CatLogenzyme kinetics catalog

EC 3.2.1.18: exo-alpha-sialidase

HydrolasesOpen in Browse

CatLog read 168 records for EC 3.2.1.18 from 11 papers, for 6 organisms. Names in these papers: neuraminidase (lysosomal sialidase), cytosolic sialidase HsNEU2, human membrane-associated ganglioside sialidase, A2/Singapore/57 neuraminidase and 35 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 95 records for EC 3.2.1.18 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.2.1.18 in Browse.

Papers

PaperOrganismsRecords
A comparative study of influenza virus neuraminidases, using automated techniquesInfluenza A virus, Influenza B virus74
Km defect in neuraminidase of dysmorphic type sialidosis with and without beta-galactosidase deficiencyHomo sapiens17
Properties of recombinant human cytosolic sialidase HsNEU2. The enzyme hydrolyzes monomerically dispersed GM1 ganglioside moleculesHomo sapiens14
Site-directed mutagenesis of human membrane-associated ganglioside sialidase: identification of amino-acid residues contributing to substrate specificityHomo sapiens13
Variation in the divalent cation requirements of influenza A virus N1 neuraminidasesInfluenza A virus12
Site-directed mutagenesis of catalytic residues of influenza virus neuraminidase as an aid to drug designInfluenza B virus8
Insight into substrate recognition and catalysis by the human neuraminidase 3 (NEU3) through molecular modeling and site-directed mutagenesisHomo sapiens7
Kinetic, Thermodynamic, and Structural Analysis of Drug Resistance Mutations in Neuraminidase from the 2009 Pandemic Influenza VirusInfluenza A virus6
Characterization of Porphyromonas gingivalis sialidase and disruption of its role in host-pathogen interactionsPorphyromonas gingivalis6
The release of N-acetyl- and N-glycolloyl-neuraminic acid from soluble complex carbohydrates and erythrocytes by bacterial, viral and mammalian sialidasesClostridium perfringens6
Structural and biochemical characterization of the broad substrate specificity of Bacteroides thetaiotaomicron commensal sialidaseBacteroides thetaiotaomicron5

Records

EnzymeOrganismSubstratekcat (s⁻¹)Km (mM)kcat/Km (mM⁻¹ s⁻¹)ConditionsPaper
A/Brescia neuraminidaseInfluenza A virusN-acetylneuraminyllactose—0.77—pH 6.8PMID 5816010Open
A/Brescia neuraminidaseInfluenza A virusN-acetylneuraminyllactose—0.89—pH 6.8PMID 5816010Open
A/Brescia neuraminidaseInfluenza A virusN-acetylneuraminyllactose—0.83—pH 6.8PMID 5816010Open
A/Chicken/Scotland/59 neuraminidaseInfluenza A virusN-acetylneuraminyllactose—0.87—pH 6.8PMID 5816010Open
A/Chicken/Scotland/59 neuraminidaseInfluenza A virusN-acetylneuraminyllactose—0.81—pH 6.8PMID 5816010Open
A/Dutch neuraminidaseInfluenza A virusN-acetylneuraminyllactose—2.5—pH 6.8PMID 5816010Open
A/Dutch neuraminidaseInfluenza A virusN-acetylneuraminyllactose—2.2—pH 6.8PMID 5816010Open
A/Rostock neuraminidaseInfluenza A virusN-acetylneuraminyllactose—1.4—pH 6.8PMID 5816010Open
A/Rostock neuraminidaseInfluenza A virusN-acetylneuraminyllactose—1.2—pH 6.8PMID 5816010Open
A/Rostock neuraminidaseInfluenza A virusN-acetylneuraminyllactose—1.3—pH 6.8PMID 5816010Open
A/Tern/South Africa/61 neuraminidaseInfluenza A virusN-acetylneuraminyllactose—0.8—pH 6.8PMID 5816010Open
A/Tern/South Africa/61 neuraminidaseInfluenza A virusN-acetylneuraminyllactose—0.69—pH 6.8PMID 5816010Open
A/Tern/South Africa/61 neuraminidaseInfluenza A virusN-acetylneuraminyllactose—0.75—pH 6.8PMID 5816010Open
