EC 1.1.1.85: 3-isopropylmalate dehydrogenase

OxidoreductasesOpen in Browse

CatLog read 249 records for EC 1.1.1.85 from 16 papers, for 12 organisms. Names in these papers: 3-isopropylmalate dehydrogenase, 3-isopropylmalate dehydrogenase (TtIPMDH), isopropylmalate dehydrogenase (IMDH), 3-isopropylmalate dehydrogenase (IPMDH) and 12 more.

Read from the paper by an AI model and checked against the paper by a second, separate AI run; code converted the units.

CatLog also holds 95 records for EC 1.1.1.85 that are not yet re-read: from its earlier version, built from the enzyme databases and partly checked against the papers. All records for EC 1.1.1.85 in Browse.

Papers

Papers with records for EC 1.1.1.85
Paper	Organisms	Records
Random mutagenesis improves the low-temperature activity of the tetrameric 3-isopropylmalate dehydrogenase from the hyperthermophile Sulfolobus tokodaii	Sulfolobus tokodaii	36
Establishment of mesophilic-like catalytic properties in a thermophilic enzyme without affecting its thermal stability	Escherichia coli, Thermus thermophilus	30
Cold-adaptation mechanism of mutant enzymes of 3-isopropylmalate dehydrogenase from Thermus thermophilus	Thermus thermophilus	28
Ancestral sequence reconstruction produces thermally stable enzymes with mesophilic enzyme-like catalytic properties	Bacillus subtilis, Saccharomyces cerevisiae	26
The role of glutamate 87 in the kinetic mechanism of Thermus thermophilus isopropylmalate dehydrogenase	Thermus thermophilus	26
Adaptation of a thermophilic enzyme, 3-isopropylmalate dehydrogenase, to low temperatures	Thermus thermophilus	20
The effects of multiple ancestral residues on the Thermus thermophilus 3-isopropylmalate dehydrogenase	Thermus thermophilus	18
Piezo-adapted 3-isopropylmalate dehydrogenase of the obligate piezophile Shewanella benthica DB21MT-2 isolated from the 11,000-m depth of the Mariana Trench	Shewanella benthica, Shewanella oneidensis	12
Structural and functional evolution of isopropylmalate dehydrogenases in the leucine and glucosinolate pathways of Arabidopsis thaliana	Arabidopsis thaliana	12
Structure and Mechanism of Isopropylmalate Dehydrogenase from Arabidopsis thaliana: INSIGHTS ON LEUCINE AND ALIPHATIC GLUCOSINOLATE BIOSYNTHESIS	Arabidopsis thaliana	12
Molecular and phylogenetic characterization of isopropylmalate dehydrogenase of a thermoacidophilic archaeon, Sulfolobus sp. strain 7	Sulfolobus sp.	9
Purification, catalytic properties and thermostability of 3-isopropylmalate dehydrogenase from Escherichia coli	Escherichia coli, Thermus thermophilus	8
3-Isopropylmalate dehydrogenase from chemolithoautotroph Thiobacillus ferrooxidans: DNA sequence, enzyme purification, and characterization	Thiobacillus ferrooxidans	4
Enhancement of the latent 3-isopropylmalate dehydrogenase activity of promiscuous homoisocitrate dehydrogenase by directed evolution	Thermus thermophilus	3
Characterization of two β-decarboxylating dehydrogenases from Sulfolobus acidocaldarius	Sulfolobus acidocaldarius	3
Enzymology and evolution of the pyruvate pathway to 2-oxobutyrate in Methanocaldococcus jannaschii	Methanocaldococcus jannaschii	2

Records

Records for EC 1.1.1.85 read from the paper
Enzyme	Organism	Substrate	k_cat (s⁻¹)	K_m (mM)	k_cat/K_m (mM⁻¹ s⁻¹)	Conditions	Paper	Open record
3-isopropylmalate dehydrogenase	Bacillus subtilis	D-3-isopropylmalate	—	7.8 × 10⁻⁴	—	pH 8, 40 °C	PMID 32968141	Open record: 3-isopropylmalate dehydrogenase, D-3-isopropylmalate
3-isopropylmalate dehydrogenase	Bacillus subtilis	nicotinamide adenine dinucleotide (oxidized)	2.8	0.11	25 calc.	pH 8, 25 °C	PMID 32968141	Open record: 3-isopropylmalate dehydrogenase, nicotinamide adenine dinucleotide (oxidized)
3-isopropylmalate dehydrogenase	Bacillus subtilis	nicotinamide adenine dinucleotide (oxidized)	9.4	0.42	22 calc.	pH 8, 40 °C	PMID 32968141	Open record: 3-isopropylmalate dehydrogenase, nicotinamide adenine dinucleotide (oxidized)
3-isopropylmalate dehydrogenase	Escherichia coli	3-ethylmalate	70	0.09	747	pH 7.6, 40 °C	PMID 9003442	Open record: 3-isopropylmalate dehydrogenase, 3-ethylmalate
3-isopropylmalate dehydrogenase	Escherichia coli	3-tert-butylmalate	6	0.214	26	pH 7.6, 40 °C	PMID 9003442	Open record: 3-isopropylmalate dehydrogenase, 3-tert-butylmalate
3-isopropylmalate dehydrogenase	Escherichia coli	NAD+	—	0.321	—	pH 7.6, 40 °C	PMID 9003442	Open record: 3-isopropylmalate dehydrogenase, NAD+
3-isopropylmalate dehydrogenase	Escherichia coli	threo-D,L-3-isopropylmalic acid	69	0.105	656	pH 7.6, 40 °C	PMID 9003442	Open record: 3-isopropylmalate dehydrogenase, threo-D,L-3-isopropylmalic acid
3-isopropylmalate dehydrogenase	Saccharomyces cerevisiae	D-3-isopropylmalate	—	0.0045	—	pH 8, 40 °C	PMID 32968141	Open record: 3-isopropylmalate dehydrogenase, D-3-isopropylmalate
3-isopropylmalate dehydrogenase	Saccharomyces cerevisiae	nicotinamide adenine dinucleotide (oxidized)	5.1	0.13	39 calc.	pH 8, 25 °C	PMID 32968141	Open record: 3-isopropylmalate dehydrogenase, nicotinamide adenine dinucleotide (oxidized)
3-isopropylmalate dehydrogenase	Saccharomyces cerevisiae	nicotinamide adenine dinucleotide (oxidized)	20	0.65	31 calc.	pH 8, 40 °C	PMID 32968141	Open record: 3-isopropylmalate dehydrogenase, nicotinamide adenine dinucleotide (oxidized)
3-isopropylmalate dehydrogenase	Sulfolobus tokodaii	D-3-isopropylmalate	0.15	—	—	pH 7.5, 25 °C	PMID 18854331	Open record: 3-isopropylmalate dehydrogenase, D-3-isopropylmalate
3-isopropylmalate dehydrogenase	Sulfolobus tokodaii	D-3-isopropylmalate	0.7	0.0042	170	pH 7.5, 40 °C	PMID 18854331	Open record: 3-isopropylmalate dehydrogenase, D-3-isopropylmalate
3-isopropylmalate dehydrogenase	Sulfolobus tokodaii	D-3-isopropylmalate	6.9	0.0055	1.3 × 10³	pH 7.5, 70 °C	PMID 18854331	Open record: 3-isopropylmalate dehydrogenase, D-3-isopropylmalate
3-isopropylmalate dehydrogenase	Sulfolobus tokodaii	nicotinamide adenine dinucleotide	—	0.24	0.62	pH 7.5, 25 °C	PMID 18854331	Open record: 3-isopropylmalate dehydrogenase, nicotinamide adenine dinucleotide
3-isopropylmalate dehydrogenase	Sulfolobus tokodaii	nicotinamide adenine dinucleotide	—	0.26	2.7	pH 7.5, 40 °C	PMID 18854331	Open record: 3-isopropylmalate dehydrogenase, nicotinamide adenine dinucleotide
3-isopropylmalate dehydrogenase	Sulfolobus tokodaii	nicotinamide adenine dinucleotide	—	0.39	18	pH 7.5, 70 °C	PMID 18854331	Open record: 3-isopropylmalate dehydrogenase, nicotinamide adenine dinucleotide
3-isopropylmalate dehydrogenasevariant F3S	Sulfolobus tokodaii	D-3-isopropylmalate	0.16	—	—	pH 7.5, 25 °C	PMID 18854331	Open record: 3-isopropylmalate dehydrogenase variant F3S, D-3-isopropylmalate
3-isopropylmalate dehydrogenasevariant F3S	Sulfolobus tokodaii	D-3-isopropylmalate	0.79	0.0035	230	pH 7.5, 40 °C	PMID 18854331	Open record: 3-isopropylmalate dehydrogenase variant F3S, D-3-isopropylmalate
3-isopropylmalate dehydrogenasevariant F3S	Sulfolobus tokodaii	D-3-isopropylmalate	6.8	0.0076	900	pH 7.5, 70 °C	PMID 18854331	Open record: 3-isopropylmalate dehydrogenase variant F3S, D-3-isopropylmalate
3-isopropylmalate dehydrogenasevariant F3S	Sulfolobus tokodaii	nicotinamide adenine dinucleotide	—	0.15	1.1	pH 7.5, 25 °C	PMID 18854331	Open record: 3-isopropylmalate dehydrogenase variant F3S, nicotinamide adenine dinucleotide
