EC 3.5.1.2: glutaminase

HydrolasesOpen in Browse

CatLog read 125 records for EC 3.5.1.2 from 10 papers, for 7 organisms. Names in these papers: imidazole glycerol phosphate synthase (IGP synthase), imidazole glycerol phosphate synthase, imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunit, GatCAB (Glu-tRNAGln/Asp-tRNAAsn amidotransferase) and 11 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 53 records for EC 3.5.1.2 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 3.5.1.2 in Browse.

Papers

Papers with records for EC 3.5.1.2
Paper	Organisms	Records
Substrate-induced changes in the ammonia channel for imidazole glycerol phosphate synthase	Saccharomyces cerevisiae	46
Reaction coupling through interdomain contacts in imidazole glycerol phosphate synthase	Saccharomyces cerevisiae	25
The Helicobacter pylori amidotransferase GatCAB is equally efficient in glutamine-dependent transamidation of Asp-tRNAAsn and Glu-tRNAGln	Helicobacter pylori	11
Altering the allosteric pathway in IGPS suppresses millisecond motions and catalytic activity	Thermotoga maritima	10
Glutamine Hydrolysis by Imidazole Glycerol Phosphate Synthase Displays Temperature Dependent Allosteric Activation	Thermotoga maritima	10
Functional and structural characterization of four glutaminases from Escherichia coli and Bacillus subtilis	Bacillus subtilis, Escherichia coli	8
Structure and enzymology of glutaminase S482C and H461L variants associated with excess brain glutamate and neurological disease	Homo sapiens	6
Full-length human glutaminase in complex with an allosteric inhibitor	Homo sapiens	5
Imidazole glycerol phosphate synthase from Thermotoga maritima. Quaternary structure, steady-state kinetics, and reaction mechanism of the bienzyme complex	Thermotoga maritima	2
Anticancer, antioxidant and antibacterial potential of L-Glutaminase (Streptomyces roseolus strain ZKB1) capped silver and zinc oxide nanoparticles and its molecular characterization	Streptomyces roseolus	2

Records

Records for EC 3.5.1.2 read from the paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Paper	Open record
GAC	Homo sapiens	L-glutamine	22	1.4	16	pH 8.5	PMID 22049910	Open record: GAC, L-glutamine
GACvariant F322S/F318Y	Homo sapiens	L-glutamine	40	2.5	16	pH 8.5	PMID 22049910	Open record: GAC variant F322S/F318Y, L-glutamine
GACvariant Y394L	Homo sapiens	L-glutamine	20	0.4	47	pH 8.5	PMID 22049910	Open record: GAC variant Y394L, L-glutamine
GatCAB (Glu-tRNAGln/Asp-tRNAAsn amidotransferase)	Helicobacter pylori	adenosine 5'-triphosphate	6.1	0.2068	29.5	pH 7.2, 37 °C	PMID 17329242	Open record: GatCAB (Glu-tRNAGln/Asp-tRNAAsn amidotransferase), adenosine 5'-triphosphate
GatCAB (Glu-tRNAGln/Asp-tRNAAsn amidotransferase)	Helicobacter pylori	L-asparagine	0.027	0.0224	1.2	pH 7.2, 37 °C	PMID 17329242	Open record: GatCAB (Glu-tRNAGln/Asp-tRNAAsn amidotransferase), L-asparagine
GatCAB (Glu-tRNAGln/Asp-tRNAAsn amidotransferase)	Helicobacter pylori	L-aspartyl-tRNA(Asn) (H. pylori tRNAAsn)	1.3	9.5 × 10⁻⁴	1368	pH 7.2, 37 °C	PMID 17329242	Open record: GatCAB (Glu-tRNAGln/Asp-tRNAAsn amidotransferase), L-aspartyl-tRNA(Asn) (H. pylori tRNAAsn)
GatCAB (Glu-tRNAGln/Asp-tRNAAsn amidotransferase)	Helicobacter pylori	L-glutamineamidotransferase (transamidation) assay; 1 nM enzyme	3.49	0.0207	168.6	pH 7.2, 37 °C	PMID 17329242	Open record: GatCAB (Glu-tRNAGln/Asp-tRNAAsn amidotransferase), L-glutamine
GatCAB (Glu-tRNAGln/Asp-tRNAAsn amidotransferase)	Helicobacter pylori	L-glutamineglutaminase assay (L-[14C]Gln -> Glu, cellulose TLC); no ATP	0.34	0.0265	12.8	pH 7.2, 37 °C	PMID 17329242	Open record: GatCAB (Glu-tRNAGln/Asp-tRNAAsn amidotransferase), L-glutamine
GatCAB (Glu-tRNAGln/Asp-tRNAAsn amidotransferase)	Helicobacter pylori	L-glutamineglutaminase assay (L-[14C]Gln -> Glu, cellulose TLC)	0.2	0.0119	16.8	pH 7.2, 37 °C	PMID 17329242	Open record: GatCAB (Glu-tRNAGln/Asp-tRNAAsn amidotransferase), L-glutamine