A/Turkey/England/63 neuraminidaseInfluenza A virusN-acetylneuraminyllactose—0.87—pH 6.8PMID 5816010Open
A/Turkey/England/66 neuraminidaseInfluenza A virusN-acetylneuraminyllactoselike another record—0.8—pH 6.8PMID 5816010Open
A/Turkey/England/66 neuraminidaseInfluenza A virusN-acetylneuraminyllactoselike another record—0.8—pH 6.8PMID 5816010Open
A/Turkey/England/66 neuraminidaseInfluenza A virusN-acetylneuraminyllactoselike another record—0.8—pH 6.8PMID 5816010Open
A/Turkey/Massachusetts/65 neuraminidaseInfluenza A virusN-acetylneuraminyllactose—0.48—pH 6.8PMID 5816010Open
A/Turkey/Massachusetts/65 neuraminidaseInfluenza A virusN-acetylneuraminyllactose—0.43—pH 6.8PMID 5816010Open
A/Turkey/Massachusetts/65 neuraminidaseInfluenza A virusN-acetylneuraminyllactose—0.37—pH 6.8PMID 5816010Open
A/Turkey/Massachusetts/65 neuraminidaseInfluenza A virusN-acetylneuraminyllactose—0.44—pH 6.8PMID 5816010Open
A/Turkey/Wilmot/63 neuraminidaseInfluenza A virusN-acetylneuraminyllactoselike another record—0.8—pH 6.8PMID 5816010Open
A/Turkey/Wilmot/63 neuraminidaseInfluenza A virusN-acetylneuraminyllactoselike another record—0.8—pH 6.8PMID 5816010Open
A/Turkey/Wilmot/63 neuraminidaseInfluenza A virusN-acetylneuraminyllactoselike another record—0.8—pH 6.8PMID 5816010Open
A/Turkey/Wilmot/65 neuraminidaseInfluenza A virusN-acetylneuraminyllactose—0.65—pH 6.8PMID 5816010Open
A0/MEL/35 neuraminidaseInfluenza A virusN-acetylneuraminyllactose—0.33—pH 6.8PMID 5816010Open
A0/NWS/39 neuraminidaseInfluenza A virusN-acetylneuraminyllactose—0.29—pH 6.8PMID 5816010Open
A0/NWS/39 neuraminidaseInfluenza A virusN-acetylneuraminyllactose—0.42—pH 6.8PMID 5816010Open
A0/NWS/39 neuraminidaseInfluenza A virusN-acetylneuraminyllactose—0.33—pH 6.8PMID 5816010Open
A0/NWS/39 neuraminidaseInfluenza A virusN-acetylneuraminyllactose—0.35—pH 6.8PMID 5816010Open
A0/PR8/34 neuraminidaseInfluenza A virusN-acetylneuraminyllactoselike another record—0.26—pH 6.8PMID 5816010Open
A0/PR8/34 neuraminidaseInfluenza A virusN-acetylneuraminyllactoselike another record—0.26—pH 6.8PMID 5816010Open
A1/Firenze/68 neuraminidaseInfluenza A virusN-acetylneuraminyllactoselike another record—0.62—pH 6.8PMID 5816010Open
A1/Firenze/68 neuraminidaseInfluenza A virusN-acetylneuraminyllactoselike another record—0.62—pH 6.8PMID 5816010Open
A1/Firenze/68 neuraminidaseInfluenza A virusN-acetylneuraminyllactoselike another record—0.62—pH 6.8PMID 5816010Open
A1/HAL/51 neuraminidaseInfluenza A virusN-acetylneuraminyllactose—0.53—pH 6.8PMID 5816010Open
A1/HAL/51 neuraminidaseInfluenza A virusN-acetylneuraminyllactose—0.58—pH 6.8PMID 5816010Open
A1/HAL/51 neuraminidaseInfluenza A virusN-acetylneuraminyllactose—0.56—pH 6.8PMID 5816010Open
A2/Hong Kong/68 neuraminidaseInfluenza A virusN-acetylneuraminyllactoselike another record—0.59—pH 6.8PMID 5816010Open
A2/Hong Kong/68 neuraminidaseInfluenza A virusN-acetylneuraminyllactoselike another record—0.59—pH 6.8PMID 5816010Open
A2/Hong Kong/68 neuraminidaseInfluenza A virusN-acetylneuraminyllactose—0.62—pH 6.8PMID 5816010Open
A2/Hong Kong/68 neuraminidaseInfluenza A virusN-acetylneuraminyllactose—0.6—pH 6.8PMID 5816010Open
A2/Singapore/57 neuraminidaseInfluenza A virusN-acetylneuraminyllactose—1.8—pH 6.8PMID 5816010Open
A2/Singapore/57 neuraminidaseInfluenza A virusN-acetylneuraminyllactoselike another record—1.3—pH 6.8PMID 5816010Open
A2/Singapore/57 neuraminidaseInfluenza A virusN-acetylneuraminyllactoselike another record—1.1—pH 6.8PMID 5816010Open