3-isopropylmalate dehydrogenasevariant F3S	Sulfolobus tokodaii	nicotinamide adenine dinucleotide	—	0.27	2.9	pH 7.5, 40 °C	PMID 18854331	Open record: 3-isopropylmalate dehydrogenase variant F3S, nicotinamide adenine dinucleotide
3-isopropylmalate dehydrogenasevariant F3S	Sulfolobus tokodaii	nicotinamide adenine dinucleotide	—	0.39	18	pH 7.5, 70 °C	PMID 18854331	Open record: 3-isopropylmalate dehydrogenase variant F3S, nicotinamide adenine dinucleotide
3-isopropylmalate dehydrogenasevariant F3S/L288P	Sulfolobus tokodaii	D-3-isopropylmalate	0.17	—	—	pH 7.5, 25 °C	PMID 18854331	Open record: 3-isopropylmalate dehydrogenase variant F3S/L288P, D-3-isopropylmalate
3-isopropylmalate dehydrogenasevariant F3S/L288P	Sulfolobus tokodaii	D-3-isopropylmalate	0.9	0.0046	200	pH 7.5, 40 °C	PMID 18854331	Open record: 3-isopropylmalate dehydrogenase variant F3S/L288P, D-3-isopropylmalate
3-isopropylmalate dehydrogenasevariant F3S/L288P	Sulfolobus tokodaii	D-3-isopropylmalate	7.8	0.0067	1.2 × 10³	pH 7.5, 70 °C	PMID 18854331	Open record: 3-isopropylmalate dehydrogenase variant F3S/L288P, D-3-isopropylmalate
3-isopropylmalate dehydrogenasevariant F3S/L288P	Sulfolobus tokodaii	nicotinamide adenine dinucleotide	—	0.21	0.8	pH 7.5, 25 °C	PMID 18854331	Open record: 3-isopropylmalate dehydrogenase variant F3S/L288P, nicotinamide adenine dinucleotide
3-isopropylmalate dehydrogenasevariant F3S/L288P	Sulfolobus tokodaii	nicotinamide adenine dinucleotide	—	0.21	4.3	pH 7.5, 40 °C	PMID 18854331	Open record: 3-isopropylmalate dehydrogenase variant F3S/L288P, nicotinamide adenine dinucleotide
3-isopropylmalate dehydrogenasevariant F3S/L288P	Sulfolobus tokodaii	nicotinamide adenine dinucleotide	—	0.4	20	pH 7.5, 70 °C	PMID 18854331	Open record: 3-isopropylmalate dehydrogenase variant F3S/L288P, nicotinamide adenine dinucleotide
3-isopropylmalate dehydrogenasevariant F3S/S232G	Sulfolobus tokodaii	D-3-isopropylmalate	0.1	—	—	pH 7.5, 25 °C	PMID 18854331	Open record: 3-isopropylmalate dehydrogenase variant F3S/S232G, D-3-isopropylmalate
3-isopropylmalate dehydrogenasevariant F3S/S232G	Sulfolobus tokodaii	D-3-isopropylmalate	0.55	0.0025	220	pH 7.5, 40 °C	PMID 18854331	Open record: 3-isopropylmalate dehydrogenase variant F3S/S232G, D-3-isopropylmalate
3-isopropylmalate dehydrogenasevariant F3S/S232G	Sulfolobus tokodaii	D-3-isopropylmalate	3.8	0.0039	1 × 10³	pH 7.5, 70 °C	PMID 18854331	Open record: 3-isopropylmalate dehydrogenase variant F3S/S232G, D-3-isopropylmalate
3-isopropylmalate dehydrogenasevariant F3S/S232G	Sulfolobus tokodaii	nicotinamide adenine dinucleotide	—	0.1	0.99	pH 7.5, 25 °C	PMID 18854331	Open record: 3-isopropylmalate dehydrogenase variant F3S/S232G, nicotinamide adenine dinucleotide
3-isopropylmalate dehydrogenasevariant F3S/S232G	Sulfolobus tokodaii	nicotinamide adenine dinucleotide	—	0.1	5.4	pH 7.5, 40 °C	PMID 18854331	Open record: 3-isopropylmalate dehydrogenase variant F3S/S232G, nicotinamide adenine dinucleotide
3-isopropylmalate dehydrogenasevariant F3S/S232G	Sulfolobus tokodaii	nicotinamide adenine dinucleotide	—	0.22	17	pH 7.5, 70 °C	PMID 18854331	Open record: 3-isopropylmalate dehydrogenase variant F3S/S232G, nicotinamide adenine dinucleotide
3-isopropylmalate dehydrogenasevariant L288P	Sulfolobus tokodaii	D-3-isopropylmalate	0.18	—	—	pH 7.5, 25 °C	PMID 18854331	Open record: 3-isopropylmalate dehydrogenase variant L288P, D-3-isopropylmalate
3-isopropylmalate dehydrogenasevariant L288P	Sulfolobus tokodaii	D-3-isopropylmalate	0.81	0.0026	310	pH 7.5, 40 °C	PMID 18854331	Open record: 3-isopropylmalate dehydrogenase variant L288P, D-3-isopropylmalate
3-isopropylmalate dehydrogenasevariant L288P	Sulfolobus tokodaii	D-3-isopropylmalate	7.5	0.0044	1.7 × 10³	pH 7.5, 70 °C	PMID 18854331	Open record: 3-isopropylmalate dehydrogenase variant L288P, D-3-isopropylmalate
3-isopropylmalate dehydrogenasevariant L288P	Sulfolobus tokodaii	nicotinamide adenine dinucleotide	—	0.18	1	pH 7.5, 25 °C	PMID 18854331	Open record: 3-isopropylmalate dehydrogenase variant L288P, nicotinamide adenine dinucleotide
3-isopropylmalate dehydrogenasevariant L288P	Sulfolobus tokodaii	nicotinamide adenine dinucleotide	—	0.19	4.4	pH 7.5, 40 °C	PMID 18854331	Open record: 3-isopropylmalate dehydrogenase variant L288P, nicotinamide adenine dinucleotide
3-isopropylmalate dehydrogenasevariant L288P	Sulfolobus tokodaii	nicotinamide adenine dinucleotide	—	0.37	20	pH 7.5, 70 °C	PMID 18854331	Open record: 3-isopropylmalate dehydrogenase variant L288P, nicotinamide adenine dinucleotide
3-isopropylmalate dehydrogenasevariant R284G	Sulfolobus tokodaii	D-3-isopropylmalate	0.18	—	—	pH 7.5, 25 °C	PMID 18854331	Open record: 3-isopropylmalate dehydrogenase variant R284G, D-3-isopropylmalate
3-isopropylmalate dehydrogenasevariant R284G	Sulfolobus tokodaii	D-3-isopropylmalate	0.81	0.0053	150	pH 7.5, 40 °C	PMID 18854331	Open record: 3-isopropylmalate dehydrogenase variant R284G, D-3-isopropylmalate
3-isopropylmalate dehydrogenasevariant R284G	Sulfolobus tokodaii	D-3-isopropylmalate	6	0.008	750	pH 7.5, 70 °C	PMID 18854331	Open record: 3-isopropylmalate dehydrogenase variant R284G, D-3-isopropylmalate
3-isopropylmalate dehydrogenasevariant R284G	Sulfolobus tokodaii	nicotinamide adenine dinucleotide	—	0.18	1	pH 7.5, 25 °C	PMID 18854331	Open record: 3-isopropylmalate dehydrogenase variant R284G, nicotinamide adenine dinucleotide
3-isopropylmalate dehydrogenasevariant R284G	Sulfolobus tokodaii	nicotinamide adenine dinucleotide	—	0.22	3.7	pH 7.5, 40 °C	PMID 18854331	Open record: 3-isopropylmalate dehydrogenase variant R284G, nicotinamide adenine dinucleotide
3-isopropylmalate dehydrogenasevariant R284G	Sulfolobus tokodaii	nicotinamide adenine dinucleotide	—	0.25	24	pH 7.5, 70 °C	PMID 18854331	Open record: 3-isopropylmalate dehydrogenase variant R284G, nicotinamide adenine dinucleotide
3-isopropylmalate dehydrogenase	Thermus thermophilus	D,L-3-isopropylmalate	—	0.0044	4.55 × 10³	pH 8, 60 °C	PMID 12082165	Open record: 3-isopropylmalate dehydrogenase, D,L-3-isopropylmalate
3-isopropylmalate dehydrogenase	Thermus thermophilus	NAD+	—	0.139	—	60 °C	PMID 9003442	Open record: 3-isopropylmalate dehydrogenase, NAD+
3-isopropylmalate dehydrogenase	Thermus thermophilus	NAD+	—	0.157	—	40 °C	PMID 9003442	Open record: 3-isopropylmalate dehydrogenase, NAD+
3-isopropylmalate dehydrogenase	Thermus thermophilus	NAD+	20	0.166	121	pH 8, 60 °C	PMID 12082165	Open record: 3-isopropylmalate dehydrogenase, NAD+
3-isopropylmalate dehydrogenase	Thermus thermophilus	nicotinamide adenine dinucleotide (oxidized)	13.4	0.514	26	pH 8, 70 °C	PMID 16797545	Open record: 3-isopropylmalate dehydrogenase, nicotinamide adenine dinucleotide (oxidized)
3-isopropylmalate dehydrogenase	Thermus thermophilus	threo-D,L-3-isopropylmalic acid	19	0.044	428	60 °C	PMID 9003442	Open record: 3-isopropylmalate dehydrogenase, threo-D,L-3-isopropylmalic acid
3-isopropylmalate dehydrogenase	Thermus thermophilus	threo-D,L-3-isopropylmalic acid	8	0.316	26.6	40 °C	PMID 9003442	Open record: 3-isopropylmalate dehydrogenase, threo-D,L-3-isopropylmalic acid