GatCAB (Glu-tRNAGln/Asp-tRNAAsn amidotransferase)	Helicobacter pylori	L-glutamineglutaminase assay (L-[14C]Gln -> Glu, cellulose TLC); no ATP	0.97	0.0383	25.3	pH 7.2, 37 °C	PMID 17329242	Open record: GatCAB (Glu-tRNAGln/Asp-tRNAAsn amidotransferase), L-glutamine
GatCAB (Glu-tRNAGln/Asp-tRNAAsn amidotransferase)	Helicobacter pylori	L-glutamineglutaminase assay (L-[14C]Gln -> Glu, cellulose TLC); no ATP	1.32	0.0557	23.7	pH 7.2, 37 °C	PMID 17329242	Open record: GatCAB (Glu-tRNAGln/Asp-tRNAAsn amidotransferase), L-glutamine
GatCAB (Glu-tRNAGln/Asp-tRNAAsn amidotransferase)	Helicobacter pylori	L-glutamineglutaminase assay (L-[14C]Gln -> Glu, cellulose TLC)	11.8	0.0402	293.5	pH 7.2, 37 °C	PMID 17329242	Open record: GatCAB (Glu-tRNAGln/Asp-tRNAAsn amidotransferase), L-glutamine
GatCAB (Glu-tRNAGln/Asp-tRNAAsn amidotransferase)	Helicobacter pylori	L-glutamineglutaminase assay (L-[14C]Gln -> Glu, cellulose TLC)	10.29	0.0509	202.2	pH 7.2, 37 °C	PMID 17329242	Open record: GatCAB (Glu-tRNAGln/Asp-tRNAAsn amidotransferase), L-glutamine
GatCAB (Glu-tRNAGln/Asp-tRNAAsn amidotransferase)	Helicobacter pylori	L-glutamyl-tRNA(Gln) (H. pylori tRNAGln)	3.61	0.00118	3059	pH 7.2, 37 °C	PMID 17329242	Open record: GatCAB (Glu-tRNAGln/Asp-tRNAAsn amidotransferase), L-glutamyl-tRNA(Gln) (H. pylori tRNAGln)
GLS1	Homo sapiens	L-glutamine	10	1.9	5.3	pH 8.5	PMID 22049910	Open record: GLS1, L-glutamine
GLS2	Homo sapiens	L-glutamine	2.5	4	0.63	pH 8.5	PMID 22049910	Open record: GLS2, L-glutamine
glutaminase C (GAC)	Homo sapiens	glutamine	16	—	—	pH 8.6	PMID 42055345	Open record: glutaminase C (GAC), glutamine
glutaminase C (GAC)variant H461L	Homo sapiens	glutamine	13.4	—	—	pH 8.6	PMID 42055345	Open record: glutaminase C (GAC) variant H461L, glutamine
glutaminase C (GAC)variant S482C	Homo sapiens	glutamine	13.1	—	—	pH 8.6	PMID 42055345	Open record: glutaminase C (GAC) variant S482C, glutamine
imidazole glycerol phosphate synthasevariant D359A	Saccharomyces cerevisiae	L-glutamineassay per ref 16; 1 h incubation	7.8 × 10⁻⁴	1.4	5.5 × 10⁻⁴		PMID 16142895	Open record: imidazole glycerol phosphate synthase variant D359A, L-glutamine
imidazole glycerol phosphate synthasevariant D359A	Saccharomyces cerevisiae	L-glutaminePRFAR fixed at 100 µM; assay per ref 16	0.004	4.2	0.001		PMID 16142895	Open record: imidazole glycerol phosphate synthase variant D359A, L-glutamine
imidazole glycerol phosphate synthasevariant D359A	Saccharomyces cerevisiae	L-glutaminereaction A (Figure 1); PRFAR fixed at 100 µM	0.0059	14	4.2 × 10⁻⁴		PMID 16142895	Open record: imidazole glycerol phosphate synthase variant D359A, L-glutamine
imidazole glycerol phosphate synthasevariant D359A	Saccharomyces cerevisiae	N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide	2.9 × 10⁻⁴	0.0055	0.52		PMID 16142895	Open record: imidazole glycerol phosphate synthase variant D359A, N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide
imidazole glycerol phosphate synthasevariant D359A	Saccharomyces cerevisiae	N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide	0.39	0.109	3.6	pH 7	PMID 16142895	Open record: imidazole glycerol phosphate synthase variant D359A, N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide
imidazole glycerol phosphate synthasevariant K196A	Saccharomyces cerevisiae	L-glutamineassay per ref 16; 1 h incubation	0.021	1.72	0.0127		PMID 16142895	Open record: imidazole glycerol phosphate synthase variant K196A, L-glutamine
imidazole glycerol phosphate synthasevariant K196A	Saccharomyces cerevisiae	L-glutaminePRFAR fixed at 100 µM; assay per ref 16	9.8	0.44	25		PMID 16142895	Open record: imidazole glycerol phosphate synthase variant K196A, L-glutamine
imidazole glycerol phosphate synthasevariant K196A	Saccharomyces cerevisiae	L-glutaminereaction A (Figure 1); PRFAR fixed at 100 µM	0.6	0.49	1.2		PMID 16142895	Open record: imidazole glycerol phosphate synthase variant K196A, L-glutamine