A2/Singapore/57 neuraminidaseInfluenza A virusN-acetylneuraminyllactoselike another record—1.1—pH 6.8PMID 5816010Open
A2/Singapore/57 neuraminidaseInfluenza A virusN-acetylneuraminyllactose—0.9—pH 6.8PMID 5816010Open
A2/Singapore/57 neuraminidaseInfluenza A virusN-acetylneuraminyllactoselike another record—1.3—pH 6.8PMID 5816010Open
A2/Singapore/57 neuraminidaseInfluenza A virusN-acetylneuraminyllactoselike another record—1.3—pH 6.8PMID 5816010Open
A2/Singapore/57 neuraminidaseInfluenza A virusN-acetylneuraminyllactose—0.97—pH 6.8PMID 5816010Open
A2/Singapore/57 plaque-forming variant neuraminidaseInfluenza A virusN-acetylneuraminyllactose—1.3—pH 6.8PMID 5816010Open
A2/Singapore/57 v-inhibitor-resistant variant neuraminidaseInfluenza A virusN-acetylneuraminyllactose—1.5—pH 6.8PMID 5816010Open
A2/Singapore/57 v-inhibitor-resistant variant neuraminidaseInfluenza A virusN-acetylneuraminyllactose—1.3—pH 6.8PMID 5816010Open
A2/Tokyo/67 neuraminidaseInfluenza A virusN-acetylneuraminyllactoselike another record—0.5—pH 6.8PMID 5816010Open
A2/Tokyo/67 neuraminidaseInfluenza A virusN-acetylneuraminyllactoselike another record—0.5—pH 6.8PMID 5816010Open
A2/Tokyo/67 neuraminidaseInfluenza A virusN-acetylneuraminyllactose—0.47—pH 6.8PMID 5816010Open
A2/Tokyo/67 neuraminidaseInfluenza A virusN-acetylneuraminyllactose—0.49—pH 6.8PMID 5816010Open
B/England/65 neuraminidaseInfluenza B virusN-acetylneuraminyllactoselike another record—0.26—pH 6.8PMID 5816010Open
B/England/65 neuraminidaseInfluenza B virusN-acetylneuraminyllactoselike another record—0.26—pH 6.8PMID 5816010Open
B/England/65 neuraminidaseInfluenza B virusN-acetylneuraminyllactoselike another record—0.26—pH 6.8PMID 5816010Open
B/LEE/40 neuraminidaseInfluenza B virusN-acetylneuraminyllactose—0.32—pH 6.8PMID 5816010Open
B/LEE/40 neuraminidaseInfluenza B virusN-acetylneuraminyllactose—0.33—pH 6.8PMID 5816010Open
B/LEE/40 neuraminidaseInfluenza B virusN-acetylneuraminyllactose—0.22—pH 6.8PMID 5816010Open
B/LEE/40 neuraminidaseInfluenza B virusN-acetylneuraminyllactose—0.21—pH 6.8PMID 5816010Open
B/LEE/40 neuraminidaseInfluenza B virusN-acetylneuraminyllactose—0.25—pH 6.8PMID 5816010Open
B/LEE/40 neuraminidaseInfluenza B virusN-acetylneuraminyllactose—0.26—pH 6.8PMID 5816010Open
B/ROB/55 neuraminidaseInfluenza B virusN-acetylneuraminyllactose—0.26—pH 6.8PMID 5816010Open
B/ROB/55 neuraminidaseInfluenza B virusN-acetylneuraminyllactose—0.23—pH 6.8PMID 5816010Open
B/ROB/55 neuraminidaseInfluenza B virusN-acetylneuraminyllactose—0.4—pH 6.8PMID 5816010Open
B/ROB/55 neuraminidaseInfluenza B virusN-acetylneuraminyllactoselike another record—0.27—pH 6.8PMID 5816010Open
B/ROB/55 neuraminidaseInfluenza B virusN-acetylneuraminyllactose—0.29—pH 6.8PMID 5816010Open
B/ROB/55 neuraminidaseInfluenza B virusN-acetylneuraminyllactoselike another record—0.27—pH 6.8PMID 5816010Open
cytosolic sialidase HsNEU2Homo sapiens4-methylumbelliferyl α-N-acetyl-D-neuraminic acid—0.44—pH 5.6, 37 °CPMID 14613940Open
cytosolic sialidase HsNEU2Homo sapiensGD1awithout detergent; GD1a as homogeneous micelles—0.91—pH 5.6, 37 °CPMID 14613940Open
cytosolic sialidase HsNEU2Homo sapiensGD1awith 0.02% (w/v) Triton X-100—0.14—pH 5.6, 37 °CPMID 14613940Open
cytosolic sialidase HsNEU2Homo sapiensGD1bwithout detergent; GD1b as homogeneous micelles—0.59—pH 5.6, 37 °CPMID 14613940Open