3-isopropylmalate dehydrogenase	Thermus thermophilus	threo-DL-3-isopropylmalate	—	0.0061	—	pH 8, 70 °C	PMID 16797545	Open record: 3-isopropylmalate dehydrogenase, threo-DL-3-isopropylmalate
3-isopropylmalate dehydrogenasevariant A335E	Thermus thermophilus	nicotinamide adenine dinucleotide (oxidized)	18.2	0.359	51	pH 8, 70 °C	PMID 16797545	Open record: 3-isopropylmalate dehydrogenase variant A335E, nicotinamide adenine dinucleotide (oxidized)
3-isopropylmalate dehydrogenasevariant D184H	Thermus thermophilus	nicotinamide adenine dinucleotide (oxidized)	11.2	0.673	17	pH 8, 70 °C	PMID 16797545	Open record: 3-isopropylmalate dehydrogenase variant D184H, nicotinamide adenine dinucleotide (oxidized)
3-isopropylmalate dehydrogenasevariant F53L	Thermus thermophilus	nicotinamide adenine dinucleotide (oxidized)	15	0.468	32	pH 8, 70 °C	PMID 16797545	Open record: 3-isopropylmalate dehydrogenase variant F53L, nicotinamide adenine dinucleotide (oxidized)
3-isopropylmalate dehydrogenasevariant H179K	Thermus thermophilus	nicotinamide adenine dinucleotide (oxidized)	21.3	0.336	63	pH 8, 70 °C	PMID 16797545	Open record: 3-isopropylmalate dehydrogenase variant H179K, nicotinamide adenine dinucleotide (oxidized)
3-isopropylmalate dehydrogenasevariant L134N	Thermus thermophilus	nicotinamide adenine dinucleotide (oxidized)	29.9	0.172	174	pH 8, 70 °C	PMID 16797545	Open record: 3-isopropylmalate dehydrogenase variant L134N, nicotinamide adenine dinucleotide (oxidized)
3-isopropylmalate dehydrogenasevariant L134N	Thermus thermophilus	threo-DL-3-isopropylmalate	—	0.007	—	pH 8, 70 °C	PMID 16797545	Open record: 3-isopropylmalate dehydrogenase variant L134N, threo-DL-3-isopropylmalate
3-isopropylmalate dehydrogenasevariant L134N/V181T/P324T/A335E	Thermus thermophilus	nicotinamide adenine dinucleotide (oxidized)	25.2	0.255	99	pH 8, 70 °C	PMID 16797545	Open record: 3-isopropylmalate dehydrogenase variant L134N/V181T/P324T/A335E, nicotinamide adenine dinucleotide (oxidized)
3-isopropylmalate dehydrogenasevariant L134N/V181T/P324T/A335E	Thermus thermophilus	threo-DL-3-isopropylmalate	—	0.0161	—	pH 8, 70 °C	PMID 16797545	Open record: 3-isopropylmalate dehydrogenase variant L134N/V181T/P324T/A335E, threo-DL-3-isopropylmalate
3-isopropylmalate dehydrogenasevariant P324T	Thermus thermophilus	nicotinamide adenine dinucleotide (oxidized)	13.8	0.371	37	pH 8, 70 °C	PMID 16797545	Open record: 3-isopropylmalate dehydrogenase variant P324T, nicotinamide adenine dinucleotide (oxidized)
3-isopropylmalate dehydrogenasevariant P56E	Thermus thermophilus	nicotinamide adenine dinucleotide (oxidized)	14.6	0.428	34	pH 8, 70 °C	PMID 16797545	Open record: 3-isopropylmalate dehydrogenase variant P56E, nicotinamide adenine dinucleotide (oxidized)
3-isopropylmalate dehydrogenasevariant R58L	Thermus thermophilus	nicotinamide adenine dinucleotide (oxidized)	17.7	0.401	44	pH 8, 70 °C	PMID 16797545	Open record: 3-isopropylmalate dehydrogenase variant R58L, nicotinamide adenine dinucleotide (oxidized)
3-isopropylmalate dehydrogenasevariant S261N	Thermus thermophilus	nicotinamide adenine dinucleotide (oxidized)	18.2	0.625	29	pH 8, 70 °C	PMID 16797545	Open record: 3-isopropylmalate dehydrogenase variant S261N, nicotinamide adenine dinucleotide (oxidized)
3-isopropylmalate dehydrogenasevariant V126A	Thermus thermophilus	D,L-3-isopropylmalate	—	0.00256	3.5 × 10³	pH 8, 60 °C	PMID 12082165	Open record: 3-isopropylmalate dehydrogenase variant V126A, D,L-3-isopropylmalate
3-isopropylmalate dehydrogenasevariant V126A	Thermus thermophilus	NAD+	8.97	0.0598	150	pH 8, 60 °C	PMID 12082165	Open record: 3-isopropylmalate dehydrogenase variant V126A, NAD+
3-isopropylmalate dehydrogenasevariant V126A	Thermus thermophilus	NAD+	1.23	0.00917	134	pH 8, 40 °C	PMID 12082165	Open record: 3-isopropylmalate dehydrogenase variant V126A, NAD+
3-isopropylmalate dehydrogenasevariant V126E	Thermus thermophilus	D,L-3-isopropylmalate	—	0.0061	3.38 × 10³	pH 8, 60 °C	PMID 12082165	Open record: 3-isopropylmalate dehydrogenase variant V126E, D,L-3-isopropylmalate
3-isopropylmalate dehydrogenasevariant V126E	Thermus thermophilus	NAD+	20.6	0.109	189	pH 8, 60 °C	PMID 12082165	Open record: 3-isopropylmalate dehydrogenase variant V126E, NAD+
3-isopropylmalate dehydrogenasevariant V126E	Thermus thermophilus	NAD+	3.46	0.0515	67.1	pH 8, 40 °C	PMID 12082165	Open record: 3-isopropylmalate dehydrogenase variant V126E, NAD+
3-isopropylmalate dehydrogenasevariant V126F	Thermus thermophilus	D,L-3-isopropylmalate	—	0.0133	3.19 × 10³	pH 8, 60 °C	PMID 12082165	Open record: 3-isopropylmalate dehydrogenase variant V126F, D,L-3-isopropylmalate
3-isopropylmalate dehydrogenasevariant V126F	Thermus thermophilus	NAD+	42.4	0.378	112	pH 8, 60 °C	PMID 12082165	Open record: 3-isopropylmalate dehydrogenase variant V126F, NAD+
3-isopropylmalate dehydrogenasevariant V126F	Thermus thermophilus	NAD+	10.9	0.144	75.9	pH 8, 40 °C	PMID 12082165	Open record: 3-isopropylmalate dehydrogenase variant V126F, NAD+
3-isopropylmalate dehydrogenasevariant V126G	Thermus thermophilus	D,L-3-isopropylmalate	—	0.00202	5.15 × 10³	pH 8, 60 °C	PMID 12082165	Open record: 3-isopropylmalate dehydrogenase variant V126G, D,L-3-isopropylmalate
3-isopropylmalate dehydrogenasevariant V126G	Thermus thermophilus	NAD+	10.4	0.0725	144	pH 8, 60 °C	PMID 12082165	Open record: 3-isopropylmalate dehydrogenase variant V126G, NAD+
3-isopropylmalate dehydrogenasevariant V126G	Thermus thermophilus	NAD+	1.67	0.0239	69.7	pH 8, 40 °C	PMID 12082165	Open record: 3-isopropylmalate dehydrogenase variant V126G, NAD+
3-isopropylmalate dehydrogenasevariant V126I	Thermus thermophilus	D,L-3-isopropylmalate	—	0.00838	3.64 × 10³	pH 8, 60 °C	PMID 12082165	Open record: 3-isopropylmalate dehydrogenase variant V126I, D,L-3-isopropylmalate
3-isopropylmalate dehydrogenasevariant V126I	Thermus thermophilus	NAD+	30.5	0.198	154	pH 8, 60 °C	PMID 12082165	Open record: 3-isopropylmalate dehydrogenase variant V126I, NAD+
3-isopropylmalate dehydrogenasevariant V126I	Thermus thermophilus	NAD+	6.05	0.0618	97.9	pH 8, 40 °C	PMID 12082165	Open record: 3-isopropylmalate dehydrogenase variant V126I, NAD+
3-isopropylmalate dehydrogenasevariant V126L	Thermus thermophilus	D,L-3-isopropylmalate	—	0.0121	3.68 × 10³	pH 8, 60 °C	PMID 12082165	Open record: 3-isopropylmalate dehydrogenase variant V126L, D,L-3-isopropylmalate
3-isopropylmalate dehydrogenasevariant V126L	Thermus thermophilus	NAD+	44.5	0.391	114	pH 8, 60 °C	PMID 12082165	Open record: 3-isopropylmalate dehydrogenase variant V126L, NAD+
3-isopropylmalate dehydrogenasevariant V126L	Thermus thermophilus	NAD+	8.54	0.111	77.1	pH 8, 40 °C	PMID 12082165	Open record: 3-isopropylmalate dehydrogenase variant V126L, NAD+
3-isopropylmalate dehydrogenasevariant V126M	Thermus thermophilus	D,L-3-isopropylmalate	—	0.005	1.08 × 10⁴	pH 8, 60 °C	PMID 12082165	Open record: 3-isopropylmalate dehydrogenase variant V126M, D,L-3-isopropylmalate
3-isopropylmalate dehydrogenasevariant V126M	Thermus thermophilus	NAD+	54.1	1.97	27.5	pH 8, 60 °C	PMID 12082165	Open record: 3-isopropylmalate dehydrogenase variant V126M, NAD+
3-isopropylmalate dehydrogenasevariant V126S	Thermus thermophilus	D,L-3-isopropylmalate	—	0.00324	3.92 × 10³	pH 8, 60 °C	PMID 12082165	Open record: 3-isopropylmalate dehydrogenase variant V126S, D,L-3-isopropylmalate
