BuChE)Homo sapiensButyrylthiocholine1.47 × 10³0.03474.20 × 10⁴ calc.pH 8, 23 °CPMID 16504521Open
butyrylcholinesterase (BuChE)Homo sapiensN-(2-Nitrophenyl)acetamide0.050.6030.083 calc.pH 8, 23 °CPMID 16504521Open
butyrylcholinesterase (BuChE)Homo sapiensN-(2-Nitrophenyl)butanamide0.580.3551.6 calc.pH 8, 23 °CPMID 16504521Open
butyrylcholinesterase (BuChE)Homo sapiensN-(2-Nitrophenyl)heptanamide4.980.37713.2 calc.pH 8, 23 °CPMID 16504521Open
butyrylcholinesterase (BuChE)Homo sapiensN-(2-Nitrophenyl)hexanamide3.80.4857.9 calc.pH 8, 23 °CPMID 16504521Open
butyrylcholinesterase (BuChE)Homo sapiensN-(2-Nitrophenyl)octanamide5.430.14338.0 calc.pH 8, 23 °CPMID 16504521Open
butyrylcholinesterase (BuChE)Homo sapiensN-(2-Nitrophenyl)pentanamide2.870.5625.10 calc.pH 8, 23 °CPMID 16504521Open
butyrylcholinesterase (BuChE)Homo sapiensN-(2-Nitrophenyl)propanamide0.771.780.43 calc.pH 8, 23 °CPMID 16504521Open
butyrylcholinesterase (BuChE)Homo sapiensN-(2-Nitrophenyl)trifluoroacetamide167214111.9 calc.pH 8, 23 °CPMID 16504521Open
butyrylcholinesterase (BuChE)Homo sapiensOctanoylthiocholine1.2 × 10³0.01995.9 × 10⁴ calc.pH 8, 23 °CPMID 16504521Open
butyrylcholinesterase (BuChE)Homo sapiensPropionylthiocholine1.2 × 10³0.04023.0 × 10⁴ calc.pH 8, 23 °CPMID 16504521Open
butyrylcholinesterase (BuChE)variant A328FHomo sapiensbutyrylthiocholinebuffer5330.0173.3 × 10⁴pH 7, 25 °CPMID 11341926Open
butyrylcholinesterase (BuChE)variant A328FHomo sapiensbutyrylthiocholinebuffer with 24% (w/v) fructose4500.0133.7 × 10⁴pH 7, 25 °CPMID 11341926Open
butyrylcholinesterase (BuChE)variant A328GHomo sapiensbutyrylthiocholinebuffer3330.0281.18 × 10⁴pH 7, 25 °CPMID 11341926Open
butyrylcholinesterase (BuChE)variant A328GHomo sapiensbutyrylthiocholinebuffer with 24% (w/v) fructose—0.027—pH 7, 25 °CPMID 11341926Open
butyrylcholinesterase (BuChE)variant A328YHomo sapiensbutyrylthiocholinebuffer6670.0116 × 10⁴pH 7, 25 °CPMID 11341926Open
butyrylcholinesterase (BuChE)variant A328YHomo sapiensbutyrylthiocholinebuffer with 24% (w/v) fructose8330.0117 × 10⁴pH 7, 25 °CPMID 11341926Open
butyrylcholinesterase (BuChE)variant E197DHomo sapiensbutyrylthiocholinebuffer66.70.1670pH 7, 25 °CPMID 11341926Open
butyrylcholinesterase (BuChE)variant E197DHomo sapiensbutyrylthiocholinebuffer with 24% (w/v) fructose66.70.1670pH 7, 25 °CPMID 11341926Open
butyrylcholinesterase (BuChE)variant E197GHomo sapiensbutyrylthiocholinebuffer—0.2—pH 7, 25 °CPMID 11341926Open
butyrylcholinesterase (BuChE)variant E197GHomo sapiensbutyrylthiocholinebuffer with 24% (w/v) fructose—0.17—pH 7, 25 °CPMID 11341926Open
butyrylcholinesterase (BuChE)variant E197QHomo sapiensbutyrylthiocholinebuffer1500.11.5 × 10³pH 7, 25 °CPMID 11341926Open