cytosolic sialidase HsNEU2Homo sapiensGD1bwith 0.02% (w/v) Triton X-100—0.51—pH 5.6, 37 °CPMID 14613940Open
cytosolic sialidase HsNEU2Homo sapiensGM1GM1 1-20 nM—1 × 10⁻⁵—pH 5.6, 37 °CPMID 14613940Open
cytosolic sialidase HsNEU2Homo sapiensGM1—1.5 × 10⁻⁵—pH 5.6, 37 °CPMID 14613940Open
cytosolic sialidase HsNEU2Homo sapiensGM3without detergent; GM3 as homogeneous vesicles—0.4—pH 5.6, 37 °CPMID 14613940Open
cytosolic sialidase HsNEU2Homo sapiensGM3with 0.02% (w/v) Triton X-100—0.24—pH 5.6, 37 °CPMID 14613940Open
cytosolic sialidase HsNEU2Homo sapiensGT1bwithout detergent; GT1b as homogeneous micelles—0.62—pH 5.6, 37 °CPMID 14613940Open
cytosolic sialidase HsNEU2Homo sapiensGT1bwith 0.02% (w/v) Triton X-100—0.38—pH 5.6, 37 °CPMID 14613940Open
cytosolic sialidase HsNEU2Homo sapiensα2→3 sialosylparaglobosidewithout detergent; α2→3SPG as homogeneous micelles—0.43—pH 5.6, 37 °CPMID 14613940Open
cytosolic sialidase HsNEU2Homo sapiensα2→3 sialosylparaglobosidewith 0.02% (w/v) Triton X-100—0.28—pH 5.6, 37 °CPMID 14613940Open
cytosolic sialidase HsNEU2Homo sapiensα2→3 sialyllactose—0.31—pH 5.6, 37 °CPMID 14613940Open
human membrane-associated ganglioside sialidaseHomo sapiensganglioside GD1a—0.047—pH 4.6, 37 °CPMID 11298736Open
human membrane-associated ganglioside sialidaseHomo sapiensganglioside GM2—0.0776—pH 4.6, 37 °CPMID 11298736Open
human membrane-associated ganglioside sialidasevariant E51DHomo sapiensganglioside GD1a—0.04—pH 4.6, 37 °CPMID 11298736Open
human membrane-associated ganglioside sialidasevariant E51DHomo sapiensganglioside GM2—0.0617—pH 4.6, 37 °CPMID 11298736Open
human membrane-associated ganglioside sialidasevariant G162AHomo sapiensganglioside GD1a—0.037—pH 4.6, 37 °CPMID 11298736Open
human membrane-associated ganglioside sialidasevariant N88DHomo sapiensganglioside GD1a—0.032—pH 4.6, 37 °CPMID 11298736Open
human membrane-associated ganglioside sialidasevariant R114AHomo sapiensganglioside GD1a—0.043—pH 4.6, 37 °CPMID 11298736Open
human membrane-associated ganglioside sialidasevariant R114AHomo sapiensganglioside GM2—0.0855—pH 4.6, 37 °CPMID 11298736Open
human membrane-associated ganglioside sialidasevariant R114QHomo sapiensganglioside GD1a—0.041—pH 4.6, 37 °CPMID 11298736Open
human membrane-associated ganglioside sialidasevariant R114QHomo sapiensganglioside GM2—0.051—pH 4.6, 37 °CPMID 11298736Open
human membrane-associated ganglioside sialidasevariant R25HHomo sapiensganglioside GD1a—0.038—pH 4.6, 37 °CPMID 11298736Open
human membrane-associated ganglioside sialidasevariant V107MHomo sapiensganglioside GD1a—0.046—pH 4.6, 37 °CPMID 11298736Open
human membrane-associated ganglioside sialidasevariant Y370CHomo sapiensganglioside GD1a—0.031—pH 4.6, 37 °CPMID 11298736Open
neuraminidase (lysosomal sialidase)Homo sapiens2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid—0.136—pH 4.3, 37 °CPMID 6811161Open
neuraminidase (lysosomal sialidase)variant patient cell line A.R. (sialidosis 2 juvenile onset (dysmorphic); mutation not characterized)Homo sapiens2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid—1.19—pH 4.3, 37 °CPMID 6811161Open
neuraminidase (lysosomal sialidase)variant patient cell line B.J. (sialidosis 1 (normomorphic); mutation not characterized)Homo sapiens2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid—0.144—pH 4.3, 37 °CPMID 6811161Open
neuraminidase (lysosomal sialidase)variant patient cell line F.A. (mucolipidosis II; mutation not characterized)Homo sapiens2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid—0.151—pH 4.3, 37 °CPMID 6811161Open