imidazole glycerol phosphate synthasevariant K196A	Saccharomyces cerevisiae	N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide	0.74	2.7 × 10⁻⁴	2.8 × 10³		PMID 16142895	Open record: imidazole glycerol phosphate synthase variant K196A, N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide
imidazole glycerol phosphate synthasevariant K196A	Saccharomyces cerevisiae	N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide	0.46	0.034	14	pH 7	PMID 16142895	Open record: imidazole glycerol phosphate synthase variant K196A, N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide
imidazole glycerol phosphate synthasevariant K196A/D359A	Saccharomyces cerevisiae	L-glutamineassay per ref 16; 1 h incubation	0.003	1.6	0.0022		PMID 16142895	Open record: imidazole glycerol phosphate synthase variant K196A/D359A, L-glutamine
imidazole glycerol phosphate synthasevariant K196A/D359A	Saccharomyces cerevisiae	L-glutaminePRFAR fixed at 100 µM; assay per ref 16	0.209	0.5	0.39		PMID 16142895	Open record: imidazole glycerol phosphate synthase variant K196A/D359A, L-glutamine
imidazole glycerol phosphate synthasevariant K196A/D359A	Saccharomyces cerevisiae	L-glutaminereaction A (Figure 1); PRFAR fixed at 100 µM	0.007	2.3	0.0032		PMID 16142895	Open record: imidazole glycerol phosphate synthase variant K196A/D359A, L-glutamine
imidazole glycerol phosphate synthasevariant K196A/D359A	Saccharomyces cerevisiae	N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide	0.007	0.0141	0.51		PMID 16142895	Open record: imidazole glycerol phosphate synthase variant K196A/D359A, N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide
imidazole glycerol phosphate synthasevariant K196A/D359A	Saccharomyces cerevisiae	N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide	0.11	0.026	3.8	pH 7	PMID 16142895	Open record: imidazole glycerol phosphate synthase variant K196A/D359A, N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide
imidazole glycerol phosphate synthasevariant N13A	Saccharomyces cerevisiae	L-glutamineassay per ref 16; 1 h incubation	0.0014	6.2	2.3 × 10⁻⁴		PMID 16142895	Open record: imidazole glycerol phosphate synthase variant N13A, L-glutamine
imidazole glycerol phosphate synthasevariant N13A	Saccharomyces cerevisiae	L-glutaminePRFAR fixed at 100 µM; assay per ref 16	0.1	5	0.023		PMID 16142895	Open record: imidazole glycerol phosphate synthase variant N13A, L-glutamine
imidazole glycerol phosphate synthasevariant N13A	Saccharomyces cerevisiae	L-glutaminereaction A (Figure 1); PRFAR fixed at 100 µM	0.019	4.8	0.004		PMID 16142895	Open record: imidazole glycerol phosphate synthase variant N13A, L-glutamine
imidazole glycerol phosphate synthasevariant N13A	Saccharomyces cerevisiae	N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide	0.0112	0.0013	9		PMID 16142895	Open record: imidazole glycerol phosphate synthase variant N13A, N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide
imidazole glycerol phosphate synthasevariant N13A	Saccharomyces cerevisiae	N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide	0.35	0.071	4.9	pH 7	PMID 16142895	Open record: imidazole glycerol phosphate synthase variant N13A, N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide
imidazole glycerol phosphate synthasevariant Q397A	Saccharomyces cerevisiae	L-glutamineassay per ref 16; 1 h incubation	0.0018	8.3	2.2 × 10⁻⁴		PMID 16142895	Open record: imidazole glycerol phosphate synthase variant Q397A, L-glutamine
imidazole glycerol phosphate synthasevariant Q397A	Saccharomyces cerevisiae	L-glutaminePRFAR fixed at 100 µM; assay per ref 16	1.1	2.5	0.45		PMID 16142895	Open record: imidazole glycerol phosphate synthase variant Q397A, L-glutamine
imidazole glycerol phosphate synthasevariant Q397A	Saccharomyces cerevisiae	L-glutaminereaction A (Figure 1); PRFAR fixed at 100 µM	1.4	7	0.21		PMID 16142895	Open record: imidazole glycerol phosphate synthase variant Q397A, L-glutamine