3-isopropylmalate dehydrogenasevariant V126S	Thermus thermophilus	NAD+	12.7	0.0949	134	pH 8, 60 °C	PMID 12082165	Open record: 3-isopropylmalate dehydrogenase variant V126S, NAD+
3-isopropylmalate dehydrogenasevariant V126S	Thermus thermophilus	NAD+	1.49	0.00908	164	pH 8, 40 °C	PMID 12082165	Open record: 3-isopropylmalate dehydrogenase variant V126S, NAD+
3-isopropylmalate dehydrogenasevariant V126T	Thermus thermophilus	D,L-3-isopropylmalate	—	0.00268	5.49 × 10³	pH 8, 60 °C	PMID 12082165	Open record: 3-isopropylmalate dehydrogenase variant V126T, D,L-3-isopropylmalate
3-isopropylmalate dehydrogenasevariant V126T	Thermus thermophilus	NAD+	14.7	0.103	143	pH 8, 60 °C	PMID 12082165	Open record: 3-isopropylmalate dehydrogenase variant V126T, NAD+
3-isopropylmalate dehydrogenasevariant V126T	Thermus thermophilus	NAD+	1.88	0.022	85.4	pH 8, 40 °C	PMID 12082165	Open record: 3-isopropylmalate dehydrogenase variant V126T, NAD+
3-isopropylmalate dehydrogenasevariant V181T	Thermus thermophilus	nicotinamide adenine dinucleotide (oxidized)	10.2	0.642	16	pH 8, 70 °C	PMID 16797545	Open record: 3-isopropylmalate dehydrogenase variant V181T, nicotinamide adenine dinucleotide (oxidized)
3-isopropylmalate dehydrogenasevariant V181T/P324T/A335E	Thermus thermophilus	nicotinamide adenine dinucleotide (oxidized)	13.2	0.567	23	pH 8, 70 °C	PMID 16797545	Open record: 3-isopropylmalate dehydrogenase variant V181T/P324T/A335E, nicotinamide adenine dinucleotide (oxidized)
3-isopropylmalate dehydrogenasevariant V181T/P324T/A335E	Thermus thermophilus	threo-DL-3-isopropylmalate	—	0.0063	—	pH 8, 70 °C	PMID 16797545	Open record: 3-isopropylmalate dehydrogenase variant V181T/P324T/A335E, threo-DL-3-isopropylmalate
3-isopropylmalate dehydrogenasevariant V61I	Thermus thermophilus	nicotinamide adenine dinucleotide (oxidized)	15	0.52	29	pH 8, 70 °C	PMID 16797545	Open record: 3-isopropylmalate dehydrogenase variant V61I, nicotinamide adenine dinucleotide (oxidized)
3-isopropylmalate dehydrogenase	Thiobacillus ferrooxidans	3-isopropylmalate	—	0.026	—	pH 9	PMID 8282728	Open record: 3-isopropylmalate dehydrogenase, 3-isopropylmalate
3-isopropylmalate dehydrogenase	Thiobacillus ferrooxidans	D-malate	—	4	—	pH 9	PMID 8282728	Open record: 3-isopropylmalate dehydrogenase, D-malate
3-isopropylmalate dehydrogenase	Thiobacillus ferrooxidans	L-malate	—	12	—	pH 9	PMID 8282728	Open record: 3-isopropylmalate dehydrogenase, L-malate
3-isopropylmalate dehydrogenase	Thiobacillus ferrooxidans	NAD+	—	0.8	—	pH 9	PMID 8282728	Open record: 3-isopropylmalate dehydrogenase, NAD+
3-isopropylmalate dehydrogenase (EcIPMDH)	Escherichia coli	D-3-isopropylmalate	—	0.004	—	pH 8, 40 °C	PMID 31249343	Open record: 3-isopropylmalate dehydrogenase (EcIPMDH), D-3-isopropylmalate
3-isopropylmalate dehydrogenase (EcIPMDH)	Escherichia coli	D-3-isopropylmalate	—	0.034	—	pH 8, 70 °C	PMID 31249343	Open record: 3-isopropylmalate dehydrogenase (EcIPMDH), D-3-isopropylmalate
3-isopropylmalate dehydrogenase (EcIPMDH)	Escherichia coli	nicotinamide adenine dinucleotide (NAD+)	13	0.062	210 calc.	pH 8, 25 °C	PMID 31249343	Open record: 3-isopropylmalate dehydrogenase (EcIPMDH), nicotinamide adenine dinucleotide (NAD+)
3-isopropylmalate dehydrogenase (EcIPMDH)	Escherichia coli	nicotinamide adenine dinucleotide (NAD+)	56	0.17	330 calc.	pH 8, 40 °C	PMID 31249343	Open record: 3-isopropylmalate dehydrogenase (EcIPMDH), nicotinamide adenine dinucleotide (NAD+)
3-isopropylmalate dehydrogenase (EcIPMDH)	Escherichia coli	nicotinamide adenine dinucleotide (NAD+)	190	1.2	160 calc.	pH 8, 70 °C	PMID 31249343	Open record: 3-isopropylmalate dehydrogenase (EcIPMDH), nicotinamide adenine dinucleotide (NAD+)
3-isopropylmalate dehydrogenase (IPMDH)	Thermus thermophilus	D-3-isopropylmalate	2.36	0.00125	1.89 × 10³ calc.	pH 8, 40 °C	PMID 11297666	Open record: 3-isopropylmalate dehydrogenase (IPMDH), D-3-isopropylmalate
3-isopropylmalate dehydrogenase (IPMDH)	Thermus thermophilus	D-3-isopropylmalate	45.8	0.0089	5.2 × 10³ calc.	pH 8, 70 °C	PMID 11297666	Open record: 3-isopropylmalate dehydrogenase (IPMDH), D-3-isopropylmalate
3-isopropylmalate dehydrogenase (IPMDH)	Thermus thermophilus	NAD+	—	0.0258	—	pH 8, 40 °C	PMID 11297666	Open record: 3-isopropylmalate dehydrogenase (IPMDH), NAD+
3-isopropylmalate dehydrogenase (IPMDH)	Thermus thermophilus	NAD+	—	0.341	—	pH 8, 70 °C	PMID 11297666	Open record: 3-isopropylmalate dehydrogenase (IPMDH), NAD+
3-isopropylmalate dehydrogenase (IPMDH)variant I11V/V15I/N237D (P415)	Thermus thermophilus	D-3-isopropylmalate	7.2	0.0013	5.5 × 10³ calc.	pH 8, 40 °C	PMID 11297666	Open record: 3-isopropylmalate dehydrogenase (IPMDH) variant I11V/V15I/N237D (P415), D-3-isopropylmalate
3-isopropylmalate dehydrogenase (IPMDH)variant I11V/V15I/N237D (P415)	Thermus thermophilus	D-3-isopropylmalate	50.1	0.0096	5.2 × 10³ calc.	pH 8, 70 °C	PMID 11297666	Open record: 3-isopropylmalate dehydrogenase (IPMDH) variant I11V/V15I/N237D (P415), D-3-isopropylmalate
3-isopropylmalate dehydrogenase (IPMDH)variant I11V/V15I/N237D (P415)	Thermus thermophilus	NAD+	—	0.157	—	pH 8, 40 °C	PMID 11297666	Open record: 3-isopropylmalate dehydrogenase (IPMDH) variant I11V/V15I/N237D (P415), NAD+
3-isopropylmalate dehydrogenase (IPMDH)variant I11V/V15I/N237D (P415)	Thermus thermophilus	NAD+	—	0.917	—	pH 8, 70 °C	PMID 11297666	Open record: 3-isopropylmalate dehydrogenase (IPMDH) variant I11V/V15I/N237D (P415), NAD+
3-isopropylmalate dehydrogenase (IPMDH)variant S92F (T1155)	Thermus thermophilus	D-3-isopropylmalate	2.41	0.001	2.4 × 10³ calc.	pH 8, 40 °C	PMID 11297666	Open record: 3-isopropylmalate dehydrogenase (IPMDH) variant S92F (T1155), D-3-isopropylmalate
3-isopropylmalate dehydrogenase (IPMDH)variant S92F (T1155)	Thermus thermophilus	D-3-isopropylmalate	44.7	0.0078	5.7 × 10³ calc.	pH 8, 70 °C	PMID 11297666	Open record: 3-isopropylmalate dehydrogenase (IPMDH) variant S92F (T1155), D-3-isopropylmalate
3-isopropylmalate dehydrogenase (IPMDH)variant S92F (T1155)	Thermus thermophilus	NAD+	—	0.0149	—	pH 8, 40 °C	PMID 11297666	Open record: 3-isopropylmalate dehydrogenase (IPMDH) variant S92F (T1155), NAD+
3-isopropylmalate dehydrogenase (IPMDH)variant S92F (T1155)	Thermus thermophilus	NAD+	—	0.225	—	pH 8, 70 °C	PMID 11297666	Open record: 3-isopropylmalate dehydrogenase (IPMDH) variant S92F (T1155), NAD+
3-isopropylmalate dehydrogenase (IPMDH)variant V126M (P215)	Thermus thermophilus	D-3-isopropylmalate	17.7	0.0012	1.5 × 10⁴ calc.	pH 8, 40 °C	PMID 11297666	Open record: 3-isopropylmalate dehydrogenase (IPMDH) variant V126M (P215), D-3-isopropylmalate
3-isopropylmalate dehydrogenase (IPMDH)variant V126M (P215)	Thermus thermophilus	D-3-isopropylmalate	100	0.01	1.0 × 10⁴ calc.	pH 8, 70 °C	PMID 11297666	Open record: 3-isopropylmalate dehydrogenase (IPMDH) variant V126M (P215), D-3-isopropylmalate
3-isopropylmalate dehydrogenase (IPMDH)variant V126M (P215)	Thermus thermophilus	NAD+	—	1.01	—	pH 8, 40 °C	PMID 11297666	Open record: 3-isopropylmalate dehydrogenase (IPMDH) variant V126M (P215), NAD+
3-isopropylmalate dehydrogenase (IPMDH)variant V126M (P215)	Thermus thermophilus	NAD+	—	3.56	—	pH 8, 70 °C	PMID 11297666	Open record: 3-isopropylmalate dehydrogenase (IPMDH) variant V126M (P215), NAD+