neuraminidase (lysosomal sialidase)variant patient cell line GM 1494 (mucolipidosis III; mutation not characterized)Homo sapiens2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid—0.123—pH 4.3, 37 °CPMID 6811161Open
neuraminidase (lysosomal sialidase)variant patient cell line GM 1718 (sialidosis 2 infantile onset (dysmorphic); mutation not characterized)Homo sapiens2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid—1.48—pH 4.3, 37 °CPMID 6811161Open
neuraminidase (lysosomal sialidase)variant patient cell line GM 2048 (mucolipidosis IV; mutation not characterized)Homo sapiens2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid—0.152—pH 4.3, 37 °CPMID 6811161Open
neuraminidase (lysosomal sialidase)variant patient cell line GM 2065 (mucolipidosis III; mutation not characterized)Homo sapiens2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid—0.149—pH 4.3, 37 °CPMID 6811161Open
neuraminidase (lysosomal sialidase)variant patient cell line GM 2527 (mucolipidosis IV; mutation not characterized)Homo sapiens2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid—0.151—pH 4.3, 37 °CPMID 6811161Open
neuraminidase (lysosomal sialidase)variant patient cell line GM 2685 (sialidosis 2 infantile onset (dysmorphic); mutation not characterized)Homo sapiens2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid—1.12—pH 4.3, 37 °CPMID 6811161Open
neuraminidase (lysosomal sialidase)variant patient cell line M.K. (GM1 gangliosidosis I; mutation not characterized)Homo sapiens2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid—0.143—pH 4.3, 37 °CPMID 6811161Open
neuraminidase (lysosomal sialidase)variant patient cell line M.L. (sialidosis 1 (normomorphic); mutation not characterized)Homo sapiens2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid—0.148—pH 4.3, 37 °CPMID 6811161Open
neuraminidase (lysosomal sialidase)variant patient cell line N.G. (mucolipidosis II; mutation not characterized)Homo sapiens2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid—0.129—pH 4.3, 37 °CPMID 6811161Open
neuraminidase (lysosomal sialidase)variant patient cell line T.R. (GM1 gangliosidosis II; mutation not characterized)Homo sapiens2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid—0.137—pH 4.3, 37 °CPMID 6811161Open
neuraminidase (lysosomal sialidase)variant patient cell line [15] (sialidosis 1 (normomorphic); mutation not characterized)Homo sapiens2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid—0.154—pH 4.3, 37 °CPMID 6811161Open
neuraminidase (lysosomal sialidase)variant patient cell line [16] (sialidosis 2 juvenile onset (dysmorphic); mutation not characterized)Homo sapiens2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid—1.01—pH 4.3, 37 °CPMID 6811161Open
neuraminidase (lysosomal sialidase)variant patient cell line [17] (sialidosis 2 juvenile onset (dysmorphic); mutation not characterized)Homo sapiens2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid—1.05—pH 4.3, 37 °CPMID 6811161Open
neuraminidase (N1 NA) A/Fort Monmouth/1/47Influenza A virus2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acidno added Ca2+—0.045—pH 5.9, 37 °CPMID 16567409Open
neuraminidase (N1 NA) A/Fort Monmouth/1/47Influenza A virus2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid50 mM Ca2+ (CaCl2)—0.041—pH 5.9, 37 °CPMID 16567409Open