imidazole glycerol phosphate synthasevariant Q397A	Saccharomyces cerevisiae	N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide	0.56	0.0036	160		PMID 16142895	Open record: imidazole glycerol phosphate synthase variant Q397A, N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide
imidazole glycerol phosphate synthasevariant Q397A	Saccharomyces cerevisiae	N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide	0.38	0.03	12	pH 7	PMID 16142895	Open record: imidazole glycerol phosphate synthase variant Q397A, N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide
imidazole glycerol phosphate synthase (IGP synthase)	Saccharomyces cerevisiae	L-glutamine	6.9	1.8	3.8		PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase), L-glutamine
imidazole glycerol phosphate synthase (IGP synthase)	Saccharomyces cerevisiae	L-glutamine1 h incubation; Table 5	0.0055	4.7	0.00118	pH 7, 30 °C	PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase), L-glutamine
imidazole glycerol phosphate synthase (IGP synthase)	Saccharomyces cerevisiae	L-glutaminePRFAR constant at 100 µM; 15 min incubation; Table 5	6.8	1.2	5.8	pH 7, 30 °C	PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase), L-glutamine
imidazole glycerol phosphate synthase (IGP synthase)	Saccharomyces cerevisiae	L-glutamineno PRFAR; effector concentration not stated; Table 3	2.15	0.9	2.3	pH 7, 30 °C	PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase), L-glutamine
imidazole glycerol phosphate synthase (IGP synthase)	Saccharomyces cerevisiae	L-glutamineno PRFAR; effector concentration not stated; Table 3	0.14	1.1	0.13	pH 7, 30 °C	PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase), L-glutamine
imidazole glycerol phosphate synthase (IGP synthase)	Saccharomyces cerevisiae	L-glutamineno PRFAR; effector concentration not stated; Table 3	0.06	1.8	0.031	pH 7, 30 °C	PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase), L-glutamine
imidazole glycerol phosphate synthase (IGP synthase)	Saccharomyces cerevisiae	L-glutamineno PRFAR; effector concentration not stated; Table 3	0.04	0.5	0.084	pH 7, 30 °C	PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase), L-glutamine
imidazole glycerol phosphate synthase (IGP synthase)	Saccharomyces cerevisiae	L-glutamineno PRFAR; effector concentration not stated; Table 3	0.12	0.3	0.38	pH 7, 30 °C	PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase), L-glutamine
imidazole glycerol phosphate synthase (IGP synthase)	Saccharomyces cerevisiae	L-glutamineno PRFAR; effector concentration not stated; Table 3	0.14	1.8	0.078	pH 7, 30 °C	PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase), L-glutamine
imidazole glycerol phosphate synthase (IGP synthase)	Saccharomyces cerevisiae	N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide	5.4	0.005	1.2 × 10³		PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase), N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide
imidazole glycerol phosphate synthase (IGP synthase)	Saccharomyces cerevisiae	N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide	0.845	0.055	15	pH 7	PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase), N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide
imidazole glycerol phosphate synthase (IGP synthase)variant K258A	Saccharomyces cerevisiae	L-glutamine	0.025	6.5	0.0036		PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase) variant K258A, L-glutamine
imidazole glycerol phosphate synthase (IGP synthase)variant K258A	Saccharomyces cerevisiae	L-glutamine1 h incubation	0.0081	2.7	0.0031	pH 7, 30 °C	PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase) variant K258A, L-glutamine
imidazole glycerol phosphate synthase (IGP synthase)variant K258A	Saccharomyces cerevisiae	L-glutaminePRFAR constant at 100 µM; 15 min incubation	0.172	1.2	0.14	pH 7, 30 °C	PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase) variant K258A, L-glutamine