3-isopropylmalate dehydrogenase (IPMDH)variant V15I (P115)	Thermus thermophilus	D-3-isopropylmalate	10.7	0.0024	4.5 × 10³ calc.	pH 8, 40 °C	PMID 11297666	Open record: 3-isopropylmalate dehydrogenase (IPMDH) variant V15I (P115), D-3-isopropylmalate
3-isopropylmalate dehydrogenase (IPMDH)variant V15I (P115)	Thermus thermophilus	D-3-isopropylmalate	63.6	0.011	5.8 × 10³ calc.	pH 8, 70 °C	PMID 11297666	Open record: 3-isopropylmalate dehydrogenase (IPMDH) variant V15I (P115), D-3-isopropylmalate
3-isopropylmalate dehydrogenase (IPMDH)variant V15I (P115)	Thermus thermophilus	NAD+	—	0.16	—	pH 8, 40 °C	PMID 11297666	Open record: 3-isopropylmalate dehydrogenase (IPMDH) variant V15I (P115), NAD+
3-isopropylmalate dehydrogenase (IPMDH)variant V15I (P115)	Thermus thermophilus	NAD+	—	0.82	—	pH 8, 70 °C	PMID 11297666	Open record: 3-isopropylmalate dehydrogenase (IPMDH) variant V15I (P115), NAD+
3-isopropylmalate dehydrogenase (SbIPMDH)	Shewanella benthica	(2R,3S)-3-isopropylmalatepressure 0.1 MPa	15	0.025	600	20 °C	PMID 19897891	Open record: 3-isopropylmalate dehydrogenase (SbIPMDH), (2R,3S)-3-isopropylmalate
3-isopropylmalate dehydrogenase (SbIPMDH)	Shewanella benthica	(2R,3S)-3-isopropylmalatepressure 50 MPa	17	0.043	400	20 °C	PMID 19897891	Open record: 3-isopropylmalate dehydrogenase (SbIPMDH), (2R,3S)-3-isopropylmalate
3-isopropylmalate dehydrogenase (SbIPMDH)	Shewanella benthica	(2R,3S)-3-isopropylmalatepressure 100 MPa	14	0.02	700	20 °C	PMID 19897891	Open record: 3-isopropylmalate dehydrogenase (SbIPMDH), (2R,3S)-3-isopropylmalate
3-isopropylmalate dehydrogenase (SbIPMDH)	Shewanella benthica	(2R,3S)-3-isopropylmalatepressure 150 MPa	14	0.032	440	20 °C	PMID 19897891	Open record: 3-isopropylmalate dehydrogenase (SbIPMDH), (2R,3S)-3-isopropylmalate
3-isopropylmalate dehydrogenase (SbIPMDH)	Shewanella benthica	(2R,3S)-3-isopropylmalatepressure 200 MPa	13	0.038	340	20 °C	PMID 19897891	Open record: 3-isopropylmalate dehydrogenase (SbIPMDH), (2R,3S)-3-isopropylmalate
3-isopropylmalate dehydrogenase (SbIPMDH)	Shewanella benthica	(2R,3S)-3-isopropylmalatepressure 250 MPa	10	0.108	93	20 °C	PMID 19897891	Open record: 3-isopropylmalate dehydrogenase (SbIPMDH), (2R,3S)-3-isopropylmalate
3-isopropylmalate dehydrogenase (SoIPMDH)	Shewanella oneidensis	(2R,3S)-3-isopropylmalatepressure 0.1 MPa	14	0.015	930	20 °C	PMID 19897891	Open record: 3-isopropylmalate dehydrogenase (SoIPMDH), (2R,3S)-3-isopropylmalate
3-isopropylmalate dehydrogenase (SoIPMDH)	Shewanella oneidensis	(2R,3S)-3-isopropylmalatepressure 50 MPa	15	0.027	560	20 °C	PMID 19897891	Open record: 3-isopropylmalate dehydrogenase (SoIPMDH), (2R,3S)-3-isopropylmalate
3-isopropylmalate dehydrogenase (SoIPMDH)	Shewanella oneidensis	(2R,3S)-3-isopropylmalatepressure 100 MPa	7.6	0.0087	870	20 °C	PMID 19897891	Open record: 3-isopropylmalate dehydrogenase (SoIPMDH), (2R,3S)-3-isopropylmalate
3-isopropylmalate dehydrogenase (SoIPMDH)	Shewanella oneidensis	(2R,3S)-3-isopropylmalatepressure 150 MPa	8.4	0.053	160	20 °C	PMID 19897891	Open record: 3-isopropylmalate dehydrogenase (SoIPMDH), (2R,3S)-3-isopropylmalate
3-isopropylmalate dehydrogenase (SoIPMDH)	Shewanella oneidensis	(2R,3S)-3-isopropylmalatepressure 200 MPa	5.8	0.055	110	20 °C	PMID 19897891	Open record: 3-isopropylmalate dehydrogenase (SoIPMDH), (2R,3S)-3-isopropylmalate
3-isopropylmalate dehydrogenase (SoIPMDH)	Shewanella oneidensis	(2R,3S)-3-isopropylmalatepressure 250 MPa	3.1	0.092	34	20 °C	PMID 19897891	Open record: 3-isopropylmalate dehydrogenase (SoIPMDH), (2R,3S)-3-isopropylmalate
3-isopropylmalate dehydrogenase (TtIPMDH)	Thermus thermophilus	3-isopropylmalate	5.7	0.0031	1.8 × 10³	pH 8, 37 °C	PMID 20735360	Open record: 3-isopropylmalate dehydrogenase (TtIPMDH), 3-isopropylmalate
3-isopropylmalate dehydrogenase (TtIPMDH)	Thermus thermophilus	3-isopropylmalate	21	—	—	pH 8, 60 °C	PMID 20735360	Open record: 3-isopropylmalate dehydrogenase (TtIPMDH), 3-isopropylmalate
3-isopropylmalate dehydrogenase (TtIPMDH)	Thermus thermophilus	D-3-isopropylmalate	—	0.0023	—	pH 8, 40 °C	PMID 31249343	Open record: 3-isopropylmalate dehydrogenase (TtIPMDH), D-3-isopropylmalate
3-isopropylmalate dehydrogenase (TtIPMDH)	Thermus thermophilus	D-3-isopropylmalate	—	0.0037	—	pH 8, 70 °C	PMID 31249343	Open record: 3-isopropylmalate dehydrogenase (TtIPMDH), D-3-isopropylmalate
3-isopropylmalate dehydrogenase (TtIPMDH)	Thermus thermophilus	NAD+	—	0.047	120	pH 8, 37 °C	PMID 20735360	Open record: 3-isopropylmalate dehydrogenase (TtIPMDH), NAD+
3-isopropylmalate dehydrogenase (TtIPMDH)	Thermus thermophilus	nicotinamide adenine dinucleotide (NAD+)	0.37	0.0022	170 calc.	pH 8, 25 °C	PMID 31249343	Open record: 3-isopropylmalate dehydrogenase (TtIPMDH), nicotinamide adenine dinucleotide (NAD+)
3-isopropylmalate dehydrogenase (TtIPMDH)	Thermus thermophilus	nicotinamide adenine dinucleotide (NAD+)	2.4	0.012	200 calc.	pH 8, 40 °C	PMID 31249343	Open record: 3-isopropylmalate dehydrogenase (TtIPMDH), nicotinamide adenine dinucleotide (NAD+)
3-isopropylmalate dehydrogenase (TtIPMDH)	Thermus thermophilus	nicotinamide adenine dinucleotide (NAD+)	79	0.21	380 calc.	pH 8, 70 °C	PMID 31249343	Open record: 3-isopropylmalate dehydrogenase (TtIPMDH), nicotinamide adenine dinucleotide (NAD+)
3-isopropylmalate dehydrogenase (TtIPMDH)variant A220T	Thermus thermophilus	nicotinamide adenine dinucleotide (NAD+)	0.7	0.0086	81 calc.	pH 8, 25 °C	PMID 31249343	Open record: 3-isopropylmalate dehydrogenase (TtIPMDH) variant A220T, nicotinamide adenine dinucleotide (NAD+)
3-isopropylmalate dehydrogenase (TtIPMDH)variant A220T/V272A/H273G	Thermus thermophilus	D-3-isopropylmalate	—	0.003	—	pH 8, 40 °C	PMID 31249343	Open record: 3-isopropylmalate dehydrogenase (TtIPMDH) variant A220T/V272A/H273G, D-3-isopropylmalate
3-isopropylmalate dehydrogenase (TtIPMDH)variant A220T/V272A/H273G	Thermus thermophilus	D-3-isopropylmalate	—	0.0036	—	pH 8, 70 °C	PMID 31249343	Open record: 3-isopropylmalate dehydrogenase (TtIPMDH) variant A220T/V272A/H273G, D-3-isopropylmalate
3-isopropylmalate dehydrogenase (TtIPMDH)variant A220T/V272A/H273G	Thermus thermophilus	nicotinamide adenine dinucleotide (NAD+)	4.3	0.1	43 calc.	pH 8, 25 °C	PMID 31249343	Open record: 3-isopropylmalate dehydrogenase (TtIPMDH) variant A220T/V272A/H273G, nicotinamide adenine dinucleotide (NAD+)
3-isopropylmalate dehydrogenase (TtIPMDH)variant A220T/V272A/H273G	Thermus thermophilus	nicotinamide adenine dinucleotide (NAD+)	16	0.22	73 calc.	pH 8, 40 °C	PMID 31249343	Open record: 3-isopropylmalate dehydrogenase (TtIPMDH) variant A220T/V272A/H273G, nicotinamide adenine dinucleotide (NAD+)
3-isopropylmalate dehydrogenase (TtIPMDH)variant A220T/V272A/H273G	Thermus thermophilus	nicotinamide adenine dinucleotide (NAD+)	100	1.6	62 calc.	pH 8, 70 °C	PMID 31249343	Open record: 3-isopropylmalate dehydrogenase (TtIPMDH) variant A220T/V272A/H273G, nicotinamide adenine dinucleotide (NAD+)
3-isopropylmalate dehydrogenase (TtIPMDH)variant I130C	Thermus thermophilus	nicotinamide adenine dinucleotide (NAD+)	0.66	0.016	41 calc.	pH 8, 25 °C	PMID 31249343	Open record: 3-isopropylmalate dehydrogenase (TtIPMDH) variant I130C, nicotinamide adenine dinucleotide (NAD+)