neuraminidase (N1 NA) A/Puerto Rico/8/34Influenza A virus2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acidno added Ca2+—0.047—pH 5.9, 37 °CPMID 16567409Open
neuraminidase (N1 NA) A/Puerto Rico/8/34Influenza A virus2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid50 mM Ca2+ (CaCl2)—0.045—pH 5.9, 37 °CPMID 16567409Open
neuraminidase (N1 NA) A/Taiwan/1/86Influenza A virus2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acidno added Ca2+—0.046—pH 5.9, 37 °CPMID 16567409Open
neuraminidase (N1 NA) A/Taiwan/1/86Influenza A virus2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid50 mM Ca2+ (CaCl2)—0.044—pH 5.9, 37 °CPMID 16567409Open
neuraminidase (N1 NA) A/Texas/36/91Influenza A virus2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acidno added Ca2+—0.041—pH 5.9, 37 °CPMID 16567409Open
neuraminidase (N1 NA) A/Texas/36/91Influenza A virus2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid50 mM Ca2+ (CaCl2)—0.04—pH 5.9, 37 °CPMID 16567409Open
neuraminidase (N1 NA) A/USSR/90/77Influenza A virus2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acidno added Ca2+—0.049—pH 5.9, 37 °CPMID 16567409Open
neuraminidase (N1 NA) A/USSR/90/77Influenza A virus2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid50 mM Ca2+ (CaCl2)—0.043—pH 5.9, 37 °CPMID 16567409Open
neuraminidase (N1 NA) A/Weiss/43Influenza A virus2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acidno added Ca2+—0.062—pH 5.9, 37 °CPMID 16567409Open
neuraminidase (N1 NA) A/Weiss/43Influenza A virus2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid50 mM Ca2+ (CaCl2)—0.063—pH 5.9, 37 °CPMID 16567409Open
neuraminidase (NA)Influenza B virus2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid0.50.04810.4pH 6, 37 °CPMID 9874196Open
neuraminidase (NA)variant D149EInfluenza B virus2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid0.030.0074.3pH 6, 37 °CPMID 9874196Open
neuraminidase (NA)variant E117GInfluenza B virus2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid0.10.0166.2pH 6, 37 °CPMID 9874196Open
neuraminidase (NA)variant E275DInfluenza B virus2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid0.018 × 10⁻⁴12.5pH 6, 37 °CPMID 9874196Open
neuraminidase (NA)variant R150KInfluenza B virus2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid0.30.0310pH 6, 37 °CPMID 9874196Open
neuraminidase (NA)variant R223KInfluenza B virus2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid0.170.0266.5pH 6, 37 °CPMID 9874196Open
neuraminidase (NA)variant R374KInfluenza B virus2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid0.110.0652pH 6, 37 °CPMID 9874196Open
neuraminidase (NA)variant R374NInfluenza B virus2-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid0.020.0330.6pH 6, 37 °CPMID 9874196Open
neuraminidase (NA2009)Influenza A virus2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid0.91.10.8237 °CPMID 29933553Open
neuraminidase (NA2009)variant H275YInfluenza A virus2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid0.0541.10.04837 °CPMID 29933553Open
neuraminidase (NA2009)variant H275Y/I223VInfluenza A virus2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid0.0451.30.03537 °CPMID 29933553Open
neuraminidase (NA2009)variant H275Y/S247NInfluenza A virus2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid0.13.30.03137 °CPMID 29933553Open
neuraminidase (NA2009)variant I223VInfluenza A virus2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid0.61.20.5137 °CPMID 29933553Open