imidazole glycerol phosphate synthase (IGP synthase)variant K258A	Saccharomyces cerevisiae	N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide	0.045	0.098	0.46		PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase) variant K258A, N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide
imidazole glycerol phosphate synthase (IGP synthase)variant K258A	Saccharomyces cerevisiae	N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide	0.0054	0.139	0.039	pH 7	PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase) variant K258A, N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide
imidazole glycerol phosphate synthase (IGP synthase)variant K258R	Saccharomyces cerevisiae	L-glutamine	0.159	1.9	0.084		PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase) variant K258R, L-glutamine
imidazole glycerol phosphate synthase (IGP synthase)variant K258R	Saccharomyces cerevisiae	L-glutamine1 h incubation	0.0075	3.3	0.0023	pH 7, 30 °C	PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase) variant K258R, L-glutamine
imidazole glycerol phosphate synthase (IGP synthase)variant K258R	Saccharomyces cerevisiae	L-glutaminePRFAR constant at 100 µM; 15 min incubation	0.164	0.64	0.26	pH 7, 30 °C	PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase) variant K258R, L-glutamine
imidazole glycerol phosphate synthase (IGP synthase)variant K258R	Saccharomyces cerevisiae	N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide	0.126	0.002	60		PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase) variant K258R, N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide
imidazole glycerol phosphate synthase (IGP synthase)variant K258R	Saccharomyces cerevisiae	N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide	0.005	0.046	0.12	pH 7	PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase) variant K258R, N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide
imidazole glycerol phosphate synthase (IGP synthase)variant K360A	Saccharomyces cerevisiae	L-glutamine	0.49	1.96	0.247		PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase) variant K360A, L-glutamine
imidazole glycerol phosphate synthase (IGP synthase)variant K360A	Saccharomyces cerevisiae	L-glutamine1 h incubation	0.002	4.4	4.5 × 10⁻⁴	pH 7, 30 °C	PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase) variant K360A, L-glutamine
imidazole glycerol phosphate synthase (IGP synthase)variant K360A	Saccharomyces cerevisiae	L-glutaminePRFAR constant at 100 µM; 15 min incubation	7.8	1.9	4.1	pH 7, 30 °C	PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase) variant K360A, L-glutamine
imidazole glycerol phosphate synthase (IGP synthase)variant K360A	Saccharomyces cerevisiae	N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide	0.24	0.0018	130		PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase) variant K360A, N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide
imidazole glycerol phosphate synthase (IGP synthase)variant K360A	Saccharomyces cerevisiae	N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide	0.7	0.065	11	pH 7	PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase) variant K360A, N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide
imidazole glycerol phosphate synthase (IGP synthase)variant K360R	Saccharomyces cerevisiae	L-glutamine	1.13	1.9	0.59		PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase) variant K360R, L-glutamine
imidazole glycerol phosphate synthase (IGP synthase)variant K360R	Saccharomyces cerevisiae	L-glutamine1 h incubation	0.00131	1.7	7 × 10⁻⁴	pH 7, 30 °C	PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase) variant K360R, L-glutamine
imidazole glycerol phosphate synthase (IGP synthase)variant K360R	Saccharomyces cerevisiae	L-glutaminePRFAR constant at 100 µM; 15 min incubation	0.61	1.24	0.49	pH 7, 30 °C	PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase) variant K360R, L-glutamine