butyrylcholinesterase (BuChE)variant E197QHomo sapiensbutyrylthiocholinebuffer with 24% (w/v) fructose2000.111.8 × 10³pH 7, 25 °CPMID 11341926Open
butyrylcholinesterase (BuChE)variant K339MHomo sapiensbutyrylthiocholinebuffer2500.064.7 × 10³pH 7, 25 °CPMID 11341926Open
butyrylcholinesterase (BuChE)variant K339MHomo sapiensbutyrylthiocholinebuffer with 24% (w/v) fructose3330.084.2 × 10³pH 7, 25 °CPMID 11341926Open
butyrylcholinesterase (BuChE)variant K339MHomo sapienso-nitrophenyl butyrate2500.161.57 × 10³pH 7, 25 °CPMID 11341926Open
butyrylcholinesterase (BuChE)variant K339MHomo sapienssuccinyldithiocholine3.30.019170pH 7, 25 °CPMID 11341926Open
butyrylcholinesterase (BuChE)variant N83AHomo sapiensbutyrylthiocholinebuffer6170.051.23 × 10⁴pH 7, 25 °CPMID 11341926Open
butyrylcholinesterase (BuChE)variant N83AHomo sapiensbutyrylthiocholinebuffer with 24% (w/v) fructose6670.061.1 × 10⁴pH 7, 25 °CPMID 11341926Open
butyrylcholinesterase (BuChE)variant N83QHomo sapiensbutyrylthiocholinebuffer7670.061.28 × 10⁴pH 7, 25 °CPMID 11341926Open
butyrylcholinesterase (BuChE)variant N83QHomo sapiensbutyrylthiocholinebuffer with 24% (w/v) fructose9170.061.52 × 10⁴pH 7, 25 °CPMID 11341926Open
butyrylcholinesterase (BuChE)variant W430AHomo sapiensbutyrylthiocholinebuffer83.3613pH 7, 25 °CPMID 11341926Open
butyrylcholinesterase (BuChE)variant W430AHomo sapiensbutyrylthiocholinebuffer with 24% (w/v) fructose100425pH 7, 25 °CPMID 11341926Open
butyrylcholinesterase (BuChE)variant W430AHomo sapienso-nitrophenyl butyrate3331.9170pH 7, 25 °CPMID 11341926Open
butyrylcholinesterase (BuChE)variant W430AHomo sapienssuccinyldithiocholine3.3110.33pH 7, 25 °CPMID 11341926Open
butyrylcholinesterase (BuChE)variant W82AHomo sapiensbutyrylthiocholine0.1 M potassium phosphate buffer20.45pH 7, 25 °CPMID 11341926Open
butyrylcholinesterase (BuChE)variant W82AHomo sapiensbutyrylthiocholine0.1 M potassium phosphate buffer with 24% (w/v) fructose6.71.74pH 7, 25 °CPMID 11341926Open
butyrylcholinesterase (BuChE)variant W82AHomo sapiensbutyrylthiocholine0.1 M potassium phosphate buffer; the remaining 80% assayed—0.9—pH 7, 25 °CPMID 11341926Open
CocH1 (cocaine hydrolase derived from human BChE)variant A199S/F227A/S287G/A328WHomo sapiens3,6-diacetylmorphine35.830.245146.3pH 7.4, 37 °CPMID 30080993Open
CocH1 (cocaine hydrolase derived from human BChE)variant A199S/F227A/S287G/A328WHomo sapiens6-monoacetylmorphine0.003720.2920.01273pH 7.4, 37 °CPMID 30080993Open
hBChE (human butyrylcholinesterase)Homo sapiens1RS trans-permethrin3.3 × 10⁻⁵——PMID 16387282Open
human serum butyrylcholinesterase (HuBChE)Homo sapiensacetylthiocholine8300.0352.38 × 10⁴pH 8, 27 °CPMID 8349597Open
human serum butyrylcholinesterase (HuBChE)Homo sapiensbutyrylthiocholine1.83 × 10³0.053.67 × 10⁴pH 8, 27 °CPMID 8349597Open