3-isopropylmalate dehydrogenase (TtIPMDH)variant I130C/V272A/H273G	Thermus thermophilus	D-3-isopropylmalate	—	0.0017	—	pH 8, 40 °C	PMID 31249343	Open record: 3-isopropylmalate dehydrogenase (TtIPMDH) variant I130C/V272A/H273G, D-3-isopropylmalate
3-isopropylmalate dehydrogenase (TtIPMDH)variant I130C/V272A/H273G	Thermus thermophilus	D-3-isopropylmalate	—	0.0033	—	pH 8, 70 °C	PMID 31249343	Open record: 3-isopropylmalate dehydrogenase (TtIPMDH) variant I130C/V272A/H273G, D-3-isopropylmalate
3-isopropylmalate dehydrogenase (TtIPMDH)variant I130C/V272A/H273G	Thermus thermophilus	nicotinamide adenine dinucleotide (NAD+)	4.2	0.051	82 calc.	pH 8, 25 °C	PMID 31249343	Open record: 3-isopropylmalate dehydrogenase (TtIPMDH) variant I130C/V272A/H273G, nicotinamide adenine dinucleotide (NAD+)
3-isopropylmalate dehydrogenase (TtIPMDH)variant I130C/V272A/H273G	Thermus thermophilus	nicotinamide adenine dinucleotide (NAD+)	15	0.11	140 calc.	pH 8, 40 °C	PMID 31249343	Open record: 3-isopropylmalate dehydrogenase (TtIPMDH) variant I130C/V272A/H273G, nicotinamide adenine dinucleotide (NAD+)
3-isopropylmalate dehydrogenase (TtIPMDH)variant I130C/V272A/H273G	Thermus thermophilus	nicotinamide adenine dinucleotide (NAD+)	80	1.2	67 calc.	pH 8, 70 °C	PMID 31249343	Open record: 3-isopropylmalate dehydrogenase (TtIPMDH) variant I130C/V272A/H273G, nicotinamide adenine dinucleotide (NAD+)
3-isopropylmalate dehydrogenase (TtIPMDH)variant V272A/H273G	Thermus thermophilus	nicotinamide adenine dinucleotide (NAD+)	3.5	0.027	130 calc.	pH 8, 25 °C	PMID 31249343	Open record: 3-isopropylmalate dehydrogenase (TtIPMDH) variant V272A/H273G, nicotinamide adenine dinucleotide (NAD+)
3-isopropylmalate dehydrogenase (TtIPMDH)variant mut#11	Thermus thermophilus	nicotinamide adenine dinucleotide (NAD+)	2.9	0.074	39 calc.	pH 8, 25 °C	PMID 31249343	Open record: 3-isopropylmalate dehydrogenase (TtIPMDH) variant mut#11, nicotinamide adenine dinucleotide (NAD+)
3-isopropylmalate dehydrogenase (TtIPMDH)variant mut#15	Thermus thermophilus	nicotinamide adenine dinucleotide (NAD+)	0.55	0.15	3.7 calc.	pH 8, 25 °C	PMID 31249343	Open record: 3-isopropylmalate dehydrogenase (TtIPMDH) variant mut#15, nicotinamide adenine dinucleotide (NAD+)
3-isopropylmalate dehydrogenase (TtIPMDH)variant mut#18	Thermus thermophilus	nicotinamide adenine dinucleotide (NAD+)	0.36	0.007	51 calc.	pH 8, 25 °C	PMID 31249343	Open record: 3-isopropylmalate dehydrogenase (TtIPMDH) variant mut#18, nicotinamide adenine dinucleotide (NAD+)
3-isopropylmalate dehydrogenase (TtIPMDH)variant mut#20	Thermus thermophilus	nicotinamide adenine dinucleotide (NAD+)	0.66	0.092	7.2 calc.	pH 8, 25 °C	PMID 31249343	Open record: 3-isopropylmalate dehydrogenase (TtIPMDH) variant mut#20, nicotinamide adenine dinucleotide (NAD+)
3-isopropylmalate dehydrogenase (TtIPMDH)variant mut#28	Thermus thermophilus	nicotinamide adenine dinucleotide (NAD+)	3.3	0.56	5.9 calc.	pH 8, 25 °C	PMID 31249343	Open record: 3-isopropylmalate dehydrogenase (TtIPMDH) variant mut#28, nicotinamide adenine dinucleotide (NAD+)
3-isopropylmalate dehydrogenase (TtIPMDH)variant mut#3	Thermus thermophilus	nicotinamide adenine dinucleotide (NAD+)	1.1	0.019	58 calc.	pH 8, 25 °C	PMID 31249343	Open record: 3-isopropylmalate dehydrogenase (TtIPMDH) variant mut#3, nicotinamide adenine dinucleotide (NAD+)
3-isopropylmalate dehydrogenase (TtIPMDH)variant mut#5	Thermus thermophilus	nicotinamide adenine dinucleotide (NAD+)	1.3	0.2	6.5 calc.	pH 8, 25 °C	PMID 31249343	Open record: 3-isopropylmalate dehydrogenase (TtIPMDH) variant mut#5, nicotinamide adenine dinucleotide (NAD+)
3-isopropylmalate dehydrogenase ancIPMDH-IQ	—	D-3-isopropylmalate	—	0.0053	—	pH 8, 40 °C	PMID 32968141	Open record: 3-isopropylmalate dehydrogenase ancIPMDH-IQ, D-3-isopropylmalate
3-isopropylmalate dehydrogenase ancIPMDH-IQ	—	D-3-isopropylmalate	—	0.01	—	pH 8, 70 °C	PMID 32968141	Open record: 3-isopropylmalate dehydrogenase ancIPMDH-IQ, D-3-isopropylmalate
3-isopropylmalate dehydrogenase ancIPMDH-IQ	—	nicotinamide adenine dinucleotide (oxidized)	1.7	0.045	38 calc.	pH 8, 25 °C	PMID 32968141	Open record: 3-isopropylmalate dehydrogenase ancIPMDH-IQ, nicotinamide adenine dinucleotide (oxidized)
3-isopropylmalate dehydrogenase ancIPMDH-IQ	—	nicotinamide adenine dinucleotide (oxidized)	4.6	0.067	69 calc.	pH 8, 40 °C	PMID 32968141	Open record: 3-isopropylmalate dehydrogenase ancIPMDH-IQ, nicotinamide adenine dinucleotide (oxidized)
3-isopropylmalate dehydrogenase ancIPMDH-IQ	—	nicotinamide adenine dinucleotide (oxidized)	22	0.96	23 calc.	pH 8, 70 °C	PMID 32968141	Open record: 3-isopropylmalate dehydrogenase ancIPMDH-IQ, nicotinamide adenine dinucleotide (oxidized)
3-isopropylmalate dehydrogenase ancIPMDH-IQvariant V277A/H278G	—	D-3-isopropylmalate	—	0.005	—	pH 8, 40 °C	PMID 32968141	Open record: 3-isopropylmalate dehydrogenase ancIPMDH-IQ variant V277A/H278G, D-3-isopropylmalate
3-isopropylmalate dehydrogenase ancIPMDH-IQvariant V277A/H278G	—	D-3-isopropylmalate	—	0.013	—	pH 8, 70 °C	PMID 32968141	Open record: 3-isopropylmalate dehydrogenase ancIPMDH-IQ variant V277A/H278G, D-3-isopropylmalate
3-isopropylmalate dehydrogenase ancIPMDH-IQvariant V277A/H278G	—	nicotinamide adenine dinucleotide (oxidized)	2	0.077	26 calc.	pH 8, 25 °C	PMID 32968141	Open record: 3-isopropylmalate dehydrogenase ancIPMDH-IQ variant V277A/H278G, nicotinamide adenine dinucleotide (oxidized)
3-isopropylmalate dehydrogenase ancIPMDH-IQvariant V277A/H278G	—	nicotinamide adenine dinucleotide (oxidized)	8.5	0.23	37 calc.	pH 8, 40 °C	PMID 32968141	Open record: 3-isopropylmalate dehydrogenase ancIPMDH-IQ variant V277A/H278G, nicotinamide adenine dinucleotide (oxidized)
3-isopropylmalate dehydrogenase ancIPMDH-IQvariant V277A/H278G	—	nicotinamide adenine dinucleotide (oxidized)	34	4.1	8.3 calc.	pH 8, 70 °C	PMID 32968141	Open record: 3-isopropylmalate dehydrogenase ancIPMDH-IQ variant V277A/H278G, nicotinamide adenine dinucleotide (oxidized)
3-isopropylmalate dehydrogenase ancIPMDH-ML	—	D-3-isopropylmalate	—	0.0047	—	pH 8, 40 °C	PMID 32968141	Open record: 3-isopropylmalate dehydrogenase ancIPMDH-ML, D-3-isopropylmalate
3-isopropylmalate dehydrogenase ancIPMDH-ML	—	D-3-isopropylmalate	—	0.01	—	pH 8, 70 °C	PMID 32968141	Open record: 3-isopropylmalate dehydrogenase ancIPMDH-ML, D-3-isopropylmalate
3-isopropylmalate dehydrogenase ancIPMDH-ML	—	nicotinamide adenine dinucleotide (oxidized)	1.2	0.037	32 calc.	pH 8, 25 °C	PMID 32968141	Open record: 3-isopropylmalate dehydrogenase ancIPMDH-ML, nicotinamide adenine dinucleotide (oxidized)
3-isopropylmalate dehydrogenase ancIPMDH-ML	—	nicotinamide adenine dinucleotide (oxidized)	4.3	0.054	80 calc.	pH 8, 40 °C	PMID 32968141	Open record: 3-isopropylmalate dehydrogenase ancIPMDH-ML, nicotinamide adenine dinucleotide (oxidized)
3-isopropylmalate dehydrogenase ancIPMDH-ML	—	nicotinamide adenine dinucleotide (oxidized)	22	0.73	30 calc.	pH 8, 70 °C	PMID 32968141	Open record: 3-isopropylmalate dehydrogenase ancIPMDH-ML, nicotinamide adenine dinucleotide (oxidized)
3-isopropylmalate dehydrogenase ancIPMDH-MLvariant V277A/H278G	—	D-3-isopropylmalate	—	0.005	—	pH 8, 40 °C	PMID 32968141	Open record: 3-isopropylmalate dehydrogenase ancIPMDH-ML variant V277A/H278G, D-3-isopropylmalate