imidazole glycerol phosphate synthase (IGP synthase)variant K360R	Saccharomyces cerevisiae	N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide	0.29	0.0023	110		PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase) variant K360R, N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide
imidazole glycerol phosphate synthase (IGP synthase)variant K360R	Saccharomyces cerevisiae	N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide	0.31	0.072	4.3	pH 7	PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase) variant K360R, N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide
imidazole glycerol phosphate synthase (IGP synthase)variant R239A	Saccharomyces cerevisiae	L-glutamine	0.0069	6.5	0.0011		PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase) variant R239A, L-glutamine
imidazole glycerol phosphate synthase (IGP synthase)variant R239A	Saccharomyces cerevisiae	L-glutamine1 h incubation	0.0014	2.3	6 × 10⁻⁴	pH 7, 30 °C	PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase) variant R239A, L-glutamine
imidazole glycerol phosphate synthase (IGP synthase)variant R239A	Saccharomyces cerevisiae	L-glutaminePRFAR constant at 100 µM; 15 min incubation	0.18	0.35	0.52	pH 7, 30 °C	PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase) variant R239A, L-glutamine
imidazole glycerol phosphate synthase (IGP synthase)variant R239A	Saccharomyces cerevisiae	N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide	0.0043	0.003	1.4		PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase) variant R239A, N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide
imidazole glycerol phosphate synthase (IGP synthase)variant R239A	Saccharomyces cerevisiae	N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide	0.15	0.053	2.8	pH 7	PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase) variant R239A, N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide
imidazole glycerol phosphate synthase (IGP synthase)variant R239H	Saccharomyces cerevisiae	L-glutamine	0.006	2.1	0.0028		PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase) variant R239H, L-glutamine
imidazole glycerol phosphate synthase (IGP synthase)variant R239H	Saccharomyces cerevisiae	L-glutamine1 h incubation	0.0016	0.8	0.0021	pH 7, 30 °C	PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase) variant R239H, L-glutamine
imidazole glycerol phosphate synthase (IGP synthase)variant R239H	Saccharomyces cerevisiae	L-glutaminePRFAR constant at 100 µM; 15 min incubation	0.24	1.62	0.15	pH 7, 30 °C	PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase) variant R239H, L-glutamine
imidazole glycerol phosphate synthase (IGP synthase)variant R239H	Saccharomyces cerevisiae	N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide	0.039	0.0079	0.5		PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase) variant R239H, N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide
imidazole glycerol phosphate synthase (IGP synthase)variant R239H	Saccharomyces cerevisiae	N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide	0.21	0.075	2.9	pH 7	PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase) variant R239H, N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide
imidazole glycerol phosphate synthase (IGP synthase)variant R239K	Saccharomyces cerevisiae	L-glutamine	0.009	1.3	0.007		PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase) variant R239K, L-glutamine
imidazole glycerol phosphate synthase (IGP synthase)variant R239K	Saccharomyces cerevisiae	L-glutamine1 h incubation	5 × 10⁻⁴	0.6	8 × 10⁻⁴	pH 7, 30 °C	PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase) variant R239K, L-glutamine
imidazole glycerol phosphate synthase (IGP synthase)variant R239K	Saccharomyces cerevisiae	L-glutaminePRFAR constant at 100 µM; 15 min incubation	0.366	1.04	0.35	pH 7, 30 °C	PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase) variant R239K, L-glutamine