neuraminidase (NA2009)variant S247NInfluenza A virus2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid0.171.10.1637 °CPMID 29933553Open
neuraminidase 3 (NEU3)Homo sapiens2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid0.00640.0450.14 calc.pH 5, 37 °CPMID 20511247Open
neuraminidase 3 (NEU3)variant A160GHomo sapiens2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid0.00750.0210.36 calc.pH 5, 37 °CPMID 20511247Open
neuraminidase 3 (NEU3)variant E51SHomo sapiens2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid0.01420.0380.37 calc.pH 5, 37 °CPMID 20511247Open
neuraminidase 3 (NEU3)variant H277FHomo sapiens2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid0.00750.0180.42 calc.pH 5, 37 °CPMID 20511247Open
neuraminidase 3 (NEU3)variant M87GHomo sapiens2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid0.00220.140.016 calc.pH 5, 37 °CPMID 20511247Open
neuraminidase 3 (NEU3)variant R48NHomo sapiens2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid0.00890.0330.27 calc.pH 5, 37 °CPMID 20511247Open
neuraminidase 3 (NEU3)variant R48SHomo sapiens2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid0.01220.0320.38 calc.pH 5, 37 °CPMID 20511247Open
sialidaseClostridium perfringensN-acetylneuraminyl-(2->3)-lactose—0.4—pH 5.1PMID 7325957Open
sialidaseClostridium perfringensN-acetylneuraminyl-(2->6)-N-acetylgalactosamine—0.5—pH 5.1PMID 7325957Open
sialidaseClostridium perfringensN-acetylneuraminyl-(alpha2->3)-galactosyl-(beta1->4)-glucosyl-(beta1->1)-ceramide (ganglioside GM3)—1.4—pH 5.1PMID 7325957Open
sialidaseClostridium perfringensN-glycolloylneuraminyl-(2->3)-lactose—6.6—pH 5.1PMID 7325957Open
sialidaseClostridium perfringensN-glycolloylneuraminyl-(2->6)-N-acetylgalactosamine—2.6—pH 5.1PMID 7325957Open
sialidaseClostridium perfringensN-glycolloylneuraminyl-(alpha2->3)-galactosyl-(beta1->4)-glucosyl-(beta1->1)-ceramide (ganglioside GM3)—0.05—pH 5.1PMID 7325957Open
sialidase (BTSA)Bacteroides thetaiotaomicron2'-(4-methylumbelliferyl)-alpha-D-N-acetylneuraminic acid146.70.16916.9pH 7, 37 °CPMID 23665536Open
sialidase (BTSA)Bacteroides thetaiotaomicroncolominic acid (alpha-2,8-linked polysialic acid)157.6——pH 7, 37 °CPMID 23665536Open
sialidase (BTSA)Bacteroides thetaiotaomicronp-nitrophenyl-alpha-D-N-acetylneuraminic acid82.40.11729.2pH 7, 37 °CPMID 23665536Open
sialidase (BTSA)Bacteroides thetaiotaomicronsialyl-alpha-2,3-lactose (Neu5Acalpha2,3Galbeta1,4Glc)313.51.47213.3pH 7, 37 °CPMID 23665536Open
sialidase (BTSA)Bacteroides thetaiotaomicronsialyl-alpha-2,6-lactose (Neu5Acalpha2,6Galbeta1,4Glc)1610.49328.6pH 7, 37 °CPMID 23665536Open
SiaPGPorphyromonas gingivalis3-sialyllactose5.9472.2342.7pH 7.4PMID 31517596Open
SiaPGPorphyromonas gingivalis4-methylumbelliferyl-N-acetylneuraminic acid200 mM NaCl13.160.0158832pH 7.4PMID 31517596Open
SiaPGPorphyromonas gingivalis4-methylumbelliferyl-N-acetylneuraminic acidno added NaCl6.2470.0103607pH 7.4PMID 31517596Open
SiaPGPorphyromonas gingivalis4-methylumbelliferyl-N-acetylneuraminic acid200 mM NaCl31.930.01192683pH 5.6PMID 31517596Open
SiaPGPorphyromonas gingivalis4-methylumbelliferyl-N-acetylneuraminic acidno added NaCl23.470.01132078pH 5.6PMID 31517596Open
SiaPGPorphyromonas gingivalis6-sialyllactose1.2400.68491.8pH 7.4PMID 31517596Open
Virus 'N' neuraminidaseInfluenza A virusN-acetylneuraminyllactose—1.8—pH 6.8PMID 5816010Open
Virus 'N' neuraminidaseInfluenza A virusN-acetylneuraminyllactose—2—pH 6.8PMID 5816010Open