3-isopropylmalate dehydrogenase ancIPMDH-MLvariant V277A/H278G	—	D-3-isopropylmalate	—	0.011	—	pH 8, 70 °C	PMID 32968141	Open record: 3-isopropylmalate dehydrogenase ancIPMDH-ML variant V277A/H278G, D-3-isopropylmalate
3-isopropylmalate dehydrogenase ancIPMDH-MLvariant V277A/H278G	—	nicotinamide adenine dinucleotide (oxidized)	1.6	0.033	48 calc.	pH 8, 25 °C	PMID 32968141	Open record: 3-isopropylmalate dehydrogenase ancIPMDH-ML variant V277A/H278G, nicotinamide adenine dinucleotide (oxidized)
3-isopropylmalate dehydrogenase ancIPMDH-MLvariant V277A/H278G	—	nicotinamide adenine dinucleotide (oxidized)	5	0.24	21 calc.	pH 8, 40 °C	PMID 32968141	Open record: 3-isopropylmalate dehydrogenase ancIPMDH-ML variant V277A/H278G, nicotinamide adenine dinucleotide (oxidized)
3-isopropylmalate dehydrogenase ancIPMDH-MLvariant V277A/H278G	—	nicotinamide adenine dinucleotide (oxidized)	24	3.3	7.3 calc.	pH 8, 70 °C	PMID 32968141	Open record: 3-isopropylmalate dehydrogenase ancIPMDH-ML variant V277A/H278G, nicotinamide adenine dinucleotide (oxidized)
AtIPMDH1	Arabidopsis thaliana	3-(2'-methylthio)ethylmalate	0.85	0.0453	18.76		PMID 21697089	Open record: AtIPMDH1, 3-(2'-methylthio)ethylmalate
AtIPMDH1	Arabidopsis thaliana	3-isopropylmalate	0.62	0.0252	24.47		PMID 21697089	Open record: AtIPMDH1, 3-isopropylmalate
AtIPMDH1variant F137L	Arabidopsis thaliana	3-(2'-methylthio)ethylmalate	0.033	0.323	0.103		PMID 21697089	Open record: AtIPMDH1 variant F137L, 3-(2'-methylthio)ethylmalate
AtIPMDH1variant F137L	Arabidopsis thaliana	3-isopropylmalate	3.83	0.0114	336.3		PMID 21697089	Open record: AtIPMDH1 variant F137L, 3-isopropylmalate
AtIPMDH2	Arabidopsis thaliana	3-(2'-methylthio)ethylmalate	0.017	0.435	0.0383		PMID 21697089	Open record: AtIPMDH2, 3-(2'-methylthio)ethylmalate
AtIPMDH2	Arabidopsis thaliana	3-isopropylmalate	6.22	0.0109	570.3		PMID 21697089	Open record: AtIPMDH2, 3-isopropylmalate
AtIPMDH2variant L133F	Arabidopsis thaliana	3-(2'-methylthio)ethylmalate	0.37	0.077	4.761		PMID 21697089	Open record: AtIPMDH2 variant L133F, 3-(2'-methylthio)ethylmalate
AtIPMDH2variant L133F	Arabidopsis thaliana	3-isopropylmalate	0.62	0.0303	20.35		PMID 21697089	Open record: AtIPMDH2 variant L133F, 3-isopropylmalate
AtIPMDH3	Arabidopsis thaliana	3-(2'-methylthio)ethylmalate	0.017	0.502	0.0332		PMID 21697089	Open record: AtIPMDH3, 3-(2'-methylthio)ethylmalate
AtIPMDH3	Arabidopsis thaliana	3-isopropylmalate	9.05	0.0092	983.7		PMID 21697089	Open record: AtIPMDH3, 3-isopropylmalate
AtIPMDH3variant L134F	Arabidopsis thaliana	3-(2'-methylthio)ethylmalate	0.27	0.103	2.589		PMID 21697089	Open record: AtIPMDH3 variant L134F, 3-(2'-methylthio)ethylmalate
AtIPMDH3variant L134F	Arabidopsis thaliana	3-isopropylmalate	0.73	0.0285	25.73		PMID 21697089	Open record: AtIPMDH3 variant L134F, 3-isopropylmalate
isopropylmalate dehydrogenase (IMDH)	Thermus thermophilus	(2R)-2-hydroxybutanedioatecosubstrate NAD	10.59	1.51	7.01 calc.	pH 7.3, 21 °C	PMID 8535253	Open record: isopropylmalate dehydrogenase (IMDH), (2R)-2-hydroxybutanedioate
isopropylmalate dehydrogenase (IMDH)	Thermus thermophilus	(2R)-2-hydroxybutanedioatecosubstrate NADP	4.69	31.57	0.149 calc.	pH 7.3, 21 °C	PMID 8535253	Open record: isopropylmalate dehydrogenase (IMDH), (2R)-2-hydroxybutanedioate
isopropylmalate dehydrogenase (IMDH)	Thermus thermophilus	(2R,3S)-2,3-dihydroxybutanedioate (meso-tartrate)cosubstrate NAD	0.19	0.0407	4.7 calc.	pH 7.3, 21 °C	PMID 8535253	Open record: isopropylmalate dehydrogenase (IMDH), (2R,3S)-2,3-dihydroxybutanedioate (meso-tartrate)
isopropylmalate dehydrogenase (IMDH)	Thermus thermophilus	(2R,3S)-2,3-dihydroxybutanedioate (meso-tartrate)cosubstrate NADP	0.1	0.817	0.12 calc.	pH 7.3, 21 °C	PMID 8535253	Open record: isopropylmalate dehydrogenase (IMDH), (2R,3S)-2,3-dihydroxybutanedioate (meso-tartrate)
isopropylmalate dehydrogenase (IMDH)	Thermus thermophilus	(2R,3S)-2-hydroxy-3-(propan-2-yl)butanedioatecosubstrate NAD; Table 1	0.24	1.7 × 10⁻⁵	1.4 × 10⁴ calc.	pH 7.3, 21 °C	PMID 8535253	Open record: isopropylmalate dehydrogenase (IMDH), (2R,3S)-2-hydroxy-3-(propan-2-yl)butanedioate
isopropylmalate dehydrogenase (IMDH)	Thermus thermophilus	(2R,3S)-2-hydroxy-3-(propan-2-yl)butanedioatecosubstrate NADP; Table 1	1.66	0.00298	557 calc.	pH 7.3, 21 °C	PMID 8535253	Open record: isopropylmalate dehydrogenase (IMDH), (2R,3S)-2-hydroxy-3-(propan-2-yl)butanedioate
isopropylmalate dehydrogenase (IMDH)	Thermus thermophilus	(2R,3S)-2-hydroxy-3-(propan-2-yl)butanedioatecosubstrate NAD; in the text	—	—	1.4 × 10⁴	pH 7.3, 21 °C	PMID 8535253	Open record: isopropylmalate dehydrogenase (IMDH), (2R,3S)-2-hydroxy-3-(propan-2-yl)butanedioate
isopropylmalate dehydrogenase (IMDH)	Thermus thermophilus	NAD+cosubstrate 2R,3S-isopropylmalate	—	0.00321	—	pH 7.3, 21 °C	PMID 8535253	Open record: isopropylmalate dehydrogenase (IMDH), NAD+
isopropylmalate dehydrogenase (IMDH)	Thermus thermophilus	NAD+cosubstrate 2R,3S-tartrate	—	0.0454	—	pH 7.3, 21 °C	PMID 8535253	Open record: isopropylmalate dehydrogenase (IMDH), NAD+
isopropylmalate dehydrogenase (IMDH)	Thermus thermophilus	NAD+cosubstrate 2R-malate	—	0.1065	—	pH 7.3, 21 °C	PMID 8535253	Open record: isopropylmalate dehydrogenase (IMDH), NAD+
isopropylmalate dehydrogenase (IMDH)	Thermus thermophilus	NADP+cosubstrate 2R,3S-isopropylmalate	—	1.836	—	pH 7.3, 21 °C	PMID 8535253	Open record: isopropylmalate dehydrogenase (IMDH), NADP+
isopropylmalate dehydrogenase (IMDH)	Thermus thermophilus	NADP+cosubstrate 2R,3S-tartrate	—	1.573	—	pH 7.3, 21 °C	PMID 8535253	Open record: isopropylmalate dehydrogenase (IMDH), NADP+
isopropylmalate dehydrogenase (IMDH)	Thermus thermophilus	NADP+cosubstrate 2R-malate	—	6.579	—	pH 7.3, 21 °C	PMID 8535253	Open record: isopropylmalate dehydrogenase (IMDH), NADP+
isopropylmalate dehydrogenase (IMDH)variant E87G	Thermus thermophilus	(2R)-2-hydroxybutanedioate	0.26	35.59	0.0073 calc.	pH 7.3, 21 °C	PMID 8535253	Open record: isopropylmalate dehydrogenase (IMDH) variant E87G, (2R)-2-hydroxybutanedioate
isopropylmalate dehydrogenase (IMDH)variant E87G	Thermus thermophilus	(2R,3S)-2,3-dihydroxybutanedioate (meso-tartrate)	0.21	1.21	0.17 calc.	pH 7.3, 21 °C	PMID 8535253	Open record: isopropylmalate dehydrogenase (IMDH) variant E87G, (2R,3S)-2,3-dihydroxybutanedioate (meso-tartrate)
isopropylmalate dehydrogenase (IMDH)variant E87G	Thermus thermophilus	(2R,3S)-2-hydroxy-3-(propan-2-yl)butanedioate	0.2	4.8 × 10⁻⁴	420 calc.	pH 7.3, 21 °C	PMID 8535253	Open record: isopropylmalate dehydrogenase (IMDH) variant E87G, (2R,3S)-2-hydroxy-3-(propan-2-yl)butanedioate
isopropylmalate dehydrogenase (IMDH)variant E87G	Thermus thermophilus	NAD+cosubstrate 2R,3S-isopropylmalate	—	0.131	—	pH 7.3, 21 °C	PMID 8535253	Open record: isopropylmalate dehydrogenase (IMDH) variant E87G, NAD+
isopropylmalate dehydrogenase (IMDH)variant E87G	Thermus thermophilus	NAD+cosubstrate 2R,3S-tartrate	—	0.386	—	pH 7.3, 21 °C	PMID 8535253	Open record: isopropylmalate dehydrogenase (IMDH) variant E87G, NAD+
isopropylmalate dehydrogenase (IMDH)variant E87G	Thermus thermophilus	NAD+cosubstrate 2R-malate	—	2.584	—	pH 7.3, 21 °C	PMID 8535253	Open record: isopropylmalate dehydrogenase (IMDH) variant E87G, NAD+