imidazole glycerol phosphate synthase (IGP synthase)variant R239K	Saccharomyces cerevisiae	N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide	0.0087	0.0016	5.5		PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase) variant R239K, N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide
imidazole glycerol phosphate synthase (IGP synthase)variant R239K	Saccharomyces cerevisiae	N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide	0.3	0.08	3.8	pH 7	PMID 12795596	Open record: imidazole glycerol phosphate synthase (IGP synthase) variant R239K, N1-[(5'-phosphoribulosyl)-formimino]-5-aminoimidazole-4-carboxamide ribonucleotide
imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunit	Thermotoga maritima	L-glutamine	3.62	1.74	2.08	pH 8, 30 °C	PMID 28396388	Open record: imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunit, L-glutamine
imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunit	Thermotoga maritima	L-glutaminebasal: no PRFAR	0.00165	3.57	4.6 × 10⁻⁴	pH 8, 30 °C	PMID 28396388	Open record: imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunit, L-glutamine
imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunit	Thermotoga maritima	L-glutamine	4.09	1.3	3.15	pH 8, 30 °C	PMID 29468164	Open record: imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunit, L-glutamine
imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunit	Thermotoga maritima	L-glutaminebasal: no PRFAR	0.00372	4.91	7.58 × 10⁻⁴	pH 8, 30 °C	PMID 29468164	Open record: imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunit, L-glutamine
imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunit	Thermotoga maritima	L-glutamine	4.37	1.35	3.24	pH 8, 40 °C	PMID 29468164	Open record: imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunit, L-glutamine
imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunit	Thermotoga maritima	L-glutaminebasal: no PRFAR	0.0571	4.71	0.0121	pH 8, 40 °C	PMID 29468164	Open record: imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunit, L-glutamine
imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunit	Thermotoga maritima	L-glutamine	4.89	1.64	2.98	pH 8, 50 °C	PMID 29468164	Open record: imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunit, L-glutamine
imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunit	Thermotoga maritima	L-glutaminebasal: no PRFAR	0.139	3.8	0.0365	pH 8, 50 °C	PMID 29468164	Open record: imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunit, L-glutamine
imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunit	Thermotoga maritima	L-glutamine	5.5	1.36	4.04	pH 8, 60 °C	PMID 29468164	Open record: imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunit, L-glutamine
imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunit	Thermotoga maritima	L-glutaminebasal: no PRFAR	0.212	3.89	0.0544	pH 8, 60 °C	PMID 29468164	Open record: imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunit, L-glutamine
imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunit	Thermotoga maritima	L-glutamine	5.92	1.32	4.48	pH 8, 70 °C	PMID 29468164	Open record: imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunit, L-glutamine
imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunit	Thermotoga maritima	L-glutaminebasal: no PRFAR	0.204	2.96	0.0688	pH 8, 70 °C	PMID 29468164	Open record: imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunit, L-glutamine
imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunitvariant HisF D98A	Thermotoga maritima	L-glutamine	0.18	3.11	0.0579	pH 8, 30 °C	PMID 28396388	Open record: imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunit variant HisF D98A, L-glutamine
imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunitvariant HisF D98A	Thermotoga maritima	L-glutaminebasal: no PRFAR	0.00311	2.88	0.00107	pH 8, 30 °C	PMID 28396388	Open record: imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunit variant HisF D98A, L-glutamine
imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunitvariant HisF K19A	Thermotoga maritima	L-glutamine	0.57	3.41	0.166	pH 8, 30 °C	PMID 28396388	Open record: imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunit variant HisF K19A, L-glutamine
imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunitvariant HisF K19A	Thermotoga maritima	L-glutaminebasal: no PRFAR	0.0054	3	0.0018	pH 8, 30 °C	PMID 28396388	Open record: imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunit variant HisF K19A, L-glutamine
imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunitvariant HisF V12A	Thermotoga maritima	L-glutamine	1.88	1.4	1.34	pH 8, 30 °C	PMID 28396388	Open record: imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunit variant HisF V12A, L-glutamine
imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunitvariant HisF V12A	Thermotoga maritima	L-glutaminebasal: no PRFAR	0.00173	4.12	4.2 × 10⁻⁴	pH 8, 30 °C	PMID 28396388	Open record: imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunit variant HisF V12A, L-glutamine
imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunitvariant HisF V48A	Thermotoga maritima	L-glutamine	0.24	1.99	0.122	pH 8, 30 °C	PMID 28396388	Open record: imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunit variant HisF V48A, L-glutamine
imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunitvariant HisF V48A	Thermotoga maritima	L-glutaminebasal: no PRFAR	0.00328	3.76	8.72 × 10⁻⁴	pH 8, 30 °C	PMID 28396388	Open record: imidazole glycerol phosphate synthase (IGPS; HisH/HisF complex), glutaminase activity of the HisH subunit variant HisF V48A, L-glutamine
imidazole glycerol phosphate synthase glutaminase subunit HisH (tHisH, in tHisH-tHisF complex)	Thermotoga maritima	L-glutamineImGP	0.1	0.5	0.2	pH 8, 25 °C	PMID 11264293	Open record: imidazole glycerol phosphate synthase glutaminase subunit HisH (tHisH, in tHisH-tHisF complex), L-glutamine
imidazole glycerol phosphate synthase glutaminase subunit HisH (tHisH, in tHisH-tHisF complex)	Thermotoga maritima	L-glutamineProFAR	0.1	—	—	pH 8, 25 °C	PMID 11264293	Open record: imidazole glycerol phosphate synthase glutaminase subunit HisH (tHisH, in tHisH-tHisF complex), L-glutamine
kidney-type glutaminase (KGA)	Homo sapiens	glutamine	7	—	—	pH 8.6	PMID 42055345	Open record: kidney-type glutaminase (KGA), glutamine
kidney-type glutaminase (KGA)variant H461L	Homo sapiens	glutamine	3.9	—	—	pH 8.6	PMID 42055345	Open record: kidney-type glutaminase (KGA) variant H461L, glutamine
kidney-type glutaminase (KGA)variant S482C	Homo sapiens	glutamine	6.6	—	—	pH 8.6	PMID 42055345	Open record: kidney-type glutaminase (KGA) variant S482C, glutamine
L-glutaminase	Streptomyces roseolus	L-glutamine	0.5897	13.89	0.0423	pH 7, 37 °C	PMID 40121594	Open record: L-glutaminase, L-glutamine
L-glutaminase	Streptomyces roseolus	L-glutamine	0.7758	7.13	0.1087	pH 7	PMID 40121594	Open record: L-glutaminase, L-glutamine
YbaS	Escherichia coli	L-glutamine	91.4	—	—	pH 7.5	PMID 18459799	Open record: YbaS, L-glutamine
YbaS	Escherichia coli	L-glutaminewith 1.5 mM ampicillin	82.5	—	—	pH 7.5	PMID 18459799	Open record: YbaS, L-glutamine
YbaS	Escherichia coli	L-glutaminewith 3.0 mM ampicillin	84.6	—	—	pH 7.5	PMID 18459799	Open record: YbaS, L-glutamine
YbaSvariant G261A	Escherichia coli	L-glutamine	49.9	—	—	pH 7.5	PMID 18459799	Open record: YbaS variant G261A, L-glutamine
YbaSvariant Q162A	Escherichia coli	L-glutamine	79.9	—	—	pH 7.5	PMID 18459799	Open record: YbaS variant Q162A, L-glutamine
YbgJ	Bacillus subtilis	L-glutamine	67.7	—	—	pH 8	PMID 18459799	Open record: YbgJ, L-glutamine
YlaM	Bacillus subtilis	L-glutamine	38.8	—	—	pH 7.5	PMID 18459799	Open record: YlaM, L-glutamine
YneH	Escherichia coli	L-glutamine	101	—	—	pH 7.5	PMID 18459799	Open record: YneH, L-glutamine