isopropylmalate dehydrogenase (IMDH)variant E87Q	Thermus thermophilus	(2R)-2-hydroxybutanedioateTable 1	0.19	32.6	0.0058 calc.	pH 7.3, 21 °C	PMID 8535253	Open record: isopropylmalate dehydrogenase (IMDH) variant E87Q, (2R)-2-hydroxybutanedioate
isopropylmalate dehydrogenase (IMDH)variant E87Q	Thermus thermophilus	(2R)-2-hydroxybutanedioatein the text	—	—	0.006	pH 7.3, 21 °C	PMID 8535253	Open record: isopropylmalate dehydrogenase (IMDH) variant E87Q, (2R)-2-hydroxybutanedioate
isopropylmalate dehydrogenase (IMDH)variant E87Q	Thermus thermophilus	(2R,3S)-2,3-dihydroxybutanedioate (meso-tartrate)	0.26	0.761	0.34 calc.	pH 7.3, 21 °C	PMID 8535253	Open record: isopropylmalate dehydrogenase (IMDH) variant E87Q, (2R,3S)-2,3-dihydroxybutanedioate (meso-tartrate)
isopropylmalate dehydrogenase (IMDH)variant E87Q	Thermus thermophilus	(2R,3S)-2-hydroxy-3-(propan-2-yl)butanedioate	0.21	0.0053	40 calc.	pH 7.3, 21 °C	PMID 8535253	Open record: isopropylmalate dehydrogenase (IMDH) variant E87Q, (2R,3S)-2-hydroxy-3-(propan-2-yl)butanedioate
isopropylmalate dehydrogenase (IMDH)variant E87Q	Thermus thermophilus	NAD+cosubstrate 2R,3S-isopropylmalate	—	0.778	—	pH 7.3, 21 °C	PMID 8535253	Open record: isopropylmalate dehydrogenase (IMDH) variant E87Q, NAD+
isopropylmalate dehydrogenase (IMDH)variant E87Q	Thermus thermophilus	NAD+cosubstrate 2R,3S-tartrate	—	0.181	—	pH 7.3, 21 °C	PMID 8535253	Open record: isopropylmalate dehydrogenase (IMDH) variant E87Q, NAD+
isopropylmalate dehydrogenase (IMDH)variant E87Q	Thermus thermophilus	NAD+cosubstrate 2R-malate	—	1.853	—	pH 7.3, 21 °C	PMID 8535253	Open record: isopropylmalate dehydrogenase (IMDH) variant E87Q, NAD+
isopropylmalate dehydrogenase (IPMDH)	Sulfolobus sp.	D-3-ethylmalate	3.1	0.0011	2.7 × 10³	pH 8, 70 °C	PMID 9023199	Open record: isopropylmalate dehydrogenase (IPMDH), D-3-ethylmalate
isopropylmalate dehydrogenase (IPMDH)	Sulfolobus sp.	D-3-isobutylmalate	3.1	0.0015	2 × 10³	pH 8, 70 °C	PMID 9023199	Open record: isopropylmalate dehydrogenase (IPMDH), D-3-isobutylmalate
isopropylmalate dehydrogenase (IPMDH)	Sulfolobus sp.	D-3-isopentylmalate	2.7	0.0058	460	pH 8, 70 °C	PMID 9023199	Open record: isopropylmalate dehydrogenase (IPMDH), D-3-isopentylmalate
isopropylmalate dehydrogenase (IPMDH)	Sulfolobus sp.	D-3-isopropylmalate	3.6	0.0012	3 × 10³	pH 8, 70 °C	PMID 9023199	Open record: isopropylmalate dehydrogenase (IPMDH), D-3-isopropylmalate
isopropylmalate dehydrogenase (IPMDH)	Sulfolobus sp.	D-3-methylmalate	3.5	0.0037	940	pH 8, 70 °C	PMID 9023199	Open record: isopropylmalate dehydrogenase (IPMDH), D-3-methylmalate
isopropylmalate dehydrogenase (IPMDH)	Sulfolobus sp.	D-3-tert-butylmalate	0.96	0.0023	420	pH 8, 70 °C	PMID 9023199	Open record: isopropylmalate dehydrogenase (IPMDH), D-3-tert-butylmalate
isopropylmalate dehydrogenase (IPMDH)	Sulfolobus sp.	D-malate	4	0.39	10	pH 8, 70 °C	PMID 9023199	Open record: isopropylmalate dehydrogenase (IPMDH), D-malate
isopropylmalate dehydrogenase (IPMDH)	Sulfolobus sp.	NAD	—	0.15	—	pH 8	PMID 9023199	Open record: isopropylmalate dehydrogenase (IPMDH), NAD
isopropylmalate dehydrogenase (IPMDH)	Sulfolobus sp.	NADP	—	3.9	—	pH 8	PMID 9023199	Open record: isopropylmalate dehydrogenase (IPMDH), NADP
isopropylmalate dehydrogenase (IPMDHMj, MJ0720)	Methanocaldococcus jannaschii	(R)-malate	—	0.41	14	pH 8.5, 60 °C	PMID 17449626	Open record: isopropylmalate dehydrogenase (IPMDHMj, MJ0720), (R)-malate
isopropylmalate dehydrogenase (IPMDHMj, MJ0720)	Methanocaldococcus jannaschii	DL-threo-3-isopropylmalate (racemic; physiological isomer (2R,3S)-3-isopropylmalate)	—	0.024	88	pH 8.5, 60 °C	PMID 17449626	Open record: isopropylmalate dehydrogenase (IPMDHMj, MJ0720), DL-threo-3-isopropylmalate (racemic; physiological isomer (2R,3S)-3-isopropylmalate)
isopropylmalate dehydrogenase 2 (AtIPMDH2)	Arabidopsis thaliana	3-isopropyl-L-malate	4.57	0.0035	1303	pH 7.5, 25 °C	PMID 27137927	Open record: isopropylmalate dehydrogenase 2 (AtIPMDH2), 3-isopropyl-L-malate
isopropylmalate dehydrogenase 2 (AtIPMDH2)variant D292N	Arabidopsis thaliana	3-isopropyl-L-malate	0.0033	0.0278	0.109	pH 7.5, 25 °C	PMID 27137927	Open record: isopropylmalate dehydrogenase 2 (AtIPMDH2) variant D292N, 3-isopropyl-L-malate
isopropylmalate dehydrogenase 2 (AtIPMDH2)variant L132A	Arabidopsis thaliana	3-isopropyl-L-malate	0.467	0.0242	19.29	pH 7.5, 25 °C	PMID 27137927	Open record: isopropylmalate dehydrogenase 2 (AtIPMDH2) variant L132A, 3-isopropyl-L-malate
isopropylmalate dehydrogenase 2 (AtIPMDH2)variant L133A	Arabidopsis thaliana	3-isopropyl-L-malate	3.1	0.125	24.83	pH 7.5, 25 °C	PMID 27137927	Open record: isopropylmalate dehydrogenase 2 (AtIPMDH2) variant L133A, 3-isopropyl-L-malate
isopropylmalate dehydrogenase 2 (AtIPMDH2)variant R136K	Arabidopsis thaliana	3-isopropyl-L-malate	0.033	3.73	0.009	pH 7.5, 25 °C	PMID 27137927	Open record: isopropylmalate dehydrogenase 2 (AtIPMDH2) variant R136K, 3-isopropyl-L-malate
isopropylmalate dehydrogenase 2 (AtIPMDH2)variant R146A	Arabidopsis thaliana	3-isopropyl-L-malate	0.03	0.0707	0.429	pH 7.5, 25 °C	PMID 27137927	Open record: isopropylmalate dehydrogenase 2 (AtIPMDH2) variant R146A, 3-isopropyl-L-malate
isopropylmalate dehydrogenase 2 (AtIPMDH2)variant R146K	Arabidopsis thaliana	3-isopropyl-L-malate	0.023	0.119	0.192	pH 7.5, 25 °C	PMID 27137927	Open record: isopropylmalate dehydrogenase 2 (AtIPMDH2) variant R146K, 3-isopropyl-L-malate
isopropylmalate dehydrogenase 2 (AtIPMDH2)variant R174K	Arabidopsis thaliana	3-isopropyl-L-malate	1.62	0.753	2.14	pH 7.5, 25 °C	PMID 27137927	Open record: isopropylmalate dehydrogenase 2 (AtIPMDH2) variant R174K, 3-isopropyl-L-malate
isopropylmalate dehydrogenase 2 (AtIPMDH2)variant V235A	Arabidopsis thaliana	3-isopropyl-L-malate	2	0.0114	180.3	pH 7.5, 25 °C	PMID 27137927	Open record: isopropylmalate dehydrogenase 2 (AtIPMDH2) variant V235A, 3-isopropyl-L-malate
isopropylmalate dehydrogenase 2 (AtIPMDH2)variant Y181A	Arabidopsis thaliana	3-isopropyl-L-malate	0.017	0.0083	1.92	pH 7.5, 25 °C	PMID 27137927	Open record: isopropylmalate dehydrogenase 2 (AtIPMDH2) variant Y181A, 3-isopropyl-L-malate
isopropylmalate dehydrogenase 2 (AtIPMDH2)variant Y181F	Arabidopsis thaliana	3-isopropyl-L-malate	0.23	0.0074	32.32	pH 7.5, 25 °C	PMID 27137927	Open record: isopropylmalate dehydrogenase 2 (AtIPMDH2) variant Y181F, 3-isopropyl-L-malate
isopropylmalate dehydrogenase 2 (AtIPMDH2)variant Y181H	Arabidopsis thaliana	3-isopropyl-L-malate	0.58	0.0063	91.21	pH 7.5, 25 °C	PMID 27137927	Open record: isopropylmalate dehydrogenase 2 (AtIPMDH2) variant Y181H, 3-isopropyl-L-malate
Saci_0600 (3-isopropylmalate dehydrogenase, SaIPMDH)	Sulfolobus acidocaldarius	3-isopropylmalate	8.5	0.005	1.7 × 10³	pH 8, 60 °C	PMID 27590116	Open record: Saci_0600 (3-isopropylmalate dehydrogenase, SaIPMDH), 3-isopropylmalate
Saci_0600 (3-isopropylmalate dehydrogenase, SaIPMDH)	Sulfolobus acidocaldarius	homoisocitrate	0.26	5.9	0.044	pH 8, 60 °C	PMID 27590116	Open record: Saci_0600 (3-isopropylmalate dehydrogenase, SaIPMDH), homoisocitrate
Saci_0600 (3-isopropylmalate dehydrogenase, SaIPMDH)	Sulfolobus acidocaldarius	NAD+	—	0.12	—	pH 8, 60 °C	PMID 27590116	Open record: Saci_0600 (3-isopropylmalate dehydrogenase, SaIPMDH), NAD+